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List of works by Luiz Pedro S de Carvalho

"Salmonella, meet mycobacteria."

scientific article published on 01 March 2019

A novel dimeric structure of the RimL Nalpha-acetyltransferase from Salmonella typhimurium

scientific article

A philosophy of anti-infectives as a guide in the search for new drugs for tuberculosis.

scientific article

A protecting group-free synthesis of deazathiamine: a step toward inhibitor design

scientific article published on 16 September 2010

Activity-based metabolomic profiling of enzymatic function: identification of Rv1248c as a mycobacterial 2-hydroxy-3-oxoadipate synthase

scientific journal article

Activity-based substrate profiling for Gcn5-related N-acetyltransferases: the use of chloroacetyl-coenzyme A to identify protein substrates

scientific article published on December 2006

An NAD Phosphorylase Toxin Triggers Mycobacterium tuberculosis Cell Death

scientific article published on 18 February 2019

An essential bifunctional enzyme in Mycobacterium tuberculosis for itaconate dissimilation and leucine catabolism

scientific article published on 18 July 2019

Antibiotic resistance evasion is explained by rare mutation frequency and not by lack of compensatory mechanisms

scholarly article published 23 July 2018

Biosynthesis and translocation of unsulfated acyltrehaloses in Mycobacterium tuberculosis

scientific article

Cell-Envelope Remodeling as a Determinant of Phenotypic Antibacterial Tolerance in Mycobacterium tuberculosis

scientific article published on 28 March 2016

Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier

scientific article published on 10 May 2011

Cloning, overexpression, and purification of functional human purine nucleoside phosphorylase

scientific article

Comparative fitness analysis of D-cycloserine resistant mutants reveals both fitness-neutral and high-fitness cost genotypes

scientific article published on 13 September 2019

Correction to Reinterpreting the Mechanism of Inhibition of Mycobacterium tuberculosis d-Alanine:d-Alanine Ligase by d-Cycloserine

scientific article published on 6 November 2013

Crucial role for central carbon metabolism in the bacterial L-form switch and killing by β-lactam antibiotics

scientific article published on 08 July 2019

Crystal structure of human purine nucleoside phosphorylase at 2.3A resolution

scientific article

D-Cycloserine destruction by alanine racemase and the limit of irreversible inhibition

scientific article published on 16 March 2020

Discovery of a glycerol 3-phosphate phosphatase reveals glycerophospholipid polar head recycling in Mycobacterium tuberculosis

scientific article

Discovery of a novel stereospecific β-hydroxyacyl-CoA lyase/thioesterase shared by three metabolic pathways in Mycobacterium tuberculosis

scholarly article published 15 May 2018

Flexible nitrogen utilisation by the metabolic generalist pathogen

scientific article published on 31 January 2019

Fragment-Based Approaches to the Development of Mycobacterium tuberculosis CYP121 Inhibitors

scientific article published on 22 March 2016

Functional assignment of Mycobacterium tuberculosis proteome revealed by genome-scale fold-recognition

scientific article published on January 2013

Glutamate Racemase Is the Primary Target of β-Chloro-d-Alanine in Mycobacterium tuberculosis

scientific article published on August 2016

HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase

scientific article

Hybrid Mass Spectrometry Approaches to Determine How L-Histidine Feedback Regulates the Enzyzme MtATP-Phosphoribosyltransferase

scientific article published on 30 March 2017

Inhibition of D-Ala:D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine. ⬇️

scientific article published on 5 December 2017

Inhibitors selective for mycobacterial versus human proteasomes

scientific article

Kinetic analysis of the effects of monovalent cations and divalent metals on the activity of Mycobacterium tuberculosis alpha-isopropylmalate synthase

scientific journal article

Kinetic and chemical mechanism of alpha-isopropylmalate synthase from Mycobacterium tuberculosis

scientific article

Kinetic evidence for interdomain communication in the allosteric regulation of alpha-isopropylmalate synthase from Mycobacterium tuberculosis

scientific article published in March 2009

Kinetic mechanism and inhibition of Mycobacterium tuberculosis d‐alanine:d‐alanine ligase by the antibiotic d‐cycloserine ⬇️

scientific article published on February 1, 2013

Mechanism of feedback allosteric inhibition of ATP phosphoribosyltransferase

scientific article

Metabolomic strategies for the identification of new enzyme functions and metabolic pathways

scientific article

Metabolomics Reveal d-Alanine:d-Alanine Ligase As the Target of d-Cycloserine in Mycobacterium tuberculosis

scientific article published on 05 October 2013

Metabolomics of Mycobacterium tuberculosis

scientific article published on January 2015

Metabolomics of Mycobacterium tuberculosis reveals compartmentalized co-catabolism of carbon substrates

scientific article published on October 29, 2010

Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein (ACP) reductase: kinetic and chemical mechanisms

scientific journal article

Mycobacterium tuberculosis exploits asparagine to assimilate nitrogen and resist acid stress during infection

scientific article (publication date: February 2014)

Mycobacterium tuberculosis expresses methionine sulphoxide reductases A and B that protect from killing by nitrite and hypochlorite

scientific journal article

Mycobacterium tuberculosis nitrogen assimilation and host colonization require aspartate

scientific article published on 29 September 2013

Mycobacterium tuberculosis requires glyoxylate shunt and reverse methylcitrate cycle for lactate and pyruvate metabolism

scientific article published on 23 August 2019

Nitazoxanide Disrupts Membrane Potential and Intrabacterial pH Homeostasis of Mycobacterium tuberculosis ⬇️

scientific article published on January 1, 2011

Nitazoxanide kills replicating and nonreplicating Mycobacterium tuberculosis and evades resistance

scientific article published in October 2009

Nitrogen utilisation by the metabolic generalist pathogen Mycobacterium tuberculosis

scholarly article published 5 August 2018

Novel Aryl Substituted Pyrazoles as Small Molecule Inhibitors of Cytochrome P450 CYP121A1: Synthesis and Antimycobacterial Evaluation

scientific article published on 29 November 2017

On the chemical mechanism of succinic semialdehyde dehydrogenase (GabD1) from Mycobacterium tuberculosis

scientific article

Phylogenetic analysis of vitamin B12-related metabolism in Mycobacterium tuberculosis.

scientific article

Protein CoAlation: a redox-linked post-translational modification

scientific article published on 10 August 2017

Reinterpreting the mechanism of inhibition of Mycobacterium tuberculosis D-alanine:D-alanine ligase by D-cycloserine

scientific article published on 25 September 2013

Selection of an Escherichia coli host that expresses mutant forms of Mycobacterium tuberculosis 2-trans enoyl-ACP(CoA) reductase and 3-ketoacyl-ACP(CoA) reductase enzymes

scientific article published in March 2004

Slow-onset feedback inhibition: inhibition of Mycobacterium tuberculosis alpha-isopropylmalate synthase by L-leucine

scientific article

The Mechanism of Acetyl Transfer Catalyzed by Mycobacterium tuberculosis GlmU.

scientific article published on 23 April 2018

Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG

scientific article published on 18 June 2015

Two enzymes with redundant fructose bisphosphatase activity sustain gluconeogenesis and virulence in Mycobacterium tuberculosis

scientific article

Uncoupling conformational states from activity in an allosteric enzyme

scientific article published on 07 August 2017

microbeMASST: a taxonomically informed mass spectrometry search tool for microbial metabolomics data ⬇️

scientific article published in 2024

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