List of works - Vincent Villeret

1H, 15N and 13C assignments of the N-terminal domain of the Mediator complex subunit MED26.

scientific article

A Salmonella type three secretion effector/chaperone complex adopts a hexameric ring-like structure

scientific article

A new variant of the Ntn hydrolase fold revealed by the crystal structure of L-aminopeptidase D-ala-esterase/amidase from Ochrobactrum anthropi

scientific article

Allosteric regulation in Pseudomonas aeruginosa catabolic ornithine carbamoyltransferase revisited: association of concerted homotropic cooperative interactions and local heterotropic effects

scientific article published on 01 October 1998

Aspartate carbamoyltransferase from the thermoacidophilic archaeon Sulfolobus acidocaldarius. Cloning, sequence analysis, enzyme purification and characterization.

scientific article

Biochemical characterisation of ornithine carbamoyltransferase from Pyrococcus furiosus.

scientific article published in August 1997

Catabolic ornithine carbamoyltransferase of Pseudomonas aeruginosa. Changes of allosteric properties resulting from modifications at the C-terminus

scientific article published on 01 April 1994

Characterization of ERM transactivation domain binding to the ACID/PTOV domain of the Mediator subunit MED25

scientific article

Computational characterization of the binding mode between oncoprotein Ets-1 and DNA-repair enzymes

scientific article published on 25 September 2018

Conserved Omp85 lid-lock structure and substrate recognition in FhaC

scientific article

Crystal structure of Bordetella pertussis BugD solute receptor unveils the basis of ligand binding in a new family of periplasmic binding proteins

scientific article

Crystal structure of Pseudomonas aeruginosa catabolic ornithine transcarbamoylase at 3.0-A resolution: a different oligomeric organization in the transcarbamoylase family

scientific article

Crystal structure of a D-aminopeptidase from Ochrobactrum anthropi, a new member of the 'penicillin-recognizing enzyme' family

scientific article

Crystal structure of human Mediator subunit MED23

scientific article published in Nature Communications

Crystal structure of papaya glutaminyl cyclase, an archetype for plant and bacterial glutaminyl cyclases

scientific article published on 4 January 2006

Crystal structure of spinach chloroplast fructose-1,6-bisphosphatase at 2.8 A resolution

scientific article

Crystal structures of a psychrophilic metalloprotease reveal new insights into catalysis by cold-adapted proteases

scientific article (publication date: March 2003)

Crystal structures of two Bordetella pertussis periplasmic receptors contribute to defining a novel pyroglutamic acid binding DctP subfamily

scientific article

Crystallization and preliminary X-ray analysis of a family 19 glycosyl hydrolase from Carica papaya latex.

scientific article published on 5 April 2008

Crystallization and preliminary X-ray diffraction analysis of the peptidylprolyl isomerase Par27 of Bordetella pertussis

scientific article published on 9 August 2008

Crystallization and preliminary X-ray diffraction analysis of two extracytoplasmic solute receptors of the DctP family from Bordetella pertussis.

scientific article

Crystallization and preliminary X-ray diffraction studies of the glutaminyl cyclase from Carica papaya latex

scientific article

DNA binding of the cell cycle transcriptional regulator GcrA depends on N6-adenosine methylation in Caulobacter crescentus and other Alphaproteobacteria

scientific article

Deletion of flagellin's hypervariable region abrogates antibody-mediated neutralization and systemic activation of TLR5-dependent immunity.

scientific article published in August 2008

Discovery of novel N-phenylphenoxyacetamide derivatives as EthR inhibitors and ethionamide boosters by combining high-throughput screening and synthesis

scientific article

Ethionamide boosters. 2. Combining bioisosteric replacement and structure-based drug design to solve pharmacokinetic issues in a series of potent 1,2,4-oxadiazole EthR inhibitors

scientific article

Ethionamide boosters: synthesis, biological activity, and structure-activity relationships of a series of 1,2,4-oxadiazole EthR inhibitors

scientific article published on April 2011

Ets-1 interacts through a similar binding interface with Ku70 and Poly (ADP-Ribose) Polymerase-1

scientific article published on 18 June 2018

Exploring drug target flexibility using in situ click chemistry: application to a mycobacterial transcriptional regulator

scientific article

Expression and purification in high yield of a functionally active recombinant human Type I inositol(1,4,5)P3 5-phosphatase

scientific article published on 24 April 2007

First structural insights into the TpsB/Omp85 superfamily.

scientific article

Functional importance of a conserved sequence motif in FhaC, a prototypic member of the TpsB/Omp85 superfamily

scientific article

Glycine 122 is essential for cooperativity and binding of Mg2+ to porcine fructose-1,6-bisphosphatase

scientific article published on 01 January 1995

Insights into mechanisms of induction and ligands recognition in the transcriptional repressor EthR from Mycobacterium tuberculosis

scientific article

Ligand efficiency driven design of new inhibitors of Mycobacterium tuberculosis transcriptional repressor EthR using fragment growing, merging, and linking approaches

scientific article

Linker insertion mutagenesis based on IS21 transposition: isolation of an AMP-insensitive variant of catabolic ornithine carbamoyltransferase from Pseudomonas aeruginosa

scientific article published on 01 May 2000

Methionine-321 in the C-terminal alpha-helix of catabolic ornithine carbamoyltransferase from Pseudomonas aeruginosa is important for positive homotropic cooperativity

scientific article published on 01 December 1994

NMR structure of the human Mediator MED25 ACID domain

scientific article

Ornithine carbamoyltransferase from Pyrococcus furiosus

scientific article published on 01 January 2001

Periplasmic domain of the sensor-kinase BvgS reveals a new paradigm for the Venus flytrap mechanism

scientific article

Phosphorylation of the MET receptor on juxtamembrane tyrosine residue 1001 inhibits its caspase-dependent cleavage.

scientific article

Preliminary crystal structure determination of the alkaline protease from the Antarctic psychrophile pseudomonas aeruginosa ⬇️

scientific article published on November 1, 1997

Preliminary structural studies of Escherichia coli isopentenyl diphosphate isomerase

scientific article published in February 2001

Probing the conformation of FhaC with small-angle neutron scattering and molecular modeling.

scientific article

Purification of SUMO-1 modified IκBα and complex formation with NF-κB

scientific article published on 25 June 2011

Secretion signal of the filamentous haemagglutinin, a model two-partner secretion substrate

scientific article published on 12 June 2006

Serine 948 and threonine 1042 are crucial residues for allosteric regulation of Escherichia coli carbamoylphosphate synthetase and illustrate coupling effects of activation and inhibition pathways

scientific article published on 01 March 1999

Solution Structure of the N-Terminal Domain of Mediator Subunit MED26 and Molecular Characterization of Its Interaction with EAF1 and TAF7.

scientific article published on 9 September 2017

Solution structure of the N-terminal transactivation domain of ERM modified by SUMO-1

scientific article published on 18 July 2010

Structural activation of the transcriptional repressor EthR from Mycobacterium tuberculosis by single amino acid change mimicking natural and synthetic ligands

scientific article

Structural analysis of Bordetella pertussis BugE solute receptor in a bound conformation

scientific article published on 18 October 2006

Structural analysis of Escherichia coli OpgG, a protein required for the biosynthesis of osmoregulated periplasmic glucans.

scientific article

Structural and phylogenetic relationships among plant and animal cystatins

scientific article published on 01 November 1998

Structural aspects of the allosteric inhibition of fructose-1,6-bisphosphatase by AMP: the binding of both the substrate analogue 2,5-anhydro-D-glucitol 1,6-bisphosphate and catalytic metal ions monitored by X-ray crystallography

scientific article

Structural basis for haem piracy from host haemopexin by Haemophilus influenzae.

scientific article published on 18 May 2016

Structural insights into ChpT, an essential dimeric histidine phosphotransferase regulating the cell cycle inCaulobacter crescentus

scientific article

Structure and plasticity of the peptidyl-prolyl isomerase Par27 of Bordetella pertussis revealed by X-ray diffraction and small-angle X-ray scattering.

scientific article published on 20 November 2009

Structure of EthR in a ligand bound conformation reveals therapeutic perspectives against tuberculosis

scientific article published in October 2004

Structure of the membrane protein FhaC: a member of the Omp85-TpsB transporter superfamily.

scientific article

Structure of the secretion domain of HxuA fromHaemophilus influenzae

scientific article

Structure-based mechanism of ligand binding for periplasmic solute-binding protein of the Bug family

scientific article published in 2007

Substrate recognition by the POTRA domains of TpsB transporter FhaC.

scientific article

Synthetic EthR inhibitors boost antituberculous activity of ethionamide

scientific article

The DivJ, CbrA and PleC system controls DivK phosphorylation and symbiosis in Sinorhizobium meliloti

scientific article published on 19 August 2013

The Mediator complex subunit MED25 is targeted by the N-terminal transactivation domain of the PEA3 group members

scientific article published on 26 March 2013

The crystal structure of Pyrococcus furiosus ornithine carbamoyltransferase reveals a key role for oligomerization in enzyme stability at extremely high temperatures

scientific article

The crystal structure of filamentous hemagglutinin secretion domain and its implications for the two-partner secretion pathway

scholarly article

The influence of anionic lipids on SHIP2 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase activity

scientific article published on 23 May 2006

The level of Ets-1 protein is regulated by poly(ADP-ribose) polymerase-1 (PARP-1) in cancer cells to prevent DNA damage.

scientific article

The structural organization of the N-terminus domain of SopB, a virulence factor of Salmonella, depends on the nature of its protein partners.

scientific article

Virulence regulation with Venus flytrap domains: structure and function of the periplasmic moiety of the sensor-kinase BvgS

scientific article

X-ray structure of papaya chitinase reveals the substrate binding mode of glycosyl hydrolase family 19 chitinases

scientific article

List of works by Vincent Villeret

1H, 15N and 13C assignments of the N-terminal domain of the Mediator complex subunit MED26.

A Salmonella type three secretion effector/chaperone complex adopts a hexameric ring-like structure

A new variant of the Ntn hydrolase fold revealed by the crystal structure of L-aminopeptidase D-ala-esterase/amidase from Ochrobactrum anthropi

Allosteric regulation in Pseudomonas aeruginosa catabolic ornithine carbamoyltransferase revisited: association of concerted homotropic cooperative interactions and local heterotropic effects

Aspartate carbamoyltransferase from the thermoacidophilic archaeon Sulfolobus acidocaldarius. Cloning, sequence analysis, enzyme purification and characterization.

Biochemical characterisation of ornithine carbamoyltransferase from Pyrococcus furiosus.

Catabolic ornithine carbamoyltransferase of Pseudomonas aeruginosa. Changes of allosteric properties resulting from modifications at the C-terminus

Characterization of ERM transactivation domain binding to the ACID/PTOV domain of the Mediator subunit MED25

Computational characterization of the binding mode between oncoprotein Ets-1 and DNA-repair enzymes

Conserved Omp85 lid-lock structure and substrate recognition in FhaC

Crystal structure of Bordetella pertussis BugD solute receptor unveils the basis of ligand binding in a new family of periplasmic binding proteins

Crystal structure of Pseudomonas aeruginosa catabolic ornithine transcarbamoylase at 3.0-A resolution: a different oligomeric organization in the transcarbamoylase family

Crystal structure of a D-aminopeptidase from Ochrobactrum anthropi, a new member of the 'penicillin-recognizing enzyme' family

Crystal structure of human Mediator subunit MED23

Crystal structure of papaya glutaminyl cyclase, an archetype for plant and bacterial glutaminyl cyclases

Crystal structure of spinach chloroplast fructose-1,6-bisphosphatase at 2.8 A resolution

Crystal structures of a psychrophilic metalloprotease reveal new insights into catalysis by cold-adapted proteases

Crystal structures of two Bordetella pertussis periplasmic receptors contribute to defining a novel pyroglutamic acid binding DctP subfamily

Crystallization and preliminary X-ray analysis of a family 19 glycosyl hydrolase from Carica papaya latex.

Crystallization and preliminary X-ray diffraction analysis of the peptidylprolyl isomerase Par27 of Bordetella pertussis

Crystallization and preliminary X-ray diffraction analysis of two extracytoplasmic solute receptors of the DctP family from Bordetella pertussis.

Crystallization and preliminary X-ray diffraction studies of the glutaminyl cyclase from Carica papaya latex

DNA binding of the cell cycle transcriptional regulator GcrA depends on N6-adenosine methylation in Caulobacter crescentus and other Alphaproteobacteria

Deletion of flagellin's hypervariable region abrogates antibody-mediated neutralization and systemic activation of TLR5-dependent immunity.

Discovery of novel N-phenylphenoxyacetamide derivatives as EthR inhibitors and ethionamide boosters by combining high-throughput screening and synthesis

Ethionamide boosters. 2. Combining bioisosteric replacement and structure-based drug design to solve pharmacokinetic issues in a series of potent 1,2,4-oxadiazole EthR inhibitors

Ethionamide boosters: synthesis, biological activity, and structure-activity relationships of a series of 1,2,4-oxadiazole EthR inhibitors

Ets-1 interacts through a similar binding interface with Ku70 and Poly (ADP-Ribose) Polymerase-1

Exploring drug target flexibility using in situ click chemistry: application to a mycobacterial transcriptional regulator

Expression and purification in high yield of a functionally active recombinant human Type I inositol(1,4,5)P3 5-phosphatase

First structural insights into the TpsB/Omp85 superfamily.

Functional importance of a conserved sequence motif in FhaC, a prototypic member of the TpsB/Omp85 superfamily

Glycine 122 is essential for cooperativity and binding of Mg2+ to porcine fructose-1,6-bisphosphatase

Insights into mechanisms of induction and ligands recognition in the transcriptional repressor EthR from Mycobacterium tuberculosis

Ligand efficiency driven design of new inhibitors of Mycobacterium tuberculosis transcriptional repressor EthR using fragment growing, merging, and linking approaches

Linker insertion mutagenesis based on IS21 transposition: isolation of an AMP-insensitive variant of catabolic ornithine carbamoyltransferase from Pseudomonas aeruginosa

Methionine-321 in the C-terminal alpha-helix of catabolic ornithine carbamoyltransferase from Pseudomonas aeruginosa is important for positive homotropic cooperativity

NMR structure of the human Mediator MED25 ACID domain

Ornithine carbamoyltransferase from Pyrococcus furiosus

Periplasmic domain of the sensor-kinase BvgS reveals a new paradigm for the Venus flytrap mechanism

Phosphorylation of the MET receptor on juxtamembrane tyrosine residue 1001 inhibits its caspase-dependent cleavage.

Preliminary crystal structure determination of the alkaline protease from the Antarctic psychrophile pseudomonas aeruginosa ⬇️

Preliminary structural studies of Escherichia coli isopentenyl diphosphate isomerase

Probing the conformation of FhaC with small-angle neutron scattering and molecular modeling.

Purification of SUMO-1 modified IκBα and complex formation with NF-κB

Secretion signal of the filamentous haemagglutinin, a model two-partner secretion substrate

Serine 948 and threonine 1042 are crucial residues for allosteric regulation of Escherichia coli carbamoylphosphate synthetase and illustrate coupling effects of activation and inhibition pathways

Solution Structure of the N-Terminal Domain of Mediator Subunit MED26 and Molecular Characterization of Its Interaction with EAF1 and TAF7.

Solution structure of the N-terminal transactivation domain of ERM modified by SUMO-1

Structural activation of the transcriptional repressor EthR from Mycobacterium tuberculosis by single amino acid change mimicking natural and synthetic ligands

Structural analysis of Bordetella pertussis BugE solute receptor in a bound conformation

Structural analysis of Escherichia coli OpgG, a protein required for the biosynthesis of osmoregulated periplasmic glucans.

Structural and phylogenetic relationships among plant and animal cystatins

Structural aspects of the allosteric inhibition of fructose-1,6-bisphosphatase by AMP: the binding of both the substrate analogue 2,5-anhydro-D-glucitol 1,6-bisphosphate and catalytic metal ions monitored by X-ray crystallography

Structural basis for haem piracy from host haemopexin by Haemophilus influenzae.

Structural insights into ChpT, an essential dimeric histidine phosphotransferase regulating the cell cycle inCaulobacter crescentus

Structure and plasticity of the peptidyl-prolyl isomerase Par27 of Bordetella pertussis revealed by X-ray diffraction and small-angle X-ray scattering.

Structure of EthR in a ligand bound conformation reveals therapeutic perspectives against tuberculosis

Structure of the membrane protein FhaC: a member of the Omp85-TpsB transporter superfamily.

Structure of the secretion domain of HxuA fromHaemophilus influenzae

Structure-based mechanism of ligand binding for periplasmic solute-binding protein of the Bug family

Substrate recognition by the POTRA domains of TpsB transporter FhaC.

Synthetic EthR inhibitors boost antituberculous activity of ethionamide

The DivJ, CbrA and PleC system controls DivK phosphorylation and symbiosis in Sinorhizobium meliloti

The Mediator complex subunit MED25 is targeted by the N-terminal transactivation domain of the PEA3 group members

The crystal structure of Pyrococcus furiosus ornithine carbamoyltransferase reveals a key role for oligomerization in enzyme stability at extremely high temperatures

The crystal structure of filamentous hemagglutinin secretion domain and its implications for the two-partner secretion pathway

The influence of anionic lipids on SHIP2 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase activity

The level of Ets-1 protein is regulated by poly(ADP-ribose) polymerase-1 (PARP-1) in cancer cells to prevent DNA damage.

The structural organization of the N-terminus domain of SopB, a virulence factor of Salmonella, depends on the nature of its protein partners.

Virulence regulation with Venus flytrap domains: structure and function of the periplasmic moiety of the sensor-kinase BvgS

X-ray structure of papaya chitinase reveals the substrate binding mode of glycosyl hydrolase family 19 chitinases