List of works - Ralph J DeBerardinis

6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling

scientific article

A mitochondrial RNAi screen defines cellular bioenergetic determinants and identifies an adenylate kinase as a key regulator of ATP levels

scientific article (publication date: 8 May 2014)

A nanobuffer reporter library for fine-scale imaging and perturbation of endocytic organelles

scientific article published on 5 October 2015

A roadmap for interpreting (13)C metabolite labeling patterns from cells

scientific article

A role for the mitochondrial pyruvate carrier as a repressor of the Warburg effect and colon cancer cell growth

scientific article

Analysis of cancer metabolism by imaging hyperpolarized nuclei: prospects for translation to clinical research.

scientific article

Both GLS silencing and GLS2 overexpression synergize with oxidative stress against proliferation of glioma cells.

scientific article

Brick by brick: metabolism and tumor cell growth

scientific article

Cancer. Silencing a metabolic oncogene

scientific article

Cell-autonomous immune gene expression is repressed in pulmonary neuroendocrine cells and small cell lung cancer

scientific article published on 09 March 2021

D2HGDH regulates alpha-ketoglutarate levels and dioxygenase function by modulating IDH2

scientific article published on 16 July 2015

Designing a broad-spectrum integrative approach for cancer prevention and treatment.

scientific article

Dysregulated metabolism contributes to oncogenesis

scientific article

Evidence of Glycolysis Up-Regulation and Pyruvate Mitochondrial Oxidation Mismatch During Mechanical Unloading of the Failing Human Heart: Implications for Cardiac Reloading and Conditioning

scientific article

Exploring a glycolytic inhibitor for the treatment of an FH-deficient type-2 papillary RCC

scientific article

Fundamentals of cancer metabolism

scientific article

Genetically-defined metabolic reprogramming in cancer

scientific article

Glutamate dehydrogenase 1 signals through antioxidant glutathione peroxidase 1 to regulate redox homeostasis and tumor growth

scientific article

Glutamine and cancer: cell biology, physiology, and clinical opportunities

scientific article

Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase

scientific article

Hyperpolarized (13)C Magnetic Resonance and Its Use in Metabolic Assessment of Cultured Cells and Perfused Organs

scientific article

Hypoxic metabolism in human hematopoietic stem cells.

scientific article published on 17 July 2015

In vivo analysis of lung cancer metabolism: nothing like the real thing

scientific article

In vivo detection of citrate in brain tumors by 1H magnetic resonance spectroscopy at 3T.

scientific article

Inhibition of cancer cell proliferation by PPARγ is mediated by a metabolic switch that increases reactive oxygen species levels

scientific article

Lysine acetylation activates 6-phosphogluconate dehydrogenase to promote tumor growth.

scientific article

Measurement of glycine in the human brain in vivo by 1H-MRS at 3 T: application in brain tumors

scientific article

Mechanism by which a recently discovered allosteric inhibitor blocks glutamine metabolism in transformed cells

scientific article

Metabolic pathways promoting cancer cell survival and growth

scientific article

Metabolic plasticity maintains proliferation in pyruvate dehydrogenase deficient cells

scientific article published on 29 June 2015

Metabolic regulation of transcription through compartmentalized NAD+ biosynthesis.

scientific article published in May 2018

Metabolic reprogramming and cancer progression

scientific article published on 01 April 2020

Metformin Antagonizes Cancer Cell Proliferation by Suppressing Mitochondrial-Dependent Biosynthesis

scientific article (publication date: December 2015)

Mitochondrial reactive oxygen species promote epidermal differentiation and hair follicle development

scientific article

Oxidation of alpha-ketoglutarate is required for reductive carboxylation in cancer cells with mitochondrial defects.

scientific article

Phosphoglycerate Mutase 1 Coordinates Glycolysis and Biosynthesis to Promote Tumor Growth

scientific article

Principles of reproducible metabolite profiling of enriched lymphocytes in tumors and ascites from human ovarian cancer

scientific article published in 2022

Pyruvate carboxylase is required for glutamine-independent growth of tumor cells

scientific article

RETRACTED: MAVS, cGAS, and endogenous retroviruses in T-independent B cell responses

retracted scientific article

Real-time detection of hepatic gluconeogenic and glycogenolytic states using hyperpolarized [2-13C]dihydroxyacetone

scientific article

Reductive carboxylation supports growth in tumour cells with defective mitochondria.

scientific article published on 20 November 2011

Role of PFKFB3-driven glycolysis in vessel sprouting

scientific article

Role of glutamine in cancer: therapeutic and imaging implications

scientific article published on 16 June 2011

Spectrum of mutations in the renin-angiotensin system genes in autosomal recessive renal tubular dysgenesis.

scientific article

Stable isotope tracing to assess tumor metabolism in vivo

scientific article published in 2021

The abundance of metabolites related to protein methylation correlates with the metastatic capacity of human melanoma xenografts.

scientific article published in November 2017

The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche.

scientific article

The gut commensal Bacteroides thetaiotaomicron exacerbates enteric infection through modification of the metabolic landscape.

scientific article

The hexosamine biosynthesis pathway is a targetable liability in KRAS/LKB1 mutant lung cancer

scientific article published on 30 November 2020

The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling.

scientific article

The transcription factor HIF-1alpha plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis

scientific journal article

Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation

scientific article

Using arterial-venous analysis to characterize cancer metabolic consumption in patients

scientific article published on 23 June 2020

We need to talk about the Warburg effect

scientific article published on 01 February 2020

List of works by Ralph J DeBerardinis

6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling

A mitochondrial RNAi screen defines cellular bioenergetic determinants and identifies an adenylate kinase as a key regulator of ATP levels

A nanobuffer reporter library for fine-scale imaging and perturbation of endocytic organelles

A roadmap for interpreting (13)C metabolite labeling patterns from cells

A role for the mitochondrial pyruvate carrier as a repressor of the Warburg effect and colon cancer cell growth

Analysis of cancer metabolism by imaging hyperpolarized nuclei: prospects for translation to clinical research.

Both GLS silencing and GLS2 overexpression synergize with oxidative stress against proliferation of glioma cells.

Brick by brick: metabolism and tumor cell growth

Cancer. Silencing a metabolic oncogene

Cell-autonomous immune gene expression is repressed in pulmonary neuroendocrine cells and small cell lung cancer

D2HGDH regulates alpha-ketoglutarate levels and dioxygenase function by modulating IDH2

Designing a broad-spectrum integrative approach for cancer prevention and treatment.

Dysregulated metabolism contributes to oncogenesis

Evidence of Glycolysis Up-Regulation and Pyruvate Mitochondrial Oxidation Mismatch During Mechanical Unloading of the Failing Human Heart: Implications for Cardiac Reloading and Conditioning

Exploring a glycolytic inhibitor for the treatment of an FH-deficient type-2 papillary RCC

Fundamentals of cancer metabolism

Genetically-defined metabolic reprogramming in cancer

Glutamate dehydrogenase 1 signals through antioxidant glutathione peroxidase 1 to regulate redox homeostasis and tumor growth

Glutamine and cancer: cell biology, physiology, and clinical opportunities

Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase

Hyperpolarized (13)C Magnetic Resonance and Its Use in Metabolic Assessment of Cultured Cells and Perfused Organs

Hypoxic metabolism in human hematopoietic stem cells.

In vivo analysis of lung cancer metabolism: nothing like the real thing

In vivo detection of citrate in brain tumors by 1H magnetic resonance spectroscopy at 3T.

Inhibition of cancer cell proliferation by PPARγ is mediated by a metabolic switch that increases reactive oxygen species levels

Lysine acetylation activates 6-phosphogluconate dehydrogenase to promote tumor growth.

Measurement of glycine in the human brain in vivo by 1H-MRS at 3 T: application in brain tumors

Mechanism by which a recently discovered allosteric inhibitor blocks glutamine metabolism in transformed cells

Metabolic pathways promoting cancer cell survival and growth

Metabolic plasticity maintains proliferation in pyruvate dehydrogenase deficient cells

Metabolic regulation of transcription through compartmentalized NAD+ biosynthesis.

Metabolic reprogramming and cancer progression

Metformin Antagonizes Cancer Cell Proliferation by Suppressing Mitochondrial-Dependent Biosynthesis

Mitochondrial reactive oxygen species promote epidermal differentiation and hair follicle development

Oxidation of alpha-ketoglutarate is required for reductive carboxylation in cancer cells with mitochondrial defects.

Phosphoglycerate Mutase 1 Coordinates Glycolysis and Biosynthesis to Promote Tumor Growth

Principles of reproducible metabolite profiling of enriched lymphocytes in tumors and ascites from human ovarian cancer

Pyruvate carboxylase is required for glutamine-independent growth of tumor cells

RETRACTED: MAVS, cGAS, and endogenous retroviruses in T-independent B cell responses

Real-time detection of hepatic gluconeogenic and glycogenolytic states using hyperpolarized [2-13C]dihydroxyacetone

Reductive carboxylation supports growth in tumour cells with defective mitochondria.

Role of PFKFB3-driven glycolysis in vessel sprouting

Role of glutamine in cancer: therapeutic and imaging implications

Spectrum of mutations in the renin-angiotensin system genes in autosomal recessive renal tubular dysgenesis.

Stable isotope tracing to assess tumor metabolism in vivo

The abundance of metabolites related to protein methylation correlates with the metastatic capacity of human melanoma xenografts.

The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche.

The gut commensal Bacteroides thetaiotaomicron exacerbates enteric infection through modification of the metabolic landscape.

The hexosamine biosynthesis pathway is a targetable liability in KRAS/LKB1 mutant lung cancer

The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling.

The transcription factor HIF-1alpha plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis

Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation

Using arterial-venous analysis to characterize cancer metabolic consumption in patients

We need to talk about the Warburg effect