List of works - Torleif Härd

1H NMR studies of the glucocorticoid receptor DNA-binding domain: sequential assignments and identification of secondary structure elements

scientific article published in September 1990

1H, 13C and 15N resonance assignments of an affibody-target complex

scientific article published on 01 November 2002

A comparison of15N NMR relaxation measurements with a molecular dynamics simulation: Backbone dynamics of the glucocorticoid receptor DNA-binding domain

article

A complete Hermitian operator basis set for any spin quantum number.

scientific article published in November 2001

A fine-tuned composition of protein nanofibrils yields an upgraded functionality of displayed antibody binding domains

scientific article published on 3 April 2017

A hexameric peptide barrel as building block of amyloid-β protofibrils

scientific article published on 26 September 2014

A method for production of 13C/15N double labelled RNA in E. coli, and subsequent in vitro synthesis of ribonucleotide 5' triphosphates.

scientific article

A method for simulation of NOESY, ROESY, and off-resonance ROESY spectra

scientific article published in November 1997

A non-conservative polymorphism in the IL-6 signal transducer (IL6ST)/gp130 is associated with myocardial infarction in a hypertensive population

article

A potential role for Drosophila mucins in development and physiology

scientific article

A truncated and dimeric format of an Affibody library on bacteria enables FACS-mediated isolation of amyloid-beta aggregation inhibitors with subnanomolar affinity

scientific article published on 14 July 2015

A β-hairpin-binding protein for three different disease-related amyloidogenic proteins

scientific article published on 30 December 2014

Affibody-Mediated Sequestration of Amyloid β Demonstrates Preventive Efficacy in a Transgenic Alzheimer's Disease Mouse Model

scholarly article by Allal Boutajangout et al published 2019 in Frontiers in Aging Neuroscience

Amyloid Fibrils: Formation, Polymorphism, and Inhibition

scientific article

Amyloid-β protofibrils: size, morphology and synaptotoxicity of an engineered mimic

scientific article (publication date: 2013)

An affibody in complex with a target protein: Structure and coupled folding

scientific article (publication date: 18 March 2003)

Anisotropic overall and internal motions of short DNA fragments

scientific article published on May 1986

Another piece of the ribosome: solution structure of S16 and its location in the 30S subunit

scientific article

Ansig for Windows: an interactive computer program for semiautomatic assignment of protein NMR spectra.

scientific article

Architecture of nonspecific protein-DNA interactions in the Sso7d-DNA complex

scientific article

Autoproteolysis coupled to protein folding in the SEA domain of the membrane-bound MUC1 mucin

scientific article published on 20 December 2005

Backbone dynamics of the glucocorticoid receptor DNA-binding domain

scientific article published on December 8, 1992

Binding of human proteins to amyloid-β protofibrils

scientific article published on 12 December 2014

Biophysical characterization of Z(SPA-1)--a phage-display selected binder to protein A.

scientific article

Both proline-rich sequences in the TH region of Bruton's tyrosine kinase stabilize intermolecular interactions with the SH3 domain.

scientific article

Chloride binding by the AML1/Runx1 transcription factor studied by NMR

scientific article published on 01 January 2001

Comparing the folding free-energy landscapes of Abeta42 variants with different aggregation properties

scientific article published in September 2010

Conformational Dynamics and Molecular Recognition: Backbone Dynamics of the Estrogen Receptor DNA-binding Domain

article

Conformational stabilization of an engineered binding protein

scientific article published in June 2006

Conserved hydrophobic clusters on the surface of the Caf1A usher C-terminal domain are important for F1 antigen assembly

scientific article

Contact between the β1 and β2 Segments of α-Synuclein that Inhibits Amyloid Formation.

scientific article published on 26 June 2015

Cooperativity and specificity in the interactions between DNA and the glucocorticoid receptor DNA-binding domain

scientific article

Coupled chemistry kinetics demonstrate the utility of functionalized Sup35 amyloid nanofibrils in biocatalytic cascades

scientific article published on 15 August 2019

Crystallization and preliminary studies of the DNA-binding runt domain of AML1

scientific article published on 01 February 2001

DNA-binding surface of the Sso7d protein from Sulfolobus solfataricus.

scientific article published in April 1995

Effect of N-terminal solubility enhancing fusion proteins on yield of purified target protein.

scientific article

Enantioselective interactions of inversion-labile trigonal iron(II) complexes upon binding to DNA

scientific article published in 1986

Erratum to “SEA Domain Autoproteolysis Accelerated by Conformational Strain: Energetic Aspects” [J. Mol. Biol. 377 (2008) 1117–1129]

scholarly article published in Journal of Molecular Biology

Folding-Reaction Coupling in a Self-Cleaving Protein

scientific article published on 3 May 2012

High-affinity binding to staphylococcal protein A by an engineered dimeric Affibody molecule

scientific article

His tag effect on solubility of human proteins produced in Escherichia coli: a comparison between four expression vectors

scientific article published on 01 January 2004

Improved solubility of TEV protease by directed evolution

scientific article

Induced CD of DNA intercalators: Electric dipole allowed transitions

scientific article published in 1987

Inhibition of amyloid formation

scientific article published on 05 January 2012

Interaction of Alzheimer's A beta peptide with an engineered binding protein--thermodynamics and kinetics of coupled folding-binding

scientific article published on 4 March 2008

Intermolecular interactions between the SH3 domain and the proline-rich TH region of Bruton's tyrosine kinase.

scientific article

Letter to the editor: assignment and secondary structure identification of the ribosomal protein L18 from Thermus thermophilus

scientific article published on 01 July 2000

Molecular flexibility of extended and compacted polynucleosomes

article

Monte Carlo Study of the Formation and Conformational Properties of Dimers of Aβ42 Variants

NMR Relaxation Mechanisms for Backbone Carbonyl Carbons in a13C,15N-Labeled Protein ⬇️

scientific article published on 01 May 1997

NMR assignments of the free and bound-state protein components of an anti-idiotypic affibody complex

scientific article published in January 2006

NMR structure of the ribosomal protein L23 from Thermus thermophilus

scientific article (publication date: June 2003)

New insights into multiple coagulation factor deficiency from the solution structure of human MCFD2

scientific article

On the Use of Chiral Compounds for Probing the DNA Handedness: Z to B Conversion in Poly(dGm5dC) Upon Binding of Fe(phen)32+and Ru(phen)32+

Photo-CIDNP study of the interaction between the glucocorticoid receptor DNA-binding domain and glucocorticoid response elements

scientific article

Preliminary NMR studies of Thermus thermophilus ribosomal protein S19 overproduced in Escherichia coli

scientific article published in September 1997

Protein autoproteolysis: conformational strain linked to the rate of peptide cleavage by the pH dependence of the N --> O acyl shift reaction.

scientific article

Protein engineering to stabilize soluble amyloid β-protein aggregates for structural and functional studies

scientific article published on 06 September 2011

Protofibrillar and Fibrillar Amyloid-β Binding Proteins in Cerebrospinal Fluid

Rapid screening for improved solubility of small human proteins produced as fusion proteins in Escherichia coli

scientific article

Recombinant amyloid beta-peptide production by coexpression with an affibody ligand

scientific article

Refined solution structure of the glucocorticoid receptor DNA-binding domain

scientific article

SEA domain autoproteolysis accelerated by conformational strain: energetic aspects

scientific article published on 30 January 2008

SEA domain autoproteolysis accelerated by conformational strain: mechanistic aspects

scientific article published on 30 January 2008

Salt Dependence of the Free Energy, Enthalpy, and Entropy of Nonsequence Specific DNA Binding

Screening methods to determine biophysical properties of proteins in structural genomics.

scientific article

Self-Cleaving Mucins

Sequence-Specific DNA Binding by the Glucocorticoid Receptor DNA-Binding Domain Is Linked to a Salt-Dependent Histidine Protonation†

scientific article published on 01 August 2000

Sequestration of the Abeta peptide prevents toxicity and promotes degradation in vivo

scientific article

Simulations of NMR pulse sequences during equilibrium and non-equilibrium chemical exchange.

scientific article published in September 2000

Solution properties of the free and DNA-bound Runt domain of AML1.

scientific article

Solution structure and DNA-binding properties of a thermostable protein from the archaeon Sulfolobus solfataricus

scientific article

Solution structure of a mammalian PCB-binding protein in complex with a PCB ⬇️

scientific article published on November 1, 1995

Solution structure of the SH3 domain from Bruton's tyrosine kinase

scientific article

Solution structure of the glucocorticoid receptor DNA-binding domain

scientific article

Solution structure of the ribosomal RNA binding protein S15 from Thermus thermophilus

scientific article

Solution structure of the ribosomal protein S19 from Thermus thermophilus

scientific article

Stabilization of a -hairpin in monomeric Alzheimer's amyloid- peptide inhibits amyloid formation

scientific article

Stabilization of neurotoxic Alzheimer amyloid-beta oligomers by protein engineering

scientific article

Staphylococcal display for combinatorial protein engineering of a head-to-tail affibody dimer binding the Alzheimer amyloid-β peptide.

scientific article

Structural basis for high-affinity HER2 receptor binding by an engineered protein

scientific article

Structural basis for molecular recognition in an affibody:affibody complex

scientific article

Structural characterization of a minimal functional transactivation domain from the human glucocorticoid receptor

scientific article

Structural characterization of a short peptide fragment that mediates estrogen-receptor dimerization

scientific article published on June 1995

Structural transitions of chromatin at low salt concentrations: a flow linear dichroism study

scientific article

Structure and Dynamics of the Glucocorticoid Receptor DNA-Binding Domain: Comparison of Wild Type and a Mutant with Altered Specificity†

article

Structure and backbone dynamics of Apo-CBFbeta in solution

scientific article

The N-terminal regions of estrogen receptor alpha and beta are unstructured in vitro and show different TBP binding properties

scientific journal article

The RUNX1 Runt domain at 1.25A resolution: a structural switch and specifically bound chloride ions modulate DNA binding

scientific article

The complete homogeneous master equation for a heteronuclear two-spin system in the basis of cartesian product operators

scientific article published in September 1998

The kinetics of TEM1 antibiotic degrading enzymes that are displayed on Ure2 protein nanofibrils in a flow reactor.

scientific article

The solution structure of ribosomal protein L18 from Thermus thermophilus reveals a conserved RNA-binding fold

scientific article

The solution structure of ribosomal protein L36 from Thermus thermophilus reveals a zinc-ribbon-like fold

scientific article

Thermodynamic characterization of non-sequence-specific DNA-binding by the Sso7d protein from Sulfolobus solfataricus

article published in 1998

Thermodynamics of folding and binding in an affibody:affibody complex

scientific article

Thermodynamics of folding, stabilization, and binding in an engineered protein--protein complex.

scientific article published in September 2004

Thermodynamics of sequence-specific glucocorticoid receptor-DNA interactions

scientific article published on 01 May 1994

Thermodynamics of sequence-specific protein-DNA interactions.

scientific article published on November 1996

Thermodynamics of the glucocorticoid receptor-DNA interaction: Binding of wild-type GR DBD to different response elements

article

List of works by Torleif Härd

1H NMR studies of the glucocorticoid receptor DNA-binding domain: sequential assignments and identification of secondary structure elements

1H, 13C and 15N resonance assignments of an affibody-target complex

A comparison of15N NMR relaxation measurements with a molecular dynamics simulation: Backbone dynamics of the glucocorticoid receptor DNA-binding domain

A complete Hermitian operator basis set for any spin quantum number.

A fine-tuned composition of protein nanofibrils yields an upgraded functionality of displayed antibody binding domains

A hexameric peptide barrel as building block of amyloid-β protofibrils

A method for production of 13C/15N double labelled RNA in E. coli, and subsequent in vitro synthesis of ribonucleotide 5' triphosphates.

A method for simulation of NOESY, ROESY, and off-resonance ROESY spectra

A non-conservative polymorphism in the IL-6 signal transducer (IL6ST)/gp130 is associated with myocardial infarction in a hypertensive population

A potential role for Drosophila mucins in development and physiology

A truncated and dimeric format of an Affibody library on bacteria enables FACS-mediated isolation of amyloid-beta aggregation inhibitors with subnanomolar affinity

A β-hairpin-binding protein for three different disease-related amyloidogenic proteins

Affibody-Mediated Sequestration of Amyloid β Demonstrates Preventive Efficacy in a Transgenic Alzheimer's Disease Mouse Model

Amyloid Fibrils: Formation, Polymorphism, and Inhibition

Amyloid-β protofibrils: size, morphology and synaptotoxicity of an engineered mimic

An affibody in complex with a target protein: Structure and coupled folding

Anisotropic overall and internal motions of short DNA fragments

Another piece of the ribosome: solution structure of S16 and its location in the 30S subunit

Ansig for Windows: an interactive computer program for semiautomatic assignment of protein NMR spectra.

Architecture of nonspecific protein-DNA interactions in the Sso7d-DNA complex

Autoproteolysis coupled to protein folding in the SEA domain of the membrane-bound MUC1 mucin

Backbone dynamics of the glucocorticoid receptor DNA-binding domain

Binding of human proteins to amyloid-β protofibrils

Biophysical characterization of Z(SPA-1)--a phage-display selected binder to protein A.

Both proline-rich sequences in the TH region of Bruton's tyrosine kinase stabilize intermolecular interactions with the SH3 domain.

Chloride binding by the AML1/Runx1 transcription factor studied by NMR

Comparing the folding free-energy landscapes of Abeta42 variants with different aggregation properties

Conformational Dynamics and Molecular Recognition: Backbone Dynamics of the Estrogen Receptor DNA-binding Domain

Conformational stabilization of an engineered binding protein

Conserved hydrophobic clusters on the surface of the Caf1A usher C-terminal domain are important for F1 antigen assembly

Contact between the β1 and β2 Segments of α-Synuclein that Inhibits Amyloid Formation.

Cooperativity and specificity in the interactions between DNA and the glucocorticoid receptor DNA-binding domain

Coupled chemistry kinetics demonstrate the utility of functionalized Sup35 amyloid nanofibrils in biocatalytic cascades

Crystallization and preliminary studies of the DNA-binding runt domain of AML1

DNA-binding surface of the Sso7d protein from Sulfolobus solfataricus.

Effect of N-terminal solubility enhancing fusion proteins on yield of purified target protein.

Enantioselective interactions of inversion-labile trigonal iron(II) complexes upon binding to DNA

Erratum to “SEA Domain Autoproteolysis Accelerated by Conformational Strain: Energetic Aspects” [J. Mol. Biol. 377 (2008) 1117–1129]

Folding-Reaction Coupling in a Self-Cleaving Protein

High-affinity binding to staphylococcal protein A by an engineered dimeric Affibody molecule

His tag effect on solubility of human proteins produced in Escherichia coli: a comparison between four expression vectors

Improved solubility of TEV protease by directed evolution

Induced CD of DNA intercalators: Electric dipole allowed transitions

Inhibition of amyloid formation

Interaction of Alzheimer's A beta peptide with an engineered binding protein--thermodynamics and kinetics of coupled folding-binding

Intermolecular interactions between the SH3 domain and the proline-rich TH region of Bruton's tyrosine kinase.

Letter to the editor: assignment and secondary structure identification of the ribosomal protein L18 from Thermus thermophilus

Molecular flexibility of extended and compacted polynucleosomes

Monte Carlo Study of the Formation and Conformational Properties of Dimers of Aβ42 Variants

NMR Relaxation Mechanisms for Backbone Carbonyl Carbons in a13C,15N-Labeled Protein ⬇️

NMR assignments of the free and bound-state protein components of an anti-idiotypic affibody complex

NMR structure of the ribosomal protein L23 from Thermus thermophilus

New insights into multiple coagulation factor deficiency from the solution structure of human MCFD2

On the Use of Chiral Compounds for Probing the DNA Handedness: Z to B Conversion in Poly(dGm5dC) Upon Binding of Fe(phen)32+and Ru(phen)32+

Photo-CIDNP study of the interaction between the glucocorticoid receptor DNA-binding domain and glucocorticoid response elements

Preliminary NMR studies of Thermus thermophilus ribosomal protein S19 overproduced in Escherichia coli

Protein autoproteolysis: conformational strain linked to the rate of peptide cleavage by the pH dependence of the N --> O acyl shift reaction.

Protein engineering to stabilize soluble amyloid β-protein aggregates for structural and functional studies

Protofibrillar and Fibrillar Amyloid-β Binding Proteins in Cerebrospinal Fluid

Protofibrillar and Fibrillar Amyloid-β Binding Proteins in Cerebrospinal Fluid

Rapid screening for improved solubility of small human proteins produced as fusion proteins in Escherichia coli

Recombinant amyloid beta-peptide production by coexpression with an affibody ligand

Refined solution structure of the glucocorticoid receptor DNA-binding domain

SEA domain autoproteolysis accelerated by conformational strain: energetic aspects

SEA domain autoproteolysis accelerated by conformational strain: mechanistic aspects

Salt Dependence of the Free Energy, Enthalpy, and Entropy of Nonsequence Specific DNA Binding

Screening methods to determine biophysical properties of proteins in structural genomics.

Self-Cleaving Mucins

Sequence-Specific DNA Binding by the Glucocorticoid Receptor DNA-Binding Domain Is Linked to a Salt-Dependent Histidine Protonation†

Sequestration of the Abeta peptide prevents toxicity and promotes degradation in vivo

Simulations of NMR pulse sequences during equilibrium and non-equilibrium chemical exchange.

Solution properties of the free and DNA-bound Runt domain of AML1.

Solution structure and DNA-binding properties of a thermostable protein from the archaeon Sulfolobus solfataricus

Solution structure of a mammalian PCB-binding protein in complex with a PCB ⬇️

Solution structure of the SH3 domain from Bruton's tyrosine kinase

Solution structure of the glucocorticoid receptor DNA-binding domain

Solution structure of the ribosomal RNA binding protein S15 from Thermus thermophilus

Solution structure of the ribosomal protein S19 from Thermus thermophilus

Stabilization of a -hairpin in monomeric Alzheimer's amyloid- peptide inhibits amyloid formation