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List of works by Evy Lobbestael

Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers

scientific article

Chemical genetic approach identifies microtubule affinity-regulating kinase 1 as a leucine-rich repeat kinase 2 substrate.

scientific article published on 8 April 2015

Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways

scientific article

Divergent Effects of G2019S and R1441C LRRK2 Mutations on LRRK2 and Rab10 Phosphorylations in Mouse Tissues

scientific article published on 22 October 2020

Editorial: Protein Degradation Pathways in Parkinson's Disease and Neurodegeneration

scientific article published on 28 July 2020

Editorial: The Role of Lipids in the Pathogenesis of Parkinson's Disease

scientific article published on 24 March 2020

Expression, purification and preliminary biochemical and structural characterization of the leucine rich repeat namesake domain of leucine rich repeat kinase 2.

scientific article

Identification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycle

scientific article

Immunohistochemical detection of transgene expression in the brain using small epitope tags

scientific article

In silico, in vitro and cellular analysis with a kinome-wide inhibitor panel correlates cellular LRRK2 dephosphorylation to inhibitor activity on LRRK2.

scientific article published on 3 June 2014

Inflammatory bowel disease and Parkinson's disease: common pathophysiological links

scientific article published on 16 October 2020

Inhibition of LRRK2 or Casein Kinase 1 Results in LRRK2 Protein Destabilization

scientific article published on 27 December 2018

Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant

scientific article

Kinase inhibition of G2019S-LRRK2 enhances autolysosome formation and function to reduce endogenous alpha-synuclein intracellular inclusions

scientific article published on 08 June 2020

Kinases as targets for Parkinson's disease: from genetics to therapy

scientific article published on September 2011

LRRK2 Ablation Attenuates Αlpha-Synuclein-Induced Neuroinflammation Without Affecting Neurodegeneration or Neuropathology In Vivo

scientific article published on 16 February 2021

LRRK2 Phosphorylation: Behind the Scenes

scientific article published in January 2018

LRRK2 kinase activity is dependent on LRRK2 GTP binding capacity but independent of LRRK2 GTP binding

scientific article

Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain

scientific article

Long-term overexpression of human wild-type and T240R mutant Parkin in rat substantia nigra induces progressive dopaminergic neurodegeneration

scientific article published on February 2014

MicroRNA-205 regulates the expression of Parkinson's disease-related leucine-rich repeat kinase 2 protein.

scientific article published on 2 November 2012

Multiple-Hit Hypothesis in Parkinson's Disease: LRRK2 and Inflammation

scientific article published on 28 April 2020

PAK6 Phosphorylates 14-3-3γ to Regulate Steady State Phosphorylation of LRRK2.

scientific article published on 14 December 2017

Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation

scientific article

Pathogenic LRRK2 requires secondary factors to induce cellular toxicity

scientific article published on 25 September 2020

Pharmacological LRRK2 kinase inhibition induces LRRK2 protein destabilization and proteasomal degradation

scientific article published on 23 September 2016

Phosphorylation of LRRK2: from kinase to substrate

scientific article published on October 2012

Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis

scientific article

RAB7L1-Mediated Relocalization of LRRK2 to the Golgi Complex Causes Centrosomal Deficits via RAB8A

scientific article published on 13 November 2018

RAB8, RAB10 and RILPL1 contribute to both LRRK2 kinase-mediated centrosomal cohesion and ciliogenesis deficits

scientific article published on 01 November 2019

Rab32 interacts with SNX6 and affects retromer-dependent Golgi trafficking

scientific article published in PLoS ONE

Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease

scientific article

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