List of works - Pierre-Yves Renard

1,5-Benzodiazepin-2-ones: Investigation of a Family of Photoluminescent Materials

scientific article

A HTS assay for the detection of organophosphorus nerve agent scavengers

scientific article

A comparative study of the self-immolation of para-aminobenzylalcohol and hemithioaminal-based linkers in the context of protease-sensitive fluorogenic probes.

scientific article published in April 2010

A highly sensitive competitive enzyme immunoassay of broad specificity quantifying microcystins and nodularins in water samples.

scientific article published in April 2009

A novel and unusually long-lived chemiluminophore based on the 7-hydroxycoumarin scaffold

scientific article published on 13 May 2011

A novel bio-orthogonal cross-linker for improved protein/protein interaction analysis

scientific article published on 12 January 2015

A novel heterotrifunctional peptide-based cross-linking reagent for facile access to bioconjugates. Applications to peptide fluorescent labelling and immobilisation.

scientific article published on 30 June 2008

A novel sulfonated prosthetic group for [18F]-radiolabelling and imparting water solubility of biomolecules and cyanine fluorophores.

scientific article

A selective and sensitive near-infrared fluorescent probe for acetylcholinesterase imaging.

scientific article published on 7 September 2016

A universal and ready-to-use heterotrifunctional cross-linking reagent for facile synthetic access to sophisticated bioconjugates ⬇️

scientific article published on August 6, 2010

Aminopropargyl derivative of terpyridine-bis(methyl-enamine) tetraacetic acid chelate of europium (Eu (TMT)-AP3): a new reagent for fluorescent labelling of proteins and peptides

scientific article published on 01 November 2006

An easy method for the determination of active concentrations of cholinesterase reactivators in blood samples: Application to the efficacy assessment of non quaternary reactivators compared to HI-6 and pralidoxime in VX-poisoned mice

scientific article published on 10 March 2016

Aryldithioethyloxycarbonyl (Ardec): a new family of amine protecting groups removable under mild reducing conditions and their applications to peptide synthesis.

scientific article

Azo-sulforhodamine dyes: a novel class of broad spectrum dark quenchers

scientific article published on 18 July 2014

Azobenzene-caged sulforhodamine dyes: a novel class of 'turn-on' reactive probes for hypoxic tumor cell imaging

scientific article published in October 2015

Bifunctional mannoside-glucosinolate glycoconjugates as enzymatically triggered isothiocyanates and FimH ligands

scientific article published on 01 July 2018

Biochemical characterization of a Caspase-3 far-red fluorescent probe for non-invasive optical imaging of neuronal apoptosis.

scientific article published on 28 May 2014

Chemiluminescent probe for the in vitro detection of protease activity

scientific article published on 16 October 2007

Design and synthesis of chemiluminescent probes for the detection of cholinesterase activity.

scientific article published in May 2002

Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3

scientific article published on 13 February 2019

Design, synthesis and biological evaluation of novel tetrahydroacridine pyridine- aldoxime and -amidoxime hybrids as efficient uncharged reactivators of nerve agent-inhibited human acetylcholinesterase

scientific article published on 15 March 2014

Development of a new nonpeptidic self-immolative spacer. Application to the design of protease sensing fluorogenic probes

scientific article published on 22 March 2008

Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice

scientific article published on 28 December 2020

Diverted Natural Lossen-type Rearrangement for Bioconjugation through in Situ Myrosinase-Triggered Isothiocyanate Synthesis

scientific article published on 16 April 2019

Easy access to phosphonothioates

scientific article published on 01 July 2002

Expeditious microwave-assisted synthesis of 5-alkoxyoxazoles from α-triflyloxy esters and nitriles

scientific article published on 25 September 2012

Facile and rapid access to linear and truncated microcystin analogues for the implementation of immunoassays.

scientific article

First efficient uncharged reactivators for the dephosphylation of poisoned human acetylcholinesterase

scientific article published on 31 March 2011

First enzymatic hydrolysis/thio-Michael addition cascade route to synthesis of AChE inhibitors

article

Fluorogenic Behaviour of the Hetero-Diels-Alder Ligation of 5-Alkoxyoxazoles with Maleimides and their Applications.

scientific article

Fluorophore-Assisted Click Chemistry through Copper(I) Complexation

scientific article published on 16 April 2020

Human butyrylcholinesterase produced in insect cells: huprine-based affinity purification and crystal structure

scientific article

Huprine derivatives as sub-nanomolar human acetylcholinesterase inhibitors: from rational design to validation by X-ray crystallography

scientific article

Immunologically driven chemical engineering of antibodies for catalytic activity.

scientific article

Investigation of tetrazine reactivity towards C-nucleophiles: pyrazolone-based modification of biomolecules

scientific article published on 01 January 2019

Kondrat'eva ligation: Diels-Alder-based irreversible reaction for bioconjugation

scientific article published on 27 October 2014

Latent fluorophores based on a self-immolative linker strategy and suitable for protease sensing.

scientific article published on 22 July 2008

Lewis acid catalyzed room-temperature Michaelis-Arbuzov rearrangement

scientific article published on 01 May 2003

Metal-free decarboxylative hetero-Diels–Alder synthesis of 3-hydroxypyridines: a rapid access to N-fused bicyclic hydroxypiperidine scaffolds.

scientific article published in February 2014

N-Fmoc-α-sulfo-β-alanine: a versatile building block for the water solubilisation of chromophores and fluorophores by solid-phase strategy.

scientific article

New 3-(heteroaryl)-2-iminocoumarin-based borate complexes: synthesis, photophysical properties, and rational functionalization for biosensing/biolabeling applications.

scientific article published on 26 August 2015

New Huprine Derivatives Functionalized at Position 9 as Highly Potent Acetylcholinesterase Inhibitors

scientific article published on 23 February 2011

New insights into the kinetic target-guided synthesis of protein ligands

scientific article published on July 2015

New insights into the water-solubilisation of fluorophores by post-synthetic "click" and Sonogashira reactions

scientific article published on 02 May 2012

Novel water-soluble near-infrared cyanine dyes: synthesis, spectral properties, and use in the preparation of internally quenched fluorescent probes

scientific article published on 21 June 2007

On the Influence of the Protonation States of Active Site Residues on AChE Reactivation: A QM/MM Approach.

scientific article published on 19 January 2017

Optimized strategies to synthesize β-cyclodextrin-oxime conjugates as a new generation of organophosphate scavengers

scientific article published on 04 March 2011

Pharmacokinetic Evaluation of Brain Penetrating Morpholine-3-hydroxy-2-pyridine Oxime as an Antidote for Nerve Agent Poisoning

scientific article published on 11 March 2020

Postsynthetic derivatization of fluorophores with alpha-sulfo-beta-alanine dipeptide linker. Application to the preparation of water-soluble cyanine and rhodamine dyes.

scientific article

Potent 3-hydroxy-2-pyridine aldoxime reactivators of organophosphate-inhibited cholinesterases with predicted blood-brain barrier penetration.

scientific article published on 19 April 2018

Probing the cholinergic system to understand neurodegenerative diseases.

scientific article published on 18 January 2017

Radiosynthesis and in vivo evaluation of fluorinated huprine derivates as PET radiotracers of acetylcholinesterase.

scientific article published on 20 March 2013

Reaction site-driven regioselective synthesis of AChE inhibitors

scientific article published on 11 November 2013

Readily functionalizable phosphonium-tagged fluorescent coumarins for enhanced detection of conjugates by mass spectrometry

scientific article published on 01 August 2016

Real-time molecular optical micro-imaging of EGFR mutations using a fluorescent erlotinib based tracer

scientific article published on 07 January 2019

Screening of new huprines—Inhibitors of acetylcholinesterases by electrospray ionization ion trap mass spectrometry

scientific article published on 17 February 2012

Self-cleavable chemiluminescent probes suitable for protease sensing.

scientific article published in June 2009

Straightforward access to protected syn alpha-amino-beta-hydroxy acid derivatives.

scientific article published in January 2008

Straightforward access to water-soluble unsymmetrical sulfoxanthene dyes: application to the preparation of far-red fluorescent dyes with large stokes' shifts.

scientific article

Syntheses and in vitro evaluations of uncharged reactivators for human acetylcholinesterase inhibited by organophosphorus nerve agents.

scientific article

Synthesis and luminescence properties of new red-shifted absorption lanthanide(III) chelates suitable for peptide and protein labelling.

scientific article published on 14 February 2011

Synthesis and reactivity of a bis-sultone cross-linker for peptide conjugation and [18F]-radiolabelling via unusual "double click" approach

scientific article published on 13 December 2011

Synthesis of fluorinated agonist of sphingosine-1-phosphate receptor 1.

scientific article

Synthesis of polysubstituted 3-hydroxypyridines via the revisited hetero-Diels–Alder reaction of 5-alkoxyoxazoles with dienophiles

scientific article published on 25 November 2011

Tailored Bioorthogonal and Bioconjugate Chemistry: A Source of Inspiration for Developing Kinetic Target-Guided Synthesis Strategies

scientific article published on 24 November 2020

The first "ready-to-use" benzene-based heterotrifunctional cross-linker for multiple bioconjugation

scientific article published on 01 April 2013

The first latent green fluorophores for the detection of azoreductase activity in bacterial cultures.

scientific article published in October 2013

The first metal-free water-soluble cryptophane-111.

scientific article

The use of enzyme immunoassays for the detection of abzymatic activities. Application to an enantioselective thioacetal hydrolysis activity.

scientific article published in November 2002

Thermally controlled decarboxylative [4 + 2] cycloaddition between alkoxyoxazoles and acrylic acid: expedient access to 3-hydroxypyridines

scientific article published on 06 May 2013

Thyroid hormone improves postischaemic recovery of function while limiting apoptosis: a new therapeutic approach to support hemodynamics in the setting of ischaemia-reperfusion?

scientific article

Trimethylsilyl halide-promoted Michaelis-Arbuzov rearrangement

scientific article published on 01 May 2003

Tryptoline-3-hydroxypyridinaldoxime conjugates as efficient reactivators of phosphylated human acetyl and butyrylcholinesterases

scientific article published on 05 March 2014

Universal dark quencher based on "clicked" spectrally distinct azo dyes.

scientific article

Use of an Air-stable Cu(I)-NHC Catalyst for the Synthesis of Peptidotriazoles

scientific article published on 12 October 2018

Water-solubilisation and bio-conjugation of a red-emitting BODIPY marker.

scientific article published on 18 November 2010

Water-soluble BODIPY derivatives

scientific article published on 01 May 2009

Water-soluble red-emitting distyryl-borondipyrromethene (BODIPY) dyes for biolabeling.

scientific article published on 27 April 2012

List of works by Pierre-Yves Renard

1,5-Benzodiazepin-2-ones: Investigation of a Family of Photoluminescent Materials

A HTS assay for the detection of organophosphorus nerve agent scavengers

A comparative study of the self-immolation of para-aminobenzylalcohol and hemithioaminal-based linkers in the context of protease-sensitive fluorogenic probes.

A highly sensitive competitive enzyme immunoassay of broad specificity quantifying microcystins and nodularins in water samples.

A novel and unusually long-lived chemiluminophore based on the 7-hydroxycoumarin scaffold

A novel bio-orthogonal cross-linker for improved protein/protein interaction analysis

A novel heterotrifunctional peptide-based cross-linking reagent for facile access to bioconjugates. Applications to peptide fluorescent labelling and immobilisation.

A novel sulfonated prosthetic group for [18F]-radiolabelling and imparting water solubility of biomolecules and cyanine fluorophores.

A selective and sensitive near-infrared fluorescent probe for acetylcholinesterase imaging.

A universal and ready-to-use heterotrifunctional cross-linking reagent for facile synthetic access to sophisticated bioconjugates ⬇️

Aminopropargyl derivative of terpyridine-bis(methyl-enamine) tetraacetic acid chelate of europium (Eu (TMT)-AP3): a new reagent for fluorescent labelling of proteins and peptides

An easy method for the determination of active concentrations of cholinesterase reactivators in blood samples: Application to the efficacy assessment of non quaternary reactivators compared to HI-6 and pralidoxime in VX-poisoned mice

Aryldithioethyloxycarbonyl (Ardec): a new family of amine protecting groups removable under mild reducing conditions and their applications to peptide synthesis.

Azo-sulforhodamine dyes: a novel class of broad spectrum dark quenchers

Azobenzene-caged sulforhodamine dyes: a novel class of 'turn-on' reactive probes for hypoxic tumor cell imaging

Bifunctional mannoside-glucosinolate glycoconjugates as enzymatically triggered isothiocyanates and FimH ligands

Biochemical characterization of a Caspase-3 far-red fluorescent probe for non-invasive optical imaging of neuronal apoptosis.

Chemiluminescent probe for the in vitro detection of protease activity

Design and synthesis of chemiluminescent probes for the detection of cholinesterase activity.

Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3

Design, synthesis and biological evaluation of novel tetrahydroacridine pyridine- aldoxime and -amidoxime hybrids as efficient uncharged reactivators of nerve agent-inhibited human acetylcholinesterase

Development of a new nonpeptidic self-immolative spacer. Application to the design of protease sensing fluorogenic probes

Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice

Diverted Natural Lossen-type Rearrangement for Bioconjugation through in Situ Myrosinase-Triggered Isothiocyanate Synthesis

Easy access to phosphonothioates

Expeditious microwave-assisted synthesis of 5-alkoxyoxazoles from α-triflyloxy esters and nitriles

Facile and rapid access to linear and truncated microcystin analogues for the implementation of immunoassays.

First efficient uncharged reactivators for the dephosphylation of poisoned human acetylcholinesterase

First enzymatic hydrolysis/thio-Michael addition cascade route to synthesis of AChE inhibitors

Fluorogenic Behaviour of the Hetero-Diels-Alder Ligation of 5-Alkoxyoxazoles with Maleimides and their Applications.

Fluorophore-Assisted Click Chemistry through Copper(I) Complexation

Human butyrylcholinesterase produced in insect cells: huprine-based affinity purification and crystal structure

Huprine derivatives as sub-nanomolar human acetylcholinesterase inhibitors: from rational design to validation by X-ray crystallography

Immunologically driven chemical engineering of antibodies for catalytic activity.

Investigation of tetrazine reactivity towards C-nucleophiles: pyrazolone-based modification of biomolecules

Kondrat'eva ligation: Diels-Alder-based irreversible reaction for bioconjugation

Latent fluorophores based on a self-immolative linker strategy and suitable for protease sensing.

Lewis acid catalyzed room-temperature Michaelis-Arbuzov rearrangement

Metal-free decarboxylative hetero-Diels–Alder synthesis of 3-hydroxypyridines: a rapid access to N-fused bicyclic hydroxypiperidine scaffolds.

N-Fmoc-α-sulfo-β-alanine: a versatile building block for the water solubilisation of chromophores and fluorophores by solid-phase strategy.

New 3-(heteroaryl)-2-iminocoumarin-based borate complexes: synthesis, photophysical properties, and rational functionalization for biosensing/biolabeling applications.

New Huprine Derivatives Functionalized at Position 9 as Highly Potent Acetylcholinesterase Inhibitors

New insights into the kinetic target-guided synthesis of protein ligands

New insights into the water-solubilisation of fluorophores by post-synthetic "click" and Sonogashira reactions

Novel water-soluble near-infrared cyanine dyes: synthesis, spectral properties, and use in the preparation of internally quenched fluorescent probes

On the Influence of the Protonation States of Active Site Residues on AChE Reactivation: A QM/MM Approach.

Optimized strategies to synthesize β-cyclodextrin-oxime conjugates as a new generation of organophosphate scavengers

Pharmacokinetic Evaluation of Brain Penetrating Morpholine-3-hydroxy-2-pyridine Oxime as an Antidote for Nerve Agent Poisoning

Postsynthetic derivatization of fluorophores with alpha-sulfo-beta-alanine dipeptide linker. Application to the preparation of water-soluble cyanine and rhodamine dyes.

Potent 3-hydroxy-2-pyridine aldoxime reactivators of organophosphate-inhibited cholinesterases with predicted blood-brain barrier penetration.

Probing the cholinergic system to understand neurodegenerative diseases.

Radiosynthesis and in vivo evaluation of fluorinated huprine derivates as PET radiotracers of acetylcholinesterase.

Reaction site-driven regioselective synthesis of AChE inhibitors

Readily functionalizable phosphonium-tagged fluorescent coumarins for enhanced detection of conjugates by mass spectrometry

Real-time molecular optical micro-imaging of EGFR mutations using a fluorescent erlotinib based tracer

Screening of new huprines—Inhibitors of acetylcholinesterases by electrospray ionization ion trap mass spectrometry

Self-cleavable chemiluminescent probes suitable for protease sensing.

Straightforward access to protected syn alpha-amino-beta-hydroxy acid derivatives.

Straightforward access to water-soluble unsymmetrical sulfoxanthene dyes: application to the preparation of far-red fluorescent dyes with large stokes' shifts.

Syntheses and in vitro evaluations of uncharged reactivators for human acetylcholinesterase inhibited by organophosphorus nerve agents.

Synthesis and luminescence properties of new red-shifted absorption lanthanide(III) chelates suitable for peptide and protein labelling.

Synthesis and reactivity of a bis-sultone cross-linker for peptide conjugation and [18F]-radiolabelling via unusual "double click" approach

Synthesis of fluorinated agonist of sphingosine-1-phosphate receptor 1.

Synthesis of polysubstituted 3-hydroxypyridines via the revisited hetero-Diels–Alder reaction of 5-alkoxyoxazoles with dienophiles

Tailored Bioorthogonal and Bioconjugate Chemistry: A Source of Inspiration for Developing Kinetic Target-Guided Synthesis Strategies

The first "ready-to-use" benzene-based heterotrifunctional cross-linker for multiple bioconjugation

The first latent green fluorophores for the detection of azoreductase activity in bacterial cultures.

The first metal-free water-soluble cryptophane-111.

The use of enzyme immunoassays for the detection of abzymatic activities. Application to an enantioselective thioacetal hydrolysis activity.

Thermally controlled decarboxylative [4 + 2] cycloaddition between alkoxyoxazoles and acrylic acid: expedient access to 3-hydroxypyridines

Thyroid hormone improves postischaemic recovery of function while limiting apoptosis: a new therapeutic approach to support hemodynamics in the setting of ischaemia-reperfusion?

Trimethylsilyl halide-promoted Michaelis-Arbuzov rearrangement

Tryptoline-3-hydroxypyridinaldoxime conjugates as efficient reactivators of phosphylated human acetyl and butyrylcholinesterases

Universal dark quencher based on "clicked" spectrally distinct azo dyes.

Use of an Air-stable Cu(I)-NHC Catalyst for the Synthesis of Peptidotriazoles

Water-solubilisation and bio-conjugation of a red-emitting BODIPY marker.

Water-soluble BODIPY derivatives

Water-soluble red-emitting distyryl-borondipyrromethene (BODIPY) dyes for biolabeling.