List of works - Christopher B Little

1H NMR spectroscopy of serum reveals unique metabolic fingerprints associated with subtypes of surgically induced osteoarthritis in sheep

scientific article published on 25 July 2012

A commentary on modelling osteoarthritis pain in small animals

scientific article

A detailed microscopic examination of alterations in normal anular structure induced by mechanical destabilization in an ovine model of disc degeneration.

scientific article

A hexadecylamide derivative of hyaluronan (HYMOVIS®) has superior beneficial effects on human osteoarthritic chondrocytes and synoviocytes than unmodified hyaluronan

scientific article

A retrospective study of head fractures in 21 horses

ADAMTS-1-knockout mice do not exhibit abnormalities in aggrecan turnover in vitro or in vivo

scientific article published on 01 May 2005

ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro

scientific article

Ablation of Perlecan Domain 1 Heparan Sulfate Reduces Progressive Cartilage Degradation, Synovitis, and Osteophyte Size in a Preclinical Model of Posttraumatic Osteoarthritis.

scientific article published on 4 December 2015

Activation of cartilage matrix metalloproteinases by activated protein C.

scientific article published in March 2009

Activation of matrix metalloproteinases 2, 9, and 13 by activated protein C in human osteoarthritic cartilage chondrocytes.

scientific article published in June 2014

Advances in the understanding of tendinopathies: A report on the Second Havemeyer Workshop on equine tendon disease

article

Aggrecan, versican and type VI collagen are components of annular translamellar crossbridges in the intervertebral disc.

scientific article published on 31 October 2007

Aggrecanase versus matrix metalloproteinases in the catabolism of the interglobular domain of aggrecan in vitro.

scientific article published in November 1999

Altered stress induced by partial transection of the infraspinatus tendon leads to perlecan (HSPG2) accumulation in an ovine model of tendinopathy.

scientific article

Anti-IgD antibody attenuates collagen-induced arthritis by selectively depleting mature B-cells and promoting immune tolerance

scientific article

Are animal models useful for studying human disc disorders/degeneration?

scientific article published on 14 July 2007

Bioengineered Temporomandibular Joint Disk Implants: Study Protocol for a Two-Phase Exploratory Randomized Preclinical Pilot Trial in 18 Black Merino Sheep (TEMPOJIMS).

scientific article

Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repair

scientific article published on 17 May 2007

Calcification in the ovine intervertebral disc: a model of hydroxyapatite deposition disease.

scientific article

Can Proinflammatory Cytokine Gene Expression Explain Multifidus Muscle Fiber Changes After an Intervertebral Disc Lesion?

article

Cartilage intermediate layer protein 2 (CILP-2) is expressed in articular and meniscal cartilage and down-regulated in experimental osteoarthritis.

scientific article

Catabolism of aggrecan, decorin and biglycan in tendon.

scientific article

Chondroitin sulphate and heparan sulphate sulphation motifs and their proteoglycans are involved in articular cartilage formation during human foetal knee joint development

scientific article published on 23 May 2012

Chondroitin sulphate glycosaminoglycans contribute to widespread inferior biomechanics in tendon after focal injury

scientific article published on 6 June 2016

Comparison of gait and pathology outcomes of three meniscal procedures for induction of knee osteoarthritis in sheep.

scientific article

Considerations for the design and execution of protocols for animal research and treatment to improve reproducibility and standardization: "DEPART well-prepared and ARRIVE safely".

scientific article published on 2 November 2016

Correction: Focal Experimental Injury Leads to Widespread Gene Expression and Histologic Changes in Equine Flexor Tendons

scientific article published on March 2016

Cytokine induced metalloproteinase expression and activity does not correlate with focal susceptibility of articular cartilage to degeneration.

scientific article published on February 2005

Depletion of protease-activated receptor 2 but not protease-activated receptor 1 may confer protection against osteoarthritis in mice through extracartilaginous mechanisms.

scientific article

Detection of aggrecanase- and MMP-generated catabolic neoepitopes in the rat iodoacetate model of cartilage degeneration.

scientific article

Detection of aggregatable proteoglycan populations by affinity blotting using biotinylated hyaluronan.

scientific article published in February 1998

Differential Expression of Aggrecanase and Matrix Metalloproteinase Activity in Chondrocytes Isolated from Bovine and Porcine Articular Cartilage

scientific article published in Journal of Biological Chemistry

Drug insight: aggrecanases as therapeutic targets for osteoarthritis.

scientific article published on 24 June 2008

Dynamic biomechanics correlate with histopathology in human tibial cartilage: a preliminary study

scientific article published on 01 September 2007

Effect of Manuka honey gel on the transforming growth factor β1 and β3 concentrations, bacterial counts and histomorphology of contaminated full-thickness skin wounds in equine distal limbs

scientific article published on 01 January 2016

Effects of n-3 fatty acids on cartilage metabolism

article

Endothelial protein C receptor-associated invasiveness of rheumatoid synovial fibroblasts is likely driven by group V secretory phospholipase A2.

scientific article published on 05 February 2014

Evidence for articular cartilage regeneration in MRL/MpJ mice

scientific article published on 01 May 2008

Focal experimental injury leads to widespread gene expression and histologic changes in equine flexor tendons

scientific article published in 2015

Fragmentation of decorin, biglycan, lumican and keratocan is elevated in degenerate human meniscus, knee and hip articular cartilages compared with age-matched macroscopically normal and control tissues

scientific article published on 14 July 2008

Functionally distinct tendons have different biomechanical, biochemical and histological responses to in vitro unloading

scientific article published on 19 August 2019

Fungal granuloma in a horse

scientific article published on 01 September 1984

Histopathology atlas of animal model systems - overview of guiding principles.

scientific article published on October 2010

Identification of the skeletal progenitor cells forming osteophytes in osteoarthritis

scientific article published on 22 September 2020

Immunolocalization and distribution of proteoglycans in carious dentine

scientific article published on 5 October 2015

Immunolocalization of lymphatic vessels in human fetal knee joint tissues.

scientific article published in August 2010

Increased chondrocyte sclerostin may protect against cartilage degradation in osteoarthritis

scientific article published on 12 May 2011

Interleukin-1α induces focal degradation of biglycan and tissue degeneration in an in-vitro ovine meniscal model

scientific article published on 8 September 2016

Investigating ADAMTS-mediated aggrecanolysis in mouse cartilage.

scientific article published on 3 March 2011

Is cartilage matrix breakdown an appropriate therapeutic target in osteoarthritis--insights from studies of aggrecan and collagen proteolysis?

scientific article published on May 2010

Joint loads resulting in ACL rupture: Effects of age, sex, and body mass on injury load and mode of failure in a mouse model

scientific article published on 7 September 2016

Low molecular weight isoforms of the aggrecanases are responsible for the cytokine-induced proteolysis of aggrecan in a porcine chondrocyte culture system

scientific article published in September 2007

Macrophage polarization contributes to local inflammation and structural change in the multifidus muscle after intervertebral disc injury

scientific article published on 12 June 2018

Maintaining mRNA integrity during decalcification of mineralized tissues

scientific article

Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development.

scientific article

Matrix metalloproteinases are involved in C-terminal and interglobular domain processing of cartilage aggrecan in late stage cartilage degradation

scientific article

Matrix metalloproteinases are not essential for aggrecan turnover during normal skeletal growth and development

scientific article

Mechanical Destabilization Induced by Controlled Annular Incision of the Intervertebral Disc Dysregulates Metalloproteinase Expression and Induces Disc Degeneration

scientific article published on 01 January 2012

Mesenchymal Stem Cell Treatment of Intervertebral Disc Lesion Prevents Fatty Infiltration and Fibrosis of the Multifidus Muscle, but not Cytokine and Muscle Fiber Changes.

scientific article

Molecular cloning and sequence analysis of the aggrecan interglobular domain from porcine, equine, bovine and ovine cartilage: comparison of proteinase-susceptible regions and sites of keratan sulfate substitution.

scientific article published in March 1998

Multifidus Muscle Changes After Back Injury Are Characterized by Structural Remodeling of Muscle, Adipose and Connective Tissue, but Not Muscle Atrophy: Molecular and Morphological Evidence

scientific article published on July 2015

Mutations in TRPV4 cause an inherited arthropathy of hands and feet.

scientific article published on 2 October 2011

Neoepitope Antibodies Against MMP-Cleaved and Aggrecanase-Cleaved Aggrecan

scientific article published on 01 January 2010

OATargets: a knowledge base of genes associated with osteoarthritis joint damage in animals

scientific article published on 19 October 2020

On the predictive utility of animal models of osteoarthritis

scientific article

Pathologic indicators of degradation and inflammation in human osteoarthritic cartilage are abrogated by exposure to n-3 fatty acids.

scientific article

Perlecan, the "jack of all trades" proteoglycan of cartilaginous weight-bearing connective tissues.

scientific article published on May 2008

Products resulting from cleavage of the interglobular domain of aggrecan in samples of synovial fluid collected from dogs with early- and late-stage osteoarthritis

scientific article published on 01 October 2005

Reducing the suicide rate in the profession

scientific article published on 01 November 2010

Reduction of arthritis severity in protease-activated receptor-deficient mice.

scientific article published in April 2005

S100A8 and S100A9 in experimental osteoarthritis.

scientific article

Spatial and temporal localization of transforming growth factor-beta, fibroblast growth factor-2, and osteonectin, and identification of cells expressing alpha-smooth muscle actin in the injured anulus fibrosus: implications for extracellular matrix

scientific article published in August 2002

Stem Cell-Derived Extracellular Vesicles for Treating Joint Injury and Osteoarthritis

scientific article published on 14 February 2019

Tetanus in the horse: a review of 20 cases (1970 to 1990).

scientific article published on March 1994

The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the mouse.

scientific article published on October 2010

The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in sheep and goats ⬇️

scientific article published on October 1, 2010

The effect of strenuous versus moderate exercise on the metabolism of proteoglycans in articular cartilage from different weight-bearing regions of the equine third carpal bone ⬇️

scientific article published on May 1, 1997

The great debate: Should Osteoarthritis Research Focus on "Mice" or "Men"?

scientific article published in January 2016

The interaction of canonical bone morphogenetic protein- and Wnt-signaling pathways may play an important role in regulating cartilage degradation in osteoarthritis.

scientific article published on 6 June 2012

The ovine newborn and human foetal intervertebral disc contain perlecan and aggrecan variably substituted with native 7D4 CS sulphation motif: spatiotemporal immunolocalisation and co-distribution with Notch-1 in the human foetal disc

scientific article published on 13 June 2013

The recent paper "Multimodal imaging demonstrates concomitant changes in bone and cartilage after destabilization of the medial meniscus and increased joint laxity"

scientific article published on 01 June 2011

The relationship between synovial inflammation, structural pathology, and pain in post-traumatic osteoarthritis: differential effect of stem cell and hyaluronan treatment

scientific article published on 14 February 2020

The role of proteoglycans in the nanoindentation creep behavior of human dentin

scientific article published on 01 March 2015

Topographic variation in biglycan and decorin synthesis by articular cartilage in the early stages of osteoarthritis: an experimental study in sheep.

scientific article published in May 1996

Transcriptomics of wild-type mice and mice lacking ADAMTS-5 activity identifies genes involved in osteoarthritis initiation and cartilage destruction.

scientific article published in June 2013

Treatment of experimentally induced osteoarthritis in horses using an intravenous combination of sodium pentosan polysulfate, N-acetyl glucosamine, and sodium hyaluronan

scientific article

Using mouse models to investigate the pathophysiology, treatment, and prevention of post-traumatic osteoarthritis.

scientific article published on 17 June 2016

Utility of circulating serum miRNAs as biomarkers of early cartilage degeneration in animal models of post-traumatic osteoarthritis and inflammatory arthritis

scientific article published on 9 September 2016

Variation in proteoglycan metabolism by articular chondrocytes in different joint regions is determined by post-natal mechanical loading

scientific article published on 01 January 1997

What constitutes an “animal model of osteoarthritis” – the need for consensus? ⬇️

scientific article published on February 2, 2012

Zonal differences in meniscus matrix turnover and cytokine response.

scientific article

List of works by Christopher B Little

1H NMR spectroscopy of serum reveals unique metabolic fingerprints associated with subtypes of surgically induced osteoarthritis in sheep

A commentary on modelling osteoarthritis pain in small animals

A detailed microscopic examination of alterations in normal anular structure induced by mechanical destabilization in an ovine model of disc degeneration.

A hexadecylamide derivative of hyaluronan (HYMOVIS®) has superior beneficial effects on human osteoarthritic chondrocytes and synoviocytes than unmodified hyaluronan

A retrospective study of head fractures in 21 horses

ADAMTS-1-knockout mice do not exhibit abnormalities in aggrecan turnover in vitro or in vivo

ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro

Ablation of Perlecan Domain 1 Heparan Sulfate Reduces Progressive Cartilage Degradation, Synovitis, and Osteophyte Size in a Preclinical Model of Posttraumatic Osteoarthritis.

Activation of cartilage matrix metalloproteinases by activated protein C.

Activation of matrix metalloproteinases 2, 9, and 13 by activated protein C in human osteoarthritic cartilage chondrocytes.

Advances in the understanding of tendinopathies: A report on the Second Havemeyer Workshop on equine tendon disease

Aggrecan, versican and type VI collagen are components of annular translamellar crossbridges in the intervertebral disc.

Aggrecanase versus matrix metalloproteinases in the catabolism of the interglobular domain of aggrecan in vitro.

Altered stress induced by partial transection of the infraspinatus tendon leads to perlecan (HSPG2) accumulation in an ovine model of tendinopathy.

Anti-IgD antibody attenuates collagen-induced arthritis by selectively depleting mature B-cells and promoting immune tolerance

Are animal models useful for studying human disc disorders/degeneration?

Bioengineered Temporomandibular Joint Disk Implants: Study Protocol for a Two-Phase Exploratory Randomized Preclinical Pilot Trial in 18 Black Merino Sheep (TEMPOJIMS).

Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repair

Calcification in the ovine intervertebral disc: a model of hydroxyapatite deposition disease.

Can Proinflammatory Cytokine Gene Expression Explain Multifidus Muscle Fiber Changes After an Intervertebral Disc Lesion?

Cartilage intermediate layer protein 2 (CILP-2) is expressed in articular and meniscal cartilage and down-regulated in experimental osteoarthritis.

Catabolism of aggrecan, decorin and biglycan in tendon.

Chondroitin sulphate and heparan sulphate sulphation motifs and their proteoglycans are involved in articular cartilage formation during human foetal knee joint development

Chondroitin sulphate glycosaminoglycans contribute to widespread inferior biomechanics in tendon after focal injury

Comparison of gait and pathology outcomes of three meniscal procedures for induction of knee osteoarthritis in sheep.

Considerations for the design and execution of protocols for animal research and treatment to improve reproducibility and standardization: "DEPART well-prepared and ARRIVE safely".

Correction: Focal Experimental Injury Leads to Widespread Gene Expression and Histologic Changes in Equine Flexor Tendons

Cytokine induced metalloproteinase expression and activity does not correlate with focal susceptibility of articular cartilage to degeneration.

Depletion of protease-activated receptor 2 but not protease-activated receptor 1 may confer protection against osteoarthritis in mice through extracartilaginous mechanisms.

Detection of aggrecanase- and MMP-generated catabolic neoepitopes in the rat iodoacetate model of cartilage degeneration.

Detection of aggregatable proteoglycan populations by affinity blotting using biotinylated hyaluronan.

Differential Expression of Aggrecanase and Matrix Metalloproteinase Activity in Chondrocytes Isolated from Bovine and Porcine Articular Cartilage

Drug insight: aggrecanases as therapeutic targets for osteoarthritis.

Dynamic biomechanics correlate with histopathology in human tibial cartilage: a preliminary study

Effect of Manuka honey gel on the transforming growth factor β1 and β3 concentrations, bacterial counts and histomorphology of contaminated full-thickness skin wounds in equine distal limbs

Effects of n-3 fatty acids on cartilage metabolism

Endothelial protein C receptor-associated invasiveness of rheumatoid synovial fibroblasts is likely driven by group V secretory phospholipase A2.

Evidence for articular cartilage regeneration in MRL/MpJ mice

Focal experimental injury leads to widespread gene expression and histologic changes in equine flexor tendons

Fragmentation of decorin, biglycan, lumican and keratocan is elevated in degenerate human meniscus, knee and hip articular cartilages compared with age-matched macroscopically normal and control tissues

Functionally distinct tendons have different biomechanical, biochemical and histological responses to in vitro unloading

Fungal granuloma in a horse

Histopathology atlas of animal model systems - overview of guiding principles.

Identification of the skeletal progenitor cells forming osteophytes in osteoarthritis

Immunolocalization and distribution of proteoglycans in carious dentine

Immunolocalization of lymphatic vessels in human fetal knee joint tissues.

Increased chondrocyte sclerostin may protect against cartilage degradation in osteoarthritis

Interleukin-1α induces focal degradation of biglycan and tissue degeneration in an in-vitro ovine meniscal model

Investigating ADAMTS-mediated aggrecanolysis in mouse cartilage.

Is cartilage matrix breakdown an appropriate therapeutic target in osteoarthritis--insights from studies of aggrecan and collagen proteolysis?

Joint loads resulting in ACL rupture: Effects of age, sex, and body mass on injury load and mode of failure in a mouse model

Low molecular weight isoforms of the aggrecanases are responsible for the cytokine-induced proteolysis of aggrecan in a porcine chondrocyte culture system

Macrophage polarization contributes to local inflammation and structural change in the multifidus muscle after intervertebral disc injury

Maintaining mRNA integrity during decalcification of mineralized tissues

Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development.

Matrix metalloproteinases are involved in C-terminal and interglobular domain processing of cartilage aggrecan in late stage cartilage degradation

Matrix metalloproteinases are not essential for aggrecan turnover during normal skeletal growth and development

Mechanical Destabilization Induced by Controlled Annular Incision of the Intervertebral Disc Dysregulates Metalloproteinase Expression and Induces Disc Degeneration

Mesenchymal Stem Cell Treatment of Intervertebral Disc Lesion Prevents Fatty Infiltration and Fibrosis of the Multifidus Muscle, but not Cytokine and Muscle Fiber Changes.

Molecular cloning and sequence analysis of the aggrecan interglobular domain from porcine, equine, bovine and ovine cartilage: comparison of proteinase-susceptible regions and sites of keratan sulfate substitution.

Multifidus Muscle Changes After Back Injury Are Characterized by Structural Remodeling of Muscle, Adipose and Connective Tissue, but Not Muscle Atrophy: Molecular and Morphological Evidence

Mutations in TRPV4 cause an inherited arthropathy of hands and feet.

Neoepitope Antibodies Against MMP-Cleaved and Aggrecanase-Cleaved Aggrecan

OATargets: a knowledge base of genes associated with osteoarthritis joint damage in animals

On the predictive utility of animal models of osteoarthritis

Pathologic indicators of degradation and inflammation in human osteoarthritic cartilage are abrogated by exposure to n-3 fatty acids.

Perlecan, the "jack of all trades" proteoglycan of cartilaginous weight-bearing connective tissues.

Products resulting from cleavage of the interglobular domain of aggrecan in samples of synovial fluid collected from dogs with early- and late-stage osteoarthritis

Reducing the suicide rate in the profession

Reduction of arthritis severity in protease-activated receptor-deficient mice.

S100A8 and S100A9 in experimental osteoarthritis.

Spatial and temporal localization of transforming growth factor-beta, fibroblast growth factor-2, and osteonectin, and identification of cells expressing alpha-smooth muscle actin in the injured anulus fibrosus: implications for extracellular matrix

Stem Cell-Derived Extracellular Vesicles for Treating Joint Injury and Osteoarthritis

Tetanus in the horse: a review of 20 cases (1970 to 1990).

The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the mouse.

The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in sheep and goats ⬇️

The effect of strenuous versus moderate exercise on the metabolism of proteoglycans in articular cartilage from different weight-bearing regions of the equine third carpal bone ⬇️

The great debate: Should Osteoarthritis Research Focus on "Mice" or "Men"?

The interaction of canonical bone morphogenetic protein- and Wnt-signaling pathways may play an important role in regulating cartilage degradation in osteoarthritis.