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List of works by Fons van de Loo

A crucial role for tumor necrosis factor receptor 1 in synovial lining cells and the reticuloendothelial system in mediating experimental arthritis

scientific article

A novel Saa3-promoter reporter distinguishes inflammatory subtypes in experimental arthritis and human synovial fibroblasts ⬇️

scientific article published on April 7, 2011

A tail-anchored myotonic dystrophy protein kinase isoform induces perinuclear clustering of mitochondria, autophagy, and apoptosis

scientific article

Adenoviral transfer of murine oncostatin M elicits periosteal bone apposition in knee joints of mice, despite synovial inflammation and up-regulated expression of interleukin-6 and receptor activator of nuclear factor-kappa B ligand

scientific article published on May 2002

Commensal microbiota influence systemic autoimmune responses.

scientific article

Commercial cow milk contains physically stable extracellular vesicles expressing immunoregulatory TGF-β.

scientific article

Complementary action of granulocyte macrophage colony-stimulating factor and interleukin-17A induces interleukin-23, receptor activator of nuclear factor-κB ligand, and matrix metalloproteinases and drives bone and cartilage pathology in experimenta

scientific article published on 17 June 2015

Computational design and application of endogenous promoters for transcriptionally targeted gene therapy for rheumatoid arthritis

scientific article

Deficiency of NADPH Oxidase Components p47phox and gp91phox Caused Granulomatous Synovitis and Increased Connective Tissue Destruction in Experimental Arthritis Models ⬇️

scientific article published on October 1, 2003

Destructive role of myeloid differentiation factor 88 and protective role of TRIF in interleukin-17-dependent arthritis in mice

scientific article published on 06 December 2011

Disease-Regulated Gene Therapy with Anti-Inflammatory Interleukin-10 Under the Control of the CXCL10 Promoter for the Treatment of Rheumatoid Arthritis

scientific article published on 29 December 2015

Disease-dependent local IL-10 production ameliorates collagen induced arthritis in mice

scientific article

Disease-regulated local IL-10 gene therapy diminishes synovitis and cartilage proteoglycan depletion in experimental arthritis.

scientific article published on 15 July 2014

Divergent mitochondrial and endoplasmic reticulum association of DMPK splice isoforms depends on unique sequence arrangements in tail anchors.

scientific article

Elevated extracellular matrix production and degradation upon bone morphogenetic protein-2 (BMP-2) stimulation point toward a role for BMP-2 in cartilage repair and remodeling

scientific article published on January 2007

Enhanced suppressor of cytokine signaling 3 in arthritic cartilage dysregulates human chondrocyte function

scientific article published on October 2012

Functional Tissue Analysis Reveals Successful Cryopreservation of Human Osteoarthritic Synovium

scientific article

Gene therapy for rheumatoid arthritis. Lessons from animal models, including studies on interleukin-4, interleukin-10, and interleukin-1 receptor antagonist as potential disease modulators

scientific article

Gene therapy in animal models of rheumatoid arthritis: are we ready for the patients?

scientific article

Gene therapy works in animal models of rheumatoid arthritis...so what!

scientific article published on October 2006

Genetic modification of ER-Hoxb8 osteoclast precursors using CRISPR/Cas9 as a novel way to allow studies on osteoclast biology.

scientific article published on 05 December 2016

Higher efficacy of anti-IL-6/IL-21 combination therapy compared to monotherapy in the induction phase of Th17-driven experimental arthritis

scientific article

How to build an inducible cartilage-specific transgenic mouse

scientific article

IL-32, a proinflammatory cytokine in rheumatoid arthritis ⬇️

scholarly article

IL37 dampens the IL1β-induced catabolic status of human OA chondrocytes

scientific article

Immunocytokines: the long awaited therapeutic magic bullet in rheumatoid arthritis?

scientific article published on 6 November 2009

Inducible chondrocyte-specific overexpression of BMP2 in young mice results in severe aggravation of osteophyte formation in experimental OA without altering cartilage damage

scientific article published on 21 January 2014

Inducible nitric oxide synthase mediates bone loss in ovariectomized mice

scientific article published in March 2003

Inducible nitric oxide synthase-deficient mice exhibit resistance to the acute pancreatitis induced by cerulein

scientific article published in May 2002

Induction of Canonical Wnt Signaling by Synovial Overexpression of Selected Wnts Leads to Protease Activity and Early Osteoarthritis-Like Cartilage Damage

scientific article published on 12 May 2015

Inflammation-dependent secretion and splicing of IL-32{gamma} in rheumatoid arthritis

scientific article

Inflammation-responsive promoters for fine-tuned gene therapy in rheumatoid arthritis

scientific article

Interleukin-18 promotes joint inflammation and induces interleukin-1-driven cartilage destruction

scientific article

Interleukin-21 receptor deficiency increases the initial toll-like receptor 2 response but protects against joint pathology by reducing Th1 and Th17 cells during streptococcal cell wall arthritis

scientific article published on April 2014

Intravenous delivery of HIV-based lentiviral vectors preferentially transduces F4/80+ and Ly-6C+ cells in spleen, important target cells in autoimmune arthritis

scientific article

Local interleukin-1-driven joint pathology is dependent on toll-like receptor 4 activation

scientific article

Local interleukin-12 gene transfer promotes conversion of an acute arthritis to a chronic destructive arthritis.

scientific article published in May 2002

NADPH-oxidase-driven oxygen radical production determines chondrocyte death and partly regulates metalloproteinase-mediated cartilage matrix degradation during interferon-gamma-stimulated immune complex arthritis

scientific article

Oral administration of bovine milk derived extracellular vesicles attenuates arthritis in two mouse models

scientific article published on 5 June 2015

Organ damage in zymosan-induced multiple organ dysfunction syndrome in mice is not mediated by inducible nitric oxide synthase

scientific article

Periodontal pathogens directly promote autoimmune experimental arthritis by inducing a TLR2- and IL-1-driven Th17 response

scientific article published on 28 March 2014

Regulation of prostaglandin generation in carrageenan-induced pleurisy by inducible nitric oxide synthase in knockout mice

scientific article

Role of gene therapy in tissue engineering procedures in rheumatology: the use of animal models

scientific article published on April 2004

Role of induced nitric oxide in the initiation of the inflammatory response after postischemic injury

scientific article published in August 2002

S100A8/A9 increases the mobilization of pro-inflammatory Ly6Chigh monocytes to the synovium during experimental osteoarthritis.

scientific article published on 29 September 2017

S100A8/A9, a potent serum and molecular imaging biomarker for synovial inflammation and joint destruction in seronegative experimental arthritis

scientific article published on 24 October 2016

Selective Increment of Synovial Soluble TYRO3 Correlates with Disease Severity and Joint Inflammation in Patients with Rheumatoid Arthritis

scientific article published on 11 September 2020

Serum Amyloid A3 Gene Expression in Adipocytes is an Indicator of the Interaction with Macrophages

scientific article published on 08 December 2016

Serum samples that have been stored long-term (>10 years) can be used as a suitable data source for developing cardiovascular risk prediction models in large observational rheumatoid arthritis cohorts

scientific article

Soluble IL-18 receptor complex: a new star in the firmament of rheumatoid arthritis diagnosis? ⬇️

scientific article published on April 27, 2011

Suppression of the inflammatory response by disease-inducible interleukin-10 gene therapy in a three-dimensional micromass model of the human synovial membrane

scientific article published on 12 August 2016

Synergy between 15-lipoxygenase and secreted PLA2 promotes inflammation by formation of TLR4 agonists from extracellular vesicles

scientific article published on 24 September 2020

T cell lessons from the rheumatoid arthritis synovium SCID mouse model: CD3-rich synovium lacks response to CTLA-4ig but is successfully treated by interleukin-17 neutralization

article

TGF-β is a potent inducer of Nerve Growth Factor in articular cartilage via the ALK5-Smad2/3 pathway. Potential role in OA related pain?

scientific article published on 18 December 2014

Tetraspanin CD37 protects against the development of B cell lymphoma

scientific article

The in-vivo use of superparamagnetic iron oxide nanoparticles to detect inflammation elicits a cytokine response but does not aggravate experimental arthritis

scientific article published on 8 May 2015

Trapped in a vicious loop: Toll-like receptors sustain the spontaneous cytokine production by rheumatoid synovium ⬇️

scientific article published on March 30, 2011

Treatment of collagenase-induced osteoarthritis with a viral vector encoding TSG-6 results in ectopic bone formation.

scientific article published on 30 May 2018

Tumor Necrosis Factor, but Not Neutrophils, Alters the Metabolic Profile in Acute Experimental Arthritis

scientific article

Tumor marker nucleoporin 88 kDa regulates nucleocytoplasmic transport of NF-kappaB.

scientific article

Tyro3/Axl/Mertk-deficient mice develop bone marrow edema which is an early pathological marker in rheumatoid arthritis

scientific article published in PLoS ONE

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