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List of works by Manuela Zaccolo

A complex phosphodiesterase system controls beta-adrenoceptor signalling in cardiomyocytes

scientific article published on August 2006

A genetically encoded, fluorescent indicator for cyclic AMP in living cells

scientific article published on 01 January 2000

A novel approach combining real-time imaging and the patch-clamp technique to calibrate FRET-based reporters for cAMP in their cellular microenvironment

scientific article published on January 2015

A phosphodiesterase 3B-based signaling complex integrates exchange protein activated by cAMP 1 and phosphatidylinositol 3-kinase signals in human arterial endothelial cells

scientific article

AKAP complex regulates Ca2+ re-uptake into heart sarcoplasmic reticulum

scientific journal article

Activation of PKA in cell requires higher concentration of cAMP than in vitro: implications for compartmentalization of cAMP signalling

scientific article

Adenoviral transduction of FRET-based biosensors for cAMP in primary adult mouse cardiomyocytes

scientific article

Adrenaline Stimulates Glucagon Secretion by Tpc2-Dependent Ca2+ Mobilization from Acidic Stores in Pancreatic α-Cells

scientific article published on 21 March 2018

Alcohol disrupts levels and function of the cystic fibrosis transmembrane conductance regulator to promote development of pancreatitis.

scientific article

Analysis of compartmentalized cAMP: a method to compare signals from differently targeted FRET reporters.

scientific article published in January 2014

Beta-adrenergic- and muscarinic receptor-induced changes in cAMP activity in adult cardiac myocytes detected with FRET-based biosensor.

scientific article

Beta-oestradiol rescues DeltaF508CFTR functional expression in human cystic fibrosis airway CFBE41o- cells through the up-regulation of NHERF1.

scientific article published on July 2008

Bifunctional Ligands for Inhibition of Tight-Binding Protein-Protein Interactions

scientific article

Biochemical characterization and cellular imaging of a novel, membrane permeable fluorescent cAMP analog

scientific article

CAMP and Ca2+ interplay: a matter of oscillation patterns

scientific article published on 01 February 2003

CFTR regulation in human airway epithelial cells requires integrity of the actin cytoskeleton and compartmentalized cAMP and PKA activity

scientific article published on 2 February 2012

Cardiac Hypertrophy Is Inhibited by a Local Pool of cAMP Regulated by Phosphodiesterase 2Novelty and Significance

scientific article (publication date: 4 August 2015)

Cardiomyocyte Membrane Structure and cAMP Compartmentation Produce Anatomical Variation in β2AR-cAMP Responsiveness in Murine Hearts.

scientific article published in April 2018

Cell entry and cAMP imaging of anthrax edema toxin

scientific article published on 2 November 2006

Compartmentalisation of cAMP and Ca(2+) signals

scientific article

Compartmentalized cAMP/PKA signalling regulates cardiac excitation-contraction coupling

scientific article published on 11 August 2006

Compartmentalized phosphodiesterase-2 activity blunts beta-adrenergic cardiac inotropy via an NO/cGMP-dependent pathway

scientific article published on 15 December 2005

Components of the mitochondrial cAMP signalosome

scientific article published on February 2017

Control of βAR- and N-methyl-D-aspartate (NMDA) Receptor-Dependent cAMP Dynamics in Hippocampal Neurons

scientific article

Correctors of mutant CFTR enhance subcortical cAMP-PKA signaling through modulating ezrin phosphorylation and cytoskeleton organization

scientific article

Cyclic nucleotide phosphodiesterase 1A: a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart

scientific journal article

Defining a cellular map of cAMP nanodomains

scientific article published on 28 February 2020

Detecting cAMP-induced Epac activation by fluorescence resonance energy transfer: Epac as a novel cAMP indicator

scientific article

Developmentally acquired PKA localisation in mouse oocytes and embryos

scientific article published on 14 February 2008

Discrete microdomains with high concentration of cAMP in stimulated rat neonatal cardiac myocytes

scientific article published in March 2002

Disruption of the cyclic AMP phosphodiesterase-4 (PDE4)-HSP20 complex attenuates the β-agonist induced hypertrophic response in cardiac myocytes

scientific article published on 18 February 2011

EPAC1 activation by cAMP stabilizes CFTR at the membrane by promoting its interaction with NHERF1.

scientific article published on 20 May 2016

Efficacy of B-Type Natriuretic Peptide Is Coupled to Phosphodiesterase 2A in Cardiac Sympathetic Neurons

scientific article published on 27 April 2015

FRET biosensor uncovers cAMP nano-domains at β-adrenergic targets that dictate precise tuning of cardiac contractility

scientific article

FRET-ting about RhoA signalling in heart and vasculature: a new tool in our cardiovascular toolbox

scientific article published in April 2018

Fluorescence resonance energy transfer-based analysis of cAMP dynamics in live neonatal rat cardiac myocytes reveals distinct functions of compartmentalized phosphodiesterases

scientific article published on 3 June 2004

GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation

scientific article

Human MYO18B, a novel unconventional myosin heavy chain expressed in striated muscles moves into the myonuclei upon differentiation

scientific article

Imaging cAMP nanodomains in the heart

scientific article published on 01 October 2019

Imaging of cAMP levels and protein kinase A activity reveals that retinal waves drive oscillations in second-messenger cascades

scientific article published on December 2006

Imaging the cAMP-dependent signal transduction pathway.

scientific article

Improvement of a FRET-based indicator for cAMP by linker design and stabilization of donor-acceptor interaction

scientific article published on 21 October 2005

Local modulation of cystic fibrosis conductance regulator: cytoskeleton and compartmentalized cAMP signalling

scientific article published on May 2013

Local termination of 3'-5'-cyclic adenosine monophosphate signals: the role of A kinase anchoring protein-tethered phosphodiesterases

scientific article published on October 2011

Measuring spatiotemporal dynamics of cyclic AMP signaling in real-time using FRET-based biosensors

scientific article published in January 2011

Missense mutations in desmocollin-2 N-terminus, associated with arrhythmogenic right ventricular cardiomyopathy, affect intracellular localization of desmocollin-2 in vitro

scientific article

Modulation of Compartmentalised Cyclic Nucleotide Signalling via Local Inhibition of Phosphodiesterase Activity

scientific article

Molecular basis of the allosteric mechanism of cAMP in the regulatory PKA subunit

scientific article published on 14 April 2005

Multi-Compartment, Early Disruption of cGMP and cAMP Signalling in Cardiac Myocytes from the mdx Model of Duchenne Muscular Dystrophy

scientific article published on 25 September 2020

Mutations in the insulin-like factor 3 receptor are associated with osteoporosis

scientific article

Myosin Va cooperates with PKA RIalpha to mediate maintenance of the endplate in vivo.

scientific article

Nitroxyl improves cellular heart function by directly enhancing cardiac sarcoplasmic reticulum Ca2+ cycling

scientific article

Odorant receptors at the growth cone are coupled to localized cAMP and Ca2+ increases

scientific article

PDE2A2 regulates mitochondria morphology and apoptotic cell death via local modulation of cAMP/PKA signalling

scientific article

PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases

scientific article

PKA and PDE4D3 anchoring to AKAP9 provides distinct regulation of cAMP signals at the centrosome

scientific article

PKA microdomain organisation and cAMP handling in healthy and dystrophic muscle in vivo

scientific article published on 29 January 2009

Participation of myosin Va and Pka type I in the regeneration of neuromuscular junctions

scientific article

Phosphodiesterase 2A2 regulates mitochondria clearance through Parkin-dependent mitophagy

scientific article published on 21 October 2020

Phosphodiesterases and compartmentalized cAMP signalling in the heart

scientific article

Phosphodiesterases and subcellular compartmentalized cAMP signaling in the cardiovascular system

scientific article published on 28 October 2011

Phosphodiesterases maintain signaling fidelity via compartmentalization of cyclic nucleotides

scientific article

Phosphorylation of ezrin on Thr567 is required for the synergistic activation of cell spreading by EPAC1 and protein kinase A in HEK293T cells

scientific article published on 23 April 2015

Photon moment analysis in cells in the presence of photo-bleaching

scientific article published in February 2005

Plasma membrane calcium pump (PMCA4)-neuronal nitric-oxide synthase complex regulates cardiac contractility through modulation of a compartmentalized cyclic nucleotide microdomain

scientific article published on 29 September 2011

Protein kinase A gating of a pseudopodial-located RhoA/ROCK/p38/NHE1 signal module regulates invasion in breast cancer cell lines

scientific article

Protein kinase A type I and type II define distinct intracellular signaling compartments

scientific article published on 28 August 2008

Rapsyn mediates subsynaptic anchoring of PKA type I and stabilisation of acetylcholine receptor in vivo.

scientific article

Real-time analysis of cAMP-mediated regulation of ciliary motility in single primary human airway epithelial cells

scientific article published on 19 September 2006

Regulation of cAMP-dependent protein kinases: the human protein kinase X (PrKX) reveals the role of the catalytic subunit alphaH-alphaI loop

scientific article

Regulation of the inflammatory response of vascular endothelial cells by EPAC1.

scientific article published on May 2012

Response to Wagner et al.: phosphodiesterase-2-anti-adrenergic friend or hypertrophic foe in heart disease?

scientific article published on 27 September 2016

Restricted diffusion of a freely diffusible second messenger: mechanisms underlying compartmentalized cAMP signalling

scientific article published on August 2006

Restricted diffusion of a freely diffusible second messenger: mechanisms underlying compartmentalized cAMP signalling

article by Manuela Zaccolo et al published 1 August 2006 in Biochemical Society Transactions

Small-molecule FRET probes for protein kinase activity monitoring in living cells

scientific article published on 10 June 2010

Space and time-resolved gene expression experiments on cultured mammalian cells by a single-cell electroporation microarray

scientific article

Spatial control of cAMP signalling in health and disease ⬇️

scientific article published on October 13, 2011

Spatiotemporal coupling of cAMP transporter to CFTR chloride channel function in the gut epithelia

scientific article published on November 2007

Subcellular Organization of the cAMP Signaling Pathway

scientific article published on 01 January 2021

Sustained exposure to catecholamines affects cAMP/PKA compartmentalised signalling in adult rat ventricular myocytes

scientific article published on 14 October 2015

TCR- and CD28-mediated recruitment of phosphodiesterase 4 to lipid rafts potentiates TCR signaling

scientific article published in October 2004

Targeting FRET-Based Reporters for cAMP and PKA Activity Using AKAP79

scientific article published on 05 July 2018

Termination of cAMP signals by Ca2+ and G(alpha)i via extracellular Ca2+ sensors: a link to intracellular Ca2+ oscillations

scientific article published on October 2005

The role of type 4 phosphodiesterases in generating microdomains of cAMP: large scale stochastic simulations

scientific article (publication date: 2010)

Transgenic fruit-flies expressing a FRET-based sensor for in vivo imaging of cAMP dynamics

scientific article published on 12 July 2007

Unitary permeability of gap junction channels to second messengers measured by FRET microscopy

scientific article published on 11 March 2007

Use of chimeric fluorescent proteins and fluorescence resonance energy transfer to monitor cellular responses

scientific article published on April 2004

cAMP and cGMP signaling cross-talk: role of phosphodiesterases and implications for cardiac pathophysiology

scientific article published on June 2007

cAMP imaging of cells treated with pertussis toxin, cholera toxin, and anthrax edema toxin

scientific article published on 13 September 2008

cAMP signal transduction in the heart: understanding spatial control for the development of novel therapeutic strategies

scientific article published on 09 April 2009

cAMP signaling in subcellular compartments

scientific article published on April 2014

cAMP: From Long-Range Second Messenger to Nanodomain Signalling

scientific article published on 27 December 2017

cGMP Signals Modulate cAMP Levels in a Compartment-Specific Manner to Regulate Catecholamine-Dependent Signaling in Cardiac Myocytes

scientific article (publication date: 17 February 2011)

cGMP catabolism by phosphodiesterase 5A regulates cardiac adrenergic stimulation by NOS3-dependent mechanism

scientific article published on 2 December 2004

cGMP-cAMP interplay in cardiac myocytes: a local affair with far-reaching consequences for heart function.

scientific article

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