List of works - Keisuke Horikawa

A Double-Edged Kinase Lyn: A Positive and Negative Regulator for Antigen Receptor–mediated Signals ⬇️

scientific article published on April 20, 1998

B cell survival, surface BCR and BAFFR expression, CD74 metabolism, and CD8- dendritic cells require the intramembrane endopeptidase SPPL2A.

scientific article published on 24 December 2012

CARD11 is dispensable for homeostatic responses and suppressive activity of peripherally induced FOXP3 + regulatory T cells

scientific article published on 26 June 2019

CD83 increases MHC II and CD86 on dendritic cells by opposing IL-10-driven MARCH1-mediated ubiquitination and degradation. ⬇️

scientific article

Consequences of the recurrent MYD88(L265P) somatic mutation for B cell tolerance

scientific article published on 17 February 2014

Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity

scientific article published on 18 September 2019

Distinctive roles of Fyn and Lyn in IgD- and IgM-mediated signaling

scientific article published on 01 September 1999

Erratum: Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation

scientific article published in Nature

Human lymphoma mutations reveal CARD11 as the switch between self-antigen-induced B cell death or proliferation and autoantibody production.

scientific article

IgD attenuates the IgM-induced anergy response in transitional and mature B cells.

scientific article

Inhibiting TLR9 and other UNC93B1-dependent TLRs paradoxically increases accumulation of MYD88L265P plasmablasts in vivo

scientific article published on 25 July 2016

Ndfip1 mediates peripheral tolerance to self and exogenous antigen by inducing cell cycle exit in responding CD4+ T cells

scientific article published on 13 January 2014

Omenn syndrome associated with a functional reversion due to a somatic second-site mutation in CARD11 deficiency

scientific article

Oncogenic MYD88 mutation drives Toll pathway to lymphoma

scientific article published on 26 April 2011

Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation

scientific article published on 9 December 2015

Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity.

scientific article

Reduction of atherosclerosis despite hypercholesterolemia in lyn-deficient mice fed a high-fat diet

scientific article published on 01 January 2001

Synergistic cooperation and crosstalk between MYD88L265P and mutations that dysregulate CD79B and surface IgM.

scientific article published on 12 July 2017

Systems-guided forward genetic screen reveals a critical role of the replication stress response protein ETAA1 in T cell clonal expansion.

scientific article

Toll-Like Receptors and Cancer: MYD88 Mutation and Inflammation.

scientific article

List of works by Keisuke Horikawa

A Double-Edged Kinase Lyn: A Positive and Negative Regulator for Antigen Receptor–mediated Signals ⬇️

B cell survival, surface BCR and BAFFR expression, CD74 metabolism, and CD8- dendritic cells require the intramembrane endopeptidase SPPL2A.

CARD11 is dispensable for homeostatic responses and suppressive activity of peripherally induced FOXP3 + regulatory T cells

CD83 increases MHC II and CD86 on dendritic cells by opposing IL-10-driven MARCH1-mediated ubiquitination and degradation. ⬇️

Consequences of the recurrent MYD88(L265P) somatic mutation for B cell tolerance

Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity

Distinctive roles of Fyn and Lyn in IgD- and IgM-mediated signaling

Erratum: Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation

Human lymphoma mutations reveal CARD11 as the switch between self-antigen-induced B cell death or proliferation and autoantibody production.

IgD attenuates the IgM-induced anergy response in transitional and mature B cells.

Inhibiting TLR9 and other UNC93B1-dependent TLRs paradoxically increases accumulation of MYD88L265P plasmablasts in vivo

Ndfip1 mediates peripheral tolerance to self and exogenous antigen by inducing cell cycle exit in responding CD4+ T cells

Omenn syndrome associated with a functional reversion due to a somatic second-site mutation in CARD11 deficiency

Oncogenic MYD88 mutation drives Toll pathway to lymphoma

Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation

Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity.

Reduction of atherosclerosis despite hypercholesterolemia in lyn-deficient mice fed a high-fat diet

Synergistic cooperation and crosstalk between MYD88L265P and mutations that dysregulate CD79B and surface IgM.

Systems-guided forward genetic screen reveals a critical role of the replication stress response protein ETAA1 in T cell clonal expansion.

Toll-Like Receptors and Cancer: MYD88 Mutation and Inflammation.