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List of works by Frank Sobott

A broader view on ion heating in traveling-wave devices using fragmentation of CsI clusters and extent of H˙ migration as molecular thermometers ⬇️

scientific article published on 16 August 2017

A cryo-EM grid preparation device for time-resolved structural studies

scientific article published on 05 September 2019

A homologue of the Parkinson's disease-associated protein LRRK2 undergoes a monomer-dimer transition during GTP turnover ⬇️

scientific article published on 18 October 2017

A tandem mass spectrometer for improved transmission and analysis of large macromolecular assemblies.

scientific article published in March 2002

ATP and autophosphorylation driven conformational changes of HipA kinase revealed by ion mobility and crosslinking mass spectrometry. ⬇️

scientific article published on 20 June 2016

Advances in native high-performance liquid chromatography and intact mass spectrometry for the characterization of biopharmaceutical products. ⬇️

scientific article published on 9 October 2017

Analysis of the PcrA-RNA polymerase complex reveals a helicase interaction motif and a role for PcrA/UvrD helicase in the suppression of R-loops

scientific article published on 19 July 2021

Analysis of the natively unstructured RNA/protein-recognition core in the Escherichia coli RNA degradosome and its interactions with regulatory RNA/Hfq complexes ⬇️

scientific article

Analyzing complex mixtures of drug-like molecules: Ion mobility as an adjunct to existing liquid chromatography-(tandem) mass spectrometry methods ⬇️

scientific article published on 14 February 2017

Antarctic fish versus human cytoglobins - The same but yet so different ⬇️

scientific article published on 28 April 2017

Apparent activation energies of protein-protein complex dissociation in the gas-phase determined by electrospray mass spectrometry. ⬇️

scientific article published on 12 September 2017

Application of a proteolysis/mass spectrometry method for investigating the effects of inhibitors on hydroxylase structure.

scientific article

AtaT blocks translation initiation by N-acetylation of the initiator tRNAfMet ⬇️

scientific article published on 3 April 2017

Biochemical and structural studies of the interaction of Cdc37 with Hsp90.

scientific article published in July 2004

Biophysical studies on interactions and assembly of full-size E3 ubiquitin ligase: suppressor of cytokine signaling 2 (SOCS2)-elongin BC-cullin 5-ring box protein 2 (RBX2).

scientific article published on 11 December 2014

Bouncing off the Walls: Excited Protein Complexes Tell Their Story

scientific article published in May 2015

Cation Selectivity of Natural and Synthetic Ionophores Probed with Laser-Induced Liquid Beam Mass Spectrometry ⬇️

scientific article published on September 1, 1997

Characterising electrosprayed biomolecules using tandem-MS—the noncovalent GroEL chaperonin assembly

Characterization of Vibrio cholerae Hfq provides novel insights into the role of the Hfq C-terminal region

scientific article published on 3 April 2012

Characterization of top-down ETD in a travelling-wave ion guide

scientific article published on 23 May 2015

Characterization of β2-microglobulin conformational intermediates associated to different fibrillation conditions

article published in 2011

Codon optimization can improve expression of human genes in Escherichia coli: A multi-gene study.

scientific article published on 26 January 2008

Combining density functional theory (DFT) and collision cross-section (CCS) calculations to analyze the gas-phase behaviour of small molecules and their protonation site isomers ⬇️

scientific article

Compaction properties of an intrinsically disordered protein: Sic1 and its kinase-inhibitor domain

scientific article published in May 2011

Comparison of CID versus ETD based MS/MS fragmentation for the analysis of protein ubiquitination.

scientific article published on 18 May 2009

Conformational Space and Stability of ETD Charge Reduction Products of Ubiquitin ⬇️

scientific article published on 5 August 2016

Conformational footprinting of proteins using a combination of top-down electron transfer dissociation and ion mobility

article

Contactin-associated protein-2 antibodies in non-paraneoplastic cerebellar ataxia

scientific article published on 15 February 2012

Covalent adducts of melphalan with free amino acids and a model peptide studied by liquid chromatography/tandem mass spectrometry

scientific article published in March 2016

Development of a novel antibody-tetrazine conjugate for bioorthogonal pretargeting

scientific article published on 19 July 2016

Differences in the Elemental Isotope Definition May Lead to Errors in Modern Mass-Spectrometry-Based Proteomics

scientific article published on 22 October 2015

Do Aptamers Always Bind? The Need for a Multifaceted Analytical Approach When Demonstrating Binding Affinity between Aptamer and Low Molecular Weight Compounds

scientific article published on 09 November 2020

ETD allows for native surface mapping of a 150 kDa noncovalent complex on a commercial Q-TWIMS-TOF instrument

scientific article published on 10 January 2014

Editorial and Review: 30th ASMS Sanibel Conference on Mass Spectrometry-Computational Modelling in Mass Spectrometry and Ion Mobility: Methods for Ion Structure and Reactivity Determination ⬇️

article

Effects of Detergent on α-Synuclein Structure. A Native MS-Ion Mobility Study

scientific article published on 23 October 2020

Electron transfer dissociation provides higher-order structural information of native and partially unfolded protein complexes

scientific article published on 22 July 2015

Estimation of Rates of Reactions Triggered by Electron Transfer in Top-Down Mass Spectrometry ⬇️

scientific article

Estimation of Rates of Reactions Triggered by Electron Transfer in Top-Down Mass Spectrometry

scientific article published in 2017

Evaluation of ion mobility for the separation of glycoconjugate isomers due to different types of sialic acid linkage, at the intact glycoprotein, glycopeptide and glycan level ⬇️

scientific article

Examination of Condensation Products of Group 4 Alkoxides with Laser-Induced Liquid Beam Ionization/Desorption Mass Spectrometry

Extending native mass spectrometry approaches to integral membrane proteins

scientific article published on September 2015

Extensive Charge Reduction and Dissociation of Intact Protein Complexes Following Electron Transfer on a Quadrupole-Ion Mobility-Time-of-Flight MS.

scientific article published on 11 April 2015

Fixed-Charge Trimethyl Pyrilium Modification for Enabling Enhanced Top-Down Mass Spectrometry Sequencing of Intact Protein Complexes. ⬇️

scientific article published on 23 January 2018

Gas-phase dissociation pathways of a tetrameric protein complex

scientific article published in December 2003

Gas-phase microsolvation of ubiquitin: investigation of crown ether complexation sites using ion mobility-mass spectrometry ⬇️

scientific article published on 5 August 2016

Global structural changes of an ion channel during its gating are followed by ion mobility mass spectrometry

scientific article published on 17 November 2014

Heptameric (L12)6/L10 rather than canonical pentameric complexes are found by tandem MS of intact ribosomes from thermophilic bacteria.

scientific article published on 27 May 2005

Hfq binding changes the structure of Escherichia coli small noncoding RNAs OxyS and RprA, which are involved in the riboregulation of rpoS

scientific article published in August 2013

Hidden States within Disordered Regions of the CcdA Antitoxin Protein ⬇️

scientific article published on 26 January 2017

High-Resolution Hydrogen–Deuterium Protection Factors from Sparse Mass Spectrometry Data Validated by Nuclear Magnetic Resonance Measurements

scientific article published in 2022

Interlaboratory Study for Characterizing Monoclonal Antibodies by Top-Down and Middle-Down Mass Spectrometry

scientific article published on 19 August 2020

Ion mobility mass spectrometry for extracting spectra of N-glycans directly from incubation mixtures following glycan release: application to glycans from engineered glycoforms of intact, folded HIV gp120.

scientific article published on 8 February 2011

Ionic clathrates from aqueous solutions detected with laser induced liquid beam ionization/desorption mass spectrometry

scientific article published in April 1999

Laser desorption mass spectrometry on thin liquid jets

scientific article published on 2 April 1998

Lipids modulate the conformational dynamics of a secondary multidrug transporter ⬇️

scientific article published on 11 July 2016

LptA assembles into rod-like oligomers involving disorder-to-order transitions

scientific article published on 30 July 2013

Mechanisms of Peptide Oxidation by Hydroxyl Radicals: Insight at the Molecular Scale ⬇️

Metal and redox selectivity of protoporphyrin binding to the heme chaperone CcmE.

scientific article published on 31 January 2011

Methionine oxidation in α-synuclein inhibits its propensity for ordered secondary structure

scientific article published on 12 February 2019

Molecular basis for structural heterogeneity of an intrinsically disordered protein bound to a partner by combined ESI-IM-MS and modeling

scientific article published on 16 December 2014

Nanobody-aided crystallization of the transcription regulator PaaR2 from <i>Escherichia coli</i> O157:H7

scientific article published in 2021

Native Mass Spectrometry for the Characterization of Structure and Interactions of Membrane Proteins

scientific article published in January 2017

Native ion mobility-mass spectrometry and related methods in structural biology

scientific article published on 14 December 2012

Opposite Structural Effects of Epigallocatechin-3-gallate and Dopamine Binding to α-Synuclein ⬇️

scientific article published on 28 July 2016

Organization of the BcgI restriction-modification protein for the cleavage of eight phosphodiester bonds in DNA.

scientific article published on 11 November 2012

Organization of the BcgI restriction-modification protein for the transfer of one methyl group to DNA.

scientific article published on 11 November 2012

Phase Separation of C9orf72 Dipeptide Repeats Perturbs Stress Granule Dynamics ⬇️

scientific article published on March 2017

Phosphorylation decelerates conformational dynamics in bacterial translation elongation factors. ⬇️

scientific article published on 14 March 2018

Preprotein mature domains contain translocase targeting signals that are essential for secretion ⬇️

scientific article published on 12 April 2017

Protein complexes gain momentum.

scientific article published in December 2002

Protomers of benzocaine: solvent and permittivity dependence

scientific article published on 17 March 2015

Proton Dynamics in Protein Mass Spectrometry. ⬇️

scientific article published on 16 February 2017

Quadrupole-time-of-flight mass spectrometer modified for higher-energy dissociation reduces protein assemblies to peptide fragments.

scientific article published in February 2009

Radical solutions: Principles and application of electron-based dissociation in mass spectrometry-based analysis of protein structure ⬇️

scientific article published on 9 February 2018

Raman optical activity of human α -synuclein in intrinsically disordered, micelle-bound α -helical, molten globule and oligomeric β -sheet state ⬇️

article by Carl Mensch et al published 17 April 2017 in Journal of Raman Spectroscopy

Reactions of gold cluster cations Aun+ (n=1–12) with H2S and H2

scientific article published in May 2003

Sample deposition onto cryo-EM grids: from sprays to jets and back

scientific article published on 25 March 2020

Signal loss due to oligomerization in ELISA analysis of amyloid-beta can be recovered by a novel sample pre-treatment method

scientific article published on 27 February 2015

Sizing up DNA nanostructure assembly with native mass spectrometry and ion mobility

scientific article published in 2022

Speciation in Solution: Silicate Oligomers in Aqueous Solutions Detected by Mass Spectrometry

scientific article published on 01 November 2000

Specific and non-specific interactions of ParB with DNA: implications for chromosome segregation

scientific article published on 8 January 2015

Specific sequences in the N-terminal domain of human small heat-shock protein HSPB6 dictate preferential hetero-oligomerization with the orthologue HSPB1. ⬇️

scientific article

Structural and Functional Characterization of the Human Protein Kinase ASK1

scientific article

Structural basis for protein-protein interactions in the 14-3-3 protein family

scholarly article

Structural plasticity of histones H3-H4 facilitates their allosteric exchange between RbAp48 and ASF1

scientific article

Structure of an Hsp90-Cdc37-Cdk4 complex.

scientific article published in September 2006

Structure of the human protein kinase MPSK1 reveals an atypical activation loop architecture

scientific article published in January 2008

Studying noncovalent protein complexes in aqueous solution with laser desorption mass spectrometry

scientific article published in December 2000

Subunit Exchange of Multimeric Protein Complexes

scientific article published in Journal of Biological Chemistry

Tandem Mass Spectrometry Reveals the Quaternary Organization of Macromolecular Assemblies

scientific article published in June 2006

Tandem mass spectrometry defines the stoichiometry and quaternary structural arrangement of tryptophan molecules in the multiprotein complex TRAP.

scientific article published in May 2004

The Escherichia coli RnlA-RnlB toxin-antitoxin complex: production, characterization and crystallization

scientific article published on 01 January 2020

The centaurin gamma-1 GTPase-like domain functions as an NTPase

scientific article published in February 2007

The co-chaperone p23 arrests the Hsp90 ATPase cycle to trap client proteins

scientific article published on 15 December 2005

The effect of reactive oxygen and nitrogen species on the structure of cytoglobin: A potential tumor suppressor ⬇️

scientific article published on 24 July 2018

The flight of macromolecular complexes in a mass spectrometer

scientific article published in February 2005

The intrinsically disordered domain of the antitoxin Phd chaperones the toxin Doc against irreversible inactivation and misfolding.

scientific article published on 16 October 2014

The low-resolution solution structure of Vibrio cholerae Hfq in complex with Qrr1 sRNA

scientific article published on 22 June 2012

The preferential heterodimerization of human small heat shock proteins HSPB1 and HSPB6 is dictated by the N-terminal domain ⬇️

scientific article published on 4 October 2016

The structural basis for dynamic DNA binding and bridging interactions which condense the bacterial centromere ⬇️

scientific article published on 15 December 2017

Thermal Dissociation of Multimeric Protein Complexes by Using Nanoelectrospray Mass Spectrometry

scientific article published in May 2003

Top-down mass spectrometry of intact membrane protein complexes reveals oligomeric state and sequence information in a single experiment.

scientific article published on 29 May 2015

Travelling wave ion mobility and negative ion fragmentation for the structural determination of N-linked glycans

scientific article published on 22 July 2013

Type III restriction endonucleases are heterotrimeric: comprising one helicase-nuclease subunit and a dimeric methyltransferase that binds only one specific DNA.

scientific article published on 7 February 2014

Understanding reaction pathways in top-down ETD by dissecting isotope distributions: A mammoth task

scientific article published in November 2015

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