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List of works by Don Zack

A 5-bp deletion in ELOVL4 is associated with two related forms of autosomal dominant macular dystrophy

scientific article

A high content screening approach to identify molecules neuroprotective for photoreceptor cells

scientific article

A model to study differences between primary and secondary degeneration of retinal ganglion cells in rats by partial optic nerve transection.

scientific article published in August 2003

A novel methyl-binding domain protein enrichment method for identifying genome-wide tissue-specific DNA methylation from nanogram DNA samples.

scientific article published on 07 June 2013

A pineal regulatory element (PIRE) mediates transactivation by the pineal/retina-specific transcription factor CRX

scientific journal article

A rare penetrant mutation in CFH confers high risk of age-related macular degeneration.

scientific article published on 23 October 2011

A simple and scalable process for the differentiation of retinal pigment epithelium from human pluripotent stem cells.

scientific article published on 12 April 2013

A splice-site mutation in a retina-specific exon of BBS8 causes nonsyndromic retinitis pigmentosa

scientific article published on 14 May 2010

Alternative splicing and retinal degeneration

scientific article

Alternative splicing of neuroligin and its protein distribution in the outer plexiform layer of the chicken retina.

scientific article

Analysis of regulatory network topology reveals functionally distinct classes of microRNAs.

scientific article published on 15 October 2008

Angiopoietin 1 inhibits ocular neovascularization and breakdown of the blood-retinal barrier.

scientific article published in May 2004

Baicalein reduces E46K alpha-synuclein aggregation in vitro and protects cells against E46K alpha-synuclein toxicity in cell models of familiar Parkinsonism.

scientific article

Birth and death in the retina: more related than we thought?

scientific article

Characteristics of Progenitor Cells Derived from Adult Ciliary Body in Mouse, Rat, and Human Eyes

scientific article published on 01 April 2007

Common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in glaucoma

scientific article

Computational analysis of tissue-specific gene networks: application to murine retinal functional studies.

scientific article

Construction of human activity-based phosphorylation networks.

scientific article

Different effects of angiopoietin-2 in different vascular beds: new vessels are most sensitive.

scientific article published on 31 March 2005

Dynamic usage of alternative splicing exons during mouse retina development

scientific article

Dynamics of regulatory networks in the developing mouse retina.

scientific article

Epigenetics and cell death: DNA hypermethylation in programmed retinal cell death

scientific article

Evaluating the potential of poly(beta-amino ester) nanoparticles for reprogramming human fibroblasts to become induced pluripotent stem cells

scientific article

Expression and permeation properties of the K(+) channel Kir7.1 in the retinal pigment epithelium

scientific article

Expression of rod-derived cone viability factor: dual role of CRX in regulating promoter activity and cell-type specificity

scientific article (publication date: 7 October 2010)

Functional analysis of the rod photoreceptor cGMP phosphodiesterase alpha-subunit gene promoter: Nrl and Crx are required for full transcriptional activity

scientific article

Gene expression profiling of purified rat retinal ganglion cells.

scientific article published in August 2004

Gene expression variation in the adult human retina ⬇️

scientific article published on September 30, 2003

Gene therapy with brain-derived neurotrophic factor as a protection: retinal ganglion cells in a rat glaucoma model.

scientific article published in October 2003

Genome-wide association study and meta-analysis of intraocular pressure

scientific article published on 04 September 2013

Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC)

scientific article

Heritability and genome-wide association study to assess genetic differences between advanced age-related macular degeneration subtypes

scientific journal article

High-content screening data management for drug discovery in a small- to medium-size laboratory: results of a collaborative pilot study focused on user expectations as indicators of effectiveness.

scientific article

High-throughput and high-content bioassay enables tuning of polyester nanoparticles for cellular uptake, endosomal escape, and systemic in vivo delivery of mRNA

scientific article published on 05 January 2022

Human photoreceptors switch from autonomous axon extension to cell-mediated process pulling during synaptic marker redistribution

scientific article published on 01 May 2022

Identification and functional consequences of a new mutation (E155G) in the gene for GCAP1 that causes autosomal dominant cone dystrophy.

scientific article

Identification of gene expression changes associated with the progression of retinal degeneration in the rd1 mouse.

scientific article published on September 2004

Identification of novel genes preferentially expressed in the retina using a custom human retina cDNA microarray.

scientific article published in September 2003

Identification of regulatory targets of tissue-specific transcription factors: application to retina-specific gene regulation

scientific article

Identification of tissue-specific cis-regulatory modules based on interactions between transcription factors.

scientific article

In vivo micropathology of Best macular dystrophy with optical coherence tomography.

scientific article

Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration.

scientific article published on 22 January 2013

Increased expression of VEGF in retinal pigmented epithelial cells is not sufficient to cause choroidal neovascularization.

scientific article published in December 2004

Increased expression of iron-regulating genes in monkey and human glaucoma.

scientific article published in May 2004

Inducible expression of cre recombinase in the retinal pigmented epithelium.

scientific article published on March 2008

Inhibition of GCK-IV kinases dissociates cell death and axon regeneration in CNS neurons

scientific article published on 14 December 2020

Instability of immunoglobulin genes in S107 cell line.

scientific article published on May 1991

Integrative analysis of tissue-specific methylation and alternative splicing identifies conserved transcription factor binding motifs ⬇️

scientific article published on July 24, 2013

Investigating cone photoreceptor development using patient-derived NRL null retinal organoids

scientific article published on 21 February 2020

Kruppel-like factor 15, a zinc-finger transcriptional regulator, represses the rhodopsin and interphotoreceptor retinoid-binding protein promoters

scientific article

Leber congenital amaurosis caused by a homozygous mutation (R90W) in the homeodomain of the retinal transcription factor CRX: direct evidence for the involvement of CRX in the development of photoreceptor function

scientific article

MITF-M, a 'melanocyte-specific' isoform, is expressed in the adult retinal pigment epithelium

scientific article published on 6 August 2012

MicroRNA profile of the developing mouse retina.

scientific article

Modeling retinal dystrophies using patient-derived induced pluripotent stem cells.

scientific article published on January 2014

Mutation in the βA3/A1-crystallin gene impairs phagosome degradation in the retinal pigmented epithelium of the rat.

scientific article

Mutations in the cone-rod homeobox gene are associated with the cone-rod dystrophy photoreceptor degeneration

scientific article published in December 1997

Myelination transition zone astrocytes are constitutively phagocytic and have synuclein dependent reactivity in glaucoma.

scientific article

Neurotrophic signaling in normal and degenerating rodent retinas

scientific journal article

Nonredundant role of Akt2 for neuroprotection of rod photoreceptor cells from light-induced cell death

scientific journal article

Nonviral ocular gene transfer.

scientific article

Oncomodulin links inflammation to optic nerve regeneration.

scientific article published on 29 October 2009

Pigment epithelium-derived factor inhibits retinal and choroidal neovascularization

scientific article (publication date: August 2001)

Protein Phosphatase 1 binds strongly to the retinoblastoma protein but not to p107 or p130 in vitro and in vivo

scientific article

QRX, a novel homeobox gene, modulates photoreceptor gene expression

scientific article

RER, an Evolutionarily Conserved Sequence Upstream of the Rhodopsin Gene, Has Enhancer Activity

scientific article published in Journal of Biological Chemistry

Relating periodicity of nucleosome organization and gene regulation

scientific article published on 15 May 2009

Retinal ganglion cell morphology after optic nerve crush and experimental glaucoma.

scientific article

Retinal ganglion cells: development, function, and disease.

scientific article

Semi-automated, quantitative analysis of retinal ganglion cell morphology in mice selectively expressing yellow fluorescent protein.

scientific article

Sequence and expression analysis of bovine pigment epithelium-derived factor ⬇️

scientific article published on June 16, 1998

The Iron Carrier Transferrin Is Upregulated in Retinas from Patients with Age-Related Macular Degeneration

scientific article published on 01 May 2006

The NEIGHBOR consortium primary open-angle glaucoma genome-wide association study: rationale, study design, and clinical variables

scientific article

The Pex1-G844D mouse: a model for mild human Zellweger spectrum disorder

scientific article

The basic motif-leucine zipper transcription factor Nrl can positively regulate rhodopsin gene expression

scientific article

The leucine zipper of NRL interacts with the CRX homeodomain. A possible mechanism of transcriptional synergy in rhodopsin regulation

scientific article published in September 2000

The transcription factor GTF2IRD1 regulates the topology and function of photoreceptors by modulating photoreceptor gene expression across the retina.

scientific article

Therapeutic strategy for handling inherited retinal degenerations in a gene-independent manner using rod-derived cone viability factors

scientific article published on 20 February 2014

Three-Dimensional Retinal Organoids Facilitate the Investigation of Retinal Ganglion Cell Development, Organization and Neurite Outgrowth from Human Pluripotent Stem Cells

scientific article published in Scientific Reports

TiGER: a database for tissue-specific gene expression and regulation

scientific article

Transcription factor SOX9 plays a key role in the regulation of visual cycle gene expression in the retinal pigment epithelium

scientific article

Vascular tone pathway polymorphisms in relation to primary open-angle glaucoma

scientific article

Vitreous levels of pigment epithelium-derived factor and vascular endothelial growth factor: implications for ocular angiogenesis.

scientific article published in April 2004

What has gene expression profiling taught us about glaucoma?

scientific article published on 12 October 2010

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