List of works - Xin Chen

Aging Converts Innate B1a Cells into Potent CD8+ T Cell Inducers

scientific article published on 16 March 2016

Autoantigens signal through chemokine receptors: uveitis antigens induce CXCR3- and CXCR5-expressing lymphocytes and immature dendritic cells to migrate

scientific article

Blockade of TNFR2 signaling enhances the immunotherapeutic effect of CpG ODN in a mouse model of colon cancer.

scientific article published on 2 January 2018

Cellular pharmacology studies of shikonin derivatives.

scientific article

Characterization of MT-2 cells as a human regulatory T cell-like cell line

scientific article

Co-expression of TNFR2 and CD25 identifies more of the functional CD4+FOXP3+ regulatory T cells in human peripheral blood.

scientific article

Comment on "Interplay between TNF and regulatory T cells in a TNF-driven murine model of arthritis"

scientific article published on 01 August 2011

Contrasting effects of TNF and anti-TNF on the activation of effector T cells and regulatory T cells in autoimmunity

scientific article

Crosstalk between Tumor Cells and Macrophages in Stroma Renders Tumor Cells as the Primary Source of MCP-1/CCL2 in Lewis Lung Carcinoma

scientific article published on 26 June 2015

Cutting edge: expression of TNFR2 defines a maximally suppressive subset of mouse CD4+CD25+FoxP3+ T regulatory cells: applicability to tumor-infiltrating T regulatory cells.

scientific article published on May 2008

Cytokine storm and leukocyte changes in mild versus severe SARS-CoV-2 infection: Review of 3939 COVID-19 patients in China and emerging pathogenesis and therapy concepts

scientific article published on 13 June 2020

Development of a Curative Therapeutic Vaccine (TheraVac) for the Treatment of Large Established Tumors.

scientific article published on 27 October 2017

Development of regulatory T cells requires IL-7Ralpha stimulation by IL-7 or TSLP.

scientific article published on 29 July 2008

Dietary therapy may be sufficient for type 1 diabetes treatment

scientific article

Effective chemoimmunotherapy with anti-TGFβ antibody and cyclophosphamide in a mouse model of breast cancer

scientific article published on 09 January 2014

Effects of IL-7 and dexamethasone: induction of CD25, the high affinity IL-2 receptor, on human CD4+ cells

scientific article published on 01 November 2004

Effects of Shuanghuanglian and Qingkailing, two multi-components of traditional Chinese medicinal preparations, on human leukocyte function.

scientific article published on May 2002

Enhanced topical penetration, system exposure and anti-psoriasis activity of two particle-sized, curcumin-loaded PLGA nanoparticles in hydrogel.

scientific article published on 23 March 2017

Expression of TNFR2 by regulatory T cells in peripheral blood is correlated with clinical pathology of lung cancer patients

scientific article published on 18 August 2015

Expression of costimulatory TNFR2 induces resistance of CD4+FoxP3- conventional T cells to suppression by CD4+FoxP3+ regulatory T cells.

scientific article

Functional and genomic analyses of FOXP3-transduced Jurkat-T cells as regulatory T (Treg)-like cells

scientific article published on 10 August 2007

Glucocorticoid amplifies IL-2-dependent expansion of functional FoxP3(+)CD4(+)CD25(+) T regulatory cells in vivo and enhances their capacity to suppress EAE

scientific article published on 01 August 2006

IKKα is required for the homeostasis of regulatory T cells and for the expansion of both regulatory and effector CD4 T cells.

scientific article

In vitro generated Th17 cells support the expansion and phenotypic stability of CD4(+)Foxp3(+) regulatory T cells in vivo

scientific article published on 27 September 2013

Inhibition of two-pore channels in antigen-presenting cells promotes the expansion of TNFR2-expressing CD4+Foxp3+ regulatory T cells

scientific article published on 30 September 2020

Interaction of TNF with TNF receptor type 2 promotes expansion and function of mouse CD4+CD25+ T regulatory cells.

scientific article

Novel peptides based on HIV-1 gp120 sequence with homology to chemokines inhibit HIV infection in cell culture

scientific article

Pertussis toxin by inducing IL-6 promotes the generation of IL-17-producing CD4 cells

scientific article published on 01 May 2007

Progranulin promotes tumour necrosis factor-induced proliferation of suppressive mouse CD4⁺ Foxp3⁺ regulatory T cells.

scientific article published in June 2014

Resolving the identity myth: key markers of functional CD4+FoxP3+ regulatory T cells.

scientific article

Shikonin, a component of antiinflammatory Chinese herbal medicine, selectively blocks chemokine binding to CC chemokine receptor-1.

scientific article published on February 2001

Shikonin, a component of chinese herbal medicine, inhibits chemokine receptor function and suppresses human immunodeficiency virus type 1

scientific article

Suppressive activity of human regulatory T cells is maintained in the presence of TNF

scientific article published on 01 January 2016

Synergistic antitumor effects of a TGFβ inhibitor and cyclophosphamide.

scientific article

TNF optimally activatives regulatory T cells by inducing TNF receptor superfamily members TNFR2, 4-1BB and OX40

scientific article published on July 2011

TNF-alpha: an activator of CD4+FoxP3+TNFR2+ regulatory T cells.

scientific article published on 18 February 2010

TNFR2 expression by CD4 effector T cells is required to induce full-fledged experimental colitis

scientific article published on 07 September 2016

TNFR2 is critical for the stabilization of the CD4+Foxp3+ regulatory T. cell phenotype in the inflammatory environment.

scientific article published on 31 December 2012

Targeting TNFR2, an immune checkpoint stimulator and oncoprotein, is a promising treatment for cancer.

scientific article published on 17 January 2017

Th17 cells and Tregs: unlikely allies

scientific article published on 21 February 2014

The Alarmin HMGN1 contributes to antitumor immunity and is a potent immunoadjuvant

scientific article published on 09 September 2014

The phenotypic and functional consequences of tumour necrosis factor receptor type 2 expression on CD4(+) FoxP3(+) regulatory T cells.

scientific article published on 02 June 2011

Therapy: Paradoxical effects of targeting TNF signalling in the treatment of autoimmunity

scientific article published on 02 September 2016

Triptolide, a constituent of immunosuppressive Chinese herbal medicine, is a potent suppressor of dendritic-cell maturation and trafficking

scientific article

Yin zi huang, an injectable multicomponent chinese herbal medicine, is a potent inhibitor of T-cell activation.

scientific article published in June 2004

List of works by Xin Chen

Aging Converts Innate B1a Cells into Potent CD8+ T Cell Inducers

Autoantigens signal through chemokine receptors: uveitis antigens induce CXCR3- and CXCR5-expressing lymphocytes and immature dendritic cells to migrate

Blockade of TNFR2 signaling enhances the immunotherapeutic effect of CpG ODN in a mouse model of colon cancer.

Cellular pharmacology studies of shikonin derivatives.

Characterization of MT-2 cells as a human regulatory T cell-like cell line

Co-expression of TNFR2 and CD25 identifies more of the functional CD4+FOXP3+ regulatory T cells in human peripheral blood.

Comment on "Interplay between TNF and regulatory T cells in a TNF-driven murine model of arthritis"

Contrasting effects of TNF and anti-TNF on the activation of effector T cells and regulatory T cells in autoimmunity

Crosstalk between Tumor Cells and Macrophages in Stroma Renders Tumor Cells as the Primary Source of MCP-1/CCL2 in Lewis Lung Carcinoma

Cutting edge: expression of TNFR2 defines a maximally suppressive subset of mouse CD4+CD25+FoxP3+ T regulatory cells: applicability to tumor-infiltrating T regulatory cells.

Cytokine storm and leukocyte changes in mild versus severe SARS-CoV-2 infection: Review of 3939 COVID-19 patients in China and emerging pathogenesis and therapy concepts

Development of a Curative Therapeutic Vaccine (TheraVac) for the Treatment of Large Established Tumors.

Development of regulatory T cells requires IL-7Ralpha stimulation by IL-7 or TSLP.

Dietary therapy may be sufficient for type 1 diabetes treatment

Effective chemoimmunotherapy with anti-TGFβ antibody and cyclophosphamide in a mouse model of breast cancer

Effects of IL-7 and dexamethasone: induction of CD25, the high affinity IL-2 receptor, on human CD4+ cells

Effects of Shuanghuanglian and Qingkailing, two multi-components of traditional Chinese medicinal preparations, on human leukocyte function.

Enhanced topical penetration, system exposure and anti-psoriasis activity of two particle-sized, curcumin-loaded PLGA nanoparticles in hydrogel.

Expression of TNFR2 by regulatory T cells in peripheral blood is correlated with clinical pathology of lung cancer patients

Expression of costimulatory TNFR2 induces resistance of CD4+FoxP3- conventional T cells to suppression by CD4+FoxP3+ regulatory T cells.

Functional and genomic analyses of FOXP3-transduced Jurkat-T cells as regulatory T (Treg)-like cells

Glucocorticoid amplifies IL-2-dependent expansion of functional FoxP3(+)CD4(+)CD25(+) T regulatory cells in vivo and enhances their capacity to suppress EAE

IKKα is required for the homeostasis of regulatory T cells and for the expansion of both regulatory and effector CD4 T cells.

In vitro generated Th17 cells support the expansion and phenotypic stability of CD4(+)Foxp3(+) regulatory T cells in vivo

Inhibition of two-pore channels in antigen-presenting cells promotes the expansion of TNFR2-expressing CD4+Foxp3+ regulatory T cells

Interaction of TNF with TNF receptor type 2 promotes expansion and function of mouse CD4+CD25+ T regulatory cells.

Novel peptides based on HIV-1 gp120 sequence with homology to chemokines inhibit HIV infection in cell culture

Pertussis toxin by inducing IL-6 promotes the generation of IL-17-producing CD4 cells

Progranulin promotes tumour necrosis factor-induced proliferation of suppressive mouse CD4⁺ Foxp3⁺ regulatory T cells.

Resolving the identity myth: key markers of functional CD4+FoxP3+ regulatory T cells.

Shikonin, a component of antiinflammatory Chinese herbal medicine, selectively blocks chemokine binding to CC chemokine receptor-1.

Shikonin, a component of chinese herbal medicine, inhibits chemokine receptor function and suppresses human immunodeficiency virus type 1

Suppressive activity of human regulatory T cells is maintained in the presence of TNF

Synergistic antitumor effects of a TGFβ inhibitor and cyclophosphamide.

TNF optimally activatives regulatory T cells by inducing TNF receptor superfamily members TNFR2, 4-1BB and OX40

TNF-alpha: an activator of CD4+FoxP3+TNFR2+ regulatory T cells.

TNFR2 expression by CD4 effector T cells is required to induce full-fledged experimental colitis

TNFR2 is critical for the stabilization of the CD4+Foxp3+ regulatory T. cell phenotype in the inflammatory environment.

Targeting TNFR2, an immune checkpoint stimulator and oncoprotein, is a promising treatment for cancer.

Th17 cells and Tregs: unlikely allies

The Alarmin HMGN1 contributes to antitumor immunity and is a potent immunoadjuvant

The phenotypic and functional consequences of tumour necrosis factor receptor type 2 expression on CD4(+) FoxP3(+) regulatory T cells.

Therapy: Paradoxical effects of targeting TNF signalling in the treatment of autoimmunity

Triptolide, a constituent of immunosuppressive Chinese herbal medicine, is a potent suppressor of dendritic-cell maturation and trafficking

Yin zi huang, an injectable multicomponent chinese herbal medicine, is a potent inhibitor of T-cell activation.