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List of works by Vicente Alfaro

A Phase II multicenter, open-label, clinical and pharmokinetic trial of PM00104 in patients with advanced Ewing Family of Tumors

scientific article published on November 2013

A comprehensive safety analysis confirms rhabdomyolysis as an uncommon adverse reaction in patients treated with trabectedin.

scientific article

A physical-chemical analysis of the acid-base response to chronic obstructive pulmonary disease

scientific article published on 01 November 1996

A retrospective analysis of antitumour activity with trabectedin in translocation-related sarcomas

scientific article

Abbreviated clinical study reports with investigational medicinal products for human use: current guidelines and recommendations.

scientific article

Acid-base analysis during experimental anemia in rats

scientific article published on 01 October 2000

Acid-base disturbance during hemorrhage in rats: significant role of strong inorganic ions.

scientific article published in May 1999

Acute mild hypothermia in awake unrestrained rats induces a mixed acid-base disorder

scientific article published on 01 June 1996

Age-stratified analysis of I-PSS and QoL values in spanish patients with symptoms potentially related to BPH.

scientific article published in August 2000

Blood acid-base changes during acute experimental inflammation in rats

scientific article published on 01 March 1996

Blood sampled in rats from right ventricle may not always be truly representative of a mixed venous sample

scientific article published on 01 July 1996

CO2 in static mesenteric venous blood during intestinal ischemia and ischemic preconditioning in rats ⬇️

scientific article published on November 1, 2001

Complete and Sustained Objective Response per RECIST to Irvalec (PM02734) in Undifferentiated Large Cell Esophageal Adenocarcinoma: A Case Report and a Review of the Literature ⬇️

scientific article published on July 5, 2012

Components of the blood acid-base disturbance that accompanies urethane anaesthesia in rats during normothermia and hypothermia ⬇️

scientific article published on July 1, 1997

Differential effects of hypothermia upon blood acid-base state and blood gases in sodium pentobarbital and urethane anaesthetised rats

scientific article published on July 1, 1992

Effect of lurbinectedin on the QTc interval in patients with advanced solid tumors: an exposure-response analysis

scientific article published on 27 October 2020

Erythrocyte osmotic resistance during acute hypothermia in awake unrestrained rats

scientific article published on 01 September 1993

Evaluation of plitidepsin in patients with primary myelofibrosis and post polycythemia vera/essential thrombocythemia myelofibrosis: results of preclinical studies and a phase II clinical trial

scientific article

Exogenous adenosine enhances caspase-3 activity in warm renal ischaemia.

scientific article

Extracellular pH affects inflammatory cell production of superoxide and nitric oxide.

scientific article published in June 2002

Factors influencing acid-base status during acute severe hypothermia in unanesthetized rats.

scientific article published on May 1995

Factors influencing the acid-base changes in the air-pouch exudate following carrageenan induced inflammation in rats

scientific article published on 01 August 1996

First-in-human, phase I study of elisidepsin (PM02734) administered as a 30-min or as a 3-hour intravenous infusion every three weeks in patients with advanced solid tumors

scientific article published on 08 May 2015

First-in-man phase I trial of two schedules of the novel synthetic tetrahydroisoquinoline alkaloid PM00104 (Zalypsis) in patients with advanced solid tumours

scientific article

Gefitinib: current status in the treatment of non-small cell lung cancer.

scientific article

Glutamate-related excitotoxicity neuroprotection with memantine, an uncompetitive antagonist of NMDA-glutamate receptor, in Alzheimer's disease and vascular dementia

scientific article published in May 2006

Good Publication Practice guidelines for clinical trials?

scientific article published on 01 July 2003

Higher antitumor activity of trabectedin in germline BRCA2 carriers with advanced breast cancer as compared to BRCA1 carriers: A subset analysis of a dedicated phase II trial

scientific article published on 30 April 2017

Improvement in exercise tolerance and spirometric values in stable chronic obstructive pulmonary disease patients after an individualized outpatient rehabilitation programme

scientific article published on 01 September 1996

Intestinal ischemic preconditioning: less xanthine accumulation relates with less apoptosis.

scientific article published in May 2004

Lipocalin-2-induced renal regeneration depends on cytokines

scientific article published on 24 September 2008

Long-term domiciliary treatment with nasal intermittent positive-pressure ventilation plus supplemental oxygen in COPD with severe hypercapnia

scientific article published on 01 January 1997

Mapping the literature: role of trabectedin as a new chemotherapy option in advanced pretreated soft tissue sarcoma

scientific article published on June 2009

Modification of glyceraldehyde-3-phosphate dehydrogenase in response to nitric oxide in intestinal preconditioning

scientific article published on 01 June 1999

Multicenter Phase II Study of Lurbinectedin in BRCA-Mutated and Unselected Metastatic Advanced Breast Cancer and Biomarker Assessment Substudy

scientific article published on 21 September 2018

Multiple inert gas elimination technique for determining ventilation/perfusion distributions in rat during normoxia, hypoxia and hyperoxia

scientific article published in May 2001

NO and NOS isoforms in the development of apoptosis in renal ischemia/reperfusion

article

Nucleotides modulate renal ischaemia-reperfusion injury by different effects on nitric oxide and superoxide.

scientific article published in April 2003

Phase I and pharmacokinetic study of trabectedin 3-hour infusion every three weeks in patients with advanced cancer and alteration of hepatic function

scientific article published on 10 June 2011

Phase I and pharmacokinetic study of trabectedin as a 1- or 3-hour infusion weekly in patients with advanced solid malignancies.

scientific article published on 5 May 2009

Phase I clinical and pharmacokinetic study of trabectedin and cisplatin given every three weeks in patients with advanced solid tumors

scientific article published on 07 March 2013

Phase I dose-escalation study of plitidepsin in combination with sorafenib or gemcitabine in patients with refractory solid tumors or lymphomas

scientific article

Phase I study of PM00104 (Zalypsis®) administered as a 1-hour weekly infusion resting every fourth week in patients with advanced solid tumors

scientific article

Phase I study of carboplatin in combination with PM00104 (Zalypsis®) in patients with advanced solid tumors

scientific article

Phase II Study of Trabectedin in Pretreated Patients with Advanced Colorectal Cancer

scientific article published on 01 May 2007

Phase II clinical trial of PM00104 (Zalypsis(®)) in urothelial carcinoma patients progressing after first-line platinum-based regimen

scientific article published on 26 February 2014

Phase II clinical trial of neoadjuvant trabectedin in patients with advanced localized myxoid liposarcoma

scientific article published on 03 June 2011

Plitidepsin has a safe cardiac profile: a comprehensive analysis.

scientific article

Randomised phase III trial of trabectedin versus doxorubicin-based chemotherapy as first-line therapy in translocation-related sarcomas

scientific article published on 07 February 2014

Role of changes in tissular nucleotides on the development of apoptosis during ischemia/reperfusion in rat small bowel.

scientific article published on November 2002

Role of histamine and platelet-activating factor in allergic rhinitis.

scientific article published in June 2004

SID: a well-defined abbreviation?

scientific article published on 01 December 1999

Specification of laboratory animal use in scientific articles: current low detail in the journals' instructions for authors and some proposals.

scientific article

Spisulosine (ES-285) given as a weekly three-hour intravenous infusion: results of a phase I dose-escalating study in patients with advanced solid malignancies

scientific article published on 05 April 2011

Trabectedin has a low cardiac risk profile: a comprehensive cardiac safety analysis ⬇️

scientific article published on March 18, 2011

Trabectedin in patients with advanced non-small-cell lung cancer (NSCLC) with XPG and/or ERCC1 overexpression and BRCA1 underexpression and pretreated with platinum

scientific article published on 23 December 2011

Trabectedin plus pegylated liposomal doxorubicin in relapsed ovarian cancer: outcomes in the partially platinum-sensitive (platinum-free interval 6-12 months) subpopulation of OVA-301 phase III randomized trial

scientific article

Trabectedin plus pegylated liposomal doxorubicin in the treatment of patients with partially platinum-sensitive ovarian cancer: current evidence and future perspectives

scientific article published on 06 July 2011

Trabectedin plus pegylated liposomal doxorubicin: retrospective analysis in heavily pretreated platinum-sensitive ovarian cancer ⬇️

scientific article published on 18 June 2015

[Clinical trial registration: new ICMJE requirement]

scientific article published on 01 April 2005

[Clinical trials, good publication practice and legal regulations]

scientific article published on 01 June 2004

[Encore abstracts in medical/scientific meetings]

scientific article published on 03 September 2014

[New proposals for improving the publication of clinical trials]

scientific article published on 01 November 2004

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