List of works - Ivanhoe K. H. Leung

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

scientific article

Plant Growth Regulator Daminozide Is a Selective Inhibitor of Human KDM2/7 Histone Demethylases

scientific article

Non-enzymatic chemistry enables 2-hydroxyglutarate-mediated activation of 2-oxoglutarate oxygenases.

scientific article

Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials

scientific article published on 11 September 2017

Dynamic combinatorial chemistry employing boronic acids/boronate esters leads to potent oxygenase inhibitors.

scientific article

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.

scientific article

Structural and mechanistic studies on γ-butyrobetaine hydroxylase

scientific article

A photoreactive small-molecule probe for 2-oxoglutarate oxygenases

scientific article

Human oxygen sensing may have origins in prokaryotic elongation factor Tu prolyl-hydroxylation

scientific article

Investigating the contribution of the active site environment to the slow reaction of hypoxia-inducible factor prolyl hydroxylase domain 2 with oxygen

scientific article

Diphenylacetylene-Linked Peptide Strands Induce Bidirectional β-Sheet Formation

scholarly article by Hannah Lingard et al published 19 February 2014 in Angewandte Chemie International Edition

Studies on deacetoxycephalosporin C synthase support a consensus mechanism for 2-oxoglutarate dependent oxygenases.

scientific article

Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain

scientific article

Protein-Directed Dynamic Combinatorial Chemistry: A Guide to Protein Ligand and Inhibitor Discovery

scientific article

Protein-ligand binding affinity determination by the waterLOGSY method: An optimised approach considering ligand rebinding.

scientific article published on 3 March 2017

Targeting isocitrate lyase for the treatment of latent tuberculosis.

scientific article published on 27 April 2017

γ-Butyrobetaine hydroxylase catalyses a Stevens type rearrangement

scientific article

2-Oxoglutarate regulates binding of hydroxylated hypoxia-inducible factor to prolyl hydroxylase domain 2.

scientific article published on 9 March 2018

Comparison of the substrate selectivity and biochemical properties of human and bacterial γ-butyrobetaine hydroxylase

article

The Ugi four-component reaction enables expedient synthesis and comparison of photoaffinity probes

Fluoromethylated derivatives of carnitine biosynthesis intermediates--synthesis and applications.

scientific article published on February 2014

A Novel Class of Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Contains the Octahydro-2-chromen-4-ol Scaffold

scientific article published on 26 September 2018

MCR-1: a promising target for structure-based design of inhibitors to tackle polymyxin resistance

scientific article published on 20 July 2018

Novel Inhibitors of DNA Repair Enzyme TDP1 Combining Monoterpenoid and Adamantane Fragments

scientific article published on 01 January 2019

Studies on the Glutathione-Dependent Formaldehyde-Activating Enzyme from Paracoccus denitrificans

scientific article published on 16 December 2015

NMR studies of the non-haem Fe(II) and 2-oxoglutarate-dependent oxygenases

scientific article published on 4 September 2017

Selective recognition of the di/trimethylammonium motif by an artificial carboxycalixarene receptor

scientific article published on 16 January 2017

Virtual screening and biophysical studies lead to HSP90 inhibitors.

scientific article published on 23 November 2016

Protein-Small Molecule Interactions by WaterLOGSY

scientific article published on 20 September 2018

Harnessing ester bond chemistry for protein ligation.

scientific article published on 13 January 2017

New Hydrazinothiazole Derivatives of Usnic Acid as Potent Tdp1 Inhibitors

scientific article published on 15 October 2019

Non-competitive cyclic peptides for targeting enzyme-substrate complexes.

scientific article published on 23 April 2018

Total Synthesis and Conformational Study of Callyaerin A: Anti-Tubercular Cyclic Peptide Bearing a Rare Rigidifying (Z)-2,3- Diaminoacrylamide Moiety

scientific article published on 18 January 2018

Sensory, Microbiological and Physicochemical Characterisation of Functional Manuka Honey Yogurts Containing Probiotic Lactobacillus reuteri DPC16

scientific article published on 19 January 2020

Synthesis of the Azepinobisindole Alkaloid Iheyamine A Enabled by a Cross-Mannich Reaction.

scientific article published on 5 October 2016

Development of NMR and thermal shift assays for the evaluation of isocitrate lyase inhibitors

scientific article published in November 2017

Targeting mRNA translation in Parkinson's disease

scientific article published on 08 April 2019

Promising New Inhibitors of Tyrosyl-DNA Phosphodiesterase I (Tdp 1) Combining 4-Arylcoumarin and Monoterpenoid Moieties as Components of Complex Antitumor Therapy

scientific article published on 23 December 2019

Identification of Isoform-Selective Ligands for the Middle Domain of Heat Shock Protein 90 (Hsp90)

scientific article published on 26 October 2019

An investigation into the effect of ribosomal protein S15 phosphorylation on its intermolecular interactions by using phosphomimetic mutant

scientific article published on 25 June 2020

Phosphatidylcholine-Specific Phospholipase C as a Promising Drug Target

scientific article published on 25 July 2023

Microbial metabolic enzymes, pathways and microbial hosts for co-metabolic degradation of organic micropollutants in wastewater

scientific article published in May 2025

Mycobacterium tuberculosis Rv1916 is an Acetyl‐CoA‐Binding Protein

scientific article published on 18 June 2023

Structural remodelling of the 2OG oxygenase Rv3406 enables sulfur-scavenging in Mycobacterium tuberculosis

scientific article published in January 2025

An approach to recombinantly produce mature grape polyphenol oxidase

scientific article published on 05 July 2019

Microbial Metabolic Enzymes, Pathways and Microbial Hosts for Co-Metabolic Degradation of Organic Micropollutants in Wastewater

An optimised MALDI-TOF assay for phosphatidylcholine-specific phospholipase C

scientific article published in January 2021

Dynamic allostery drives acetyl-CoA-mediated activation of Mycobacterium tuberculosis isocitrate lyase 2

Enzymatic Degradation of PFAS: Current Status and Ongoing Challenges

scientific article published on 23 October 2024

List of works by Ivanhoe K. H. Leung

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

Plant Growth Regulator Daminozide Is a Selective Inhibitor of Human KDM2/7 Histone Demethylases

Non-enzymatic chemistry enables 2-hydroxyglutarate-mediated activation of 2-oxoglutarate oxygenases.

Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials

Dynamic combinatorial chemistry employing boronic acids/boronate esters leads to potent oxygenase inhibitors.

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.

Structural and mechanistic studies on γ-butyrobetaine hydroxylase

A photoreactive small-molecule probe for 2-oxoglutarate oxygenases

Human oxygen sensing may have origins in prokaryotic elongation factor Tu prolyl-hydroxylation

Investigating the contribution of the active site environment to the slow reaction of hypoxia-inducible factor prolyl hydroxylase domain 2 with oxygen

Diphenylacetylene-Linked Peptide Strands Induce Bidirectional β-Sheet Formation

Studies on deacetoxycephalosporin C synthase support a consensus mechanism for 2-oxoglutarate dependent oxygenases.

Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain

Protein-Directed Dynamic Combinatorial Chemistry: A Guide to Protein Ligand and Inhibitor Discovery

Protein-ligand binding affinity determination by the waterLOGSY method: An optimised approach considering ligand rebinding.

Targeting isocitrate lyase for the treatment of latent tuberculosis.

γ-Butyrobetaine hydroxylase catalyses a Stevens type rearrangement

2-Oxoglutarate regulates binding of hydroxylated hypoxia-inducible factor to prolyl hydroxylase domain 2.

Comparison of the substrate selectivity and biochemical properties of human and bacterial γ-butyrobetaine hydroxylase

The Ugi four-component reaction enables expedient synthesis and comparison of photoaffinity probes

Fluoromethylated derivatives of carnitine biosynthesis intermediates--synthesis and applications.

A Novel Class of Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Contains the Octahydro-2-chromen-4-ol Scaffold

MCR-1: a promising target for structure-based design of inhibitors to tackle polymyxin resistance

Novel Inhibitors of DNA Repair Enzyme TDP1 Combining Monoterpenoid and Adamantane Fragments

Studies on the Glutathione-Dependent Formaldehyde-Activating Enzyme from Paracoccus denitrificans

NMR studies of the non-haem Fe(II) and 2-oxoglutarate-dependent oxygenases

Selective recognition of the di/trimethylammonium motif by an artificial carboxycalixarene receptor

Virtual screening and biophysical studies lead to HSP90 inhibitors.

Protein-Small Molecule Interactions by WaterLOGSY

Harnessing ester bond chemistry for protein ligation.

New Hydrazinothiazole Derivatives of Usnic Acid as Potent Tdp1 Inhibitors

Non-competitive cyclic peptides for targeting enzyme-substrate complexes.

Total Synthesis and Conformational Study of Callyaerin A: Anti-Tubercular Cyclic Peptide Bearing a Rare Rigidifying (Z)-2,3- Diaminoacrylamide Moiety

Sensory, Microbiological and Physicochemical Characterisation of Functional Manuka Honey Yogurts Containing Probiotic Lactobacillus reuteri DPC16

Synthesis of the Azepinobisindole Alkaloid Iheyamine A Enabled by a Cross-Mannich Reaction.

Development of NMR and thermal shift assays for the evaluation of isocitrate lyase inhibitors

Targeting mRNA translation in Parkinson's disease

Promising New Inhibitors of Tyrosyl-DNA Phosphodiesterase I (Tdp 1) Combining 4-Arylcoumarin and Monoterpenoid Moieties as Components of Complex Antitumor Therapy

Identification of Isoform-Selective Ligands for the Middle Domain of Heat Shock Protein 90 (Hsp90)

An investigation into the effect of ribosomal protein S15 phosphorylation on its intermolecular interactions by using phosphomimetic mutant

Phosphatidylcholine-Specific Phospholipase C as a Promising Drug Target

Microbial metabolic enzymes, pathways and microbial hosts for co-metabolic degradation of organic micropollutants in wastewater

Mycobacterium tuberculosis Rv1916 is an Acetyl‐CoA‐Binding Protein

Structural remodelling of the 2OG oxygenase Rv3406 enables sulfur-scavenging in Mycobacterium tuberculosis

An approach to recombinantly produce mature grape polyphenol oxidase

Microbial Metabolic Enzymes, Pathways and Microbial Hosts for Co-Metabolic Degradation of Organic Micropollutants in Wastewater

An optimised MALDI-TOF assay for phosphatidylcholine-specific phospholipase C

Dynamic allostery drives acetyl-CoA-mediated activation of Mycobacterium tuberculosis isocitrate lyase 2

Enzymatic Degradation of PFAS: Current Status and Ongoing Challenges

Author comment: An integrated structural and biophysical approach to study carbon metabolism in Mycobacterium tuberculosis — R0/PR1