List of works - Stephan Lange

A novel mechanism involving four-and-a-half LIM domain protein-1 and extracellular signal-regulated kinase-2 regulates titin phosphorylation and mechanics.

scientific article

An FHL1-containing complex within the cardiomyocyte sarcomere mediates hypertrophic biomechanical stress responses in mice

scientific article published on 3 November 2008

Breaking down protein degradation mechanisms in cardiac muscle ⬇️

scientific article published on February 27, 2013

Cathepsins in heart disease-chewing on the heartache?

scientific article published on 6 March 2015

Comparative analysis of obesity-related cardiometabolic and renal biomarkers in human plasma and serum

scientific article published on 28 October 2019

Cullin E3 Ligase Activity Is Required for Myoblast Differentiation.

scientific article published on 23 February 2017

Cullin-3 dependent deregulation of ACTN1 represents a new pathogenic mechanism in nemaline myopathy.

scientific article published on 16 April 2019

Cyclic stretch of embryonic cardiomyocytes increases proliferation, growth, and expression while repressing Tgf-β signaling

scientific article

Cypher and Enigma homolog protein are essential for cardiac development and embryonic survival

scientific article

Cypher/ZASP is a novel A-kinase anchoring protein.

scientific article

Dimerisation of myomesin: implications for the structure of the sarcomeric M-band

scientific article

Evidence for a dimeric assembly of two titin/telethonin complexes induced by the telethonin C-terminus

scientific article (publication date: August 2006)

Exercise-induced alterations and loss of sarcomeric M-line organization in the diaphragm muscle of obscurin knockout mice.

scientific article

Exploration of pathomechanisms triggered by a single-nucleotide polymorphism in titin's I-band: the cardiomyopathy-linked mutation T2580I.

scientific article

From A to Z and back? Multicompartment proteins in the sarcomere.

scientific article

Interactions with titin and myomesin target obscurin and obscurin-like 1 to the M-band: implications for hereditary myopathies.

scientific article

Isolation and culture of neonatal mouse cardiomyocytes.

scientific article published on 6 September 2013

Loss-of-function mutations in co-chaperone BAG3 destabilize small HSPs and cause cardiomyopathy.

scientific article published on 24 July 2017

M-band: a safeguard for sarcomere stability?

scientific article published on January 2003

MLP and CARP are linked to chronic PKCα signalling in dilated cardiomyopathy

scientific article published on 29 June 2016

Molecular basis of the C-terminal tail-to-tail assembly of the sarcomeric filament protein myomesin

scientific article

Murine obscurin and Obsl1 have functionally redundant roles in sarcolemmal integrity, sarcoplasmic reticulum organization, and muscle metabolism

scientific article published on 09 May 2019

Mutant Muscle LIM Protein C58G causes cardiomyopathy through protein depletion

scientific article published on 23 July 2018

Myomesin 3, a novel structural component of the M-band in striated muscle

scientific journal article

Obscurin and KCTD6 regulate cullin-dependent small ankyrin-1 (sAnk1.5) protein turnover

scientific article

Obscurin determines the architecture of the longitudinal sarcoplasmic reticulum.

scientific article

Obscurin is required for ankyrinB-dependent dystrophin localization and sarcolemma integrity ⬇️

scientific article published on February 18, 2013

PKC and PKN in heart disease

scientific article published on 08 February 2019

Palindromic assembly of the giant muscle protein titin in the sarcomeric Z-disk

scientific article

Probing muscle ankyrin-repeat protein (MARP) structure and function

scientific article

Reply: Hereditary myopathy with early respiratory failure is caused by mutations in the titin FN3 119 domain

scientific article published on 24 February 2014

Rigid conformation of an immunoglobulin domain tandem repeat in the A-band of the elastic muscle protein titin

scientific article

Subcellular targeting of metabolic enzymes to titin in heart muscle may be mediated by DRAL/FHL-2

scientific article (publication date: 15 December 2002)

The M-band: The underestimated part of the sarcomere

scientific article published on 07 February 2019

The Role of Cullin-RING Ligases in Striated Muscle Development, Function, and Disease

scientific article published on 26 October 2020

The kinase domain of titin controls muscle gene expression and protein turnover

scientific article

The sarcomeric M-band during development and in disease

article

Thymosin beta 4 is dispensable for murine cardiac development and function

scientific article

miR-486 is modulated by stretch and increases ventricular growth

scientific article published on 12 September 2019

List of works by Stephan Lange

A novel mechanism involving four-and-a-half LIM domain protein-1 and extracellular signal-regulated kinase-2 regulates titin phosphorylation and mechanics.

An FHL1-containing complex within the cardiomyocyte sarcomere mediates hypertrophic biomechanical stress responses in mice

Breaking down protein degradation mechanisms in cardiac muscle ⬇️

Cathepsins in heart disease-chewing on the heartache?

Comparative analysis of obesity-related cardiometabolic and renal biomarkers in human plasma and serum

Cullin E3 Ligase Activity Is Required for Myoblast Differentiation.

Cullin-3 dependent deregulation of ACTN1 represents a new pathogenic mechanism in nemaline myopathy.

Cyclic stretch of embryonic cardiomyocytes increases proliferation, growth, and expression while repressing Tgf-β signaling

Cypher and Enigma homolog protein are essential for cardiac development and embryonic survival

Cypher/ZASP is a novel A-kinase anchoring protein.

Dimerisation of myomesin: implications for the structure of the sarcomeric M-band

Evidence for a dimeric assembly of two titin/telethonin complexes induced by the telethonin C-terminus

Exercise-induced alterations and loss of sarcomeric M-line organization in the diaphragm muscle of obscurin knockout mice.

Exploration of pathomechanisms triggered by a single-nucleotide polymorphism in titin's I-band: the cardiomyopathy-linked mutation T2580I.

From A to Z and back? Multicompartment proteins in the sarcomere.

Interactions with titin and myomesin target obscurin and obscurin-like 1 to the M-band: implications for hereditary myopathies.

Isolation and culture of neonatal mouse cardiomyocytes.

Loss-of-function mutations in co-chaperone BAG3 destabilize small HSPs and cause cardiomyopathy.

M-band: a safeguard for sarcomere stability?

MLP and CARP are linked to chronic PKCα signalling in dilated cardiomyopathy

Molecular basis of the C-terminal tail-to-tail assembly of the sarcomeric filament protein myomesin

Murine obscurin and Obsl1 have functionally redundant roles in sarcolemmal integrity, sarcoplasmic reticulum organization, and muscle metabolism

Mutant Muscle LIM Protein C58G causes cardiomyopathy through protein depletion

Myomesin 3, a novel structural component of the M-band in striated muscle

Obscurin and KCTD6 regulate cullin-dependent small ankyrin-1 (sAnk1.5) protein turnover

Obscurin determines the architecture of the longitudinal sarcoplasmic reticulum.

Obscurin is required for ankyrinB-dependent dystrophin localization and sarcolemma integrity ⬇️

PKC and PKN in heart disease

Palindromic assembly of the giant muscle protein titin in the sarcomeric Z-disk

Probing muscle ankyrin-repeat protein (MARP) structure and function

Reply: Hereditary myopathy with early respiratory failure is caused by mutations in the titin FN3 119 domain

Rigid conformation of an immunoglobulin domain tandem repeat in the A-band of the elastic muscle protein titin

Subcellular targeting of metabolic enzymes to titin in heart muscle may be mediated by DRAL/FHL-2

The M-band: The underestimated part of the sarcomere

The Role of Cullin-RING Ligases in Striated Muscle Development, Function, and Disease

The kinase domain of titin controls muscle gene expression and protein turnover

The sarcomeric M-band during development and in disease

Thymosin beta 4 is dispensable for murine cardiac development and function

miR-486 is modulated by stretch and increases ventricular growth