List of works - Andrés Francesch

Aplicyanins A–F, new cytotoxic bromoindole derivatives from the marine tunicate Aplidium cyaneum

Cytotoxic staurosporines from the marine ascidian Cystodytes solitus

scientific article

Dearomatizing anionic cyclization of phosphonamides. A route to phosphonic acid derivatives with antitumor properties.

scientific article

Development of Yondelis (trabectedin, ET-743). A semisynthetic process solves the supply problem.

scientific article published on 07 January 2009

Diazonamides C–E, new cytotoxic metabolites from the ascidian Diazona sp

Double dearomatization of bis(diphenylphosphinamides) through anionic cyclization. A facile route of accessing multifunctional systems with antitumor properties

scientific article published on 18 April 2007

Enzyme-labile protecting groups for the synthesis of natural products: solid-phase synthesis of thiocoraline.

scientific article published on 25 April 2013

Fourier transform infrared spectroscopy indicates a major conformational rearrangement in the activation of rhodopsin.

scientific article published on September 1995

Halogenated helianane derivatives from the sponge Spirastrella hartmani

scientific article

In vitro studies on the metabolism of trabectedin (YONDELIS) in monkey and man, including human CYP reaction phenotyping.

scientific article published on 10 March 2009

Isolation and first total synthesis of PM050489 and PM060184, two new marine anticancer compounds

scientific article published on 26 June 2013

Lamellarin D bioconjugates I: Synthesis and cellular internalization of PEG-derivatives.

scientific article

Lignopurines: a new family of hybrids between cyclolignans and purines. Synthesis and biological evaluation.

scientific article

MI130004, a novel antibody-drug conjugate combining trastuzumab with a molecule of marine origin, shows outstanding in vivo activity against HER2 expressing tumors.

scientific article published on 13 February 2018

Metabolite profiling of the novel anti-cancer agent, plitidepsin, in urine and faeces in cancer patients after administration of 14C-plitidepsin

scientific article published on 04 July 2018

Njaoamines A–F, new cytotoxic polycyclic alkaloids from the haplosclerid sponge Reniera sp

Optically active 1,3,4,4-tetrasubstituted β-lactams: synthesis and evaluation as tumor cell growth inhibitors.

scientific article

Plumisclerin A, a diterpene with a new skeleton from the soft coral Plumigorgia terminosclera

scientific article

Smallest peptoids with antiproliferative activity on human neoplastic cells.

scientific article

Solid-phase synthesis of oxathiocoraline by a key intermolecular disulfide dimer.

scientific article published on 10 April 2007

Stellatolides, a new cyclodepsipeptide family from the sponge Ecionemia acervus: isolation, solid-phase total synthesis, and full structural assignment of stellatolide A.

scientific article

Stolonoxides E and F, cytotoxic metabolites from the marine ascidian Stolonica socialis

scientific article

Structure-activity relationship of kahalalide F synthetic analogues

scientific article

Synthesis and antimitotic and tubulin interaction profiles of novel pinacol derivatives of podophyllotoxins.

scientific article published on 23 July 2012

Synthesis of Retinals Fluorinated at Odd-Numbered Side-Chain Positions and of the Corresponding Fluorobacteriorhodopsins

scientific article published on 01 January 1997

Synthesis of ecteinascidin ET-743 and phthalascidin Pt-650 from cyanosafracin B

scientific article (publication date: 10 August 2000)

Synthesis, cytotoxicity and antiplasmodial activity of novel ent-kaurane derivatives.

scientific article published on 20 December 2012

Tanjungides A and B: new antitumoral bromoindole derived compounds from Diazona cf formosa. isolation and total synthesis

scientific article published on 21 February 2014

The Aplidin analogs PM01215 and PM02781 inhibit angiogenesis in vitro and in vivo

scientific article published on 19 October 2015

The potent anticancer compound ecteinascidin-743 (ET-743) as its 2-propanol disolvate.

scientific article published on 21 March 2003

Topoisomerase I-mediated DNA cleavage as a guide to the development of antitumor agents derived from the marine alkaloid lamellarin D: triester derivatives incorporating amino acid residues.

scientific article published on April 2004

Total synthesis and antiproliferative activity screening of (+/-)-aplicyanins A, B and E and related analogues.

scientific article published on October 2009

Total synthesis of natural myriaporones

scientific article published in March 2004

List of works by Andrés Francesch

Aplicyanins A–F, new cytotoxic bromoindole derivatives from the marine tunicate Aplidium cyaneum

Cytotoxic staurosporines from the marine ascidian Cystodytes solitus

Dearomatizing anionic cyclization of phosphonamides. A route to phosphonic acid derivatives with antitumor properties.

Development of Yondelis (trabectedin, ET-743). A semisynthetic process solves the supply problem.

Diazonamides C–E, new cytotoxic metabolites from the ascidian Diazona sp

Double dearomatization of bis(diphenylphosphinamides) through anionic cyclization. A facile route of accessing multifunctional systems with antitumor properties

Enzyme-labile protecting groups for the synthesis of natural products: solid-phase synthesis of thiocoraline.

Fourier transform infrared spectroscopy indicates a major conformational rearrangement in the activation of rhodopsin.

Halogenated helianane derivatives from the sponge Spirastrella hartmani

In vitro studies on the metabolism of trabectedin (YONDELIS) in monkey and man, including human CYP reaction phenotyping.

Isolation and first total synthesis of PM050489 and PM060184, two new marine anticancer compounds

Lamellarin D bioconjugates I: Synthesis and cellular internalization of PEG-derivatives.

Lignopurines: a new family of hybrids between cyclolignans and purines. Synthesis and biological evaluation.

MI130004, a novel antibody-drug conjugate combining trastuzumab with a molecule of marine origin, shows outstanding in vivo activity against HER2 expressing tumors.

Metabolite profiling of the novel anti-cancer agent, plitidepsin, in urine and faeces in cancer patients after administration of 14C-plitidepsin

Njaoamines A–F, new cytotoxic polycyclic alkaloids from the haplosclerid sponge Reniera sp

Optically active 1,3,4,4-tetrasubstituted β-lactams: synthesis and evaluation as tumor cell growth inhibitors.

Plumisclerin A, a diterpene with a new skeleton from the soft coral Plumigorgia terminosclera

Smallest peptoids with antiproliferative activity on human neoplastic cells.

Solid-phase synthesis of oxathiocoraline by a key intermolecular disulfide dimer.

Stellatolides, a new cyclodepsipeptide family from the sponge Ecionemia acervus: isolation, solid-phase total synthesis, and full structural assignment of stellatolide A.

Stolonoxides E and F, cytotoxic metabolites from the marine ascidian Stolonica socialis

Structure-activity relationship of kahalalide F synthetic analogues

Synthesis and antimitotic and tubulin interaction profiles of novel pinacol derivatives of podophyllotoxins.

Synthesis of Retinals Fluorinated at Odd-Numbered Side-Chain Positions and of the Corresponding Fluorobacteriorhodopsins

Synthesis of ecteinascidin ET-743 and phthalascidin Pt-650 from cyanosafracin B

Synthesis, cytotoxicity and antiplasmodial activity of novel ent-kaurane derivatives.

Tanjungides A and B: new antitumoral bromoindole derived compounds from Diazona cf formosa. isolation and total synthesis

The Aplidin analogs PM01215 and PM02781 inhibit angiogenesis in vitro and in vivo

The potent anticancer compound ecteinascidin-743 (ET-743) as its 2-propanol disolvate.

Topoisomerase I-mediated DNA cleavage as a guide to the development of antitumor agents derived from the marine alkaloid lamellarin D: triester derivatives incorporating amino acid residues.

Total synthesis and antiproliferative activity screening of (+/-)-aplicyanins A, B and E and related analogues.

Total synthesis of natural myriaporones