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List of works by Luiz Pedro S de Carvalho

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HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase

scientific article
Metabolomics of Mycobacterium tuberculosis reveals compartmentalized co-catabolism of carbon substrates

scientific article published on October 29, 2010
Inhibitors selective for mycobacterial versus human proteasomes

scientific article
Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier

scientific article published on 10 May 2011
Mycobacterium tuberculosis exploits asparagine to assimilate nitrogen and resist acid stress during infection

scientific article (publication date: February 2014)
Nitazoxanide kills replicating and nonreplicating Mycobacterium tuberculosis and evades resistance

scientific article published in October 2009
Activity-based metabolomic profiling of enzymatic function: identification of Rv1248c as a mycobacterial 2-hydroxy-3-oxoadipate synthase

scientific journal article
Mycobacterium tuberculosis nitrogen assimilation and host colonization require aspartate

scientific article published on 29 September 2013
Nitazoxanide Disrupts Membrane Potential and Intrabacterial pH Homeostasis of Mycobacterium tuberculosis

scientific article published on January 1, 2011
Metabolomics Reveal d-Alanine:d-Alanine Ligase As the Target of d-Cycloserine in Mycobacterium tuberculosis

scientific article published on 05 October 2013
Mycobacterium tuberculosis expresses methionine sulphoxide reductases A and B that protect from killing by nitrite and hypochlorite

scientific journal article
A philosophy of anti-infectives as a guide in the search for new drugs for tuberculosis

scientific article
A novel dimeric structure of the RimL Nalpha-acetyltransferase from Salmonella typhimurium

scientific article
Biosynthesis and translocation of unsulfated acyltrehaloses in Mycobacterium tuberculosis

scientific article
Kinetic mechanism and inhibition of Mycobacterium tuberculosis d‐alanine:d‐alanine ligase by the antibiotic d‐cycloserine

scientific article published on February 1, 2013
Discovery of a glycerol 3-phosphate phosphatase reveals glycerophospholipid polar head recycling in Mycobacterium tuberculosis

scientific article
Metabolomic strategies for the identification of new enzyme functions and metabolic pathways

scientific article
Kinetic and chemical mechanism of alpha-isopropylmalate synthase from Mycobacterium tuberculosis

scientific article
Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG

scientific article published on 18 June 2015
Two enzymes with redundant fructose bisphosphatase activity sustain gluconeogenesis and virulence in Mycobacterium tuberculosis

scientific article published on August 10, 2015
Slow-onset feedback inhibition: inhibition of Mycobacterium tuberculosis alpha-isopropylmalate synthase by L-leucine

scientific article
Activity-based substrate profiling for Gcn5-related N-acetyltransferases: the use of chloroacetyl-coenzyme A to identify protein substrates

scientific article published on December 2006
Metabolomics of Mycobacterium tuberculosis

scientific article published on January 1, 2015
Fragment-Based Approaches to the Development of Mycobacterium tuberculosis CYP121 Inhibitors

scientific article published on 22 March 2016
Glutamate Racemase Is the Primary Target of β-Chloro-d-Alanine in Mycobacterium tuberculosis

scientific article published on August 2016
On the chemical mechanism of succinic semialdehyde dehydrogenase (GabD1) from Mycobacterium tuberculosis

scientific article
Reinterpreting the Mechanism of Inhibition of Mycobacterium tuberculosis d-Alanine:d-Alanine Ligase by d-Cycloserine

scientific article published on September 25, 2013
Mechanism of feedback allosteric inhibition of ATP phosphoribosyltransferase

scientific article
Crystal structure of human purine nucleoside phosphorylase at 2.3A resolution

scientific article
Kinetic analysis of the effects of monovalent cations and divalent metals on the activity of Mycobacterium tuberculosis alpha-isopropylmalate synthase

scientific journal article
Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein (ACP) reductase: kinetic and chemical mechanisms

scientific journal article
Phylogenetic analysis of vitamin B12-related metabolism in Mycobacterium tuberculosis

scientific article
Cloning, overexpression, and purification of functional human purine nucleoside phosphorylase

scientific article
Kinetic evidence for interdomain communication in the allosteric regulation of alpha-isopropylmalate synthase from Mycobacterium tuberculosis

scientific article published in March 2009
Hybrid Mass Spectrometry Approaches to Determine How L-Histidine Feedback Regulates the Enzyzme MtATP-Phosphoribosyltransferase

scientific article published on 30 March 2017
An NAD Phosphorylase Toxin Triggers Mycobacterium tuberculosis Cell Death

scientific article published on 18 February 2019
Functional assignment of Mycobacterium tuberculosis proteome revealed by genome-scale fold-recognition

scientific article published on January 2013
Cell-Envelope Remodeling as a Determinant of Phenotypic Antibacterial Tolerance in Mycobacterium tuberculosis

scientific article published on 28 March 2016
Mycobacterium tuberculosis requires glyoxylate shunt and reverse methylcitrate cycle for lactate and pyruvate metabolism

scientific article published on 23 August 2019
Novel Aryl Substituted Pyrazoles as Small Molecule Inhibitors of Cytochrome P450 CYP121A1: Synthesis and Antimycobacterial Evaluation

scientific article published on 29 November 2017
A protecting group-free synthesis of deazathiamine: a step toward inhibitor design

scientific article published on 16 September 2010
Flexible nitrogen utilisation by the metabolic generalist pathogen

scientific article published on 31 January 2019
Inhibition of D-Ala:D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine.

scientific article published on 5 December 2017
Crucial role for central carbon metabolism in the bacterial L-form switch and killing by β-lactam antibiotics

scientific article published on 08 July 2019
The Mechanism of Acetyl Transfer Catalyzed by Mycobacterium tuberculosis GlmU.

scientific article published on 23 April 2018
An essential bifunctional enzyme in Mycobacterium tuberculosis for itaconate dissimilation and leucine catabolism

scientific article published on 18 July 2019
Selection of an Escherichia coli host that expresses mutant forms of Mycobacterium tuberculosis 2-trans enoyl-ACP(CoA) reductase and 3-ketoacyl-ACP(CoA) reductase enzymes

scientific article published in March 2004
Comparative fitness analysis of D-cycloserine resistant mutants reveals both fitness-neutral and high-fitness cost genotypes

scientific article published on 13 September 2019
Uncoupling conformational states from activity in an allosteric enzyme

scientific article published on 07 August 2017
Discovery of a novel stereospecific β-hydroxyacyl-CoA lyase/thioesterase shared by three metabolic pathways in Mycobacterium tuberculosis

scholarly article published 15 May 2018

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