List of works - Linda S Wicker

A rareIL2RAhaplotype identifies SNP rs61839660 as causal for autoimmunity

A type I interferon transcriptional signature precedes autoimmunity in children genetically at risk for type 1 diabetes.

scientific article

Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

scientific article (publication date: 29 May 2003)

B cells promote hepatic inflammation, biliary cyst formation, and salivary gland inflammation in the NOD.c3c4 model of autoimmune cholangitis

scientific article

CD8 T Cells Mediate Direct Biliary Ductule Damage in Nonobese Diabetic Autoimmune Biliary Disease ⬇️

scientific article published on December 17, 2010

Capturing the systemic immune signature of a norovirus infection: an n-of-1 case study within a clinical trial.

scientific article published on 18 July 2017

Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource

scientific article published on 23 August 2009

Cells with Treg-specific FOXP3 demethylation but low CD25 are prevalent in autoimmunity

scientific article published on 23 July 2017

Chromosome contacts in activated T cells identify autoimmune disease candidate genes

scientific article published on 4 September 2017

Construction and analysis of tag single nucleotide polymorphism maps for six human-mouse orthologous candidate genes in type 1 diabetes

scientific article

Development of an integrated genome informatics, data management and workflow infrastructure: a toolbox for the study of complex disease genetics

scientific article

Discovery, linkage disequilibrium and association analyses of polymorphisms of the immune complement inhibitor, decay-accelerating factor gene (DAF/CD55) in type 1 diabetes

scientific article published on 20 April 2006

Dissection of a Complex Disease Susceptibility Region Using a Bayesian Stochastic Search Approach to Fine Mapping

scientific article

Epigenetic analysis of regulatory T cells using multiplex bisulfite sequencing.

scientific article published on 7 September 2015

Evidence that Cd101 is an autoimmune diabetes gene in nonobese diabetic mice

scientific journal article

Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes

scientific article published on 14 June 2021

Gene-gene interactions in the NOD mouse model of type 1 diabetes.

scientific article published on January 2008

Genetic and functional data identifying Cd101 as a type 1 diabetes (T1D) susceptibility gene in nonobese diabetic (NOD) mice.

scientific article

IL-21 production by CD4+ effector T cells and frequency of circulating follicular helper T cells are increased in type 1 diabetes patients

scientific article

IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production

scientific article

Interleukin-2 Therapy of Autoimmunity in Diabetes (ITAD): a phase 2, multicentre, double-blind, randomized, placebo-controlled trial

scientific article published on 20 March 2020

Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes.

scientific article

Neonatal and adult recent thymic emigrants produce IL-8 and express complement receptors CR1 and CR2.

scientific article published on 17 August 2017

Postthymic expansion in human CD4 naive T cells defined by expression of functional high-affinity IL-2 receptors

scientific article published on 15 February 2013

Rationale and study design of the Adaptive study of IL-2 dose on regulatory T cells in type 1 diabetes (DILT1D): a non-randomised, open label, adaptive dose finding trial

scientific article

Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial

scientific article

Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

scientific article

Stochastic search and joint fine-mapping increases accuracy and identifies previously unreported associations in immune-mediated diseases

scientific article published on 19 July 2019

T1DBase, a community web-based resource for type 1 diabetes research

scientific article

T1DBase: integration and presentation of complex data for type 1 diabetes research

scientific article

Targeting regulatory T cells with Interleukin-2 treatment in type 1 diabetes: a response-adaptive, non-randomised, open-label trial of repeat doses of Aldesleukin (DILfrequency)

List of works by Linda S Wicker

A rareIL2RAhaplotype identifies SNP rs61839660 as causal for autoimmunity

A type I interferon transcriptional signature precedes autoimmunity in children genetically at risk for type 1 diabetes.

Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

B cells promote hepatic inflammation, biliary cyst formation, and salivary gland inflammation in the NOD.c3c4 model of autoimmune cholangitis

CD8 T Cells Mediate Direct Biliary Ductule Damage in Nonobese Diabetic Autoimmune Biliary Disease ⬇️

Capturing the systemic immune signature of a norovirus infection: an n-of-1 case study within a clinical trial.

Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource

Cells with Treg-specific FOXP3 demethylation but low CD25 are prevalent in autoimmunity

Chromosome contacts in activated T cells identify autoimmune disease candidate genes

Construction and analysis of tag single nucleotide polymorphism maps for six human-mouse orthologous candidate genes in type 1 diabetes

Development of an integrated genome informatics, data management and workflow infrastructure: a toolbox for the study of complex disease genetics

Discovery, linkage disequilibrium and association analyses of polymorphisms of the immune complement inhibitor, decay-accelerating factor gene (DAF/CD55) in type 1 diabetes

Dissection of a Complex Disease Susceptibility Region Using a Bayesian Stochastic Search Approach to Fine Mapping

Epigenetic analysis of regulatory T cells using multiplex bisulfite sequencing.

Evidence that Cd101 is an autoimmune diabetes gene in nonobese diabetic mice

Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes

Gene-gene interactions in the NOD mouse model of type 1 diabetes.

Genetic and functional data identifying Cd101 as a type 1 diabetes (T1D) susceptibility gene in nonobese diabetic (NOD) mice.

IL-21 production by CD4+ effector T cells and frequency of circulating follicular helper T cells are increased in type 1 diabetes patients

IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production

Interleukin-2 Therapy of Autoimmunity in Diabetes (ITAD): a phase 2, multicentre, double-blind, randomized, placebo-controlled trial

Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes.

Neonatal and adult recent thymic emigrants produce IL-8 and express complement receptors CR1 and CR2.

Postthymic expansion in human CD4 naive T cells defined by expression of functional high-affinity IL-2 receptors

Rationale and study design of the Adaptive study of IL-2 dose on regulatory T cells in type 1 diabetes (DILT1D): a non-randomised, open label, adaptive dose finding trial

Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial

Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

Stochastic search and joint fine-mapping increases accuracy and identifies previously unreported associations in immune-mediated diseases

T1DBase, a community web-based resource for type 1 diabetes research

T1DBase: integration and presentation of complex data for type 1 diabetes research

Targeting regulatory T cells with Interleukin-2 treatment in type 1 diabetes: a response-adaptive, non-randomised, open-label trial of repeat doses of Aldesleukin (DILfrequency)