List of works - Lars Fugger

A clinical conundrum: the detrimental effect of TNF antagonists in multiple sclerosis

scientific article published on September 2013

A functional and structural basis for TCR cross-reactivity in multiple sclerosis

scientific article

A novel neurodegenerative spectrum disorder in patients with MLKL deficiency

scientific article published on 01 May 2020

A plasmid-encoded peptide from Staphylococcus aureus induces anti-myeloperoxidase nephritogenic autoimmunity

scientific article published on 29 July 2019

APOBEC3G-induced hypermutation of human immunodeficiency virus type-1 is typically a discrete "all or nothing" phenomenon

scientific article

Acid-sensing ion channel 1 is involved in both axonal injury and demyelination in multiple sclerosis and its animal model

scientific article published on 13 January 2011

Acid-sensing ion channel-1 contributes to axonal degeneration in autoimmune inflammation of the central nervous system

scientific article published on 11 November 2007

Activation of central orexin/hypocretin neurons by dietary amino acids

scientific article published on 01 November 2011

Adaptive sugar sensors in hypothalamic feeding circuits

scholarly article

Amiloride Clinical Trial In Optic Neuritis (ACTION) protocol: a randomised, double blind, placebo controlled trial

scientific article published on 9 November 2015

An Alternative Conformation of the T-Cell Receptor α Constant Region

scientific article

Antigen Targeting to Human HLA Class II Molecules Increases Efficacy of DNA Vaccination

scientific article published on 26 September 2016

Antigen processing influences HIV-specific cytotoxic T lymphocyte immunodominance

scientific article

Arne Svejgaard and immunogenetics in Denmark

scientific article published in March 1997

Association of MHC and rheumatoid arthritis. HLA-DR4 and rheumatoid arthritis: studies in mice and men

scientific article

Autoimmunity's next top models

scientific article published on 6 January 2012

Autoreactive CD8+ T cells in multiple sclerosis: a new target for therapy?

scientific article

Axonal injury in reverse

scientific article published on 01 April 2011

B cell tolerance and antibody production to the celiac disease autoantigen transglutaminase 2

scientific article published on 01 February 2020

Bayesian analysis of genetic association across tree-structured routine healthcare data in the UK Biobank

scientific article published on 31 July 2017

Bridging the gap from genetic association to functional understanding: the next generation of mouse models of multiple sclerosis

scientific article published on July 2012

Challenges, Progress, and Prospects of Developing Therapies to Treat Autoimmune Diseases

scientific article published on 01 April 2020

Characterization of T-cell receptor transgenic mice recognizing immunodominant HLA-DQ2.5-restricted gluten epitopes

scientific article published on 28 December 2020

Class II HLA interactions modulate genetic risk for multiple sclerosis

scientific article published on 07 September 2015

Conflicting selective forces affect T cell receptor contacts in an immunodominant human immunodeficiency virus epitope

scientific article

Constitutively active Lck kinase in T cells drives antigen receptor signal transduction

scientific article

Control of autoimmunity by "epitope theft".

scientific article

Control of hypothalamic orexin neurons by acid and CO2.

scholarly article

Convergent inputs from electrically and topographically distinct orexin cells to locus coeruleus and ventral tegmental area

scientific article published on 16 April 2012

Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsy

scientific article

Deletion of TASK1 and TASK3 channels disrupts intrinsic excitability but does not abolish glucose or pH responses of orexin/hypocretin neurons

scientific article

Destructive processing by asparagine endopeptidase limits presentation of a dominant T cell epitope in MBP.

scientific article published on 14 January 2002

Direct and indirect control of orexin/hypocretin neurons by glycine receptors

scientific article published on 6 December 2010

Dissection of the multiple sclerosis associated DR2 haplotype

scientific article published on 02 June 2008

Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells

scientific article published on 3 May 2017

Efficient presentation of myelin oligodendrocyte glycoprotein peptides but not protein by astrocytes from HLA-DR2 and HLA-DR4 transgenic mice

scientific article published on 04 January 2006

Efficient purification of unique antibodies using peptide affinity-matrix columns.

scientific article published in January 2004

Elevated genetic risk for multiple sclerosis emerged in steppe pastoralist populations

scientific article published on 10 January 2024

Factors influencing success of clinical genome sequencing across a broad spectrum of disorders

scientific article

From genes to function: the next challenge to understanding multiple sclerosis

scientific article published on June 2009

Functional epistasis on a common MHC haplotype associated with multiple sclerosis

scientific article

Genomewide Association Studies and Common Disease — Realizing Clinical Utility

article

HIV-1 adaptation to antigen processing results in population-level immune evasion and affects subtype diversification

scientific article published on 13 April 2014

HLA variation and disease.

scientific article published on 2 January 2018

Humanized mouse models for organ-specific autoimmune diseases

scientific article published on 27 September 2006

IL-21 and IL-21 receptor expression in lymphocytes and neurons in multiple sclerosis brain

scientific article

Identifying cross-disease components of genetic risk across hospital data in the UK Biobank

scientific article published on 23 December 2019

Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice.

scientific article published in November 1993

Immunomodulation in multiple sclerosis: promises and pitfalls

scientific article published on 16 September 2017

Immunopathology of multiple sclerosis

scientific article published on 07 August 2015

In vivo enhancement of peptide display by MHC class II molecules with small molecule catalysts of peptide exchange.

scientific article published on May 2009

Inflammation-related plasma and CSF biomarkers for multiple sclerosis

scientific article published on 26 May 2020

Inherited deficiency of mannan-binding lectin-associated serine protease 2.

scientific article published in August 2003

Inhibitory Interplay between Orexin Neurons and Eating

scientific article published on 17 August 2016

Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis

scientific article

Joint-specific and systemic autoreactivity in the development of inflammatory arthritis

scientific article

Limited protective effect of the CCR5Delta32/CCR5Delta32 genotype on human immunodeficiency virus infection incidence in a cohort of patients with hemophilia and selection for genotypic X4 virus

scientific article published on 6 January 2003

Longitudinal and cross-sectional studies of HIV-1 RNA and DNA loads in blood and the female genital tract

scientific article published on 01 December 2004

MHC II molecules in inflammatory diseases: interplay of qualities and quantities

scientific article

MHC class II proteins and disease: a structural perspective

scientific article

Mechanisms of neurodegeneration and axonal dysfunction in multiple sclerosis.

scientific article published on 18 March 2014

Metabolism-independent sugar sensing in central orexin neurons.

scientific article published on 30 June 2008

Misfiring in multiple sclerosis: cerebellar channelopathy, a potential novel target?

scientific article published on 01 April 2012

Multiple sclerosis: MHC associations and therapeutic implications

scientific article

Multiple sclerosis: insights into pathophysiology and novel therapeutic avenues

scientific article published on 18 April 2014

Myelin oligodendrocyte glycoprotein-35-55 peptide induces severe chronic experimental autoimmune encephalomyelitis in HLA-DR2-transgenic mice.

scientific article published in May 2004

Natural killer cells and their receptors in multiple sclerosis

scientific article published on 25 June 2012

Neuroinflammation - using big data to inform clinical practice

scientific article

Novel synthetic amino acid copolymers that inhibit autoantigen-specific T cell responses and suppress experimental autoimmune encephalomyelitis

scientific article

Opposing effects of HLA class I molecules in tuning autoreactive CD8+ T cells in multiple sclerosis

article

Orexin neurons as conditional glucosensors: paradoxical regulation of sugar sensing by intracellular fuels.

scientific article published on 17 October 2011

Pathogenic CD8(+) T cells in multiple sclerosis

scientific article published on August 2009

Please mind the gap: axonal transport deficits in multiple sclerosis neurodegeneration.

scientific article published in December 2014

Predominant selection of T cells specific for the glycosylated collagen type II epitope (263-270) in humanized transgenic mice and in rheumatoid arthritis

scientific article

Recombinant TCR ligand induces tolerance to myelin oligodendrocyte glycoprotein 35-55 peptide and reverses clinical and histological signs of chronic experimental autoimmune encephalomyelitis in HLA-DR2 transgenic mice

scientific article published in July 2003

Recovery from COVID-19 in a B-cell-depleted multiple sclerosis patient

scientific article published on 07 August 2020

Redirecting therapeutic T cells against myelin-specific T lymphocytes using a humanized myelin basic protein-HLA-DR2-zeta chimeric receptor

scientific article

Remarkably low affinity of CD4/peptide-major histocompatibility complex class II protein interactions

scientific article published on 25 April 2016

Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity

scientific article published on November 2016

Severe B-cell-mediated CNS disease secondary to alemtuzumab therapy.

scientific article

Spontaneous human squamous cell carcinomas are killed by a human cytotoxic T lymphocyte clone recognizing a wild-type p53-derived peptide

scientific article published on December 1996

Stimulation of orexin/hypocretin neurones by thyrotropin-releasing hormone

scientific article published on 9 February 2009

Structural and regulatory diversity shape HLA-C protein expression levels

scientific article

Structure of HLA-A*0301 in complex with a peptide of proteolipid protein: insights into the role of HLA-A alleles in susceptibility to multiple sclerosis

scientific article

Synthetic amino acid copolymers that bind to HLA-DR proteins and inhibit type II collagen-reactive T cell clones

scientific article published on October 1998

Systematic classification of shared components of genetic risk for common human diseases

T cell-mediated autoimmune disease due to low-affinity crossreactivity to common microbial peptides

scientific article

T cells and microglia as drivers of multiple sclerosis pathology

scientific article published on 01 November 2007

TCR transgenic mice that shed light on immune and environmental regulators in multiple sclerosis

scientific article published on 01 April 2013

TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis

scientific article

Tandem-pore K+ channels mediate inhibition of orexin neurons by glucose

scientific article

Targeting ASIC1 in primary progressive multiple sclerosis: evidence of neuroprotection with amiloride

scientific article published on January 2013

The HLA-DRB1*15:01-restricted Goodpasture's T cell epitope induces GN.

scientific article published on 14 February 2013

The Human Cell Atlas

scientific article

The Human Cell Atlas

The Human Cell Atlas White Paper ⬇️

journal article from 'arXiv:1810.05192 [q-bio]' published in 2018

The immunodominant myeloperoxidase T-cell epitope induces local cell-mediated injury in antimyeloperoxidase glomerulonephritis.

scientific article

The nature of molecular recognition by T cells

scientific article

The selection landscape and genetic legacy of ancient Eurasians

scientific article published on 10 January 2024

The value of animal models for drug development in multiple sclerosis.

scientific article

Therapeutic vaccination of active arthritis with a glycosylated collagen type II peptide in complex with MHC class II molecules

scientific article published in February 2006

Therapies for multiple sclerosis: translational achievements and outstanding needs

scientific article published on 10 April 2013

Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease

scientific article published in June 1998

Tolerance to ingested deamidated gliadin in mice is maintained by splenic, type 1 regulatory T cells.

scientific article published on 28 April 2011

Tracking of proinflammatory collagen-specific T cells in early and late collagen-induced arthritis in humanized mice.

scientific article published on December 2004

Use of calcium channel blockers and Parkinson's disease

scientific article published in March 2012

Visualization of myelin basic protein (MBP) T cell epitopes in multiple sclerosis lesions using a monoclonal antibody specific for the human histocompatibility leukocyte antigen (HLA)-DR2-MBP 85-99 complex

scientific article

Weighing in on autoimmune disease: Big data tip the scale.

scientific article

List of works by Lars Fugger

A clinical conundrum: the detrimental effect of TNF antagonists in multiple sclerosis

A functional and structural basis for TCR cross-reactivity in multiple sclerosis

A novel neurodegenerative spectrum disorder in patients with MLKL deficiency

A plasmid-encoded peptide from Staphylococcus aureus induces anti-myeloperoxidase nephritogenic autoimmunity

APOBEC3G-induced hypermutation of human immunodeficiency virus type-1 is typically a discrete "all or nothing" phenomenon

Acid-sensing ion channel 1 is involved in both axonal injury and demyelination in multiple sclerosis and its animal model

Acid-sensing ion channel-1 contributes to axonal degeneration in autoimmune inflammation of the central nervous system

Activation of central orexin/hypocretin neurons by dietary amino acids

Adaptive sugar sensors in hypothalamic feeding circuits

Amiloride Clinical Trial In Optic Neuritis (ACTION) protocol: a randomised, double blind, placebo controlled trial

An Alternative Conformation of the T-Cell Receptor α Constant Region

Antigen Targeting to Human HLA Class II Molecules Increases Efficacy of DNA Vaccination

Antigen processing influences HIV-specific cytotoxic T lymphocyte immunodominance

Arne Svejgaard and immunogenetics in Denmark

Association of MHC and rheumatoid arthritis. HLA-DR4 and rheumatoid arthritis: studies in mice and men

Autoimmunity's next top models

Autoreactive CD8+ T cells in multiple sclerosis: a new target for therapy?

Axonal injury in reverse

B cell tolerance and antibody production to the celiac disease autoantigen transglutaminase 2

Bayesian analysis of genetic association across tree-structured routine healthcare data in the UK Biobank

Bridging the gap from genetic association to functional understanding: the next generation of mouse models of multiple sclerosis

Challenges, Progress, and Prospects of Developing Therapies to Treat Autoimmune Diseases

Characterization of T-cell receptor transgenic mice recognizing immunodominant HLA-DQ2.5-restricted gluten epitopes

Class II HLA interactions modulate genetic risk for multiple sclerosis

Conflicting selective forces affect T cell receptor contacts in an immunodominant human immunodeficiency virus epitope

Constitutively active Lck kinase in T cells drives antigen receptor signal transduction

Control of autoimmunity by "epitope theft".

Control of hypothalamic orexin neurons by acid and CO2.

Convergent inputs from electrically and topographically distinct orexin cells to locus coeruleus and ventral tegmental area

Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsy

Deletion of TASK1 and TASK3 channels disrupts intrinsic excitability but does not abolish glucose or pH responses of orexin/hypocretin neurons

Destructive processing by asparagine endopeptidase limits presentation of a dominant T cell epitope in MBP.

Direct and indirect control of orexin/hypocretin neurons by glycine receptors

Dissection of the multiple sclerosis associated DR2 haplotype

Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells

Efficient presentation of myelin oligodendrocyte glycoprotein peptides but not protein by astrocytes from HLA-DR2 and HLA-DR4 transgenic mice

Efficient purification of unique antibodies using peptide affinity-matrix columns.

Elevated genetic risk for multiple sclerosis emerged in steppe pastoralist populations

Factors influencing success of clinical genome sequencing across a broad spectrum of disorders

From genes to function: the next challenge to understanding multiple sclerosis

Functional epistasis on a common MHC haplotype associated with multiple sclerosis

Genomewide Association Studies and Common Disease — Realizing Clinical Utility

HIV-1 adaptation to antigen processing results in population-level immune evasion and affects subtype diversification

HLA variation and disease.

Humanized mouse models for organ-specific autoimmune diseases

IL-21 and IL-21 receptor expression in lymphocytes and neurons in multiple sclerosis brain

Identifying cross-disease components of genetic risk across hospital data in the UK Biobank

Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice.

Immunomodulation in multiple sclerosis: promises and pitfalls

Immunopathology of multiple sclerosis

In vivo enhancement of peptide display by MHC class II molecules with small molecule catalysts of peptide exchange.

Inflammation-related plasma and CSF biomarkers for multiple sclerosis

Inherited deficiency of mannan-binding lectin-associated serine protease 2.

Inhibitory Interplay between Orexin Neurons and Eating

Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis

Joint-specific and systemic autoreactivity in the development of inflammatory arthritis

Limited protective effect of the CCR5Delta32/CCR5Delta32 genotype on human immunodeficiency virus infection incidence in a cohort of patients with hemophilia and selection for genotypic X4 virus

Longitudinal and cross-sectional studies of HIV-1 RNA and DNA loads in blood and the female genital tract

MHC II molecules in inflammatory diseases: interplay of qualities and quantities

MHC class II proteins and disease: a structural perspective

Mechanisms of neurodegeneration and axonal dysfunction in multiple sclerosis.

Metabolism-independent sugar sensing in central orexin neurons.

Misfiring in multiple sclerosis: cerebellar channelopathy, a potential novel target?

Multiple sclerosis: MHC associations and therapeutic implications

Multiple sclerosis: insights into pathophysiology and novel therapeutic avenues

Myelin oligodendrocyte glycoprotein-35-55 peptide induces severe chronic experimental autoimmune encephalomyelitis in HLA-DR2-transgenic mice.

Natural killer cells and their receptors in multiple sclerosis

Neuroinflammation - using big data to inform clinical practice

Novel synthetic amino acid copolymers that inhibit autoantigen-specific T cell responses and suppress experimental autoimmune encephalomyelitis

Opposing effects of HLA class I molecules in tuning autoreactive CD8+ T cells in multiple sclerosis

Orexin neurons as conditional glucosensors: paradoxical regulation of sugar sensing by intracellular fuels.

Pathogenic CD8(+) T cells in multiple sclerosis

Please mind the gap: axonal transport deficits in multiple sclerosis neurodegeneration.

Predominant selection of T cells specific for the glycosylated collagen type II epitope (263-270) in humanized transgenic mice and in rheumatoid arthritis

Recombinant TCR ligand induces tolerance to myelin oligodendrocyte glycoprotein 35-55 peptide and reverses clinical and histological signs of chronic experimental autoimmune encephalomyelitis in HLA-DR2 transgenic mice

Recovery from COVID-19 in a B-cell-depleted multiple sclerosis patient

Redirecting therapeutic T cells against myelin-specific T lymphocytes using a humanized myelin basic protein-HLA-DR2-zeta chimeric receptor

Remarkably low affinity of CD4/peptide-major histocompatibility complex class II protein interactions

Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity