Search filters

List of works by Ernesto Fedele

3Hglycine uptake in rat hippocampus: kinetic analysis and autoradiographic localization

scientific article published on February 14, 1992

A novel mechanism for cyclic adenosine monophosphate-mediated memory formation: Role of amyloid beta

scientific article published on 14 April 2014

Acetylcholine release from rat hippocampal slices is modulated by 5-hydroxytryptamine

Activation of brain nitric oxide synthase in depolarized human temporal cortex slices: differential role of voltage‐sensitive calcium channels ⬇️

scientific article published on November 1, 1997

Acute and Chronic Dopaminergic Depletion Differently Affect Motor Thalamic Function

scientific article published on 15 April 2020

Age-related decrease of the NMDA receptor-mediated noradrenaline release in rat hippocampus and partial restoration by D-cycloserine.

scientific article published in January 1993

Alterations of glutamate release in the spinal cord of mice with experimental autoimmune encephalomyelitis

scientific article published on 25 August 2010

Altered fronto-striatal functions in the Gdi1-null mouse model of X-linked Intellectual Disability.

scientific article published on 02 January 2017

Amyloid β: Walking on the dark side of the moon.

scientific article published on 08 September 2015

Amyloid-β Peptide Is Needed for cGMP-Induced Long-Term Potentiation and Memory

scientific article published on 16 June 2017

Antagonizing α7 nicotinic receptors with methyllycaconitine (MLA) potentiates receptor activity and memory acquisition

scientific article published on 05 June 2019

Autoradiographical evaluation of [3H]glycine uptake in rat forebrain: cellular localization in the hippocampus

scientific article published on 01 October 1993

Biochemical and electrophysiological changes of substantia nigra pars reticulata driven by subthalamic stimulation in patients with Parkinson's disease.

scientific article published in June 2006

Correlation between changes in CSF dopamine turnover and development of dyskinesia in Parkinson's disease.

scientific article published on 17 November 2008

Cyclic adenosine monophosphate as an endogenous modulator of the amyloid-β precursor protein metabolism.

scientific article published on 8 January 2013

Cyclo-oxygenase-1 and -2 differently contribute to prostaglandin E2 synthesis and lipid peroxidation after in vivo activation of N-methyl-D-aspartate receptors in rat hippocampus.

scientific article published in June 2005

D-serine modulates the NMDA receptor/nitric oxide/cGMP pathway in the rat cerebellum during in vivo microdialysis.

scientific article published in January 1997

Delayed administration may improve entacapone effects in parkinsonian patients non-responding to the drug.

scientific article published in September 2004

Effects of phosphodiesterase inhibition on cortical spreading depression and associated changes in extracellular cyclic GMP.

scientific article published in April 2004

Electrophysiology and pharmacology of striatal neuronal dysfunction induced by mitochondrial complex I inhibition

scientific article published on August 2008

Enhanced Function and Overexpression of Metabotropic Glutamate Receptors 1 and 5 in the Spinal Cord of the SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis during Disease Progression

scientific article published on 13 September 2019

Evaluating the role of hnRNP-C and FMRP in the cAMP-induced APP metabolism

scientific article

Evaluation of the mechanisms underlying the kainate-induced impairment of [3H]dopamine release in the rat striatum.

scientific article published in November 1993

Exocytosis regulates trafficking of GABA and glycine heterotransporters in spinal cord glutamatergic synapses: a mechanism for the excessive heterotransporter-induced release of glutamate in experimental amyotrophic lateral sclerosis.

scientific article published on 10 December 2014

Functional damage of dopamine nerve terminals following intrastriatal kainic acid injection

scientific article published on 01 February 1989

GABA(A), but not NMDA, receptors modulate in vivo NO-mediated cGMP synthesis in the rat cerebral cortex.

scientific article published in March 2004

GEBR-7b, a novel PDE4D selective inhibitor that improves memory in rodents at non-emetic doses ⬇️

scientific article published on December 1, 2011

Glycine enhances [3H]noradrenaline release from slices of rat hippocampus.

scientific article published in August 1990

Helicobacter pylori eradication and l-dopa absorption in patients with PD and motor fluctuations

scientific article published on 01 June 2006

Helicobacter pylori-induced reduction of acute levodopa absorption in Parkinson's disease patients.

scientific article published in November 2001

Heterocarrier-mediated reciprocal modulation of glutamate and glycine release in rat cerebral cortex and spinal cord synaptosomes.

scientific article

Homovanillic acid in CSF of mild stage Parkinson's disease patients correlates with motor impairment.

scientific article

Improvement of spatial memory function in APPswe/PS1dE9 mice after chronic inhibition of phosphodiesterase type 4D.

scientific article

In vivo NO/cGMP signalling in the hippocampus.

scientific article published in September 2001

In vivo activation of N-methyl-D-aspartate receptors in the rat hippocampus increases prostaglandin E(2) extracellular levels and triggers lipid peroxidation through cyclooxygenase-mediated mechanisms.

scientific article

In vivo microdialysis study of GABAA and GABaB receptors modulating the glutamate receptor/NO/ cyclic GMP pathway in the rat hippocampus ⬇️

scientific article published on October 1, 1997

Intracerebral administration of L-kynurenine decreases N-methyl-D-aspartate receptor-mediated production of cGMP in the cerebellum and hippocampus of unanaesthetized rats subjected to transcerebral microdialysis.

scientific article

Investigating the amyloid-beta enhancing effect of cGMP in neuro2a cells.

scientific article published on 5 August 2017

L-aspartate as an amino acid neurotransmitter: mechanisms of the depolarization-induced release from cerebrocortical synaptosomes.

scientific article published on 22 June 2009

LRRK2 kinase activity regulates synaptic vesicle trafficking and neurotransmitter release through modulation of LRRK2 macro-molecular complex

scientific article

Leucine-rich repeat kinase 2 phosphorylation on synapsin I regulates glutamate release at pre-synaptic sites

scientific article published on 10 July 2019

Mechanisms of glutamate release elicited in rat cerebrocortical nerve endings by 'pathologically' elevated extraterminal K+ concentrations.

scientific article published on 27 July 2007

Memory-enhancing effects of GEBR-32a, a new PDE4D inhibitor holding promise for the treatment of Alzheimer's disease

scientific article

Microdialysis in Parkinsonian patient basal ganglia: acute apomorphine-induced clinical and electrophysiological effects not paralleled by changes in the release of neuroactive amino acids.

scientific article

Neuropeptide S inhibits release of 5-HT and glycine in mouse amygdala and frontal/prefrontal cortex through activation of the neuropeptide S receptor.

scientific article

New insights into selective PDE4D inhibitors: 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-dimethylmorpholino)-2-oxoethyl) oxime (GEBR-7b) structural development and promising activities to restore memory impairment

scientific article published on 13 August 2016

PDE4D inhibitors: a potential strategy for the treatment of memory impairment?

scientific article published on 2 June 2014

Phosphodiesterase 4D: an enzyme to remember

scientific article

Presynaptic GLP-1 receptors enhance the depolarization-evoked release of glutamate and GABA in the mouse cortex and hippocampus

scientific article published on 19 December 2017

Presynaptic nicotinic α7 and non-α7 receptors stimulate endogenous GABA release from rat hippocampal synaptosomes through two mechanisms of action

scientific article

Re: Stereotactic microdialysis of the basal ganglia in Parkinson's disease

scientific article

Reduced GABA Content in the Motor Thalamus during Effective Deep Brain Stimulation of the Subthalamic Nucleus.

scientific article published on 5 April 2011

Reduced L-dopa absorption and increased clinical fluctuations in Helicobacter pylori-infected Parkinson's disease patients

scientific article published on 01 February 2001

Subthalamic nucleus deep brain stimulation on motor-symptoms of Parkinson's disease: Focus on neurochemistry

scientific article published on 31 January 2017

Subthalamic stimulation activates internal pallidus: evidence from cGMP microdialysis in PD patients.

scientific article published in March 2005

Synthesis, biological activities and pharmacokinetic properties of new fluorinated derivatives of selective PDE4D inhibitors

scientific article published on 16 April 2015

Synthesis, biological evaluation, and molecular modeling of new 3-(cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-dimethylmorpholino)-2-oxoethyl) Oxime (GEBR-7b) related phosphodiesterase 4D (PDE4D) inhibitors

scientific article published on 15 August 2014

The Amyloid Cascade Hypothesis in Alzheimer's Disease: It's Time to Change Our Mind

scientific article published on 16 January 2017

The Novel Phosphodiesterase 9A Inhibitor BI 409306 Increases Cyclic Guanosine Monophosphate Levels in the Brain, Promotes Synaptic Plasticity, and Enhances Memory Function in Rodents

scientific article published on 02 October 2019

The clinical efficacy of L-DOPA and STN-DBS share a common marker: reduced GABA content in the motor thalamus.

scientific article

The glutamate receptor/no/cyclic gmp pathway in the hippocampus of freely moving rats: Modulation by cyclothiazide, interaction with gaba and the behavioural consequences ⬇️

scientific article published on October 1, 1997

The pharmacological blockade of medial forebrain bundle induces an acute pathological synchronization of the cortico-subthalamic nucleus-globus pallidus pathway.

scientific article published on 21 July 2009

Transmitter release associated with long-term synaptic depression in rat corticostriatal slices

scientific article published on 01 September 1995

cAMP, cGMP and Amyloid β: Three Ideal Partners for Memory Formation

scientific article published on 28 February 2018

cGMP favors the interaction between APP and BACE1 by inhibiting Rab5 GTPase activity

scientific article published on 28 January 2020

Paulina is supported by:

About Paulina

Help