List of works - Justin L.P. Benesch

A Monte Carlo approach for assessing the specificity of protein oligomers observed in nano-electrospray mass spectra

scientific article published in June 2009

A novel mechano-enzymatic cleavage mechanism underlies transthyretin amyloidogenesis

scientific article

A weakened interface in the P182L variant of HSP27 associated with severe Charcot-Marie-Tooth neuropathy causes aberrant binding to interacting proteins

scientific article published on 01 March 2021

All three chaperonin genes in the archaeon Haloferax volcanii are individually dispensable.

scientific article published in September 2006

An ultra-stable gold-coordinated protein cage displaying reversible assembly.

scientific article

Author Correction: Origin of complexity in haemoglobin evolution

scientific article published on 26 June 2020

Bayesian deconvolution of mass and ion mobility spectra: from binary interactions to polydisperse ensembles.

scientific article published on April 2015

Biobox: a toolbox for biomolecular modelling

scientific article published in 2021

C-terminal interactions mediate the quaternary dynamics of αB-crystallin.

scientific article published on 25 March 2013

Characterisation of Shigella Spa33 and Thermotoga FliM/N reveals a new model for C-ring assembly in T3SS.

scientific article published on 5 November 2015

Collision cross sections for structural proteomics

scientific article published on 19 March 2015

Collision cross sections of high-mannose N-glycans in commonly observed adduct states--identification of gas-phase conformers unique to [M-H](-) ions

scientific article published on 01 October 2015

Collisional activation of protein complexes: picking up the pieces

scientific article published on 27 November 2008

Combining tandem mass spectrometry with ion mobility separation to determine the architecture of polydisperse proteins

Coupling microdroplet microreactors with mass spectrometry: reading the contents of single droplets online.

scientific article published in January 2009

Crystal structures of truncated alphaA and alphaB crystallins reveal structural mechanisms of polydispersity important for eye lens function

scientific article

Dehydrated but unharmed

scientific article published in Nature

Detergent-free mass spectrometry of membrane protein complexes.

scientific article published on 13 October 2013

Discovery of a Highly Selective Cell-Active Inhibitor of the Histone Lysine Demethylases KDM2/7.

scientific article

Dissecting heterogeneous molecular chaperone complexes using a mass spectrum deconvolution approach

scientific article

Dodecameric structure of the small heat shock protein Acr1 from Mycobacterium tuberculosis.

scientific article published on 26 July 2005

Dynamical structure of αB-crystallin.

scientific article published on 24 March 2014

EM∩IM: software for relating ion mobility mass spectrometry and electron microscopy data

scientific article

Ejection of structural zinc leads to inhibition of γ-butyrobetaine hydroxylase

scientific article published on 19 September 2014

Hsp70 oligomerization is mediated by an interaction between the interdomain linker and the substrate-binding domain

scientific article

HspB1 phosphorylation regulates its intramolecular dynamics and mechanosensitive molecular chaperone interaction with filamin C

scientific article published on 22 May 2019

Hyperphosphorylated tau self-assembles into amorphous aggregates eliciting TLR4-dependent responses

scientific article published on 16 May 2022

Ion mobility–mass spectrometry analysis of large protein complexes

scientific article published on 19 June 2008

It takes a dimer to tango: Oligomeric small heat shock proteins dissociate to capture substrate

scientific article published in Journal of Biological Chemistry

Lipid binding attenuates channel closure of the outer membrane protein OmpF ⬇️

article published in the Proceedings of the National Academy of Sciences of the United States of America

Local unfolding of the HSP27 monomer regulates chaperone activity

scientific article published on 06 March 2019

Mass spectrometry: come of age for structural and dynamical biology.

scientific article

Mass-selective soft-landing of protein assemblies with controlled landing energies.

scientific article

Mimicking phosphorylation of alphaB-crystallin affects its chaperone activity

scientific article published on January 2007

Origin of complexity in haemoglobin evolution

scientific article published on 20 May 2020

Phosphomimics destabilize Hsp27 oligomeric assemblies and enhance chaperone activity

scientific article

Polydispersity of a mammalian chaperone: mass spectrometry reveals the population of oligomers in alphaB-crystallin

scientific article

Probing dynamic conformations of the high-molecular-weight αB-crystallin heat shock protein ensemble by NMR spectroscopy.

scientific article

Publisher Correction: The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases

scientific article published on 01 October 2018

Quadrupole-time-of-flight mass spectrometer modified for higher-energy dissociation reduces protein assemblies to peptide fragments.

scientific article published in February 2009

Quantifying the heterogeneity of macromolecular machines by mass photometry

scientific article published on 14 April 2020

Quantitative mass imaging of single biological macromolecules.

scientific article published in April 2018

Quaternary Dynamics of αB-Crystallin as a Direct Consequence of Localised Tertiary Fluctuations in the C-Terminus ⬇️

scientific article published on August 3, 2011

Quaternary dynamics and plasticity underlie small heat shock protein chaperone function

scientific article

Real-time monitoring of protein complexes reveals their quaternary organization and dynamics.

scientific article published on March 2008

Separating and visualising protein assemblies by means of preparative mass spectrometry and microscopy.

scientific article published on 15 March 2010

Small heat shock protein activity is regulated by variable oligomeric substructure.

scientific article published on 19 August 2008

Small heat shock proteins: multifaceted proteins with important implications for life

scientific article published on 13 February 2019

Structural principles that enable oligomeric small heat-shock protein paralogs to evolve distinct functions.

scientific article

Studying the active-site loop movement of the São Paolo metallo-β-lactamase-1†Electronic supplementary information (ESI) available: Procedures for protein expression and purification, 19F-labelling, crystallisation, data collection, and structure de

scientific article published on 4 November 2014

Subunit Exchange of Multimeric Protein Complexes

scientific article published in Journal of Biological Chemistry

Subunit exchange of polydisperse proteins: mass spectrometry reveals consequences of alphaA-crystallin truncation

scientific article published on 07 February 2005

Tandem Mass Spectrometry Reveals the Quaternary Organization of Macromolecular Assemblies

scientific article published in June 2006

The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases

article

The growing world of small heat shock proteins: from structure to functions

scientific article published on 31 March 2017

The quaternary organization and dynamics of the molecular chaperone HSP26 are thermally regulated.

scientific article

The role of the detergent micelle in preserving the structure of membrane proteins in the gas phase

scientific article published on 18 February 2015

The small heat-shock proteins HSPB2 and HSPB3 form well-defined heterooligomers in a unique 3 to 1 subunit ratio.

scientific article published on 26 August 2009

The structured core domain of B-crystallin can prevent amyloid fibrillation and associated toxicity

scientific article

The unusual mycobacterial chaperonins: evidence for in vivo oligomerization and specialization of function

scientific article published on 26 July 2012

Thermal Dissociation of Multimeric Protein Complexes by Using Nanoelectrospray Mass Spectrometry

scientific article published in May 2003

Trajectory Taken by Dimeric Cu/Zn Superoxide Dismutase through the Protein Unfolding and Dissociation Landscape Is Modulated by Salt Bridge Formation

scientific article published on 03 January 2020

Two decades of studying non-covalent biomolecular assemblies by means of electrospray ionization mass spectrometry.

scientific article published on 07 February 2012

Weighing-up protein dynamics: the combination of native mass spectrometry and molecular dynamics simulations

scientific article published on 08 February 2019

αB-crystallin polydispersity is a consequence of unbiased quaternary dynamics

scientific article

List of works by Justin L.P. Benesch

A Monte Carlo approach for assessing the specificity of protein oligomers observed in nano-electrospray mass spectra

A novel mechano-enzymatic cleavage mechanism underlies transthyretin amyloidogenesis

A weakened interface in the P182L variant of HSP27 associated with severe Charcot-Marie-Tooth neuropathy causes aberrant binding to interacting proteins

All three chaperonin genes in the archaeon Haloferax volcanii are individually dispensable.

An ultra-stable gold-coordinated protein cage displaying reversible assembly.

Author Correction: Origin of complexity in haemoglobin evolution

Bayesian deconvolution of mass and ion mobility spectra: from binary interactions to polydisperse ensembles.

Biobox: a toolbox for biomolecular modelling

C-terminal interactions mediate the quaternary dynamics of αB-crystallin.

Characterisation of Shigella Spa33 and Thermotoga FliM/N reveals a new model for C-ring assembly in T3SS.

Collision cross sections for structural proteomics

Collision cross sections of high-mannose N-glycans in commonly observed adduct states--identification of gas-phase conformers unique to [M-H](-) ions

Collisional activation of protein complexes: picking up the pieces

Combining tandem mass spectrometry with ion mobility separation to determine the architecture of polydisperse proteins

Coupling microdroplet microreactors with mass spectrometry: reading the contents of single droplets online.

Crystal structures of truncated alphaA and alphaB crystallins reveal structural mechanisms of polydispersity important for eye lens function

Dehydrated but unharmed

Detergent-free mass spectrometry of membrane protein complexes.

Discovery of a Highly Selective Cell-Active Inhibitor of the Histone Lysine Demethylases KDM2/7.

Dissecting heterogeneous molecular chaperone complexes using a mass spectrum deconvolution approach

Dodecameric structure of the small heat shock protein Acr1 from Mycobacterium tuberculosis.

Dynamical structure of αB-crystallin.

EM∩IM: software for relating ion mobility mass spectrometry and electron microscopy data

Ejection of structural zinc leads to inhibition of γ-butyrobetaine hydroxylase

Hsp70 oligomerization is mediated by an interaction between the interdomain linker and the substrate-binding domain

HspB1 phosphorylation regulates its intramolecular dynamics and mechanosensitive molecular chaperone interaction with filamin C

Hyperphosphorylated tau self-assembles into amorphous aggregates eliciting TLR4-dependent responses

Ion mobility–mass spectrometry analysis of large protein complexes

It takes a dimer to tango: Oligomeric small heat shock proteins dissociate to capture substrate

Lipid binding attenuates channel closure of the outer membrane protein OmpF ⬇️

Local unfolding of the HSP27 monomer regulates chaperone activity

Mass spectrometry: come of age for structural and dynamical biology.

Mass-selective soft-landing of protein assemblies with controlled landing energies.

Mimicking phosphorylation of alphaB-crystallin affects its chaperone activity

Origin of complexity in haemoglobin evolution

Phosphomimics destabilize Hsp27 oligomeric assemblies and enhance chaperone activity

Polydispersity of a mammalian chaperone: mass spectrometry reveals the population of oligomers in alphaB-crystallin

Probing dynamic conformations of the high-molecular-weight αB-crystallin heat shock protein ensemble by NMR spectroscopy.

Publisher Correction: The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases

Quadrupole-time-of-flight mass spectrometer modified for higher-energy dissociation reduces protein assemblies to peptide fragments.

Quantifying the heterogeneity of macromolecular machines by mass photometry

Quantitative mass imaging of single biological macromolecules.

Quaternary Dynamics of αB-Crystallin as a Direct Consequence of Localised Tertiary Fluctuations in the C-Terminus ⬇️

Quaternary dynamics and plasticity underlie small heat shock protein chaperone function

Real-time monitoring of protein complexes reveals their quaternary organization and dynamics.

Separating and visualising protein assemblies by means of preparative mass spectrometry and microscopy.

Small heat shock protein activity is regulated by variable oligomeric substructure.

Small heat shock proteins: multifaceted proteins with important implications for life

Structural principles that enable oligomeric small heat-shock protein paralogs to evolve distinct functions.

Studying the active-site loop movement of the São Paolo metallo-β-lactamase-1†Electronic supplementary information (ESI) available: Procedures for protein expression and purification, 19F-labelling, crystallisation, data collection, and structure de

Subunit Exchange of Multimeric Protein Complexes

Subunit exchange of polydisperse proteins: mass spectrometry reveals consequences of alphaA-crystallin truncation

Tandem Mass Spectrometry Reveals the Quaternary Organization of Macromolecular Assemblies

The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases

The growing world of small heat shock proteins: from structure to functions

The quaternary organization and dynamics of the molecular chaperone HSP26 are thermally regulated.

The role of the detergent micelle in preserving the structure of membrane proteins in the gas phase

The small heat-shock proteins HSPB2 and HSPB3 form well-defined heterooligomers in a unique 3 to 1 subunit ratio.

The structured core domain of B-crystallin can prevent amyloid fibrillation and associated toxicity

The unusual mycobacterial chaperonins: evidence for in vivo oligomerization and specialization of function

Thermal Dissociation of Multimeric Protein Complexes by Using Nanoelectrospray Mass Spectrometry

Trajectory Taken by Dimeric Cu/Zn Superoxide Dismutase through the Protein Unfolding and Dissociation Landscape Is Modulated by Salt Bridge Formation

Two decades of studying non-covalent biomolecular assemblies by means of electrospray ionization mass spectrometry.

Weighing-up protein dynamics: the combination of native mass spectrometry and molecular dynamics simulations

αB-crystallin polydispersity is a consequence of unbiased quaternary dynamics