List of works - Yu-Jun Zhao

AM-8553: A Novel MDM2 Inhibitor with a Promising Outlook for Potential Clinical Development ⬇️

scientific article published on May 24, 2012

Allenamide as a bioisostere of acrylamide in the design and synthesis of targeted covalent inhibitors.

scientific article published on 11 December 2017

Asymmetric Syntheses of 8‐Oxabicyclo[3,2,1]octanes: A Cationic Cascade Cyclization ⬇️

scientific article published on July 2, 2012

Discovery of a Potent and Selective NF-κB-Inducing Kinase (NIK) Inhibitor That Has Anti-inflammatory Effects in Vitro and in Vivo

scientific article published on 07 April 2020

Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression.

scientific article

Discovery, structural insight, and bioactivities of BY27 as a selective inhibitor of the second bromodomains of BET proteins

scientific article published on 21 August 2019

Elucidation of Acquired Resistance to Bcl-2 and MDM2 Inhibitors in Acute Leukemia In Vitro and In Vivo.

scientific article published on 09 March 2015

Hepatic TRAF2 regulates glucose metabolism through enhancing glucagon responses.

scientific article published on 7 February 2012

Lewis Acid-Promoted Intermolecular Acetal-Initiated Cationic Polyene Cyclizations

scientific article published in January 2007

Lewis Acids Promoted 3 + 2 Cycloaddition of Oxaziridines and Cyclic Allylic Alcohols through Carbonyl Imine Intermediates

scientific article published on 25 March 2019

SAR405838: an optimized inhibitor of MDM2-p53 interaction that induces complete and durable tumor regression

scientific article

Small-molecule inhibitors of the MDM2-p53 protein-protein interaction (MDM2 Inhibitors) in clinical trials for cancer treatment.

scientific article

Structure-Based Design of γ-Carboline Analogues as Potent and Specific BET Bromodomain Inhibitors

scientific article

Structure-Based Discovery of SD-36 as a Potent, Selective, and Efficacious PROTAC Degrader of STAT3 Protein

scientific article published on 10 December 2019

Synthesis of 3‐Oxaterpenoids and Its Application in the Total Synthesis of (±)‐Moluccanic Acid Methyl Ester ⬇️

scientific article published on September 17, 2012

Targeted Degradation of BET Proteins in Triple-Negative Breast Cancer.

scientific article published on 16 February 2017

Targeting the MDM2-p53 Protein-Protein Interaction for New Cancer Therapy: Progress and Challenges.

scientific article published on 7 March 2017

The making of I-BET762, a BET bromodomain inhibitor now in clinical development

scientific article published on 25 September 2013

List of works by Yu-Jun Zhao

AM-8553: A Novel MDM2 Inhibitor with a Promising Outlook for Potential Clinical Development ⬇️

Allenamide as a bioisostere of acrylamide in the design and synthesis of targeted covalent inhibitors.

Asymmetric Syntheses of 8‐Oxabicyclo[3,2,1]octanes: A Cationic Cascade Cyclization ⬇️

Discovery of a Potent and Selective NF-κB-Inducing Kinase (NIK) Inhibitor That Has Anti-inflammatory Effects in Vitro and in Vivo

Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression.

Discovery, structural insight, and bioactivities of BY27 as a selective inhibitor of the second bromodomains of BET proteins

Elucidation of Acquired Resistance to Bcl-2 and MDM2 Inhibitors in Acute Leukemia In Vitro and In Vivo.

Hepatic TRAF2 regulates glucose metabolism through enhancing glucagon responses.

Lewis Acid-Promoted Intermolecular Acetal-Initiated Cationic Polyene Cyclizations

Lewis Acids Promoted 3 + 2 Cycloaddition of Oxaziridines and Cyclic Allylic Alcohols through Carbonyl Imine Intermediates

SAR405838: an optimized inhibitor of MDM2-p53 interaction that induces complete and durable tumor regression

Small-molecule inhibitors of the MDM2-p53 protein-protein interaction (MDM2 Inhibitors) in clinical trials for cancer treatment.

Structure-Based Design of γ-Carboline Analogues as Potent and Specific BET Bromodomain Inhibitors

Structure-Based Discovery of SD-36 as a Potent, Selective, and Efficacious PROTAC Degrader of STAT3 Protein

Synthesis of 3‐Oxaterpenoids and Its Application in the Total Synthesis of (±)‐Moluccanic Acid Methyl Ester ⬇️

Targeted Degradation of BET Proteins in Triple-Negative Breast Cancer.

Targeting the MDM2-p53 Protein-Protein Interaction for New Cancer Therapy: Progress and Challenges.

The making of I-BET762, a BET bromodomain inhibitor now in clinical development