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List of works by Claudio O. Fernandez

A moderate metal-binding hydrazone meets the criteria for a bioinorganic approach towards Parkinson's disease: Therapeutic potential, blood-brain barrier crossing evaluation and preliminary toxicological studies

scientific article published on 22 February 2017

Alkaline Transition of Rhus vernicifera Stellacyanin, an Unusual Blue Copper Protein ⬇️

scientific article published on August 26, 1997

Amino acid bulkiness defines the local conformations and dynamics of natively unfolded alpha-synuclein and tau

scientific article published on 23 February 2007

Axial Ligand Modulation of the Electronic Structures of Binuclear Copper Sites: Analysis of Paramagnetic 1H NMR Spectra of Met160Gln CuA ⬇️

scientific article published on November 28, 2001

Bioinorganic Chemistry of Parkinson's Disease: Affinity and Structural Features of Cu(I) Binding to the Full-Length β-Synuclein Protein.

scientific article

Bioinorganic Chemistry of Parkinson’s Disease: Structural Determinants for the Copper-Mediated Amyloid Formation of Alpha-Synuclein

scientific article published on 22 October 2010

Bioinorganic chemistry of synucleinopathies: deciphering the binding features of Met motifs and His-50 in AS-Cu(I) interactions.

scientific article published on 3 September 2014

Charge-induced molecular alignment of intrinsically disordered proteins

scientific article published on 01 October 2006

Conformational ensemble of human α-synuclein physiological form predicted by molecular simulations

Conserved core of amyloid fibrils of wild type and A30P mutant α‐synuclein ⬇️

scientific article published on February 1, 2011

Copper Coordination Features of Human Islet Amyloid Polypeptide: The Type 2 Diabetes Peptide.

scientific article published on 5 October 2016

Copper(II) and the pathological H50Q α-synuclein mutant: Environment meets genetics

scientific article published on 6 February 2017

Correlation of amyloid fibril beta-structure with the unfolded state of alpha-synuclein

scientific article

Disruption of zinc and copper interactions with Aβ(1-40) by a non-toxic, isoniazid-derived, hydrazone: a novel biometal homeostasis restoring agent in Alzheimer's disease therapy?

scientific article published on 10 April 2015

Dissociation of amyloid fibrils of alpha-synuclein in supercooled water.

scientific article

Environmental and genetic factors support the dissociation between α-synuclein aggregation and toxicity.

scientific article published on 05 October 2016

Exploring the Structural Details of Cu(I) Binding to α-Synuclein by NMR Spectroscopy ⬇️

scientific article published on December 15, 2010

Familial Mutants of α-Synuclein with Increased Neurotoxicity Have a Destabilized Conformation

scientific article published in Journal of Biological Chemistry

Interaction of α-Synuclein with Divalent Metal Ions Reveals Key Differences: A Link between Structure, Binding Specificity and Fibrillation Enhancement

scientific article published on 01 August 2006

Long-Range Correlated Dynamics in Intrinsically Disordered Proteins

article

Metal-ligand interactions in perturbed blue copper sites: a paramagnetic (1)H NMR study of Co(II)-pseudoazurin.

scientific article

NMR of alpha-synuclein-polyamine complexes elucidates the mechanism and kinetics of induced aggregation.

scientific article published on 22 April 2004

Phthalocyanines as Molecular Scaffolds to Block Disease-Associated Protein Aggregation.

scientific article published on 2 May 2016

Repurposing doxycycline for synucleinopathies: remodelling of α-synuclein oligomers towards non-toxic parallel beta-sheet structured species.

scientific article published on 03 February 2017

Role of N-terminal methionine residues in the redox activity of copper bound to alpha-synuclein

scientific article published on 15 July 2016

Role of Tyr-39 for the Structural Features of α-Synuclein and for the Interaction with a Strong Modulator of Its Amyloid Assembly

scientific article published on 17 July 2020

Site-specific copper-catalyzed oxidation of α-synuclein: tightening the link between metal binding and protein oxidative damage in Parkinson's disease.

scientific article published on 11 April 2014

Small molecule-mediated stabilization of vesicle-associated helical α-synuclein inhibits pathogenic misfolding and aggregation

scientific article published on 19 December 2014

Spectroscopic and Theoretical Study of Cu(I) Binding to His111 in the Human Prion Protein Fragment 106-115.

scientific article

Structural Characterization of the Intrinsically Unfolded Protein β-Synuclein, a Natural Negative Regulator of α-Synuclein Aggregation

scientific article published on 17 July 2007

Structural basis behind the interaction of Zn²⁺ with the protein α-synuclein and the Aβ peptide: a comparative analysis.

scientific article published on 29 June 2012

Structural characterization of alpha-synuclein in an aggregation prone state.

scientific article published on September 2009

Structural comparison of mouse and human α-synuclein amyloid fibrils by solid-state NMR

scientific article published on 16 April 2012

Structural properties of pore-forming oligomers of alpha-synuclein

article by Hai-Young Kim et al published 2 December 2009 in Journal of the American Chemical Society

Structures Behind the Amyloid Aggregation of α-Synuclein: An NMR based Approach ⬇️

scientific article published on May 1, 2011

Toward the discovery of effective polycyclic inhibitors of alpha-synuclein amyloid assembly.

scientific article published on 27 July 2011

X1INH, an improved next-generation affinity-optimized hydrazonic ligand, attenuates abnormal copper(i)/copper(ii)-α-Syn interactions and affects protein aggregation in a cellular model of synucleinopathy

scientific article published on 11 May 2020

cDNA cloning, sequence, and regulation of a major female-specific and growth hormone-inducible rat liver cytochrome P-450 active in 15 beta-hydroxylation of steroid sulfates.

scientific article

α-Synuclein interacts with the switch region of Rab8a in a Ser129 phosphorylation-dependent manner

scientific article

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