List of works - Christoph Spiess

A temperature-dependent switch from chaperone to protease in a widely conserved heat shock protein.

scientific article published in April 1999

Alternative molecular formats and therapeutic applications for bispecific antibodies

scientific article

Antitumor efficacy of a bispecific antibody that targets HER2 and activates T cells

scientific article published on 16 September 2014

Avidity-based binding to HER2 results in selective killing of HER2-overexpressing cells by anti-HER2/CD3

scientific article published on 01 October 2018

Characterization of Chain Pairing Variants of Bispecific IgG Expressed in a Single Host Cell by High-Resolution Native and Denaturing Mass Spectrometry.

scientific article

Design and Pharmacokinetic Characterization of Novel Antibody Formats for Ocular Therapeutics

scientific article

Determinants of Translocation and Folding of TreF, a Trehalase ofEscherichia coli

scientific article published in Journal of Biological Chemistry

Effector-attenuating Substitutions That Maintain Antibody Stability and Reduce Toxicity in Mice

scientific article published on 11 January 2017

Efficient production of bispecific IgG of different isotypes and species of origin in single mammalian cells.

scientific article published on 08 December 2016

Evading pre-existing anti-hinge antibody binding by hinge engineering.

scientific article published on 9 August 2016

High-resolution glycosylation site-engineering method identifies MICA epitope critical for shedding inhibition activity of anti-MICA antibodies

scientific article published on 22 November 2018

High-throughput antibody screening from complex matrices using intact protein electrospray mass spectrometry

scientific article published on 23 April 2020

Identification of the TRiC/CCT substrate binding sites uncovers the function of subunit diversity in eukaryotic chaperonins

scientific article published in October 2006

Mechanism of the eukaryotic chaperonin: protein folding in the chamber of secrets.

scientific article

Optimizing antibody expression by using the naturally occurring framework diversity in a live bacterial antibody display system

scientific article published on 3 December 2015

Precise quantification of mixtures of bispecific IgG produced in single host cells by liquid chromatography-Orbitrap high-resolution mass spectrometry.

scientific article published on 9 September 2016

Prediction of methionine oxidation risk in monoclonal antibodies using a machine learning method

scientific article published on 25 September 2018

Production, characterization, and in vivo half-life extension of polymeric IgA molecules in mice

scientific article published on 09 June 2019

Single cell-produced and in vitro-assembled anti-FcRH5/CD3 T-cell dependent bispecific antibodies have similar in vitro and in vivo properties

scientific article published on 17 December 2018

Susceptibility of Antibody CDR Residues to Chemical Modifications Can Be Revealed Prior to Antibody Humanization and Aid in the Lead Selection Process

scientific article published on 29 August 2018

Sustained Brown Fat Stimulation and Insulin Sensitization by a Humanized Bispecific Antibody Agonist for Fibroblast Growth Factor Receptor 1/βKlotho Complex

scientific article

Tethered-variable CL bispecific IgG: an antibody platform for rapid bispecific antibody screening.

scientific article

List of works by Christoph Spiess

A temperature-dependent switch from chaperone to protease in a widely conserved heat shock protein.

Alternative molecular formats and therapeutic applications for bispecific antibodies

Antitumor efficacy of a bispecific antibody that targets HER2 and activates T cells

Avidity-based binding to HER2 results in selective killing of HER2-overexpressing cells by anti-HER2/CD3

Characterization of Chain Pairing Variants of Bispecific IgG Expressed in a Single Host Cell by High-Resolution Native and Denaturing Mass Spectrometry.

Design and Pharmacokinetic Characterization of Novel Antibody Formats for Ocular Therapeutics

Determinants of Translocation and Folding of TreF, a Trehalase ofEscherichia coli

Effector-attenuating Substitutions That Maintain Antibody Stability and Reduce Toxicity in Mice

Efficient production of bispecific IgG of different isotypes and species of origin in single mammalian cells.

Evading pre-existing anti-hinge antibody binding by hinge engineering.

High-resolution glycosylation site-engineering method identifies MICA epitope critical for shedding inhibition activity of anti-MICA antibodies

High-throughput antibody screening from complex matrices using intact protein electrospray mass spectrometry

Identification of the TRiC/CCT substrate binding sites uncovers the function of subunit diversity in eukaryotic chaperonins

Mechanism of the eukaryotic chaperonin: protein folding in the chamber of secrets.

Optimizing antibody expression by using the naturally occurring framework diversity in a live bacterial antibody display system

Precise quantification of mixtures of bispecific IgG produced in single host cells by liquid chromatography-Orbitrap high-resolution mass spectrometry.

Prediction of methionine oxidation risk in monoclonal antibodies using a machine learning method

Production, characterization, and in vivo half-life extension of polymeric IgA molecules in mice

Single cell-produced and in vitro-assembled anti-FcRH5/CD3 T-cell dependent bispecific antibodies have similar in vitro and in vivo properties

Susceptibility of Antibody CDR Residues to Chemical Modifications Can Be Revealed Prior to Antibody Humanization and Aid in the Lead Selection Process

Sustained Brown Fat Stimulation and Insulin Sensitization by a Humanized Bispecific Antibody Agonist for Fibroblast Growth Factor Receptor 1/βKlotho Complex

Tethered-variable CL bispecific IgG: an antibody platform for rapid bispecific antibody screening.