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List of works by Isabella Derler

2-aminoethoxydiphenyl borate alters selectivity of Orai3 channels by increasing their pore size.

scientific article

A Cytosolic Homomerization and a Modulatory Domain within STIM1 C Terminus Determine Coupling to ORAI1 Channels

scientific article published on 03 February 2009

A calcium-accumulating region, CAR, in the channel Orai1 enhances Ca(2+) permeation and SOCE-induced gene transcription

scientific article published on 22 December 2015

A novel STIM1-Orai1 gating interface essential for CRAC channel activation

scientific article published on 23 February 2019

Authentic CRAC channel activity requires STIM1 and the conserved portion of the Orai N-terminus.

scientific article published on 13 December 2017

CRAC inhibitors: identification and potential

scientific article published on 01 July 2008

Cholesterol modulates Orai1 channel function

scientific article published on 26 January 2016

Communication between N-terminus and Loop2 tunes Orai activation.

scientific article published on 13 December 2017

Cooperativeness of Orai cytosolic domains tunes subtype-specific gating.

scientific article

Critical parameters maintaining authentic CRAC channel hallmarks

scientific article published on 21 March 2019

Dynamic but not constitutive association of calmodulin with rat TRPV6 channels enables fine tuning of Ca2+-dependent inactivation.

scientific article published on 7 September 2006

Dynamic coupling of the putative coiled-coil domain of ORAI1 with STIM1 mediates ORAI1 channel activation.

scientific article published on 10 January 2008

Gating and permeation of Orai channels.

scientific article published on January 2012

Inactivation-mimicking block of the epithelial calcium channel TRPV6

scientific article published on 27 November 2020

Increased hydrophobicity at the N terminus/membrane interface impairs gating of the severe combined immunodeficiency-related ORAI1 mutant

scientific article published on 14 April 2009

Molecular Determinants within N Terminus of Orai3 Protein That Control Channel Activation and Gating ⬇️

scientific article published on September 9, 2011

Molecular determinants of the coupling between STIM1 and Orai channels: differential activation of Orai1-3 channels by a STIM1 coiled-coil mutant

scientific article published on 08 June 2009

Molecular mechanisms of STIM/Orai communication.

scientific article published on 28 January 2016

Novel pyrazole compounds for pharmacological discrimination between receptor-operated and store-operated Ca(2+) entry pathways

scientific article

Plasticity in Ca2+ selectivity of Orai1/Orai3 heteromeric channel.

scientific article

Rapid NMR-scale purification of 15N,13C isotope-labeled recombinant human STIM1 coiled coil fragments.

scientific article published in February 2018

Recent progress on STIM1 domains controlling Orai activation.

scientific article published on 04 September 2009

Resting state Orai1 diffuses as homotetramer in the plasma membrane of live mammalian cells

scientific article

Sequential activation of STIM1 links Ca2+ with luminal domain unfolding

scientific article published on 19 November 2019

Structure, regulation and biophysics of I(CRAC), STIM/Orai1.

scientific article published on January 2012

TRPC3 and TRPC4 associate to form a redox-sensitive cation channel. Evidence for expression of native TRPC3-TRPC4 heteromeric channels in endothelial cells.

scientific article published on 13 March 2006

The STIM-Orai Pathway: The Interactions Between STIM and Orai.

scientific article published in January 2017

The STIM/Orai coupling machinery.

scientific article published on 21 July 2008

The STIM1/Orai signaling machinery

scientific article

The action of selective CRAC channel blockers is affected by the Orai pore geometry ⬇️

scientific article published on December 5, 2012

The first ankyrin-like repeat is the minimum indispensable key structure for functional assembly of homo- and heteromeric TRPC4/TRPC5 channels.

scientific article

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