List of works by Timothy Vyse

A Genome-wide Association Study Identifies Risk Alleles in Plasminogen and P4HA2 Associated with Giant Cell Arteritis ⬇️

scientific article published on 21 December 2016

A combined large-scale meta-analysis identifies COG6 as a novel shared risk locus for rheumatoid arthritis and systemic lupus erythematosus

scientific article published on 18 May 2016

A comprehensive analysis of shared loci between systemic lupus erythematosus (SLE) and sixteen autoimmune diseases reveals limited genetic overlap

scientific article

A defunctioning polymorphism in FCGR2B is associated with protection against malaria but susceptibility to systemic lupus erythematosus

scientific article

A functional haplotype of UBE2L3 confers risk for systemic lupus erythematosus

scientific article

A genetic association study of serum acute-phase C-reactive protein levels in rheumatoid arthritis: implications for clinical interpretation

scientific article published on 21 September 2010

A major histocompatibility Class I locus contributes to multiple sclerosis susceptibility independently from HLA-DRB1*15:01.

scientific article

A nonsynonymous functional variant in integrin-αM (encoded by ITGAM) is associated with systemic lupus erythematosus

article

A novel locus regulates both retroviral glycoprotein 70 and anti-glycoprotein 70 antibody production in New Zealand mice when crossed with BALB/c

scientific article published in April 2004

A plausibly causal functional lupus-associated risk variant in the STAT1-STAT4 locus

scholarly article by Zubin Patel published in April 2018

A polymorphism within IL21R confers risk for systemic lupus erythematosus

scientific article published on August 2009

A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci

scientific article published on 04 June 2013

ABIN1 dysfunction as a genetic basis for lupus nephritis

scientific article published on 22 August 2013

Admixture mapping in lupus identifies multiple functional variants within IFIH1 associated with apoptosis, inflammation, and autoantibody production

scientific article

Analysis of autosomal genes reveals gene-sex interactions and higher total genetic risk in men with systemic lupus erythematosus

scientific article published on 21 November 2011

Assessing association of common variation in the C1Q gene cluster with systemic lupus erythematosus

article

Assessment of complement C4 gene copy number using the paralog ratio test

scientific article published on July 2010

Association analysis of the R620W polymorphism of protein tyrosine phosphatase PTPN22 in systemic lupus erythematosus families: increased T allele frequency in systemic lupus erythematosus patients with autoimmune thyroid disease

scientific article published in August 2005

Association of LY9 in UK and Canadian SLE families

scientific article published on 24 January 2008

Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with systemic lupus erythematosus

scientific article

Association of PPP2CA polymorphisms with systemic lupus erythematosus susceptibility in multiple ethnic groups

scientific article

Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus

scientific article

Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibility

scientific article

Association of the co-stimulator OX40L with systemic lupus erythematosus

scientific article published on 16 December 2008

Association of two independent functional risk haplotypes in TNIP1 with systemic lupus erythematosus

scientific article

Audiovestibular manifestations of the antiphospholipid syndrome

scientific article published on 01 January 1994

C-reactive protein in rheumatology: biology and genetics

scientific article published on 05 April 2011

CSK regulatory polymorphism is associated with systemic lupus erythematosus and influences B-cell signaling and activation

scientific article published on 7 October 2012

Common variants within MECP2 confer risk of systemic lupus erythematosus

scientific article

Complement genes contribute sex-biased vulnerability in diverse disorders

scientific article published on 11 May 2020

Complement receptor 2 polymorphisms associated with systemic lupus erythematosus modulate alternative splicing

scientific article published on 23 April 2009

Connective tissue diseases: advances in diagnosis and management.

scientific article

Contrasting genetic association of IL2RA with SLE and ANCA-associated vasculitis

scientific article

Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humans

scientific article

Decreased SMG7 expression associates with lupus-risk variants and elevated antinuclear antibody production

scientific article published on 18 January 2016

Defining the role of the MHC in autoimmunity: a review and pooled analysis

scientific article

Dense mapping of IL18 shows no association in SLE.

scientific article

Determination of the loss of function complement C4 exon 29 CT insertion using a novel paralog-specific assay in healthy UK and Spanish populations

scientific article

Dysregulated CD46 shedding interferes with Th1-contraction in systemic lupus erythematosus.

scientific article published on 26 April 2017

Erratum: Complement receptor 2 polymorphisms associated with systemic lupus erythematosus modulate alternative splicing

article

Erratum: Genetic associations of LYN with systemic lupus erythematosus

article

Evaluation of TRAF6 in a large multiancestral lupus cohort

scientific article

Evaluation of imputation-based association in and around the integrin-alpha-M (ITGAM) gene and replication of robust association between a non-synonymous functional variant within ITGAM and systemic lupus erythematosus (SLE).

scientific article

Evaluation of the TREX1 gene in a large multi-ancestral lupus cohort

scientific article

Evidence for both copy number and allelic (NA1/NA2) risk at the FCGR3B locus in systemic lupus erythematosus

scientific article published on 5 May 2010

Evidence for gene-gene epistatic interactions among susceptibility loci for systemic lupus erythematosus

scientific article published on February 2012

F.20. Delineating SLE Susceptibility Polymorphisms at the OX40L Locus

Familial clustering of non-nuclear autoantibodies and C3 and C4 complement components in systemic lupus erythematosus

scientific article published on April 2008

Fine mapping of Xq28: both MECP2 and IRAK1 contribute to risk for systemic lupus erythematosus in multiple ancestral groups

scientific article published on 17 August 2012

Fine-mapping and transethnic genotyping establish IL2/IL21 genetic association with lupus and localize this genetic effect to IL21

scientific article

GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways

scientific article published on 31 October 2019

Genetic analyses of interferon pathway-related genes reveal multiple new loci associated with systemic lupus erythematosus

scientific article

Genetic associations of LYN with systemic lupus erythematosus

scientific article published on 16 April 2009

Genetic associations of leptin-related polymorphisms with systemic lupus erythematosus

scientific article

Genetic determinants of basal C-reactive protein expression in Filipino systemic lupus erythematosus families

scientific article published on 24 January 2008

Genetic fine mapping of systemic lupus erythematosus MHC associations in Europeans and African Americans

scholarly article by Ken B Hanscombe published in November 2018

Genetic overlap between autoimmune diseases and non-Hodgkin lymphoma subtypes

scientific article published on 13 August 2019

Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus

scientific journal article

Genetically determined partial complement C4 deficiency states are not independent risk factors for SLE in UK and Spanish populations

scientific article published in March 2012

Genome-Wide Association Study in an Amerindian Ancestry Population Reveals Novel Systemic Lupus Erythematosus Risk Loci and the Role of European Admixture

scientific article published on 25 November 2015

Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus

scientific article published on 11 July 2016

Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci

scientific article

Genome-wide meta-analysis reveals shared new loci in systemic seropositive rheumatic diseases

scientific article published on 20 December 2018

Genomic pathology of SLE-associated copy-number variation at the FCGR2C/FCGR3B/FCGR2B locus

scientific article

HLA has strongest association with IgA nephropathy in genome-wide analysis

scientific article

Haplotype analysis of tumour necrosis factor receptor genes in 1p36: no evidence for association with systemic lupus erythematosus

article

Haplotype structure of TNFRSF5-TNFSF5 (CD40-CD40L) and association analysis in systemic lupus erythematosus

scientific article published in May 2005

Hereditary complement factor I deficiency

scientific article (publication date: July 1994)

High-density genotyping of STAT4 reveals multiple haplotypic associations with systemic lupus erythematosus in different racial groups

scientific article published on April 2009

Hyper IgE in New Zealand black mice due to a dominant-negative CD23 mutation.

scientific article published on 19 October 2004

IFN-α production by plasmacytoid dendritic cell associations with polymorphisms in gene loci related to autoimmune and inflammatory diseases

scientific article

IRF5 haplotypes demonstrate diverse serological associations which predict serum interferon alpha activity and explain the majority of the genetic association with systemic lupus erythematosus

scientific article

ITGAM coding variant (rs1143679) influences the risk of renal disease, discoid rash and immunological manifestations in patients with systemic lupus erythematosus with European ancestry

scientific article

Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus

scholarly article

Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as susceptibility loci for systemic lupus erythematosus in a large-scale multiracial replication study

scientific article published on 29 March 2012

Identification of MAMDC1 as a candidate susceptibility gene for systemic lupus erythematosus (SLE)

scientific article

Identification of ST3AGL4, MFHAS1, CSNK2A2 and CD226 as loci associated with systemic lupus erythematosus (SLE) and evaluation of SLE genetics in drug repositioning

scientific article published on 06 April 2018

Identification of Susceptibility Loci in IL6, RPS9/LILRB3, and an Intergenic Locus on Chromosome 21q22 in Takayasu Arteritis in a Genome-Wide Association Study

scientific article published on May 2015

Identification of a Systemic Lupus Erythematosus Risk Locus Spanning ATG16L2, FCHSD2, and P2RY2 in Koreans

scientific article published on 14 December 2015

Identification of a systemic lupus erythematosus susceptibility locus at 11p13 between PDHX and CD44 in a multiethnic study

scientific article

Identification of chromosome intervals from 129 and C57BL/6 mouse strains linked to the development of systemic lupus erythematosus.

scientific article published on 31 August 2006

Identification of novel genetic susceptibility loci in African American lupus patients in a candidate gene association study

scientific article

Identification of susceptibility loci for Takayasu arteritis through a large multi-ancestral genome-wide association study

scientific article published on 03 December 2020

Identification of two independent risk factors for lupus within the MHC in United Kingdom families

scientific article

Impact of genetic ancestry and sociodemographic status on the clinical expression of systemic lupus erythematosus in American Indian-European populations

scientific article

Improved monitoring of clinical response in Systemic Lupus Erythematosus by longitudinal trend in soluble vascular cell adhesion molecule-1.

scientific article

In vivo evidence for apoptosis in the bone marrow in systemic lupus erythematosus

scientific article

Interferon inducible X-linked gene CXorf21 may contribute to sexual dimorphism in Systemic Lupus Erythematosus

article

Kallikrein genes are associated with lupus and glomerular basement membrane-specific antibody-induced nephritis in mice and humans

scientific article published on April 2009

Large scale replication study of the association between HLA class II/BTNL2 variants and osteoarthritis of the knee in European-descent populations

scientific article (publication date: 2011)

Large-Scale Identification of Common Trait and Disease Variants Affecting Gene Expression

scientific article published on 22 May 2017

Large-Scale Identification of Common Trait and Disease Variants Affecting Gene Expression

scientific article published on July 2017

Lupus Risk Variant Increases pSTAT1 Binding and Decreases ETS1 Expression

scientific article

Lupus risk variants in the PXK locus alter B-cell receptor internalization

scientific article

Lupus-associated causal mutation in neutrophil cytosolic factor 2 (NCF2) brings unique insights to the structure and function of NADPH oxidase

scientific article published on 27 December 2011

MHC associations with clinical and autoantibody manifestations in European SLE.

scientific article

Malabsorption caused by coeliac disease in patients who have scleroderma

scientific article published on 01 September 1995

Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases

scientific article published on 21 October 2009

Meta-analysis of GWAS on both Chinese and European populations identifies GPR173 as a novel X chromosome susceptibility gene for SLE.

scientific article published on 3 May 2018

Mice, humans and haplotypes--the hunt for disease genes in SLE.

scientific article published on 12 June 2006

MicroRNA-3148 modulates allelic expression of toll-like receptor 7 variant associated with systemic lupus erythematosus

scientific article

Multiple loci are linked with anti-red blood cell antibody production in NZB mice -- comparison with other phenotypes implies complex modes of action

scientific article published in October 2004

Multiple signals at the extended 8p23 locus are associated with susceptibility to systemic lupus erythematosus

scientific article

Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus

scientific article published on 29 July 2007

PTPN22 association in systemic lupus erythematosus (SLE) with respect to individual ancestry and clinical sub-phenotypes

scientific article

Phenotypic associations of genetic susceptibility loci in systemic lupus erythematosus

scientific article published on 30 June 2011

Polymorphism at the C-reactive protein locus influences gene expression and predisposes to systemic lupus erythematosus

scientific article

Polymorphism at the TNF superfamily gene TNFSF4 confers susceptibility to systemic lupus erythematosus

scientific article published on 02 December 2007

Preferential association of a functional variant in complement receptor 2 with antibodies to double-stranded DNA.

scientific article

Preferential binding to Elk-1 by SLE-associated IL10 risk allele upregulates IL10 expression

scientific article

Profiling RNA-Seq at multiple resolutions markedly increases the number of causal eQTLs in autoimmune disease.

scientific article published on 23 October 2017

Quantification of the genetic component of basal C-reactive protein expression in SLE nuclear families

scientific article published on 27 March 2008

Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry

scientific article

Reduced Fluorescence versus Forward Scatter Time-of-Flight and Increased Peak versus Integral Fluorescence Ratios Indicate Receptor Clustering in Flow Cytometry

scientific article published on 29 May 2015

Replication of the BANK1 genetic association with systemic lupus erythematosus in a European-derived population

scientific article published on 02 April 2009

Role of MYH9 and APOL1 in African and non-African populations with lupus nephritis

scientific article published on 22 December 2011

Sa.54. Positional Identification of Integrin- αMβ2 (ITGAM) as a Susceptibility Gene for Systematic Lupus Erythematosus (SLE)

article

Selective IgA deficiency in autoimmune diseases

scientific article published on 4 August 2011

Spontaneous autoimmunity in 129 and C57BL/6 mice-implications for autoimmunity described in gene-targeted mice

scientific article

Tartrate-Resistant Acid Phosphatase Deficiency in the Predisposition to Systemic Lupus Erythematosus.

scientific article published on 7 July 2016

Th1 responses in vivo require cell-specific provision of OX40L dictated by environmental cues

scientific article published on 09 July 2020

The candidate gene approach: have murine models informed the study of human SLE?

scientific article published on July 2004

The complement receptor 3 (CD11b/CD18) agonist Leukadherin-1 suppresses human innate inflammatory signalling

scientific article published on 26 April 2016

The genetics of SLE: an update in the light of genome-wide association studies

scientific article

The genetics of lupus: a functional perspective

scientific article

The heritability and genetics of complement C3 expression in UK SLE families

scientific article published on 23 April 2009

The human GIMAP5 gene has a common polyadenylation polymorphism increasing risk to systemic lupus erythematosus

scientific article

The molecular basis of hereditary complement factor I deficiency

scientific article published on February 1996

The organization of the human complement factor I gene (IF): a member of the serine protease gene family

scientific article published on November 1994

The role of genetic variation near interferon-kappa in systemic lupus erythematosus

scientific article

The role of inflammatory bowel disease susceptibility loci in multiple sclerosis and systemic lupus erythematosus

article

The rs1143679 (R77H) lupus associated variant of ITGAM (CD11b) impairs complement receptor 3 mediated functions in human monocytes

scientific article

Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus

scholarly article

Tissue-Restricted Adaptive Type 2 Immunity Is Orchestrated by Expression of the Costimulatory Molecule OX40L on Group 2 Innate Lymphoid Cells.

scientific article published on 12 June 2018

Trans-Ancestral Fine-Mapping and Epigenetic Annotation as Tools to Delineate Functionally Relevant Risk Alleles at IKZF1 and IKZF3 in Systemic Lupus Erythematosus

scientific article published on 09 November 2020

Transancestral mapping and genetic load in systemic lupus erythematosus

scientific article published on 17 July 2017

Transancestral mapping of the MHC region in systemic lupus erythematosus identifies new independent and interacting loci at MSH5, HLA-DPB1 and HLA-G

scientific article published on 10 January 2012

Unraveling multiple MHC gene associations with systemic lupus erythematosus: model choice indicates a role for HLA alleles and non-HLA genes in Europeans

scientific article

Using genetics to deliver personalized SLE therapy-a realistic prospect?

scientific article published on 4 May 2010

Variable association of reactive intermediate genes with systemic lupus erythematosus in populations with different African ancestry

scientific article

Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome

scientific article published on 6 October 2013

Variants within MECP2, a key transcription regulator, are associated with increased susceptibility to lupus and differential gene expression in patients with systemic lupus erythematosus

scientific article published on April 2009

Variation in the ICAM1-ICAM4-ICAM5 locus is associated with systemic lupus erythematosus susceptibility in multiple ancestries

scientific article

Variation in the upstream region of P-Selectin (SELP) is a risk factor for SLE

scientific article

X Chromosome Dose and Sex Bias in Autoimmune Diseases: Increased Prevalence of 47,XXX in Systemic Lupus Erythematosus and Sjögren's Syndrome

scientific article published on 29 December 2015

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