List of works - Raghavendra Mirmira

1,25-Dihydroxyvitamin D3 enhances glucose-stimulated insulin secretion in mouse and human islets: a role for transcriptional regulation of voltage-gated calcium channels by the vitamin D receptor

scientific article published on 30 July 2018

12-lipoxygenase promotes obesity-induced oxidative stress in pancreatic islets

scientific article

A Versatile, Portable Intravital Microscopy Platform for Studying Beta-cell Biology In Vivo

scientific article published on 11 June 2019

A zebrafish tailfin injury assay protocol for quantifying immune cell migration and infiltration

scientific article published on 23 February 2022

Abnormalities in proinsulin processing in islets from individuals with longstanding T1D

scientific article published on 09 August 2019

Amelioration of type 1 diabetes following treatment of non-obese diabetic mice with INGAP and lisofylline.

scientific article

An In Vivo Zebrafish Model for Interrogating ROS-Mediated Pancreatic β-Cell Injury, Response, and Prevention.

scientific article

Analysis of serum Hsp90 as a potential biomarker of β cell autoimmunity in type 1 diabetes

scientific article published in PLoS ONE

Biomarkers of islet beta cell stress and death in type 1 diabetes

Biomarkers of β-Cell Stress and Death in Type 1 Diabetes

scientific article

Cellular metabolism constrains innate immune responses in early human ontogeny

scientific article published in Nature Communications

Chronic high fat feeding restricts islet mRNA translation initiation independently of ER stress via DNA damage and p53 activation

scientific article

Circulating unmethylated CHTOP and INS DNA fragments provide evidence of possible islet cell death in youth with obesity and diabetes

scientific article published on 31 July 2020

Deletion of 12/15-lipoxygenase alters macrophage and islet function in NOD-Alox15(null) mice, leading to protection against type 1 diabetes development

scientific article

Deoxyhypusine synthase haploinsufficiency attenuates acute cytokine signaling

scientific article

Detection of islet β-cell death in vivo by multiplex PCR analysis of differentially methylated DNA.

scientific article published on 03 July 2013

Divergent compensatory responses to high-fat diet between C57BL6/J and C57BLKS/J inbred mouse strains

scientific article published on 29 October 2013

Elevated unmethylated and methylated insulin DNA are unique markers of A+β+ ketosis prone diabetes

scientific article published on 31 October 2017

Elevations in Circulating Methylated and Unmethylated Preproinsulin DNA in New-Onset Type 1 Diabetes

scientific article

Elevations in the Fasting Serum Proinsulin-to-C-Peptide Ratio Precede the Onset of Type 1 Diabetes

scientific article published on 6 July 2016

Hypoglycemia in a Patient With a Polyhormonal Pancreatic Neuroendocrine Tumor With Evidence of Endocrine Progenitors.

scientific article published on 16 January 2018

Hypusinated eIF5A is expressed in the pancreas and spleen of individuals with type 1 and type 2 diabetes

scientific article published on 24 March 2020

Hypusine biosynthesis in β cells links polyamine metabolism to facultative cellular proliferation to maintain glucose homeostasis

scientific article published on 03 December 2019

Immune reconstitution in ART treated, but not untreated HIV infection, is associated with abnormal beta cell function.

scientific article published on 24 May 2018

Inhibition of 12/15-Lipoxygenase Protects Against β Cell Oxidative Stress and Glycemic Deterioration in Mouse Models of Type 1 Diabetes.

scientific article published on 25 August 2017

Inhibition of deoxyhypusine synthase enhances islet {beta} cell function and survival in the setting of endoplasmic reticulum stress and type 2 diabetes

scientific article

Interleukin-6 Reduces β-Cell Oxidative Stress by Linking Autophagy With the Antioxidant Response

scientific article published on 21 May 2018

Islet β-cell endoplasmic reticulum stress precedes the onset of type 1 diabetes in the nonobese diabetic mouse model

scientific article

Longitudinal Intravital Imaging of Biosensor-labeled In Situ Islet Beta Cells

Loss of Free Fatty Acid Receptor 2 leads to impaired islet mass and beta cell survival

scientific article published on 21 June 2016

Maintenance of Pdx1 mRNA translation in islet β-cells during the unfolded protein response

scientific article

Measurement of Differentially Methylated INS DNA Species in Human Serum Samples as a Biomarker of Islet β Cell Death

scientific article published on 21 December 2016

Minireview: 12-Lipoxygenase and Islet β-Cell Dysfunction in Diabetes

scientific article

Molecular mechanisms of nonalcoholic fatty liver disease: Potential role for 12-lipoxygenase

scientific article published on 31 July 2017

Mouse islet of Langerhans isolation using a combination of purified collagenase and neutral protease

scientific article published on 7 September 2012

Noninvasive assessment of pancreatic beta-cell function in vivo with manganese-enhanced magnetic resonance imaging

scientific article

Palmitate induces mRNA translation and increases ER protein load in islet β-cells via activation of the mammalian target of rapamycin pathway

scientific article

Peroxisome proliferator-activated receptor gamma activation restores islet function in diabetic mice through reduction of endoplasmic reticulum stress and maintenance of euchromatin structure

scientific article

Persistent elevations in circulating INS DNA among subjects with longstanding type 1 diabetes

scientific article published on 24 August 2018

Profiling of RNAs from Human Islet-Derived Exosomes in a Model of Type 1 Diabetes

scientific article published on 25 November 2019

Proinsulin Secretion Is a Persistent Feature of Type 1 Diabetes

scientific article published on 10 December 2018

Protective effects of polyamine depletion in mouse models of type 1 diabetes: implications for therapy

scientific article published on 12 July 2013

Response to Comment on Sims et al. Proinsulin Secretion Is a Persistent Feature of Type 1 Diabetes. Diabetes Care 2019;42:258-264

scientific article published on 01 May 2019

Restructuring of the Gut Microbiome by Intermittent Fasting Prevents Retinopathy and Prolongs Survival in Mice

scientific article published on 30 April 2018

Single-Cell Transcriptional Profiling of Mouse Islets Following Short-Term Obesogenic Dietary Intervention

scientific article published on 18 December 2020

Sirtuin 6 regulates glucose-stimulated insulin secretion in mouse pancreatic beta cells

scientific article published on 15 October 2015

The role of beta-cell dysfunction in early type 1 diabetes

scientific article published on 01 August 2020

The unique hypusine modification of eIF5A promotes islet beta cell inflammation and dysfunction in mice

scientific article

Transcriptional activity of the islet β cell factor Pdx1 is augmented by lysine methylation catalyzed by the methyltransferase Set7/9.

scientific article

eIF5A inhibition influences T cell dynamics in the pancreatic microenvironment of the humanized mouse model of Type 1 Diabetes

scientific article published in Scientific Reports

List of works by Raghavendra Mirmira

1,25-Dihydroxyvitamin D3 enhances glucose-stimulated insulin secretion in mouse and human islets: a role for transcriptional regulation of voltage-gated calcium channels by the vitamin D receptor

12-lipoxygenase promotes obesity-induced oxidative stress in pancreatic islets

A Versatile, Portable Intravital Microscopy Platform for Studying Beta-cell Biology In Vivo

A zebrafish tailfin injury assay protocol for quantifying immune cell migration and infiltration

Abnormalities in proinsulin processing in islets from individuals with longstanding T1D

Amelioration of type 1 diabetes following treatment of non-obese diabetic mice with INGAP and lisofylline.

An In Vivo Zebrafish Model for Interrogating ROS-Mediated Pancreatic β-Cell Injury, Response, and Prevention.

Analysis of serum Hsp90 as a potential biomarker of β cell autoimmunity in type 1 diabetes

Biomarkers of islet beta cell stress and death in type 1 diabetes

Biomarkers of β-Cell Stress and Death in Type 1 Diabetes

Cellular metabolism constrains innate immune responses in early human ontogeny

Chronic high fat feeding restricts islet mRNA translation initiation independently of ER stress via DNA damage and p53 activation

Circulating unmethylated CHTOP and INS DNA fragments provide evidence of possible islet cell death in youth with obesity and diabetes

Deletion of 12/15-lipoxygenase alters macrophage and islet function in NOD-Alox15(null) mice, leading to protection against type 1 diabetes development

Deoxyhypusine synthase haploinsufficiency attenuates acute cytokine signaling

Detection of islet β-cell death in vivo by multiplex PCR analysis of differentially methylated DNA.

Divergent compensatory responses to high-fat diet between C57BL6/J and C57BLKS/J inbred mouse strains

Elevated unmethylated and methylated insulin DNA are unique markers of A+β+ ketosis prone diabetes

Elevations in Circulating Methylated and Unmethylated Preproinsulin DNA in New-Onset Type 1 Diabetes

Elevations in the Fasting Serum Proinsulin-to-C-Peptide Ratio Precede the Onset of Type 1 Diabetes

Hypoglycemia in a Patient With a Polyhormonal Pancreatic Neuroendocrine Tumor With Evidence of Endocrine Progenitors.

Hypusinated eIF5A is expressed in the pancreas and spleen of individuals with type 1 and type 2 diabetes

Hypusine biosynthesis in β cells links polyamine metabolism to facultative cellular proliferation to maintain glucose homeostasis

Immune reconstitution in ART treated, but not untreated HIV infection, is associated with abnormal beta cell function.

Inhibition of 12/15-Lipoxygenase Protects Against β Cell Oxidative Stress and Glycemic Deterioration in Mouse Models of Type 1 Diabetes.

Inhibition of deoxyhypusine synthase enhances islet {beta} cell function and survival in the setting of endoplasmic reticulum stress and type 2 diabetes

Interleukin-6 Reduces β-Cell Oxidative Stress by Linking Autophagy With the Antioxidant Response

Islet β-cell endoplasmic reticulum stress precedes the onset of type 1 diabetes in the nonobese diabetic mouse model

Longitudinal Intravital Imaging of Biosensor-labeled In Situ Islet Beta Cells

Loss of Free Fatty Acid Receptor 2 leads to impaired islet mass and beta cell survival

Maintenance of Pdx1 mRNA translation in islet β-cells during the unfolded protein response

Measurement of Differentially Methylated INS DNA Species in Human Serum Samples as a Biomarker of Islet β Cell Death

Minireview: 12-Lipoxygenase and Islet β-Cell Dysfunction in Diabetes

Molecular mechanisms of nonalcoholic fatty liver disease: Potential role for 12-lipoxygenase

Mouse islet of Langerhans isolation using a combination of purified collagenase and neutral protease

Noninvasive assessment of pancreatic beta-cell function in vivo with manganese-enhanced magnetic resonance imaging

Palmitate induces mRNA translation and increases ER protein load in islet β-cells via activation of the mammalian target of rapamycin pathway

Peroxisome proliferator-activated receptor gamma activation restores islet function in diabetic mice through reduction of endoplasmic reticulum stress and maintenance of euchromatin structure

Persistent elevations in circulating INS DNA among subjects with longstanding type 1 diabetes

Profiling of RNAs from Human Islet-Derived Exosomes in a Model of Type 1 Diabetes

Proinsulin Secretion Is a Persistent Feature of Type 1 Diabetes

Protective effects of polyamine depletion in mouse models of type 1 diabetes: implications for therapy

Response to Comment on Sims et al. Proinsulin Secretion Is a Persistent Feature of Type 1 Diabetes. Diabetes Care 2019;42:258-264

Restructuring of the Gut Microbiome by Intermittent Fasting Prevents Retinopathy and Prolongs Survival in Mice

Single-Cell Transcriptional Profiling of Mouse Islets Following Short-Term Obesogenic Dietary Intervention

Sirtuin 6 regulates glucose-stimulated insulin secretion in mouse pancreatic beta cells

The role of beta-cell dysfunction in early type 1 diabetes

The unique hypusine modification of eIF5A promotes islet beta cell inflammation and dysfunction in mice

Transcriptional activity of the islet β cell factor Pdx1 is augmented by lysine methylation catalyzed by the methyltransferase Set7/9.

eIF5A inhibition influences T cell dynamics in the pancreatic microenvironment of the humanized mouse model of Type 1 Diabetes