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List of works by Brad H Nelson

A CCR4 antagonist combined with vaccines induces antigen-specific CD8+ T cells and tumor immunity against self antigens

scientific article published on 9 September 2011

A Low Carbohydrate, High Protein Diet Slows Tumor Growth and Prevents Cancer Initiation

scientific article published on 14 June 2011

A leech homolog of twist: evidence for its inheritance as a maternal mRNA.

scientific article published in October 1997

A library-based screening method identifies neoantigen-reactive T cells in peripheral blood prior to relapse of ovarian cancer.

scientific article published on 21 September 2017

A membrane-proximal region of the interleukin-2 receptor gamma c chain sufficient for Jak kinase activation and induction of proliferation in T cells.

scientific article published on January 1996

A permissive role for phosphatidylinositol 3-kinase in the Stat5-mediated expression of cyclin D2 by the interleukin-2 receptor

scientific article published on 02 December 2003

A viral vaccine encoding prostate-specific antigen induces antigen spreading to a common set of self-proteins in prostate cancer patients

scientific article

Absolute lymphocyte count is associated with survival in ovarian cancer independent of tumor-infiltrating lymphocytes

scientific article published on 27 February 2012

An in vitro-transcribed-mRNA polyepitope construct encoding 32 distinct HLA class I-restricted epitopes from CMV, EBV, and Influenza for use as a functional control in human immune monitoring studies

scientific article published on 15 July 2010

Application of Bayesian modeling of autologous antibody responses against ovarian tumor-associated antigens to cancer detection

scientific article published in February 2006

Assessing Tumor-Infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method from the International Immuno-Oncology Biomarkers Working Group: Part 2: TILs in Melanoma, Gastrointestinal Tract Ca

scientific article published on 2 August 2017

Assessing Tumor-infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method From the International Immunooncology Biomarkers Working Group: Part 1: Assessing the Host Immune Response, TILs in I

scientific article published in September 2017

BRCA1 and BRCA2 mutations correlate with TP53 abnormalities and presence of immune cell infiltrates in ovarian high-grade serous carcinoma

scientific article published on 27 January 2012

Biology of the interleukin-2 receptor

scientific article published in January 1998

CD103 and Intratumoral Immune Response in Breast Cancer

scientific article

CD20+ B cells: the other tumor-infiltrating lymphocytes

scientific article

CD20+ tumor-infiltrating lymphocytes have an atypical CD27- memory phenotype and together with CD8+ T cells promote favorable prognosis in ovarian cancer

scientific article published on 2 May 2012

CD25 Identifies a Subset of CD4+FoxP3- TIL That Are Exhausted Yet Prognostically Favorable in Human Ovarian Cancer

scientific article published on 05 December 2014

CD8+ T cells induce complete regression of advanced ovarian cancers by an interleukin (IL)-2/IL-15 dependent mechanism

scientific article published on December 2007

Castration induces autoantibody and T cell responses that correlate with inferior outcomes in an androgen-dependent murine tumor model

scientific article

Characteristics and outcome of the COEUR Canadian validation cohort for ovarian cancer biomarkers

scientific article published on 27 March 2018

Clonal evolution of high-grade serous ovarian carcinoma from primary to recurrent disease

scientific article published on 29 November 2012

Conversion of Ectoderm to Mesoderm by Cytoplasmic Extrusion in Leech Embryos

scientific article published in Science

Cytoplasmic and cortical determinants interact to specify ectoderm and mesoderm in the leech embryo

scientific article published in May 1992

Cytoplasmic domains of the interleukin-2 receptor beta and gamma chains mediate the signal for T-cell proliferation.

scientific article published on May 1994

Defining the critical hurdles in cancer immunotherapy

scientific article published on 14 December 2011

Density of tumour stroma is correlated to outcome after adoptive transfer of CD4+ and CD8+ T cells in a murine mammary carcinoma model

scientific article published on 30 September 2009

Dysregulated hematopoiesis caused by mammary cancer is associated with epigenetic changes and hox gene expression in hematopoietic cells

scientific article

ESRRA-C11orf20 is a recurrent gene fusion in serous ovarian carcinoma

scientific article

Effects of blood collection conditions on ovarian cancer serum markers

scientific article

Elevated level of anterior gradient-2 in pancreatic juice from patients with pre-malignant pancreatic neoplasia

scientific article

Enhanced signaling through the IL-2 receptor in CD8+ T cells regulated by antigen recognition results in preferential proliferation and expansion of responding CD8+ T cells rather than promotion of cell death

scientific article

Expression of chimeric granulocyte-macrophage colony-stimulating factor/interleukin 2 receptors in human cytotoxic T lymphocyte clones results in granulocyte-macrophage colony-stimulating factor-dependent growth.

scientific article published in August 1999

FoxO3a and BCR-ABL regulate cyclin D2 transcription through a STAT5/BCL6-dependent mechanism.

scientific article

Functional repair of transected spinal cord in embryonic chick.

scientific article published on January 1991

Genetic modification of T cell clones to improve the safety and efficacy of adoptive T cell therapy

scientific article published on 01 January 1994

Genetic modification of T-cell clones for therapy of human viral and malignant diseases.

scientific article published in May 1998

Homodimerization of IL-2 receptor β chain is necessary and sufficient to activate Jak2 and dowstream signaling pathways

scientific article published on 01 January 1998

Homologous Recombination DNA Repair Pathway Disruption and Retinoblastoma Protein Loss Are Associated with Exceptional Survival in High-Grade Serous Ovarian Cancer.

scientific article

IDO and outcomes in ovarian cancer

scientific article published in November 2009

IL-2, regulatory T cells, and tolerance

scientific article published on April 2004

Immunogenicity of recurrent mutations in MYD88 and EZH2 in non-Hodgkin lymphomas.

scientific article published on 4 November 2015

Immunotherapy for gynecological cancers: opportunities abound

scientific article published on 01 June 2017

Interfaces of Malignant and Immunologic Clonal Dynamics in Ovarian Cancer

scientific article published on 10 May 2018

Interleukin-2 signaling and the maintenance of self-tolerance

scientific article

Investigation of PD-L1 Biomarker Testing Methods for PD-1 Axis Inhibition in Non-squamous Non-small Cell Lung Cancer

scientific article

Killer T cells to the rescue in ovarian cancer

scientific article published on 01 February 2012

Location, location, location: CD103 demarcates intraepithelial, prognostically favorable CD8(+) tumor-infiltrating lymphocytes in ovarian cancer

scientific article published on 10 January 2014

Loss of Parkinson's susceptibility gene LRRK2 promotes carcinogen-induced lung tumorigenesis

scientific article published on 22 January 2021

Low Mutation Burden in Ovarian Cancer May Limit the Utility of Neoantigen-Targeted Vaccines.

scientific article

MAGE-F1, a novel ubiquitously expressed member of the MAGE superfamily

scientific article (publication date: 18 April 2001)

Mammary tumors with diverse immunological phenotypes show differing sensitivity to adoptively transferred CD8+ T cells lacking the Cbl-b gene

scientific article published on 7 April 2009

Mapping the human T cell repertoire to recurrent driver mutations in MYD88 and EZH2 in lymphoma

scientific article published on 28 April 2017

Molecular Subtype Not Immune Response Drives Outcomes in Endometrial Carcinoma

scientific article published on 06 December 2018

Multiplex Droplet Digital PCR Quantification of Recurrent Somatic Mutations in Diffuse Large B-Cell and Follicular Lymphoma

scientific article

Neo-antigens predicted by tumor genome meta-analysis correlate with increased patient survival

scientific article

Neoadjuvant Chemotherapy of Ovarian Cancer Results in Three Patterns of Tumor-Infiltrating Lymphocyte Response with Distinct Implications for Immunotherapy

scientific article published on 6 September 2016

New insights into tumor immunity revealed by the unique genetic and genomic aspects of ovarian cancer

scientific article

New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway

scientific journal article

Oncolytic vesicular stomatitis virus expressing interferon-γ has enhanced therapeutic activity

scientific article

Oncolytic viruses as engineering platforms for combination immunotherapy.

scientific article published on 25 April 2018

Ovarian cancer early detection claims are biased

scientific article

PD-1 and CD103 Are Widely Coexpressed on Prognostically Favorable Intraepithelial CD8 T Cells in Human Ovarian Cancer

scientific article published on 8 May 2015

PD-L1 and intratumoral immune response in breast cancer

scientific article published on 30 May 2017

PD-L1 expression is associated with tumor-infiltrating T cells and favorable prognosis in high-grade serous ovarian cancer.

scientific article published on 16 March 2016

Phosphatidylinositol 3-kinase potentiates, but does not trigger, T cell proliferation mediated by the IL-2 receptor

scientific article published on September 2001

Polyfunctional T-cell responses are disrupted by the ovarian cancer ascites environment and only partially restored by clinically relevant cytokines.

scientific article

Profiling model T-cell metagenomes with short reads

scientific article published on 9 January 2009

Profiling the T-cell receptor beta-chain repertoire by massively parallel sequencing

scientific article published on 18 June 2009

Profound CD8+ T cell immunity elicited by sequential daily immunization with exogenous antigen plus the TLR3 agonist poly(I:C)

scholarly article by Darin A Wick et al published January 2011 in Vaccine

Profound elevation of CD8+ T cells expressing the intraepithelial lymphocyte marker CD103 (alphaE/beta7 Integrin) in high-grade serous ovarian cancer

scientific article

Prognostic Significance of Tumor-Infiltrating B Cells and Plasma Cells in Human Cancer

scientific article published on 26 July 2018

Programmed cell death ligand 1 cut-point is associated with reduced disease specific survival in resected pancreatic ductal adenocarcinoma

scientific article published on 5 September 2017

Proliferation and differentiation of CD8+ T cells in the absence of IL-2/15 receptor beta-chain expression or STAT5 activation

scientific article published on September 2004

Recurrent genomic rearrangements in primary testicular lymphoma.

scientific article published on 26 March 2015

Requirement for an initial signal from the membrane-proximal region of the interleukin 2 receptor gamma(c) chain for Janus kinase activation leading to T cell proliferation

scientific article

Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer

scientific article

Retraction. Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death

scientific article published on 01 April 2009

Role of Interleukin (IL)-2 Receptor β-Chain Subdomains and Shc in p38 Mitogen-activated Protein (MAP) Kinase and p54 MAP Kinase (Stress-activated Protein Kinase/c-Jun N-terminal Kinase) Activation

scientific article published in Journal of Biological Chemistry

STAT5 is essential for Akt/p70S6 kinase activity during IL-2-induced lymphocyte proliferation

scientific article

Serologic analysis of ovarian tumor antigens reveals a bias toward antigens encoded on 17q.

scientific article

Single-Cell Transcriptome Analysis Reveals Disease-Defining T-cell Subsets in the Tumor Microenvironment of Classic Hodgkin Lymphoma

scientific article published on 19 December 2019

Spontaneous Mammary Tumors Differ Widely in Their Inherent Sensitivity to Adoptively Transferred T Cells

scientific article published on 01 July 2007

Standard treatments induce antigen-specific immune responses in prostate cancer

scientific article

Stat5 and Sp1 regulate transcription of the cyclin D2 gene in response to IL-2.

scientific article published on February 2001

Surveillance of the tumor mutanome by T cells during progression from primary to recurrent ovarian cancer.

scientific article

Systematic analysis of immune infiltrates in high-grade serous ovarian cancer reveals CD20, FoxP3 and TIA-1 as positive prognostic factors

scientific article

Systematic evaluation of candidate blood markers for detecting ovarian cancer

scientific article

Targeting the undruggable: immunotherapy meets personalized oncology in the genomic era.

scientific article

The Apoptosis-inducing Granulocyte-Macrophage Colony-stimulating Factor (GM-CSF) Analog E21R Functions through Specific Regions of the Heterodimeric GM-CSF Receptor and Requires Interleukin-1β-converting Enzyme-like Proteases

scientific article published in Journal of Biological Chemistry

The IL-2 receptor promotes lymphocyte proliferation and induction of the c-myc, bcl-2, and bcl-x genes through the trans-activation domain of Stat5.

scientific article

The IL-2 receptor promotes proliferation, bcl-2 and bcl-x induction, but not cell viability through the adapter molecule Shc.

scientific article published on November 1998

The IL-4 receptor alpha-chain cytoplasmic domain is sufficient for activation of JAK-1 and STAT6 and the induction of IL-4-specific gene expression

scientific article published on June 1997

The chimeric TAC receptor co-opts the T cell receptor yielding robust anti-tumor activity without toxicity

scientific article published in Nature Communications

The impact of T-cell immunity on ovarian cancer outcomes

scientific article published on April 2008

The more tumors change, the more they stay tame: do T cells keep POLE ultramutated endometrial carcinomas in check?

scientific article published in July 2015

The prognostic value of FoxP3+ tumor-infiltrating lymphocytes in cancer: a critical review of the literature

scientific article

Toward Personalized Lymphoma Immunotherapy: Identification of Common Driver Mutations Recognized by Patient CD8+ T Cells

scientific article published on 02 December 2015

Transcription-induced chromatin remodeling at the c-myc gene involves the local exchange of histone H2A.Z.

scientific article published on 06 May 2005

Tumor-Infiltrating Plasma Cells Are Associated with Tertiary Lymphoid Structures, Cytolytic T-Cell Responses, and Superior Prognosis in Ovarian Cancer

scientific article

Tumor-associated autoantibodies correlate with poor outcome in prostate cancer patients treated with androgen deprivation and external beam radiation therapy

scientific article published on 25 June 2014

Tumor-infiltrating B cells and T cells: Working together to promote patient survival

scientific article published on December 2012

Tumor-infiltrating T cells correlate with NY-ESO-1-specific autoantibodies in ovarian cancer

scientific article

Tumor-infiltrating lymphocytes expressing the tissue resident memory marker CD103 are associated with increased survival in high-grade serous ovarian cancer

scientific article published on 4 November 2013

Tumor-infiltrating lymphocytes predict response to anthracycline-based chemotherapy in estrogen receptor-negative breast cancer.

scientific article published on 8 December 2011

Tumour immunotherapy: lessons from predator–prey theory

scientific article published in 2022

Tumour-infiltrating FOXP3(+) lymphocytes are associated with cytotoxic immune responses and good clinical outcome in oestrogen receptor-negative breast cancer.

scientific article published on 20 November 2012

Ultrasound emitter localization in heterogeneous media

scientific article published in January 2007

Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death

scientific article

Uncoupling of promitogenic and antiapoptotic functions of IL-2 by Smad-dependent TGF-beta signaling

scientific article published on June 2003

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