List of works - Malin E. V. Johansson

AGR2, an endoplasmic reticulum protein, is secreted into the gastrointestinal mucus

scientific article (publication date: 2014)

Altered O-glycosylation profile of MUC2 mucin occurs in active ulcerative colitis and is associated with increased inflammation.

scientific article

Altered innate defenses in the neonatal gastrointestinal tract in response to colonization by neuropathogenic Escherichia coli.

scientific article

Altered mucus glycosylation in core 1 O-glycan-deficient mice affects microbiota composition and intestinal architecture.

scientific article published on 09 January 2014

An autocatalytic cleavage in the C terminus of the human MUC2 mucin occurs at the low pH of the late secretory pathway.

scientific article published on 11 February 2003

An ex vivo method for studying mucus formation, properties, and thickness in human colonic biopsies and mouse small and large intestinal explants.

scientific article

An intercrypt subpopulation of goblet cells is essential for colonic mucus barrier function

scientific article

Analysis of Assembly of Secreted Mucins

article

Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis

scientific article published on 20 February 2013

Bicarbonate and functional CFTR channel are required for proper mucin secretion and link cystic fibrosis with its mucus phenotype.

scientific article

Blood group A glycosyltransferase occurring as alleles with high sequence difference is transiently induced during a Nippostrongylus brasiliensis parasite infection

scientific journal article

Calcium-activated Chloride Channel Regulator 1 (CLCA1) Controls Mucus Expansion in Colon by Proteolytic Activity

scientific article published on 07 June 2018

Calcium-activated chloride channel regulator 1 (CLCA1) forms non-covalent oligomers in colonic mucus and has mucin 2-processing properties

scientific article published on 29 September 2019

Detailed O-glycomics of the Muc2 mucin from colon of wild-type, core 1- and core 3-transferase-deficient mice highlights differences compared with human MUC2.

scientific article

Fast Renewal of the Distal Colonic Mucus Layers by the Surface Goblet Cells as Measured by In Vivo Labeling of Mucin Glycoproteins ⬇️

scientific article published on July 17, 2012

Gram-positive bacteria are held at a distance in the colon mucus by the lectin-like protein ZG16

scientific article

Helicobacter pylori infection impairs the mucin production rate and turnover in the murine gastric mucosa.

scientific article published on 28 December 2012

Increased levels of mucins in the cystic fibrosis mouse small intestine, and modulator effects of the Muc1 mucin expression.

scientific article published on 23 February 2006

Interleukin 4 induces rapid mucin transport, increases mucus thickness and quality and decreases colitis and Citrobacter rodentium in contact with epithelial cells

scientific article published on 01 December 2019

Is the intestinal goblet cell a major immune cell?

scientific article published on March 2014

Keeping Bacteria at a Distance

scientific article published in Science

Lactobacillus and Bifidobacterium species do not secrete protease that cleaves the MUC2 mucin which organises the colon mucus.

scientific article

Molecular characterization of the large heavily glycosylated domain glycopeptide from the rat small intestinal Muc2 mucin.

scientific article published on October 1996

Mucus and the goblet cell

scientific article

New developments in goblet cell mucus secretion and function

scientific article

Novel MUC1 splice variants contribute to mucin overexpression in CFTR-deficient mice

scientific article published on 15 January 2003

Perspectives on mucus properties and formation--lessons from the biochemical world

scientific article published on November 2012

Postnatal development of the small intestinal mucosa drives age-dependent, regio-selective susceptibility to Escherichia coli K1 infection

scientific article

Preservation of Mucus in Histological Sections, Immunostaining of Mucins in Fixed Tissue, and Localization of Bacteria with FISH

scientific article published on 01 January 2012

Proteomic analyses of the two mucus layers of the colon barrier reveal that their main component, the Muc2 mucin, is strongly bound to the Fcgbp protein

scientific article

Site-specific O-glycosylation on the MUC2 mucin protein inhibits cleavage by the Porphyromonas gingivalis secreted cysteine protease (RgpB).

scientific article published on April 2013

Slc26a3 deficiency is associated with loss of colonic HCO3 (-) secretion, absence of a firm mucus layer and barrier impairment in mice.

scientific article published on 31 January 2014

Spontaneous colitis in Muc2-deficient mice reflects clinical and cellular features of active ulcerative colitis

scientific article

Studies of mucus in mouse stomach, small intestine, and colon. II. Gastrointestinal mucus proteome reveals Muc2 and Muc5ac accompanied by a set of core proteins

scientific article published on 05 July 2013

Study of mucin turnover in the small intestine by in vivo labeling.

scientific article

The Glycosylation of Rat Intestinal Muc2 Mucin Varies between Rat Strains and the Small and Large Intestine

scientific article published in Journal of Biological Chemistry

The Goblet Cell Protein Clca1 (Alias mClca3 or Gob-5) Is Not Required for Intestinal Mucus Synthesis, Structure and Barrier Function in Naive or DSS-Challenged Mice

scientific article published on 10 July 2015

The N terminus of the MUC2 mucin forms trimers that are held together within a trypsin-resistant core fragment.

scientific article

The Nlrp6 inflammasome is not required for baseline colonic inner mucus layer formation or function

scientific article published on 16 August 2019

The central exons of the human MUC2 and MUC6 mucins are highly repetitive and variable in sequence between individuals

scientific article published in Scientific Reports

The composition of the gut microbiota shapes the colon mucus barrier.

scientific article

The gastrointestinal mucus system in health and disease

scientific article

The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria

scientific journal article

The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system

scientific article

The recombinant C-terminus of the human MUC2 mucin forms dimers in Chinese-hamster ovary cells and heterodimers with full-length MUC2 in LS 174T cells.

scientific article published on June 2003

List of works by Malin E. V. Johansson

AGR2, an endoplasmic reticulum protein, is secreted into the gastrointestinal mucus

Altered O-glycosylation profile of MUC2 mucin occurs in active ulcerative colitis and is associated with increased inflammation.

Altered innate defenses in the neonatal gastrointestinal tract in response to colonization by neuropathogenic Escherichia coli.

Altered mucus glycosylation in core 1 O-glycan-deficient mice affects microbiota composition and intestinal architecture.

An autocatalytic cleavage in the C terminus of the human MUC2 mucin occurs at the low pH of the late secretory pathway.

An ex vivo method for studying mucus formation, properties, and thickness in human colonic biopsies and mouse small and large intestinal explants.

An intercrypt subpopulation of goblet cells is essential for colonic mucus barrier function

Analysis of Assembly of Secreted Mucins

Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis

Bicarbonate and functional CFTR channel are required for proper mucin secretion and link cystic fibrosis with its mucus phenotype.

Blood group A glycosyltransferase occurring as alleles with high sequence difference is transiently induced during a Nippostrongylus brasiliensis parasite infection

Calcium-activated Chloride Channel Regulator 1 (CLCA1) Controls Mucus Expansion in Colon by Proteolytic Activity

Calcium-activated chloride channel regulator 1 (CLCA1) forms non-covalent oligomers in colonic mucus and has mucin 2-processing properties

Detailed O-glycomics of the Muc2 mucin from colon of wild-type, core 1- and core 3-transferase-deficient mice highlights differences compared with human MUC2.

Fast Renewal of the Distal Colonic Mucus Layers by the Surface Goblet Cells as Measured by In Vivo Labeling of Mucin Glycoproteins ⬇️

Gram-positive bacteria are held at a distance in the colon mucus by the lectin-like protein ZG16

Helicobacter pylori infection impairs the mucin production rate and turnover in the murine gastric mucosa.

Increased levels of mucins in the cystic fibrosis mouse small intestine, and modulator effects of the Muc1 mucin expression.

Interleukin 4 induces rapid mucin transport, increases mucus thickness and quality and decreases colitis and Citrobacter rodentium in contact with epithelial cells

Is the intestinal goblet cell a major immune cell?

Keeping Bacteria at a Distance

Lactobacillus and Bifidobacterium species do not secrete protease that cleaves the MUC2 mucin which organises the colon mucus.

Molecular characterization of the large heavily glycosylated domain glycopeptide from the rat small intestinal Muc2 mucin.

Mucus and the goblet cell

New developments in goblet cell mucus secretion and function

Novel MUC1 splice variants contribute to mucin overexpression in CFTR-deficient mice

Perspectives on mucus properties and formation--lessons from the biochemical world

Postnatal development of the small intestinal mucosa drives age-dependent, regio-selective susceptibility to Escherichia coli K1 infection

Preservation of Mucus in Histological Sections, Immunostaining of Mucins in Fixed Tissue, and Localization of Bacteria with FISH

Proteomic analyses of the two mucus layers of the colon barrier reveal that their main component, the Muc2 mucin, is strongly bound to the Fcgbp protein

Site-specific O-glycosylation on the MUC2 mucin protein inhibits cleavage by the Porphyromonas gingivalis secreted cysteine protease (RgpB).

Slc26a3 deficiency is associated with loss of colonic HCO3 (-) secretion, absence of a firm mucus layer and barrier impairment in mice.

Spontaneous colitis in Muc2-deficient mice reflects clinical and cellular features of active ulcerative colitis

Studies of mucus in mouse stomach, small intestine, and colon. II. Gastrointestinal mucus proteome reveals Muc2 and Muc5ac accompanied by a set of core proteins

Study of mucin turnover in the small intestine by in vivo labeling.

The Glycosylation of Rat Intestinal Muc2 Mucin Varies between Rat Strains and the Small and Large Intestine

The Goblet Cell Protein Clca1 (Alias mClca3 or Gob-5) Is Not Required for Intestinal Mucus Synthesis, Structure and Barrier Function in Naive or DSS-Challenged Mice

The N terminus of the MUC2 mucin forms trimers that are held together within a trypsin-resistant core fragment.

The Nlrp6 inflammasome is not required for baseline colonic inner mucus layer formation or function

The central exons of the human MUC2 and MUC6 mucins are highly repetitive and variable in sequence between individuals

The composition of the gut microbiota shapes the colon mucus barrier.

The gastrointestinal mucus system in health and disease

The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria

The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system

The recombinant C-terminus of the human MUC2 mucin forms dimers in Chinese-hamster ovary cells and heterodimers with full-length MUC2 in LS 174T cells.