List of works - Mohammed Milhem

A Phase I/II Study Targeting Angiogenesis Using Bevacizumab Combined with Chemotherapy and a Histone Deacetylase Inhibitor (Valproic Acid) in Advanced Sarcomas

scientific article published on 17 February 2018

A phase II study of tivozanib in patients with metastatic and nonresectable soft-tissue sarcomas

scientific article published on 22 October 2016

A phase IIb multicentre study comparing the efficacy of trabectedin to doxorubicin in patients with advanced or metastatic untreated soft tissue sarcoma: the TRUSTS trial.

scientific article

A positive antinuclear antibody test predicts for a poor response to initial steroid therapy in adults with idiopathic thrombocytopenic purpura

scientific article

Advanced stage melanoma therapies: Detailing the present and exploring the future

scientific article published on 15 November 2018

Clinical Challenges with Talimogene Laherparepvec: Cured Lymph Nodes Masquerading as Active Melanoma

scientific article published on 07 March 2019

Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients

article

Comprehensive Characterization of Cancer Driver Genes and Mutations

article

Cord blood stem cell expansion is permissive to epigenetic regulation and environmental cues.

scientific article published on 6 June 2009

Correction to: Genomics of NSCLC patients both affirm PD-L1 expression and predict their clinical responses to anti-PD-1 immunotherapy.

scientific article published on 12 April 2018

Cutaneous head and neck melanoma in OPTiM, a randomized phase 3 trial of talimogene laherparepvec versus granulocyte-macrophage colony-stimulating factor for the treatment of unresected stage IIIB/IIIC/IV melanoma.

scientific article published on 13 July 2016

Cutaneous metastases of malignant peripheral nerve sheath tumor: Ineffectiveness of intralesional methotrexate

scientific article published on 15 August 2018

Diagnosis of poorly differentiated thyroid cancer with radioiodine scanning after thyrotropin alfa stimulation

scientific article

Discrepancy between treatment goals documentation by oncologists and their understanding among cancer patients under active treatment with chemotherapy

scientific article published on 03 December 2018

Durable Clinical Benefit in Patients with Advanced Cutaneous Melanoma after Discontinuation of Anti-PD-1 Therapies Due to Immune-Related Adverse Events

scientific article published on 25 July 2019

Effect of selumetinib vs chemotherapy on progression-free survival in uveal melanoma: a randomized clinical trial

scientific article published on 18 June 2014

Efficacy and Safety of Trabectedin or Dacarbazine for Metastatic Liposarcoma or Leiomyosarcoma After Failure of Conventional Chemotherapy: Results of a Phase III Randomized Multicenter Clinical Trial.

scientific article published on 14 September 2015

Efficacy and safety of trabectedin or dacarbazine in patients with advanced uterine leiomyosarcoma after failure of anthracycline-based chemotherapy: Subgroup analysis of a phase 3, randomized clinical trial

scientific article

Efficacy and tolerability of trabectedin in elderly patients with sarcoma: subgroup analysis from a phase III, randomized controlled study of trabectedin or dacarbazine in patients with advanced liposarcoma or leiomyosarcoma

scientific article published on 01 September 2018

Efficacy of nelfinavir as monotherapy in refractory adenoid cystic carcinoma: Results of a phase II clinical trial

scientific article

Epigenetic silencing of the human NOS2 gene: rethinking the role of nitric oxide in human macrophage inflammatory responses

scientific article published on 29 January 2014

Functional and symptom impact of trametinib versus chemotherapy in BRAF V600E advanced or metastatic melanoma: quality-of-life analyses of the METRIC study

scientific article published on 6 February 2014

Gastrointestinal stromal tumors-are we stuck and the way forward

scientific article published on 20 November 2017

Genomics of NSCLC patients both affirm PD-L1 expression and predict their clinical responses to anti-PD-1 immunotherapy

scientific article published on 27 February 2018

Imatinib Dosing in Gastrointestinal Stromal Tumors (GISTs): When, How Much, and How Long?

scientific article published on January 2015

Impact of Sequencing Targeted Therapies With High-dose Interleukin-2 Immunotherapy: An Analysis of Outcome and Survival of Patients With Metastatic Renal Cell Carcinoma From an On-going Observational IL-2 Clinical Trial: PROCLAIMSM.

scientific article

Improved survival for extremity soft tissue sarcoma treated in high-volume facilities

scientific article published on 06 April 2018

Improved survival with MEK inhibition in BRAF-mutated melanoma

scientific article (publication date: 12 July 2012)

Insights into the Proteome of Gastrointestinal Stromal Tumors-Derived Exosomes Reveals New Potential Diagnostic Biomarkers.

scientific article

Intralesional Methotrexate for Treatment of Invasive Squamous Cell Carcinomas in a Patient Taking Vemurafenib for Treatment of Metastatic Melanoma

scientific article published on 21 April 2014

Ipilimumab: from preclinical development to future clinical perspectives in melanoma

scientific article

Jordan palliative care initiative: a WHO Demonstration Project.

scientific article published on May 2007

Keratoacanthoma-appearing melanoma metastases in a patient receiving pembrolizumab therapy.

scientific article published on May 2016

Leiomyosarcoma of the head and neck: a population-based analysis.

scientific article

Melanoma cells undergo aggressive coalescence in a 3D Matrigel model that is repressed by anti-CD44.

scientific article

Nelfinavir treatment of adenoid cystic carcinoma: A case report

scientific article published on 26 October 2011

Nivolumab with or without ipilimumab treatment for metastatic sarcoma (Alliance A091401): two open-label, non-comparative, randomised, phase 2 trials

scientific article published on 19 January 2018

Paclitaxel as neoadjuvant therapy for high grade angiosarcoma of the spleen: a brief report and literature review.

scientific article

Patterns of Clinical Response with Talimogene Laherparepvec (T-VEC) in Patients with Melanoma Treated in the OPTiM Phase III Clinical Trial

scientific article published on 24 June 2016

Pembrolizumab Therapy Triggering an Exacerbation of Preexisting Autoimmune Disease: A Report of 2 Patient Cases

scientific article published on 25 October 2016

Pityriasis lichenoides chronica-like drug eruption developing during pembrolizumab treatment for metastatic melanoma

scientific article published on July 2016

Plasma angiopoietin 2 concentrations are related to impaired lung function and organ failure in a clinical cohort receiving high-dose interleukin 2 therapy

scientific article published on August 2014

Quality-of-life outcomes in patients with advanced melanoma: A review of the literature

scientific article published on 26 September 2017

Quantitative computed tomography determined regional lung mechanics in normal nonsmokers, normal smokers and metastatic sarcoma subjects

scientific article published on 27 July 2017

Randomized, Open-Label Phase II Study Evaluating the Efficacy and Safety of Talimogene Laherparepvec in Combination With Ipilimumab Versus Ipilimumab Alone in Patients With Advanced, Unresectable Melanoma.

scientific article published on 5 October 2017

Redox active metals and H2O2 mediate the increased efficacy of pharmacological ascorbate in combination with gemcitabine or radiation in pre-clinical sarcoma models.

scientific article

Relationship between physician-adjudicated adverse events and patient-reported health-related quality of life in a phase II clinical trial (NCT01143402) of patients with metastatic uveal melanoma

scientific article published on 05 December 2016

Results of a Randomized, Double-Blinded, Placebo-Controlled, Phase 2.5 Study of Saracatinib (AZD0530), in Patients with Recurrent Osteosarcoma Localized to the Lung

scientific article published on 30 April 2020

Results of a prospective phase 2 study of pazopanib in patients with advanced intermediate-grade or high-grade liposarcoma.

scientific article

Results of an international randomized phase III trial of the mammalian target of rapamycin inhibitor ridaforolimus versus placebo to control metastatic sarcomas in patients after benefit from prior chemotherapy

scientific article

SARC006: Phase II Trial of Chemotherapy in Sporadic and Neurofibromatosis Type 1 Associated Chemotherapy-Naive Malignant Peripheral Nerve Sheath Tumors.

scientific article published on 12 September 2017

Sentinel Node Biopsy for Head and Neck Desmoplastic Melanoma

article

TAZ and YAP are frequently activated oncoproteins in sarcomas.

scientific article published on 25 April 2016

Talimogene Laherparepvec Improves Durable Response Rate in Patients With Advanced Melanoma

scientific article

Talimogene Laherparepvec in Combination With Ipilimumab in Previously Untreated, Unresectable Stage IIIB-IV Melanoma

scientific article published on 13 June 2016

Targeting Sporadic and Neurofibromatosis Type 1 (NF1) Related Refractory Malignant Peripheral Nerve Sheath Tumors (MPNST) in a Phase II Study of Everolimus in Combination with Bevacizumab (SARC016)

scientific article published on 24 July 2019

Targeting epigenetics for treatment of BRAF mutated metastatic melanoma with decitabine in combination with vemurafenib: A phase lb study.

scientific article

The feasibility of using intravenous fentanyl as sublingual drops in the treatment of incidental pain in patients with cancer.

scientific article

Toxicities with targeted therapies after immunotherapy in metastatic melanoma

scientific article published on 01 December 2018

Treatment of resistant metastatic melanoma using sequential epigenetic therapy (decitabine and panobinostat) combined with chemotherapy (temozolomide).

scientific article

Worsening solid facial edema: An unusual case of angiosarcoma

scientific article published on 14 September 2018

List of works by Mohammed Milhem

A Phase I/II Study Targeting Angiogenesis Using Bevacizumab Combined with Chemotherapy and a Histone Deacetylase Inhibitor (Valproic Acid) in Advanced Sarcomas

A phase II study of tivozanib in patients with metastatic and nonresectable soft-tissue sarcomas

A phase IIb multicentre study comparing the efficacy of trabectedin to doxorubicin in patients with advanced or metastatic untreated soft tissue sarcoma: the TRUSTS trial.

A positive antinuclear antibody test predicts for a poor response to initial steroid therapy in adults with idiopathic thrombocytopenic purpura

Advanced stage melanoma therapies: Detailing the present and exploring the future

Clinical Challenges with Talimogene Laherparepvec: Cured Lymph Nodes Masquerading as Active Melanoma

Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients

Comprehensive Characterization of Cancer Driver Genes and Mutations

Cord blood stem cell expansion is permissive to epigenetic regulation and environmental cues.

Correction to: Genomics of NSCLC patients both affirm PD-L1 expression and predict their clinical responses to anti-PD-1 immunotherapy.

Cutaneous head and neck melanoma in OPTiM, a randomized phase 3 trial of talimogene laherparepvec versus granulocyte-macrophage colony-stimulating factor for the treatment of unresected stage IIIB/IIIC/IV melanoma.

Cutaneous metastases of malignant peripheral nerve sheath tumor: Ineffectiveness of intralesional methotrexate

Diagnosis of poorly differentiated thyroid cancer with radioiodine scanning after thyrotropin alfa stimulation

Discrepancy between treatment goals documentation by oncologists and their understanding among cancer patients under active treatment with chemotherapy

Durable Clinical Benefit in Patients with Advanced Cutaneous Melanoma after Discontinuation of Anti-PD-1 Therapies Due to Immune-Related Adverse Events

Effect of selumetinib vs chemotherapy on progression-free survival in uveal melanoma: a randomized clinical trial

Efficacy and Safety of Trabectedin or Dacarbazine for Metastatic Liposarcoma or Leiomyosarcoma After Failure of Conventional Chemotherapy: Results of a Phase III Randomized Multicenter Clinical Trial.

Efficacy and safety of trabectedin or dacarbazine in patients with advanced uterine leiomyosarcoma after failure of anthracycline-based chemotherapy: Subgroup analysis of a phase 3, randomized clinical trial

Efficacy and tolerability of trabectedin in elderly patients with sarcoma: subgroup analysis from a phase III, randomized controlled study of trabectedin or dacarbazine in patients with advanced liposarcoma or leiomyosarcoma

Efficacy of nelfinavir as monotherapy in refractory adenoid cystic carcinoma: Results of a phase II clinical trial

Epigenetic silencing of the human NOS2 gene: rethinking the role of nitric oxide in human macrophage inflammatory responses

Functional and symptom impact of trametinib versus chemotherapy in BRAF V600E advanced or metastatic melanoma: quality-of-life analyses of the METRIC study

Gastrointestinal stromal tumors-are we stuck and the way forward

Genomics of NSCLC patients both affirm PD-L1 expression and predict their clinical responses to anti-PD-1 immunotherapy

Imatinib Dosing in Gastrointestinal Stromal Tumors (GISTs): When, How Much, and How Long?

Impact of Sequencing Targeted Therapies With High-dose Interleukin-2 Immunotherapy: An Analysis of Outcome and Survival of Patients With Metastatic Renal Cell Carcinoma From an On-going Observational IL-2 Clinical Trial: PROCLAIMSM.

Improved survival for extremity soft tissue sarcoma treated in high-volume facilities

Improved survival with MEK inhibition in BRAF-mutated melanoma

Insights into the Proteome of Gastrointestinal Stromal Tumors-Derived Exosomes Reveals New Potential Diagnostic Biomarkers.

Intralesional Methotrexate for Treatment of Invasive Squamous Cell Carcinomas in a Patient Taking Vemurafenib for Treatment of Metastatic Melanoma

Ipilimumab: from preclinical development to future clinical perspectives in melanoma

Jordan palliative care initiative: a WHO Demonstration Project.

Keratoacanthoma-appearing melanoma metastases in a patient receiving pembrolizumab therapy.

Leiomyosarcoma of the head and neck: a population-based analysis.

Melanoma cells undergo aggressive coalescence in a 3D Matrigel model that is repressed by anti-CD44.

Nelfinavir treatment of adenoid cystic carcinoma: A case report

Nivolumab with or without ipilimumab treatment for metastatic sarcoma (Alliance A091401): two open-label, non-comparative, randomised, phase 2 trials

Paclitaxel as neoadjuvant therapy for high grade angiosarcoma of the spleen: a brief report and literature review.

Patterns of Clinical Response with Talimogene Laherparepvec (T-VEC) in Patients with Melanoma Treated in the OPTiM Phase III Clinical Trial

Pembrolizumab Therapy Triggering an Exacerbation of Preexisting Autoimmune Disease: A Report of 2 Patient Cases

Pityriasis lichenoides chronica-like drug eruption developing during pembrolizumab treatment for metastatic melanoma

Plasma angiopoietin 2 concentrations are related to impaired lung function and organ failure in a clinical cohort receiving high-dose interleukin 2 therapy

Quality-of-life outcomes in patients with advanced melanoma: A review of the literature

Quantitative computed tomography determined regional lung mechanics in normal nonsmokers, normal smokers and metastatic sarcoma subjects

Randomized, Open-Label Phase II Study Evaluating the Efficacy and Safety of Talimogene Laherparepvec in Combination With Ipilimumab Versus Ipilimumab Alone in Patients With Advanced, Unresectable Melanoma.

Redox active metals and H2O2 mediate the increased efficacy of pharmacological ascorbate in combination with gemcitabine or radiation in pre-clinical sarcoma models.

Relationship between physician-adjudicated adverse events and patient-reported health-related quality of life in a phase II clinical trial (NCT01143402) of patients with metastatic uveal melanoma

Results of a Randomized, Double-Blinded, Placebo-Controlled, Phase 2.5 Study of Saracatinib (AZD0530), in Patients with Recurrent Osteosarcoma Localized to the Lung

Results of a prospective phase 2 study of pazopanib in patients with advanced intermediate-grade or high-grade liposarcoma.

Results of an international randomized phase III trial of the mammalian target of rapamycin inhibitor ridaforolimus versus placebo to control metastatic sarcomas in patients after benefit from prior chemotherapy

SARC006: Phase II Trial of Chemotherapy in Sporadic and Neurofibromatosis Type 1 Associated Chemotherapy-Naive Malignant Peripheral Nerve Sheath Tumors.

Sentinel Node Biopsy for Head and Neck Desmoplastic Melanoma

TAZ and YAP are frequently activated oncoproteins in sarcomas.

Talimogene Laherparepvec Improves Durable Response Rate in Patients With Advanced Melanoma

Talimogene Laherparepvec in Combination With Ipilimumab in Previously Untreated, Unresectable Stage IIIB-IV Melanoma

Targeting Sporadic and Neurofibromatosis Type 1 (NF1) Related Refractory Malignant Peripheral Nerve Sheath Tumors (MPNST) in a Phase II Study of Everolimus in Combination with Bevacizumab (SARC016)

Targeting epigenetics for treatment of BRAF mutated metastatic melanoma with decitabine in combination with vemurafenib: A phase lb study.

The feasibility of using intravenous fentanyl as sublingual drops in the treatment of incidental pain in patients with cancer.

Toxicities with targeted therapies after immunotherapy in metastatic melanoma

Treatment of resistant metastatic melanoma using sequential epigenetic therapy (decitabine and panobinostat) combined with chemotherapy (temozolomide).

Worsening solid facial edema: An unusual case of angiosarcoma