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List of works by Nicholas J Westwood

A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage.

scientific article published on 16 March 2018

A Proteomic Approach to Analyze the Aspirin-mediated Lysine Acetylome

scientific article (publication date: February 2017)

A Random Forest Model for Predicting Allosteric and Functional Sites on Proteins.

scientific article published on 21 January 2016

A class of 5-nitro-2-furancarboxylamides with potent trypanocidal activity against Trypanosoma brucei in vitro.

scientific article

A core switching strategy to pyrrolo[2,3-b]quinolines and diazocino[1,2-a]indolinones.

scientific article

A high-throughput cell migration assay using scratch wound healing, a comparison of image-based readout methods

scientific article

A high-throughput screening of a chemical compound library in ovarian cancer stem cells

scientific article published on 23 January 2018

A modular approach to triazole-containing chemical inducers of dimerisation for yeast three-hybrid screening.

scientific article

Acetylation site specificities of lysine deacetylase inhibitors in human cells

scientific article (publication date: 9 March 2015)

Advanced Model Compounds for Understanding Acid-Catalyzed Lignin Depolymerization: Identification of Renewable Aromatics and a Lignin-Derived Solvent

scientific article published on 7 July 2016

Allosteric competitive inhibitors of the glucose-1-phosphate thymidylyltransferase (RmlA) from Pseudomonas aeruginosa

scientific article

An improved understanding of the reaction of bis(bromomethyl)quinoxaline 1-N-oxides with amines using substituent effects

scientific article published on 04 April 2007

An inter-subunit protein-peptide interface that stabilizes the specific activity and oligomerization of the AAA+ chaperone Reptin

scientific article published on 09 March 2019

Application of the copper catalysed N-arylation of amidines in the synthesis of analogues of the chemical tool, blebbistatin ⬇️

scientific article published on November 15, 2010

Aromatic monomers by in situ conversion of reactive intermediates in the acid-catalyzed depolymerization of lignin.

scientific article published on 5 June 2015

Autophagic flux blockage by accumulation of weakly basic tenovins leads to elimination of B-Raf mutant tumour cells that survive vemurafenib.

scientific article published on 23 April 2018

Bacterial catabolism of β-hydroxypropiovanillone and β-hydroxypropiosyringone produced in the reductive cleavage of arylglycerol-β-aryl ether in lignin.

scientific article

Bypassing the proline/thiazoline requirement of the macrocyclase PatG.

scientific article published in November 2017

Cambinol, a novel inhibitor of neutral sphingomyelinase 2 shows neuroprotective properties

scientific article

Derivatisable Cyanobactin Analogues: A Semisynthetic Approach

scientific article published on 28 October 2015

Design, synthesis, and evaluation of 2-methyl- and 2-amino-N-aryl-4,5-dihydrothiazolo[4,5-h]quinazolin-8-amines as ring-constrained 2-anilino-4-(thiazol-5-yl)pyrimidine cyclin-dependent kinase inhibitors

scientific article

Discovery and validation of SIRT2 inhibitors based on tenovin-6: use of a ¹H-NMR method to assess deacetylase activity

scientific article published on 18 October 2012

Discovery of a novel ligand that modulates the protein-protein interactions of the AAA+ superfamily oncoprotein reptin

scientific article published on 20 March 2015

Discovery of novel enzyme genes involved in the conversion of an arylglycerol-β-aryl ether metabolite and their use in generating a metabolic pathway for lignin valorization

scientific article published on 04 August 2019

Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator.

scientific article published on May 2008

Dissecting temporal and spatial control of cytokinesis with a myosin II Inhibitor

scientific article (publication date: 14 March 2003)

Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6.

scientific article published on January 2013

Efficient genome engineering of Toxoplasma gondii using CRISPR/Cas9.

scientific article

Enzymatic Macrocyclization of 1,2,3-Triazole Peptide Mimetics

scientific article

Fractionation and DOSY NMR as Analytical Tools: From Model Polymers to a Technical Lignin

scientific article published on 30 November 2017

From Biomass to the Karrikins via Selective Catalytic Oxidation of Hemicellulose‐Derived Butyl Xylosides and Glucosides

Identification of T. gondii myosin light chain-1 as a direct target of TachypleginA-2, a small-molecule inhibitor of parasite motility and invasion ⬇️

scientific article (publication date: 2014)

Identification of TgCBAP, a novel cytoskeletal protein that localizes to three distinct subcompartments of the Toxoplasma gondii pellicle

scientific article

Iso-seco-tanapartholides: Isolation, Synthesis and Biological Evaluation.

scientific article published on 7 October 2009

Isolation of functionalized phenolic monomers through selective oxidation and C-O bond cleavage of the β-O-4 linkages in lignin.

scientific article

Isothiourea-Catalysed Acylative Kinetic Resolution of Aryl-Alkenyl (sp2 vs. sp2 ) Substituted Secondary Alcohols

scientific article published on 30 November 2016

Mechanism-specific signatures for small-molecule p53 activators ⬇️

scientific article published on May 15, 2011

Metal Triflates for the Production of Aromatics from Lignin.

scientific article published on 21 September 2016

Novel cambinol analogs as sirtuin inhibitors: synthesis, biological evaluation, and rationalization of activity.

scientific article published on May 2009

Preparation and Reactivity of Biomass-Derived Dihydro-Dioxins

scientific article published on 05 November 2018

Publisher Correction: A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage.

scientific article published on 22 May 2018

Revealing the fate of the phenylcoumaran linkage during lignin oxidation reactions

scientific article published on 2 March 2018

Selective Primary Alcohol Oxidation of Lignin Streams from Butanol-Pretreated Agricultural Waste Biomass

scientific article published on 09 January 2019

Stereochemical assignment of the protein-protein interaction inhibitor JBIR-22 by total synthesis.

scientific article published on 4 February 2015

Structure and Substrate Recognition of the Bottromycin Maturation Enzyme BotP

scientific article

Structure-Activity Relationships of the Human Immunodeficiency Virus Type 1 Maturation Inhibitor PF-46396

scientific article

Synthesis and biological characterisation of sirtuin inhibitors based on the tenovins

scientific article published on 12 January 2012

Synthesis and evaluation of indatraline-based inhibitors for trypanothione reductase

scientific article

Synthesis and structural characterisation of selective non-carbohydrate-based inhibitors of bacterial sialidases

scientific article

Synthesis of Hybrid Cyclopeptides through Enzymatic Macrocyclization

scientific article (publication date: February 2017)

Synthesis of the natural product descurainolide and cyclic peptides from lignin-derived aromatics

scientific article published on 15 December 2017

Synthetic studies on the bioactive tetramic acid JBIR-22 using a late stage Diels-Alder reaction.

scientific article

Tandem Catalytic Depolymerization of Lignin by Water-Tolerant Lewis Acids and Rhodium Complexes

scientific article published on 21 July 2016

Targeting of the MYCN protein with small molecule c-MYC inhibitors

scientific article

Tenovin-D3, a novel small-molecule inhibitor of sirtuin SirT2, increases p21 (CDKN1A) expression in a p53-independent manner.

scientific article published on 15 January 2013

The Meisenheimer Complex as a Paradigm in Drug Discovery: Reversible Covalent Inhibition through C67 of the ATP Binding Site of PLK1

scientific article published on 12 July 2018

The synthesis and analysis of lignin-bound Hibbert ketone structures in technical lignins.

scientific article published on 11 October 2016

The synthesis of melohenine B and a related natural product

scientific article published on 05 December 2012

The use of residual dipolar coupling for conformational analysis of structurally related natural products

scientific article published on 09 April 2015

Total synthesis and biological evaluation of the tetramic acid based natural product harzianic acid and its stereoisomers

scientific article published on 28 January 2015

Total synthesis of dehaloperophoramidine using a highly diastereoselective Hosomi-Sakurai reaction

scientific article published on 10 August 2016

Unravelling the enigma of ligninOX: can the oxidation of lignin be controlled?

scientific article published on 9 November 2017

Use of Bisulfite Processing To Generate High-β-O-4 Content Water-Soluble Lignosulfonates

scientific article published on 18 January 2017

Using Fractionation and Diffusion Ordered Spectroscopy to Study Lignin Molecular Weight

scientific article published on 25 April 2019

Yeast three-hybrid screen identifies TgBRADIN/GRA24 as a negative regulator of Toxoplasma gondii bradyzoite differentiation

scientific article

p53 and cell cycle independent dysregulation of autophagy in chronic lymphocytic leukaemia

scientific article published on 3 October 2013

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