List of works - Nicholas H Williams

'Rough guide' evanescent wave optrode for colorimetric metalloporphyrine sensors

scientific article published on 25 November 2016

14 Bioinspired organic chemistry

article

15 Bioinspired organic chemistry

article

A Highly Reactive Mononuclear Zn(II) Complex for Phosphodiester Cleavage

scientific article published on 01 October 2005

A Structural and Functional Model of Dinuclear Metallophosphatases

article

A Synthetic Vesicle-to-Vesicle Communication System

scientific article published on 23 October 2019

A Trojan horse transition state analogue generated by MgF3- formation in an enzyme active site.

scholarly article

A novel solid support for synthesis of 2′,3′-cyclic phosphate terminated oligonucleotides

article

Activating water: important effects of non-leaving groups on the hydrolysis of phosphate triesters.

scientific article published on 21 November 2011

Adhesion between oppositely charged polyelectrolytes

Adhesion of Grafted-to Polyelectrolyte Brushes Functionalized with Calix[4]resorcinarene and Deposited as a Monolayer

scientific article published on 10 November 2020

Altered mechanisms of reactions of phosphate esters bridging a dinuclear metal center

scientific article published in September 2004

Amino-functionalized DNA: the properties of C5-amino-alkyl substituted 2'-deoxyuridines and their application in DNA triplex formation

scientific article

Amphiphilic spin probes based on disulfide-bridged bisnitroxides

An altered mechanism of hydrolysis for a metal-complexed phosphate diester.

scientific article published in December 2002

Anionic charge is prioritized over geometry in aluminum and magnesium fluoride transition state analogs of phosphoryl transfer enzymes

scientific article published on 5 March 2008

Atomic details of near-transition state conformers for enzyme phosphoryl transfer revealed by Formula rather than by phosphoranes

scientific article

Brønsted analysis and rate-limiting steps for the T5 flap endonuclease catalyzed hydrolysis of exonucleolytic substrates

scientific article published on September 2010

Catalysis in a Cationic Coordination Cage Using a Cavity-Bound Guest and Surface-Bound Anions: Inhibition, Activation, and Autocatalysis

scientific article published on 7 February 2018

Catalytic zinc complexes for phosphate diester hydrolysis

scientific article

Cleavage and isomerization of UpU promoted by dinuclear metal ion complexes.

scientific article published on 7 March 2008

Comparing a mononuclear Zn(ii) complex with hydrogen bond donors with a dinuclear Zn(ii) complex for catalysing phosphate ester cleavage

scientific article published on 03 April 2006

Computer simulations of the catalytic mechanism of wild-type and mutant β-phosphoglucomutase.

scientific article

Controlled membrane translocation provides a mechanism for signal transduction and amplification.

scientific article published on 12 December 2016

Cooperative binding at lipid bilayer membrane surfaces

scientific article published in April 2003

Coordination Cages Based on Bis(pyrazolylpyridine) Ligands: Structures, Dynamic Behavior, Guest Binding, and Catalysis

scientific article published on 07 August 2018

Dineopentyl phosphate hydrolysis: evidence for stepwise water attack

scientific article published on 27 August 2008

Dinuclear Zn(II) complex promotes cleavage and isomerization of 2-hydroxypropyl alkyl phosphates by a common cyclic phosphate intermediate

scientific article published in March 2009

Double-network hydrogels improve pH-switchable adhesion.

scientific article

Efficient Phosphodiester Binding and Cleavage by a ZnII Complex Combining Hydrogen-Bonding Interactions and Double Lewis Acid Activation

scientific article published on 01 October 2006

Efficient intramolecular general acid catalysis of enol ether hydrolysis. Hydrogen-bonding stabilisation of the transition state for proton transfer to carbon

Efficient intramolecular general acid catalysis of vinyl ether hydrolysis by the neighbouring carboxylic acid group

Electronic effects on conformational preferences: A-values for aryloxy groups

Enhancing Phosphate Diester Cleavage by a Zinc Complex through Controlling Nucleophile Coordination

scientific article published on 18 March 2015

Fabrication of molecular nanopatterns at aluminium oxide surfaces by nanoshaving of self-assembled monolayers of alkylphosphonates.

scientific article

Fibre optic absorbance meter with low limit of detection for waterborne cations

Generation of Bioactive Materials with Rapid Self-Assembling Resorcinarene-Peptides

Guest Binding and Catalysis in the Cavity of a Cubic Coordination Cage

Highly efficient catalysis of the Kemp elimination in the cavity of a cubic coordination cage

article

Highly selective colorimetric sensing pyrophosphate in water by a NBD-phenoxo-bridged dinuclear Zn(ii) complex

scientific article published on 25 June 2012

How to name atoms in phosphates, polyphosphates, their derivatives and mimics, and transition state analogues for enzyme-catalysed phosphoryl transfer reactions (IUPAC Recommendations 2016)

Interaction of anions with the surface of a coordination cage in aqueous solution probed by their effect on a cage-catalysed Kemp elimination

scientific article published in 2021

Intramolecular general base catalysis in the hydrolysis of a phosphate diester. Calculational guidance to a choice of mechanism

scientific article published on 7 February 2013

Kinetic analysis of beta-phosphoglucomutase and its inhibition by magnesium fluoride

scientific article published in February 2009

Magnesium Ion Catalyzed ATP Hydrolysis

scholarly article by Nicholas H Williams published December 2000 in Journal of the American Chemical Society

Mechanism and transition state structure of aryl methylphosphonate esters doubly coordinated to a dinuclear cobalt(III) center

scientific article published on September 2009

Mechanistic study of protein phosphatase-1 (PP1), a catalytically promiscuous enzyme

scientific article published on 18 September 2008

MgF(3)(-) and alpha-galactose 1-phosphate in the active site of beta-phosphoglucomutase form a transition state analogue of phosphoryl transfer

scientific article published in November 2009

Models for biological phosphoryl transfer

scientific article published on March 2004

Monofunctionalised resorcinarenes

Neutralizing mutations of carboxylates that bind metal 2 in T5 flap endonuclease result in an enzyme that still requires two metal ions

scientific article

Oligonucleotide based artificial nuclease (OBAN) systems. Bulge size dependence and positioning of catalytic group in cleavage of RNA-bulges

scientific article published on May 2003

Phase emerging from intramonolayer cycloaddition on micro-patterned monolayer

Phosphate ester analogues as probes for understanding enzyme catalysed phosphoryl transfer

Photocatalytic nanolithography of self-assembled monolayers and proteins

scientific article

Preface

Reactivity of Phosphate Diesters Doubly Coordinated to a Dinuclear Cobalt(III) Complex: Dependence of the Reactivity on the Basicity of the Leaving Group

article

Recognition-Controlled Membrane Translocation for Signal Transduction across Lipid Bilayers.

scientific article

Resolving apparent conflicts between theoretical and experimental models of phosphate monoester hydrolysis

scientific article

Simulating the reactions of substituted pyridinio-N-phosphonates with pyridine as a model for biological phosphoryl transfer

scientific article published on 18 August 2017

Structure and Nuclease Activity of Simple Dinuclear Metal Complexes: Quantitative Dissection of the Role of Metal Ions

article by Nicholas H Williams et al published June 1999 in Accounts of Chemical Research

The Competing Mechanisms of Phosphate Monoester Dianion Hydrolysis

scientific article

The Mechanism of Cleavage and Isomerisation of RNA Promoted by an Efficient Dinuclear Zn2+ Complex

scientific article published on 09 December 2011

The alkaline hydrolysis of sulfonate esters: challenges in interpreting experimental and theoretical data

scientific article

The anomeric effects of aryloxy groups

The effect of magnesium ions on triphosphate hydrolysis

scholarly article by Alexandre Barrozo et al published 27 June 2017 in Pure and Applied Chemistry

The rate of hydrolysis of phosphomonoester dianions and the exceptional catalytic proficiencies of protein and inositol phosphatases

scholarly article

The solvolysis mechanism of simple secondary tosylates in 50% aqueous TFE

The time required for water attack at the phosphorus atom of simple phosphodiesters and of DNA

scholarly article

There is no evidence for electrostatic catalysis of vinyl ether hydrolysis in water

article

Three metal ions participate in the reaction catalyzed by T5 flap endonuclease.

scientific article published on 11 August 2008

Transition States and Control of Substrate Preference in the Promiscuous Phosphatase PP1.

scientific article

Triggered Release from Lipid Bilayer Vesicles by an Artificial Transmembrane Signal Transduction System

scientific article published on 6 September 2017

Trimorphism in solid resorcinarenes

scientific article published on 27 March 2007

List of works by Nicholas H Williams

'Rough guide' evanescent wave optrode for colorimetric metalloporphyrine sensors

14 Bioinspired organic chemistry

15 Bioinspired organic chemistry

A Highly Reactive Mononuclear Zn(II) Complex for Phosphodiester Cleavage

A Structural and Functional Model of Dinuclear Metallophosphatases

A Synthetic Vesicle-to-Vesicle Communication System

A Trojan horse transition state analogue generated by MgF3- formation in an enzyme active site.

A novel solid support for synthesis of 2′,3′-cyclic phosphate terminated oligonucleotides

Activating water: important effects of non-leaving groups on the hydrolysis of phosphate triesters.

Adhesion between oppositely charged polyelectrolytes

Adhesion of Grafted-to Polyelectrolyte Brushes Functionalized with Calix[4]resorcinarene and Deposited as a Monolayer

Altered mechanisms of reactions of phosphate esters bridging a dinuclear metal center

Amino-functionalized DNA: the properties of C5-amino-alkyl substituted 2'-deoxyuridines and their application in DNA triplex formation

Amphiphilic spin probes based on disulfide-bridged bisnitroxides

An altered mechanism of hydrolysis for a metal-complexed phosphate diester.

Anionic charge is prioritized over geometry in aluminum and magnesium fluoride transition state analogs of phosphoryl transfer enzymes

Atomic details of near-transition state conformers for enzyme phosphoryl transfer revealed by Formula rather than by phosphoranes

Brønsted analysis and rate-limiting steps for the T5 flap endonuclease catalyzed hydrolysis of exonucleolytic substrates

Catalysis in a Cationic Coordination Cage Using a Cavity-Bound Guest and Surface-Bound Anions: Inhibition, Activation, and Autocatalysis

Catalytic zinc complexes for phosphate diester hydrolysis

Cleavage and isomerization of UpU promoted by dinuclear metal ion complexes.

Comparing a mononuclear Zn(ii) complex with hydrogen bond donors with a dinuclear Zn(ii) complex for catalysing phosphate ester cleavage

Computer simulations of the catalytic mechanism of wild-type and mutant β-phosphoglucomutase.

Controlled membrane translocation provides a mechanism for signal transduction and amplification.

Cooperative binding at lipid bilayer membrane surfaces

Coordination Cages Based on Bis(pyrazolylpyridine) Ligands: Structures, Dynamic Behavior, Guest Binding, and Catalysis

Dineopentyl phosphate hydrolysis: evidence for stepwise water attack

Dinuclear Zn(II) complex promotes cleavage and isomerization of 2-hydroxypropyl alkyl phosphates by a common cyclic phosphate intermediate

Double-network hydrogels improve pH-switchable adhesion.

Efficient Phosphodiester Binding and Cleavage by a ZnII Complex Combining Hydrogen-Bonding Interactions and Double Lewis Acid Activation

Efficient intramolecular general acid catalysis of enol ether hydrolysis. Hydrogen-bonding stabilisation of the transition state for proton transfer to carbon

Efficient intramolecular general acid catalysis of vinyl ether hydrolysis by the neighbouring carboxylic acid group

Electronic effects on conformational preferences: A-values for aryloxy groups

Enhancing Phosphate Diester Cleavage by a Zinc Complex through Controlling Nucleophile Coordination

Fabrication of molecular nanopatterns at aluminium oxide surfaces by nanoshaving of self-assembled monolayers of alkylphosphonates.

Fibre optic absorbance meter with low limit of detection for waterborne cations

Generation of Bioactive Materials with Rapid Self-Assembling Resorcinarene-Peptides

Guest Binding and Catalysis in the Cavity of a Cubic Coordination Cage

Highly efficient catalysis of the Kemp elimination in the cavity of a cubic coordination cage

Highly selective colorimetric sensing pyrophosphate in water by a NBD-phenoxo-bridged dinuclear Zn(ii) complex

How to name atoms in phosphates, polyphosphates, their derivatives and mimics, and transition state analogues for enzyme-catalysed phosphoryl transfer reactions (IUPAC Recommendations 2016)

Interaction of anions with the surface of a coordination cage in aqueous solution probed by their effect on a cage-catalysed Kemp elimination

Intramolecular general base catalysis in the hydrolysis of a phosphate diester. Calculational guidance to a choice of mechanism

Kinetic analysis of beta-phosphoglucomutase and its inhibition by magnesium fluoride

Magnesium Ion Catalyzed ATP Hydrolysis

Mechanism and transition state structure of aryl methylphosphonate esters doubly coordinated to a dinuclear cobalt(III) center

Mechanistic study of protein phosphatase-1 (PP1), a catalytically promiscuous enzyme

MgF(3)(-) and alpha-galactose 1-phosphate in the active site of beta-phosphoglucomutase form a transition state analogue of phosphoryl transfer

Models for biological phosphoryl transfer

Monofunctionalised resorcinarenes

Neutralizing mutations of carboxylates that bind metal 2 in T5 flap endonuclease result in an enzyme that still requires two metal ions

Oligonucleotide based artificial nuclease (OBAN) systems. Bulge size dependence and positioning of catalytic group in cleavage of RNA-bulges

Phase emerging from intramonolayer cycloaddition on micro-patterned monolayer

Phosphate ester analogues as probes for understanding enzyme catalysed phosphoryl transfer

Photocatalytic nanolithography of self-assembled monolayers and proteins

Preface

Preface

Preface

Reactivity of Phosphate Diesters Doubly Coordinated to a Dinuclear Cobalt(III) Complex: Dependence of the Reactivity on the Basicity of the Leaving Group

Recognition-Controlled Membrane Translocation for Signal Transduction across Lipid Bilayers.

Resolving apparent conflicts between theoretical and experimental models of phosphate monoester hydrolysis

Simulating the reactions of substituted pyridinio-N-phosphonates with pyridine as a model for biological phosphoryl transfer

Structure and Nuclease Activity of Simple Dinuclear Metal Complexes: Quantitative Dissection of the Role of Metal Ions

The Competing Mechanisms of Phosphate Monoester Dianion Hydrolysis

The Mechanism of Cleavage and Isomerisation of RNA Promoted by an Efficient Dinuclear Zn2+ Complex

The alkaline hydrolysis of sulfonate esters: challenges in interpreting experimental and theoretical data

The anomeric effects of aryloxy groups

The effect of magnesium ions on triphosphate hydrolysis

The rate of hydrolysis of phosphomonoester dianions and the exceptional catalytic proficiencies of protein and inositol phosphatases

The solvolysis mechanism of simple secondary tosylates in 50% aqueous TFE

The time required for water attack at the phosphorus atom of simple phosphodiesters and of DNA

There is no evidence for electrostatic catalysis of vinyl ether hydrolysis in water

Three metal ions participate in the reaction catalyzed by T5 flap endonuclease.

Transition States and Control of Substrate Preference in the Promiscuous Phosphatase PP1.

Triggered Release from Lipid Bilayer Vesicles by an Artificial Transmembrane Signal Transduction System

Trimorphism in solid resorcinarenes

βLGvalues in mechanistic studies on the transesterification of RNA models and their application in a metal ion complex promoted transesterification