Search filters

List of works by Tommaso Costa

"Induced-fit" mechanism for catecholamine binding to the beta2-adrenergic receptor.

scientific article

A highly selective ligand for brain delta opiate receptors, a cyclopropyl(E)Phe(4)-enkephalin analog, suppresses mu receptor-mediated thermal analgesia by morphine

scientific article published on 01 June 1988

A mutation changes ligand selectivity and transmembrane signaling preference of the neurokinin-1 receptor

scientific article published on 01 March 1997

A very high affinity opioid binding site in rat brain: demonstration by computer modeling.

scientific article published in July 1984

Agonist efficacy and allosteric models of receptor action.

scientific article published in May 1997

Allosteric coupling and conformational fluctuations in proteins.

scientific article published in April 2009

Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation

scientific article published on 13 July 2016

Cell contact-dependent functional selectivity of β2-adrenergic receptor ligands in stimulating cAMP accumulation and extracellular signal-regulated kinase phosphorylation

scientific article published on 12 January 2012

Cholera toxin ADP-ribosylates the receptor-coupled form of pertussis toxin-sensitive G-proteins.

scientific article published on December 1989

Dehydro-enkephalins. IV. Discriminative recognition of delta and mu opiate receptors by enkephalin analogs ⬇️

scientific article published on January 29, 1982

Dehydro-enkephalins: receptor binding activity of unsaturated analogs of Leu5-enkephalin

scientific article published on 01 October 1981

Designed modification of partial agonist of ORL1 nociceptin receptor for conversion into highly potent antagonist.

scientific article

Differential effects of GTP and cations on binding of labeled dimeric and monomeric enkephalins to neuroblastoma-glioma cell delta opiate receptors.

scientific article published in September 1982

Differential roles of two consecutive phenylalanine residues in thrombin receptor-tethered ligand peptides (SFFLRNP) in thrombin receptor activation.

scientific article published on August 1994

Dimeric Pentapeptide and Tetrapeptide Enkephalins: New Tools for the Study of Delta Opioid Receptors ⬇️

scientific article published on January 1, 1983

Dimeric pentapeptide enkephalin: A novel probe of delta opiate receptors ⬇️

scientific article published on October 11, 1982

Dimeric tetrapeptide enkephalins display extraordinary selectivity for the delta opiate receptor.

scientific article published in May 1982

Direct modulation of voltage-dependent calcium channels by muscarinic activation of a pertussis toxin-sensitive G-protein in hippocampal neurons

scientific article published on 01 December 1989

Discriminatory synergistic effect of Trp-substitutions in superagonist [(Arg/Lys)(14), (Arg/Lys)(15)]nociceptin on ORL1 receptor binding and activation.

scientific article published on 13 June 2009

Divergent agonist selectivity in activating β1- and β2-adrenoceptors for G-protein and arrestin coupling.

scientific article published in August 2011

Divergent transducer-specific molecular efficacies generate biased agonism at a G protein-coupled receptor (GPCR)

scientific article

Effects of sodium and GTP on the binding kinetics of [3H]diprenorphine in NG 108-15 cell membranes

scientific article published on 01 December 1986

Enkephalin dimers: regulation of cyclic AMP levels in NG108-15 cells.

scientific article published in January 1983

Fine spatial assembly for construction of the phenol-binding pocket to capture bisphenol A in the human nuclear receptor estrogen-related receptor γ.

scientific article

Functional complementation of high-efficiency resonance energy transfer: a new tool for the study of protein binding interactions in living cells.

scientific article published in January 2008

Guanine nucleotide-mediated inhibition of opioid agonist binding. Modulatory effects of ions and of receptor occupancy.

scientific article

Historical review: Negative efficacy and the constitutive activity of G-protein-coupled receptors.

scientific article

Importance of the stereo-orientation of aromatic groups in enkephalins to opiate receptor recognition.

scientific article published in June 1984

Is the benzodiazepine receptor coupled to a chloride anion channel?

scientific article

Ligands raise the constraint that limits constitutive activation in G protein-coupled opioid receptors.

scientific article published on 08 July 2013

Morphine-like opiates selectively antagonize receptor-arrestin interactions.

scientific article

Mutations inducing divergent shifts of constitutive activity reveal different modes of binding among catecholamine analogues to the beta(2)-adrenergic receptor

scientific article published on April 2002

Opioid antinociception and positive reinforcement are mediated by different types of opioid receptors.

scientific article published in October 1983

Pertussis toxin decreases opiate receptor binding and adenylate inhibition in a neuroblastoma x glioma hybrid cell line.

scientific article published in January 1983

Pharmacological characterization of tachykinin tetrabranched derivatives

scientific article

Serotoninergic system in scrapie-infected hamsters

Sodium regulation of opioid agonist binding is potentiated by pertussis toxin.

scientific article

Spare interactions of highly potent [Arg(14),Lys(15)]nociceptin for cooperative induction of ORL1 receptor activation.

scientific article published on 30 October 2009

Structural requirements of nociceptin antagonist Ac-RYYRIK-NH2 for receptor binding.

scientific article

Synergistic effect of basic residues at positions 14-15 of nociceptin on binding affinity and receptor activation.

scientific article published on 9 September 2008

Synthesis and structure-activity relationship studies in serotonin 5-HT4 receptor ligands based on a benzo[de][2,6]naphthridine scaffold.

scientific article

The molecular size of multiple opiate receptors.

scientific article

Thrombin is a regulator of astrocytic endothelin-1.

scientific article published in January 1993

Thrombin is the major serum factor stimulating phosphoinositide turnover, but not DNA synthesis in human neuroblastoma SH-EP cells

scientific article published on 01 April 1992

Tritium-labelled isovaleryl-RYYRIK-NH2 as potential antagonist probe for ORL1 nociceptin receptor

scientific article published on 16 September 2014

Uncoupling of receptors is essential for opiate-induced desensitization (tolerance) in neuroblastoma x glioma hybrid cells NG 108-15.

scientific article published in January 1983

What is biased efficacy? Defining the relationship between intrinsic efficacy and free energy coupling.

scientific article

Where have all the active receptor states gone?

scientific article published on 18 July 2012

Paulina is supported by:

About Paulina

Help