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List of works by Ingunn Holen

A single administration of combination therapy inhibits breast tumour progression in bone and modifies both osteoblasts and osteoclasts.

scientific article

Anti-tumour activity of bisphosphonates in preclinical models of breast cancer.

scientific article

Anticancer mechanisms of doxorubicin and zoledronic acid in breast cancer tumor growth in bone.

scientific article published on 29 September 2009

Antitumor effects of doxorubicin followed by zoledronic acid in a mouse model of breast cancer.

scientific article published on 11 August 2008

Bovine joint capsule and fibroblasts derived from joint capsule express aggrecanase activity

scientific article published on 01 July 2000

Castration-induced bone loss triggers growth of disseminated prostate cancer cells in bone.

scientific article

Changes in bone resorption and vascular endothelial growth factor after a single zoledronic acid infusion in cancer patients with bone metastases from solid tumours

scientific article published on May 2006

Combination therapy inhibits development and progression of mammary tumours in immunocompetent mice

article

Combinations of Bisphosphonates and Classical Anticancer Drugs: A Preclinical Perspective ⬇️

scientific article published on January 1, 2012

Combined effects of the bisphosphonate, zoledronic acid and the aromatase inhibitor letrozole on breast cancer cells in vitro: evidence of synergistic interaction

scientific article

Combined effects of zoledronic acid and doxorubicin on breast cancer cell invasion in vitro.

scientific article published in September 2005

Combined therapies of bone disease with bisphosphonates.

scientific article published on January 2010

Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer

scientific article published on October 2013

Different molecular profiles are associated with breast cancer cell homing compared with colonisation of bone: evidence using a novel bone-seeking cell line

scientific article published on 7 March 2014

Differential effect of doxorubicin and zoledronic acid on intraosseous versus extraosseous breast tumor growth in vivo.

scientific article published in July 2008

Disruption of the cytokeratin cytoskeleton and inhibition of hepatocytic autophagy by okadaic acid.

scientific article published in June 1995

Effects of adrenergic agonists and antagonists on autophagic activity in isolated rat liver cells

scientific article published on 01 January 1991

Endogenous production of IL-1B by breast cancer cells drives metastasis and colonisation of the bone microenvironment ⬇️

scientific article published on 22 January 2019

Evaluation of the current knowledge limitations in breast cancer research: a gap analysis

scientific article published on 27 March 2008

Exploring the anti-tumour activity of bisphosphonates in early breast cancer.

scientific article published on August 2008

Expression of osteoprotegerin (OPG), TNF related apoptosis inducing ligand (TRAIL), and receptor activator of nuclear factor kappaB ligand (RANKL) in human breast tumours

scientific article published on January 2006

Expression of receptor activator of nuclear factor kappabeta ligand (RANKL) and tumour necrosis factor related, apoptosis inducing ligand (TRAIL) in breast cancer, and their relations with osteoprotegerin, oestrogen receptor, and clinicopathological

scientific article published on 17 February 2006

Hepatocytic autophagy

scientific article published on January 1, 1991

Human breast cancer bone metastasis in vitro and in vivo: a novel 3D model system for studies of tumour cell-bone cell interactions.

scientific article published in August 2015

Increased anti-tumour effects of doxorubicin and zoledronic acid in prostate cancer cells in vitro: supporting the benefits of combination therapy

scientific article published in April 2010

Location matters: osteoblast and osteoclast distribution is modified by the presence and proximity to breast cancer cells in vivo ⬇️

scientific article published on May 6, 2012

Loss of plakoglobin promotes decreased cell-cell contact, increased invasion, and breast cancer cell dissemination in vivo ⬇️

scientific article published on May 25, 2012

Lysophosphatidic acid receptor type 1 (LPA1) plays a functional role in osteoclast differentiation and bone resorption activity.

scientific article

Macrophages as potential targets for zoledronic acid outside the skeleton-evidence from in vitro and in vivo models

scientific article published on 01 November 2013

Mechanisms of disease: Preclinical reports of antineoplastic synergistic action of bisphosphonates

scientific article

Metastasis and bone loss: advancing treatment and prevention.

scientific article

Mitotic quiescence, but not unique "stemness," marks the phenotype of bone metastasis-initiating cells in prostate cancer.

scientific article published on 17 April 2015

Modifying the osteoblastic niche with zoledronic acid in vivo-potential implications for breast cancer bone metastasis

scientific article

Modulating Bone Marrow Hematopoietic Lineage Potential to Prevent Bone Metastasis in Breast Cancer

scientific article published on 31 July 2018

Morphological transformation and catalase activity of Syrian hamster embryo cells treated with hepatic peroxisome proliferators, TPA and nickel sulphate

scientific article (publication date: 1990)

Multidrug Resistance in Breast Cancer: FromIn VitroModels to Clinical Studies ⬇️

scientific article published on February 24, 2011

Neoadjuvant Chemotherapy with or without Zoledronic Acid in Early Breast Cancer--A Randomized Biomarker Pilot Study

article

OPG-Fc inhibits ovariectomy-induced growth of disseminated breast cancer cells in bone.

scientific article published on 2 February 2015

Oestrogen receptor positive breast cancer metastasis to bone: inhibition by targeting the bone microenvironment in vivo.

scientific article published on 19 November 2015

Optimizing the yield and utility of circulating cell-free DNA from plasma and serum.

scientific article

Osteoprotegerin (OPG) expression by breast cancer cells in vitro and breast tumours in vivo--a role in tumour cell survival?

scientific article published on August 2005

Osteoprotegerin (OPG) produced by bone marrow stromal cells protects breast cancer cells from TRAIL-induced apoptosis

scientific article published on 01 August 2004

Osteoprotegerin (OPG)-a potential new role in the regulation of endothelialcell phenotype and tumour angiogenesis?

scientific article published on 01 April 2006

Osteoprotegerin induces cytoskeletal reorganization and activates FAK, Src, and ERK signaling in endothelial cells.

scientific article published on 16 March 2010

Osteoprotegerin inhibits the development of osteolytic bone disease in multiple myeloma

scientific article published on 01 December 2001

Parathyroid Hormone (PTH) Increases Skeletal Tumour Growth and Alters Tumour Distribution in an In Vivo Model of Breast Cancer

scientific article published on 26 September 2018

Pathophysiological roles of osteoprotegerin (OPG).

scientific article published on 15 August 2008

Prostate cancer cells preferentially home to osteoblast-rich areas in the early stages of bone metastasis: evidence from in vivo models

scientific article

Protection by naringin and some other flavonoids of hepatocytic autophagy and endocytosis against inhibition by okadaic acid

scientific article published on 01 March 1995

Protein kinase-dependent effects of okadaic acid on hepatocytic autophagy and cytoskeletal integrity ⬇️

scientific article published on June 15, 1992

Rapid modification of the bone microenvironment following short-term treatment with Cabozantinib in vivo.

scientific article published on 13 August 2015

Role of cyclic nucleotides in the control of hepatic autophagy

scientific article published on 01 January 1991

Seed, soil and secreted hormones: potential interactions of breast cancer cells with their endocrine/paracrine microenvironment and implications for treatment with bisphosphonates.

scientific article published on 06 March 2012

Serum osteoprotegerin (OPG) levels are associated with disease progression and response to androgen ablation in patients with prostate cancer.

scientific article published in May 2004

Sustained inhibition of tumor growth and prolonged survival following sequential administration of doxorubicin and zoledronic acid in a breast cancer model.

scientific article

The anti-tumour activity of bisphosphonates.

scientific article

The differential anti-tumour effects of zoledronic acid in breast cancer - evidence for a role of the activin signaling pathway

scientific article

The frequency of osteolytic bone metastasis is determined by conditions of the soil, not the number of seeds; evidence from in vivo models of breast and prostate cancer

scientific article

The metastatic microenvironment of breast cancer: clinical implications

scientific article published on August 2013

The role of macrophages in bone metastasis

scientific article published on 22 July 2013

Tumour macrophages as potential targets of bisphosphonates.

scientific article published on 17 October 2011

Zoledronic acid has differential antitumor activity in the pre- and postmenopausal bone microenvironment in vivo

scientific article

Zoledronic acid repolarizes tumour-associated macrophages and inhibits mammary carcinogenesis by targeting the mevalonate pathway.

scientific article published on December 2010

Zoledronic acid-induced IPP/ApppI production in vivo

scientific article published on 17 August 2007

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