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List of works by Javier M Di Noia

A Combined Nuclear and Nucleolar Localization Motif in Activation-Induced Cytidine Deaminase (AID) Controls Immunoglobulin Class Switching

scientific article published on 23 November 2012

A Trypanosoma cruzi small surface molecule provides the first immunological evidence that Chagas' disease is due to a single parasite lineage

scientific article

A licensing step links AID to transcription elongation for mutagenesis in B cells

scientific article published on 28 March 2018

Activation induced deaminase C-terminal domain links DNA breaks to end protection and repair during class switch recombination

scientific article published on 03 March 2014

Activation induced deaminase: How much and where? ⬇️

scientific article published on 09 June 2012

Activation-induced cytidine deaminase (AID) is necessary for the epithelial-mesenchymal transition in mammary epithelial cells.

scientific article published on 23 July 2013

Activation-induced cytidine deaminase targets SUV4-20-mediated histone H4K20 trimethylation to class-switch recombination sites

scientific article published on 8 August 2017

Active nuclear import and cytoplasmic retention of activation-induced deaminase

scientific article published on 3 May 2009

Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase.

scientific article

Alternative end-joining and classical nonhomologous end-joining pathways repair different types of double-strand breaks during class-switch recombination

scientific article published on 21 October 2013

Autoimmunity and antibody affinity maturation are modulated by genetic variants on mouse chromosome 12.

scientific article published on 24 January 2015

Consecutive interactions with HSP90 and eEF1A underlie a functional maturation and storage pathway of AID in the cytoplasm.

scientific article

Dependence of antibody gene diversification on uracil excision.

scientific article

Differential accumulation of mutations localized in particular domains of the mucin genes expressed in the vertebrate host stage of Trypanosoma cruzi

scientific article published on January 2004

Evaluation of a recombinant Trypanosoma cruzi mucin-like antigen for serodiagnosis of Chagas' disease

scientific article published on 31 August 2011

HSP90 inhibitors decrease AID levels and activity in mice and in human cells.

scientific article

High diversity in mucin genes and mucin molecules in Trypanosoma cruzi.

scientific article published in December 1996

Ibrutinib therapy downregulates AID enzyme and proliferative fractions in chronic lymphocytic leukemia

scientific article published on 27 February 2019

Immunity through DNA deamination

scientific article (publication date: June 2003)

Immunoglobulin gene conversion in chicken DT40 cells largely proceeds through an abasic site intermediate generated by excision of the uracil produced by AID-mediated deoxycytidine deamination.

scientific article published on February 2004

Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation

scientific journal article

Molecular mechanisms of antibody somatic hypermutation.

scientific article published on January 2007

Mutations, kataegis and translocations in B cells: understanding AID promiscuous activity

scientific article

Optimal functional levels of activation-induced deaminase specifically require the Hsp40 DnaJa1

scientific article

PRMT5 is essential for B cell development and germinal center dynamics

scientific article published in Nature Communications

Pharmacological manipulation of AID.

scientific article published on 26 August 2015

Regulation of activation-induced deaminase stability and antibody gene diversification by Hsp90.

scientific article

Roles for APRIN (PDS5B) in homologous recombination and in ovarian cancer prediction.

scientific article

SMUG1 is able to excise uracil from immunoglobulin genes: insight into mutation versus repair

scientific article

Separation of Function between Isotype Switching and Affinity Maturation In Vivo during Acute Immune Responses and Circulating Autoantibodies in UNG-Deficient Mice ⬇️

scientific article published on May 10, 2013

Somatic hypermutation at A.T pairs: polymerase error versus dUTP incorporation.

scientific article published in February 2005

The Protozoan Trypanosoma cruzi Has a Family of Genes Resembling the Mucin Genes of Mammalian Cells ⬇️

scientific article published on October 13, 1995

The Trypanosoma cruzi mucin family is transcribed from hundreds of genes having hypervariable regions.

scientific article published in May 1998

The mechanisms regulating the subcellular localization of AID ⬇️

scientific article published on March 31, 2010

The uracil-DNA glycosylase UNG protects the fitness of normal and cancer B cells expressing AID

scientific article published on 27 August 2020

Trypanosoma cruzi clonal diversity and the epidemiology of Chagas’ disease ⬇️

scientific article published on April 1, 2003

Trypanosoma cruzi surface mucin TcMuc-e2 expressed on higher eukaryotic cells induces human T cell anergy, which is reversible

scientific article published on 01 January 2002

Trypanosoma cruzi surface mucins: host-dependent coat diversity

scientific article

Tumor suppressor and deubiquitinase BAP1 promotes DNA double-strand break repair

scientific article published on 17 December 2013

UNG protects B cells from AID-induced telomere loss.

scientific article published on 03 October 2016

Unequal opportunity during class switching

journal article; published in Nature on 2015-08-26

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