List of works by Swee Lay Thein

: a genetic model of fetal hemoglobin in sickle cell disease

A Plea for the Newborn Diagnosis of Hb S-Hereditary Persistence of Fetal Hemoglobin

scientific article published on 5 September 2017

A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15.

scientific article

A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium

scientific article

A novel 506kb deletion causing εγδβ thalassemia

scientific article

A novel deletion causing (epsilon gamma delta beta) degrees thalassaemia in a Chilean family

scientific article published on 01 October 2003

A novel variant on chromosome 7q22.3 associated with mean platelet volume, counts, and function

scientific article published on 12 February 2009

A randomized phase I/II trial of HQK-1001, an oral fetal globin gene inducer, in β-thalassaemia intermedia and HbE/β-thalassaemia

scientific article published on 27 March 2013

A survey of genetic fetal-haemoglobin modifiers in Nigerian patients with sickle cell anaemia.

scientific article

A ten year review of the sickle cell program in Muhimbili National Hospital, Tanzania

scholarly article by Julie Makani et al published 2018 in BMC hematology

A twins heritability study on alpha hemoglobin stabilizing protein (AHSP) expression variability

scientific article published in December 2010

Acute human parvovirus B19 infection and nephrotic syndrome in patients with sickle cell disease

scientific article published on 7 January 2010

Adult patients with Eisenmenger syndrome report flying safely on commercial airlines

scientific article

Airway hyperresponsiveness and acute chest syndrome in children with sickle cell anemia.

scientific article published in March 2007

Allosteric control of hemoglobin S fiber formation by oxygen and its relation to the pathophysiology of sickle cell disease

scientific article published on 11 June 2020

Alpha-haemoglobin stabilising protein is a quantitative trait gene that modifies the phenotype of beta-thalassaemia.

scientific article

Alpha-thalassaemia trait as a cause of unexplained microcytosis in a South African population

scientific article published on 22 February 2016

Anemia in the elderly: clinical implications and new therapeutic concepts

scientific article

Association between hemolysis and albuminuria in adults with sickle cell anemia

scientific article published on 11 October 2011

Association of plasma CD40L with acute chest syndrome in sickle cell anemia

scientific article published on 10 June 2017

Association of sickle avascular necrosis with bone morphogenic protein 6

scientific article published on 18 December 2008

Beta thalassaemia intermedia due to co-inheritance of three unique alpha globin cluster duplications characterised by next generation sequencing analysis.

scientific article published on 29 July 2016

Beta-thalassaemia prototype of a single gene disorder with multiple phenotypes

scientific article

Binding patterns of BCL11A in the globin and GATA1 loci and characterization of the BCL11A fetal hemoglobin locus

scientific article published on 12 June 2010

Blood transfusion usage among adults with sickle cell disease - a single institution experience over ten years

scientific article

Blood viscosity and its relationship to iron deficiency, symptoms, and exercise capacity in adults with cyanotic congenital heart disease.

scientific article published on 22 June 2006

Catheter-related right atrial thrombus in sickle cell disease

scientific article

Cell-free DNA levels in pregnancies at risk of sickle-cell disease and significant ethnic variation

scientific article published on December 2006

Changing pattern of hospital admissions of children with sickle cell disease over the last 50 years

scientific article published in October 2011

Circulating DNA: a potential marker of sickle cell crisis.

scientific article

Circulating mitochondrial DNA is a proinflammatory DAMP in sickle cell disease

scientific article published on 01 June 2021

Control of fetal hemoglobin: new insights emerging from genomics and clinical implications

scientific article published on October 2009

Delayed haemolytic transfusion reaction in adults with sickle cell disease: a 5-year experience

scientific article published on 5 March 2015

Detection of Hb Rothschild HBB: c.[112T>A or 112T>C], Through High Index of Suspicion on Abnormal Pulse Oximetry

scientific article published on 16 June 2017

Discovering the genetics underlying foetal haemoglobin production in adults.

scientific article published on 02 March 2008

Effects of co-existing α-thalassaemia in sickle cell disease on hydroxycarbamide therapy and circulating nucleic acids

scientific article published on 15 November 2011

Erythrocytosis and the Chuvash von Hippel‐Lindau mutation ⬇️

scientific article published on 01 October 2003

Ethnic differences in F cell levels in Jamaica: a potential tool for identifying new genetic loci controlling fetal haemoglobin

scientific article published on 20 December 2008

Evidence of genetic interaction between the beta-globin complex and chromosome 8q in the expression of fetal hemoglobin

scientific article published on 30 January 2002

Exhaled carbon monoxide levels in children with sickle cell disease

scientific article published on 15 December 2004

Experimental generation of SNP haplotype signatures in patients with sickle cell anaemia

scientific article (publication date: 24 September 2010)

Extracranial internal carotid arterial disease in children with sickle cell anemia

scientific article

Fetal Hemoglobin is Associated with Peripheral Oxygen Saturation in Sickle Cell Disease in Tanzania

scientific article published on 08 August 2017

First reported duplication of the entire beta globin gene cluster causing an unusual sickle cell trait phenotype

scientific article published on 18 December 2014

Free fetal DNA in maternal circulation: a potential prognostic marker for chromosomal abnormalities?

scientific article published on February 2007

Genetic Basis and Genetic Modifiers of β-Thalassemia and Sickle Cell Disease

scientific article published in January 2017

Genetic Modifiers of Fetal Haemoglobin in Sickle Cell Disease

scientific article published on 01 April 2019

Genetic association of fetal-hemoglobin levels in individuals with sickle cell disease in Tanzania maps to conserved regulatory elements within the MYB core enhancer

scientific article published on 10 February 2015

Genetic association studies in β-hemoglobinopathies

scientific article published on January 2013

Genetic basis of inosine triphosphate pyrophosphohydrolase deficiency.

scientific article

Genetic control of erythropoiesis

scientific article published on 15 February 2017

Genetic determinants of haemolysis in sickle cell anaemia

scientific article

Genetic insights into the clinical diversity of beta thalassaemia

scientific article published on February 2004

Genetic modifiers of beta-thalassemia.

scientific article

Genetic modifiers of sickle cell disease

scientific article published on 03 October 2011

Genetic modifiers of the beta-haemoglobinopathies

scientific article published on May 2008

Genetic regulation of fetal haemoglobin in inherited bone marrow failure syndromes

scientific article published on 29 May 2013

Genetic variants at HbF-modifier loci moderate anemia and leukocytosis in sickle cell disease in Tanzania

scientific article published on 20 October 2014

Genetic variation on chromosome 6 influences F cell levels in healthy individuals of African descent and HbF levels in sickle cell patients

scientific article

Genetics of fetal hemoglobin in Tanzanian and British patients with sickle cell anemia

scientific article

Genome annotation of a 1.5 Mb region of human chromosome 6q23 encompassing a quantitative trait locus for fetal hemoglobin expression in adults

scientific article

Genome wide association study of fetal hemoglobin in sickle cell anemia in Tanzania

scientific article

Genome-wide association analyses based on whole-genome sequencing in Sardinia provide insights into regulation of hemoglobin levels

scientific article

Global genetic architecture of an erythroid quantitative trait locus, HMIP-2

scientific article

Glucose 6 phosphate dehydrogenase deficiency is not associated with cerebrovascular disease in children with sickle cell anemia.

scientific article published in July 2009

GlycA is not a useful biomarker of inflammation in sickle cell disease.

scientific article published on 27 August 2018

HBS1L-MYB intergenic variants modulate fetal hemoglobin via long-range MYB enhancers

scientific article published on 10 March 2014

Haemoglobin Variant Screening in Jamaica: Meeting Student's Request

scientific article published on 30 June 2015

Hepatic dysfunction in sickle cell disease: a new system of classification based on global assessment.

scientific article

Heterocellular hereditary persistence of fetal haemoglobin affects the haematological parameters of beta-thalassaemia trait

scientific article published in October 2003

Heterogeneity of respiratory disease in children and young adults with sickle cell disease

scientific article published on 29 November 2017

Heterogeneity of the egammadeltabeta-thalassaemias: characterization of three novel English deletions

scientific article published on 01 March 2005

How I treat renal complications in sickle cell disease

scientific article published on 24 April 2014

How I treat the older adult with sickle cell disease

scientific article published on 11 September 2018

How we treat delayed haemolytic transfusion reactions in patients with sickle cell disease

scientific article published on 13 May 2015

Hydroxyurea therapy lowers circulating DNA levels in sickle cell anemia.

scientific article published in September 2008

Impact of acute chest syndrome on lung function of children with sickle cell disease.

scientific article

Increased prevalence of renal cysts in patients with sickle cell disease

scientific article published on 21 September 2017

Intergenic variants of HBS1L-MYB are responsible for a major quantitative trait locus on chromosome 6q23 influencing fetal hemoglobin levels in adults

scholarly article

Interim assessment of liver damage in patients with sickle cell disease using new non-invasive techniques

scientific article published on 16 December 2016

Intracranial Aneurysms in Sickle-Cell Disease Are Associated With the Hemoglobin SS Genotype But Not With Moyamoya Syndrome

scientific article published on 14 June 2016

Lamin B-receptor mutations in Pelger-Huët anomaly.

scientific article published in November 2003

Leucocyte telomere length in patients with sickle cell disease.

scientific article published on 14 February 2014

Longitudinal assessment of lung function in children with sickle cell disease

scientific article published on 22 December 2015

Loss of Major DNase I Hypersensitive Sites in Duplicated β-globin Gene Cluster Incompletely Silences HBB Gene Expression

scientific article published on 5 August 2016

Lung gas transfer in children with sickle cell anaemia

scientific article published on 08 April 2007

MYB - A regulatory factor in hematopoiesis.

scientific article

Milestones in the history of hemoglobin research (in memory of professor Titus H.J. Huisman).

scientific article published on 20 September 2011

Molecular basis of β thalassemia and potential therapeutic targets

scientific article published on 20 June 2017

Molecular therapies in beta-thalassaemia

scientific article published on 27 November 2006

Multiple loci are associated with white blood cell phenotypes

scientific article

Neurokinin-B transcription in erythroid cells: direct activation by the hematopoietic transcription factor GATA-1.

scientific article

Neutrophils remain detrimentally active in hydroxyurea-treated patients with sickle cell disease

scientific article published on 23 December 2019

New gene functions in megakaryopoiesis and platelet formation

scientific article published on 30 November 2011

Nontraumatic extradural hematoma in sickle cell anemia: a rare neurological complication not to be missed

scientific article published on 30 September 2013

Outcome of adults with sickle cell disease admitted to critical care - experience of a single institution in the UK

scientific article published on 15 June 2010

Outcome of children with sickle cell disease admitted to intensive care - a single institution experience

scientific article

Overnight auto-adjusting continuous airway pressure + standard care compared with standard care alone in the prevention of morbidity in sickle cell disease phase II (POMS2b): study protocol for a randomised controlled trial

scientific article published on 22 January 2018

Pain and opioid use after reversal of sickle cell disease following HLA-matched sibling haematopoietic stem cell transplant.

scientific article published on 12 March 2018

Pathophysiology of beta thalassemia--a guide to molecular therapies

scientific article published in January 2005

Phenotypic screening of the ReFRAME drug repurposing library to discover new drugs for treating sickle cell disease

scientific article published in 2022

Population analysis of the alpha hemoglobin stabilizing protein (AHSP) gene identifies sequence variants that alter expression and function

article

Prevention of Morbidity in sickle cell disease--qualitative outcomes, pain and quality of life in a randomised cross-over pilot trial of overnight supplementary oxygen and auto-adjusting continuous positive airways pressure (POMS2a): study protocol f

Pro-inflammatory cytokines associate with NETosis during sickle cell vaso-occlusive crises

scientific article published on 25 November 2019

Proteomic analysis of plasma from children with sickle cell anemia and silent cerebral infarction.

scientific article published on 15 March 2018

Pulmonary Haemodynamics in Sickle Cell Disease Are Driven Predominantly by a High-Output State Rather Than Elevated Pulmonary Vascular Resistance: A Prospective 3-Dimensional Echocardiography/Doppler Study

scientific article published on 13 August 2015

Pulmonary function, CT and echocardiographic abnormalities in sickle cell disease.

scientific article published on 28 March 2014

Quantification of hepcidin using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.

scientific article

Quantitation of hepcidin in human urine by liquid chromatography-mass spectrometry.

scientific article published on 5 October 2008

Quantitation of hepcidin in serum using ultra-high-pressure liquid chromatography and a linear ion trap mass spectrometer

scientific article published on 01 May 2010

Quantitative trait locus on chromosome 8q influences the switch from fetal to adult hemoglobin.

scientific article published on 17 June 2004

Red blood cell alloimmunization in sickle cell disease-prevalence and trends: a single-center cross-sectional study from United Kingdom

scientific article published in December 2013

Reduced rate of sickle-related complications in Brazilian patients carrying HbF-promoting alleles at the BCL11A and HMIP-2 loci.

scientific article published on 16 February 2016

Renal iron load in sickle cell disease is influenced by severity of haemolysis.

scientific article published on 13 March 2012

Response of iron overload to deferasirox in rare transfusion-dependent anaemias: equivalent effects on serum ferritin and labile plasma iron for haemolytic or production anaemias

scientific article published on 29 July 2011

Response to hydroxyurea among Kuwaiti patients with sickle cell disease and elevated baseline HbF levels.

scientific article

Reversible binding of hemoglobin to band 3 constitutes the molecular switch that mediates O2 regulation of erythrocyte properties

scientific article published on 29 September 2016

Seeking optimal relation between oxygen saturation and hemoglobin concentration in adults with cyanosis from congenital heart disease.

scientific article published in February 2011

Selection of housekeeping genes for gene expression studies in human reticulocytes using real-time PCR.

scientific article

Serum ferritin and total units transfused for assessing iron overload in adults with sickle cell disease

scientific article published on 15 February 2012

Sickle Cell Anemia and Its Phenotypes.

scientific article published on 11 April 2018

Sickle cell disease in a carrier with pyruvate kinase deficiency.

scientific article

Sickle cell disease in the older adult

scientific article published on 30 November 2016

Sickle cell nephropathy - a practical approach

scientific article published on 09 September 2011

Sickle cell/β0-thalassemia associated with the 1393 bp deletion can be associated with a severe phenotype.

scientific article

Spectral domain optical coherence tomography in patients with sickle cell disease

scientific article published on 16 January 2015

Super-elevated LDH and thrombocytopenia are markers of a severe subtype of vaso-occlusive crisis in sickle cell disease.

scientific article published on 22 July 2015

Survival in adults with sickle cell disease in a high-income setting

scientific article published on 20 July 2016

Systematic documentation and analysis of human genetic variation in hemoglobinopathies using the microattribution approach

scientific article

Tailoring iron chelation by iron intake and serum ferritin: the prospective EPIC study of deferasirox in 1744 patients with transfusion-dependent anemias.

scientific article

Temporal relationship of asthma to acute chest syndrome in sickle cell disease

scientific article published on 01 February 2007

The 12.6 kb-deletion in the β-globin gene cluster is the known Thai/Vietnamese (δβ)0-thalassemia commonly found in Southeast Asia

scientific article published on September 2013

The HBS1L-MYB intergenic interval associated with elevated HbF levels shows characteristics of a distal regulatory region in erythroid cells

scientific article published on 15 June 2009

The HBS1L-MYB intergenic region on chromosome 6q23.3 influences erythrocyte, platelet, and monocyte counts in humans.

scientific article published on 21 August 2007

The associations between air quality and the number of hospital admissions for acute pain and sickle-cell disease in an urban environment

scientific article published on March 2007

The clinical significance of K-Cl cotransport activity in red cells of patients with HbSC disease

scientific article published on 6 March 2015

The effect of Duffy antigen receptor for chemokines on severity in sickle cell disease

scientific article published on 10 June 2013

The effects of air quality on haematological and clinical parameters in children with sickle cell anaemia

scientific article

The emerging role of fetal hemoglobin induction in non-transfusion-dependent thalassemia

scientific article published on April 2012

The investigation of resveratrol and analogs as potential inducers of fetal hemoglobin

scientific article published in December 2015

The linear effects of alpha-thalassaemia, the UGT1A1 and HMOX1 polymorphisms on cholelithiasis in sickle cell disease

scientific article

The measurement of urinary hydroxyurea in sickle cell anaemia

scientific article published in July 2005

The molecular basis of β-thalassemia

scientific article

The platelet NLRP3 inflammasome is upregulated in sickle cell disease via HMGB1/TLR4 and Bruton tyrosine kinase

The presence of alpha-thalassaemia trait blunts the response to hydroxycarbamide in patients with sickle cell disease

scientific article published in September 2008

Therapeutic advances in sickle cell disease in the last decade

scientific article published in June 2017

Transfusion and chelation practices in sickle cell disease: a regional perspective

scientific article published on 30 July 2010

Transient aplastic crisis as presentation of a previously unknown G6PD deficiency with iron overload

scientific article published on 27 April 2011

Treating sickle cell anemia

scientific article

Two candidate genes for low platelet count identified in an Asian Indian kindred by genome-wide linkage analysis: glycoprotein IX and thrombopoietin

scientific article

Two novel mutations (HBG1: c.-250C > T and HBG2: c.-250C > T) associated with hereditary persistence of fetal hemoglobin.

scientific article

Voxelotor treatment of a patient with sickle cell disease and very severe anemia

scientific article published on 08 January 2019

Whole genome sequence-based haplotypes reveal a single origin of the 1393 bp HBB deletion

scientific article published on 30 January 2020

Windy weather and low humidity are associated with an increased number of hospital admissions for acute pain and sickle cell disease in an urban environment with a maritime temperate climate.

scientific article published on November 2005

World Sickle Cell Day 2016 : A time for appraisal

scientific article published on June 2016

cMYB is involved in the regulation of fetal hemoglobin production in adults.

scientific article

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