List of works - Arlene Sharpe

A new therapeutic strategy for malaria: targeting T cell exhaustion

scientific article published on 19 January 2012

Antigen-specific CD4 T-cell help rescues exhausted CD8 T cells during chronic viral infection.

scientific article published on 12 December 2011

Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity

scientific article

B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation

scientific article published on 01 March 1997

Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens

scientific article

Coinhibitory Pathways in Immunotherapy for Cancer

scientific article published on 25 February 2016

Coinhibitory Pathways in the B7-CD28 Ligand-Receptor Family

scientific article published on May 2016

Constitutive neuronal expression of the immune regulator, programmed death 1 (PD-1), identified during experimental autoimmune uveitis

scientific article published in January 2009

DEC-205-mediated antigen targeting to steady-state dendritic cells induces deletion of diabetogenic CD8⁺ T cells independently of PD-1 and PD-L1

scientific article published on 10 September 2013

Defective TFH Cell Function and Increased TFR Cells Contribute to Defective Antibody Production in Aging

scientific article published on 2 July 2015

Defining 'T cell exhaustion'

scientific article published on 30 September 2019

Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy

scientific article published on 02 August 2016

Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity.

scientific article

Endothelial Programmed Death-1 Ligand 1 (PD-L1) Regulates CD8 + T-Cell–Mediated Injury in the Heart

scientific article published on 15 October 2007

Endothelial expression of PD‐L1 and PD‐L2 down‐regulates CD8+ T cell activation and cytolysis ⬇️

scientific article published on 01 November 2003

Enhancing therapeutic vaccination by blocking PD-1-mediated inhibitory signals during chronic infection

scientific article

Fibroblastic reticular cells enhance T cell metabolism and survival via epigenetic remodeling

scientific article published on 21 October 2019

Follicular regulatory T cells control humoral and allergic immunity by restraining early B cell responses

scientific article published on 02 September 2019

FoxP3 and Ezh2 regulate Tfr cell suppressive function and transcriptional program

scientific article published on 31 January 2019

Glioblastoma Eradication Following Immune Checkpoint Blockade in an Orthotopic, Immunocompetent Model

scientific article published on 6 November 2015

Hepatic immune regulation by stromal cells.

scientific article

Host programmed death ligand 1 is dominant over programmed death ligand 2 expression in regulating graft-versus-host disease lethality

scientific article published on 12 September 2013

ICOS is critical for CD40-mediated antibody class switching

scientific journal article

ICOS/ICOSL interaction is required for CD4+ invariant NKT cell function and homeostatic survival

scientific article

ICOS:ICOS-ligand interaction is required for type 2 innate lymphoid cell function, homeostasis, and induction of airway hyperreactivity.

scientific article

IL-10 and PD-L1 operate through distinct pathways to suppress T-cell activity during persistent viral infection

scholarly article

IMMU-28. DEFINING MOLECULAR MECHANISMS OF RESISTANCE TO GLIOBLASTOMA (GBM) IMMUNITY USING A NOVEL CRISPR/CAS9 IN VIVO LOSS-OF-FUNCTION SCREENING PLATFORM

Immuno-PET identifies the myeloid compartment as a key contributor to the outcome of the antitumor response under PD-1 blockade

scientific article published on 02 August 2019

Immunotherapy of chronic hepatitis C virus infection with antibodies against programmed cell death-1 (PD-1).

scientific article published on 26 August 2013

Impairment of the programmed cell death-1 pathway increases atherosclerotic lesion development and inflammation

scientific article

Inclusion of CD80 in HSV targets the recombinant virus to PD-L1 on DCs and allows productive infection and robust immune responses

scientific article published on 27 January 2014

Interaction of human PD-L1 and B7-1.

scientific article

Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection

scientific article

Interplay of somatic alterations and immune infiltration modulates response to PD-1 blockade in advanced clear cell renal cell carcinoma

scientific article published on 29 May 2020

Intestinal tolerance is converted to autoimmune enteritis upon PD-1 ligand blockade

scientific article published on February 2009

Introduction to checkpoint inhibitors and cancer immunotherapy.

scientific article

LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint Blockade

scientific article published on 21 June 2018

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4 ⬇️

scientific article (publication date: November 1995)

Ox40L-Ox40 pathway plays distinct roles in regulating Th2 responses but does not determine outcome of cutaneous leishmaniasis caused by Leishmania mexicana and Leishmania major

scientific article published on 11 November 2014

PD-1 and its ligands in tolerance and immunity

scientific article (publication date: 2008)

PD-1 pathway regulates ILC2 metabolism and PD-1 agonist treatment ameliorates airway hyperreactivity

scientific article published on 10 August 2020

PD-1 regulates self-reactive CD8+ T cell responses to antigen in lymph nodes and tissues

scientific article

PD-1 restraint of regulatory T cell suppressive activity is critical for immune tolerance

scientific article published on 01 January 2021

PD-L1 Antibodies to Its Cytoplasmic Domain Most Clearly Delineate Cell Membranes in Immunohistochemical Staining of Tumor Cells

scientific article

PD-L1 and PD-L2 have distinct roles in regulating host immunity to cutaneous leishmaniasis

scientific article published on 01 January 2006

PD-L1 on tumor cells is sufficient for immune evasion in immunogenic tumors and inhibits CD8 T cell cytotoxicity.

scientific article published on 16 March 2017

PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

scientific article published on 14 December 2009

PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells

scholarly article

PTPN2 regulates the generation of exhausted CD8+ T cell subpopulations and restrains tumor immunity

scientific article published on 16 September 2019

Programmed death ligand 2 - A link between inflammation and bone loss in rheumatoid arthritis

scientific article published on 18 December 2019

Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality

scientific article published on 13 June 2016

Programmed death-1 (PD-1):PD-ligand 1 interactions inhibit TCR-mediated positive selection of thymocytes

scientific article

Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses

scientific article

Protect the killer: CTLs need defenses against the tumor

scientific article published on 01 August 2002

RGMb is a novel binding partner for PD-L2 and its engagement with PD-L2 promotes respiratory tolerance

scientific article

Rap1-GTP is a negative regulator of Th cell function and promotes the generation of CD4+CD103+ regulatory T cells in vivo

scientific article published on 01 September 2005

Regulation of PD‐1, PD‐L1, and PD‐L2 expression during normal and autoimmune responses ⬇️

scientific article published on October 1, 2003

Regulation of T-cell chemotaxis by programmed death-ligand 1 (PD-L1) in dry eye-associated corneal inflammation

scientific article published on 17 December 2009

Reinvigorating exhausted HIV-specific T cells via PD-1-PD-1 ligand blockade

scientific article

Rescue of exhausted CD8 T cells by PD-1-targeted therapies is CD28-dependent.

scientific article

Response to BRAF inhibition in melanoma is enhanced when combined with immune checkpoint blockade

scientific article

Restoring function in exhausted CD8 T cells during chronic viral infection

scientific article

Role of PD-1 during effector CD8 T cell differentiation.

scientific article published on 13 April 2018

Role of PD-1 in regulating acute infections.

scientific article

Role of the immune modulator programmed cell death-1 during development and apoptosis of mouse retinal ganglion cells

scientific article published on 6 May 2009

Roles of CD48 in regulating immunity and tolerance

scientific article published on 18 January 2016

TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells.

scientific article

TSC2-deficient tumors have evidence of T cell exhaustion and respond to anti-PD-1/anti-CTLA-4 immunotherapy.

scientific article published on 19 April 2018

Targeting of inducible costimulator (ICOS) expressed on alloreactive T cells down-regulates graft-versus-host disease (GVHD) and facilitates engraftment of allogeneic bone marrow (BM).

scientific article published on 23 December 2004

The B7 family revisited

scientific article (publication date: 2005)

The B7-CD28 superfamily

scientific article

The PD-1 Pathway Regulates Development and Function of Memory CD8+ T Cells following Respiratory Viral Infection

scientific article published on 01 June 2020

The coinhibitory receptor CTLA-4 controls B cell responses by modulating T follicular helper, T follicular regulatory, and T regulatory cells.

scientific article

The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells

scientific article

The function of donor versus recipient programmed death-ligand 1 in corneal allograft survival

scientific article published on 01 September 2007

The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection

scientific article published on March 2007

The novel costimulatory programmed death ligand 1/B7.1 pathway is functional in inhibiting alloimmune responses in vivo

scientific article

The programmed death-1 ligand 1:B7-1 pathway restrains diabetogenic effector T cells in vivo

scientific article

The receptor PD-1 controls follicular regulatory T cells in the lymph nodes and blood.

scientific article published on 16 December 2012

The role of LAT in increased CD8+ T cell exhaustion in trigeminal ganglia of mice latently infected with herpes simplex virus 1.

scientific article published on 9 February 2011

The role of the ICOS-B7h T cell costimulatory pathway in transplantation immunity.

scientific article published on July 2003

Tissue expression of PD-L1 mediates peripheral T cell tolerance.

scientific article

Type 2 innate lymphoid cell suppression by regulatory T cells attenuates airway hyperreactivity and requires inducible T-cell costimulator-inducible T-cell costimulator ligand interaction

scientific article

Viral targeting of fibroblastic reticular cells contributes to immunosuppression and persistence during chronic infection

scholarly article

irRECIST for the Evaluation of Candidate Biomarkers of Response to Nivolumab in Metastatic Clear Cell Renal Cell Carcinoma: Analysis of a Phase II Prospective Clinical Trial

scientific article published on 22 January 2019

List of works by Arlene Sharpe

A new therapeutic strategy for malaria: targeting T cell exhaustion

Antigen-specific CD4 T-cell help rescues exhausted CD8 T cells during chronic viral infection.

Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity

B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation

Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens

Coinhibitory Pathways in Immunotherapy for Cancer

Coinhibitory Pathways in the B7-CD28 Ligand-Receptor Family

Constitutive neuronal expression of the immune regulator, programmed death 1 (PD-1), identified during experimental autoimmune uveitis

DEC-205-mediated antigen targeting to steady-state dendritic cells induces deletion of diabetogenic CD8⁺ T cells independently of PD-1 and PD-L1

Defective TFH Cell Function and Increased TFR Cells Contribute to Defective Antibody Production in Aging

Defining 'T cell exhaustion'

Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy

Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity.

Endothelial Programmed Death-1 Ligand 1 (PD-L1) Regulates CD8 + T-Cell–Mediated Injury in the Heart

Endothelial expression of PD‐L1 and PD‐L2 down‐regulates CD8+ T cell activation and cytolysis ⬇️

Enhancing therapeutic vaccination by blocking PD-1-mediated inhibitory signals during chronic infection

Fibroblastic reticular cells enhance T cell metabolism and survival via epigenetic remodeling

Follicular regulatory T cells control humoral and allergic immunity by restraining early B cell responses

FoxP3 and Ezh2 regulate Tfr cell suppressive function and transcriptional program

Glioblastoma Eradication Following Immune Checkpoint Blockade in an Orthotopic, Immunocompetent Model

Hepatic immune regulation by stromal cells.

Host programmed death ligand 1 is dominant over programmed death ligand 2 expression in regulating graft-versus-host disease lethality

ICOS is critical for CD40-mediated antibody class switching

ICOS/ICOSL interaction is required for CD4+ invariant NKT cell function and homeostatic survival

ICOS:ICOS-ligand interaction is required for type 2 innate lymphoid cell function, homeostasis, and induction of airway hyperreactivity.

IL-10 and PD-L1 operate through distinct pathways to suppress T-cell activity during persistent viral infection

IMMU-28. DEFINING MOLECULAR MECHANISMS OF RESISTANCE TO GLIOBLASTOMA (GBM) IMMUNITY USING A NOVEL CRISPR/CAS9 IN VIVO LOSS-OF-FUNCTION SCREENING PLATFORM

Immuno-PET identifies the myeloid compartment as a key contributor to the outcome of the antitumor response under PD-1 blockade

Immunotherapy of chronic hepatitis C virus infection with antibodies against programmed cell death-1 (PD-1).

Impairment of the programmed cell death-1 pathway increases atherosclerotic lesion development and inflammation

Inclusion of CD80 in HSV targets the recombinant virus to PD-L1 on DCs and allows productive infection and robust immune responses

Interaction of human PD-L1 and B7-1.

Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection

Interplay of somatic alterations and immune infiltration modulates response to PD-1 blockade in advanced clear cell renal cell carcinoma

Intestinal tolerance is converted to autoimmune enteritis upon PD-1 ligand blockade

Introduction to checkpoint inhibitors and cancer immunotherapy.

LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint Blockade

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4 ⬇️

Ox40L-Ox40 pathway plays distinct roles in regulating Th2 responses but does not determine outcome of cutaneous leishmaniasis caused by Leishmania mexicana and Leishmania major

PD-1 and its ligands in tolerance and immunity

PD-1 pathway regulates ILC2 metabolism and PD-1 agonist treatment ameliorates airway hyperreactivity

PD-1 regulates self-reactive CD8+ T cell responses to antigen in lymph nodes and tissues

PD-1 restraint of regulatory T cell suppressive activity is critical for immune tolerance

PD-L1 Antibodies to Its Cytoplasmic Domain Most Clearly Delineate Cell Membranes in Immunohistochemical Staining of Tumor Cells

PD-L1 and PD-L2 have distinct roles in regulating host immunity to cutaneous leishmaniasis

PD-L1 on tumor cells is sufficient for immune evasion in immunogenic tumors and inhibits CD8 T cell cytotoxicity.

PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells

PTPN2 regulates the generation of exhausted CD8+ T cell subpopulations and restrains tumor immunity

Programmed death ligand 2 - A link between inflammation and bone loss in rheumatoid arthritis

Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality

Programmed death-1 (PD-1):PD-ligand 1 interactions inhibit TCR-mediated positive selection of thymocytes

Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses

Protect the killer: CTLs need defenses against the tumor

RGMb is a novel binding partner for PD-L2 and its engagement with PD-L2 promotes respiratory tolerance

Rap1-GTP is a negative regulator of Th cell function and promotes the generation of CD4+CD103+ regulatory T cells in vivo

Regulation of PD‐1, PD‐L1, and PD‐L2 expression during normal and autoimmune responses ⬇️

Regulation of T-cell chemotaxis by programmed death-ligand 1 (PD-L1) in dry eye-associated corneal inflammation

Reinvigorating exhausted HIV-specific T cells via PD-1-PD-1 ligand blockade

Rescue of exhausted CD8 T cells by PD-1-targeted therapies is CD28-dependent.

Response to BRAF inhibition in melanoma is enhanced when combined with immune checkpoint blockade

Restoring function in exhausted CD8 T cells during chronic viral infection

Role of PD-1 during effector CD8 T cell differentiation.

Role of PD-1 in regulating acute infections.

Role of the immune modulator programmed cell death-1 during development and apoptosis of mouse retinal ganglion cells

Roles of CD48 in regulating immunity and tolerance

TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells.

TSC2-deficient tumors have evidence of T cell exhaustion and respond to anti-PD-1/anti-CTLA-4 immunotherapy.

Targeting of inducible costimulator (ICOS) expressed on alloreactive T cells down-regulates graft-versus-host disease (GVHD) and facilitates engraftment of allogeneic bone marrow (BM).

The B7 family revisited

The B7-CD28 superfamily

The PD-1 Pathway Regulates Development and Function of Memory CD8+ T Cells following Respiratory Viral Infection

The coinhibitory receptor CTLA-4 controls B cell responses by modulating T follicular helper, T follicular regulatory, and T regulatory cells.

The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells

The function of donor versus recipient programmed death-ligand 1 in corneal allograft survival

The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection

The novel costimulatory programmed death ligand 1/B7.1 pathway is functional in inhibiting alloimmune responses in vivo

The programmed death-1 ligand 1:B7-1 pathway restrains diabetogenic effector T cells in vivo

The receptor PD-1 controls follicular regulatory T cells in the lymph nodes and blood.