List of works - Wolfgang Link

A dual-color fluorescence-based platform to identify selective inhibitors of Akt signaling

scientific article

A novel cyclometallated Pt(II)-ferrocene complex induces nuclear FOXO3a localization and apoptosis and synergizes with cisplatin to inhibit lung cancer cell proliferation.

scientific article published on 3 February 2014

A novel phosphatidylinositol 3-kinase (PI3K) inhibitor directs a potent FOXO-dependent, p53-independent cell cycle arrest phenotype characterized by the differential induction of a subset of FOXO-regulated genes

scientific article

Adaptive mechanisms of resistance to anti-neoplastic agents

scientific article published on 21 October 2016

An HTS approach to screen for antagonists of the nuclear export machinery using high content cell-based assays

scientific article

An integrated one-step system to extract, analyze and annotate all relevant information from image-based cell screening of chemical libraries

scientific article

Biological characterization of ETP-46321 a selective and efficacious inhibitor of phosphoinositide-3-kinases.

scientific article published on 24 May 2012

CRISPR/Cas9-mediated genome editing: From basic research to translational medicine

scientific article published on 25 February 2020

Chemical genetic analysis of FOXO nuclear-cytoplasmic shuttling by using image-based cell screening

scientific article

Chemical interrogation of FOXO3a nuclear translocation identifies potent and selective inhibitors of phosphoinositide 3-kinases

scientific article published on 18 August 2009

Components and regulation of nuclear transport processes

scientific article

Context-dependent therapeutic potential of FOXO proteins in oral squamous cell carcinoma ⬇️

scientific article published on 04 March 2011

Day-night changes in downstream regulatory element antagonist modulator/potassium channel interacting protein activity contribute to circadian gene expression in pineal gland.

scientific article

Discovery of 14-3-3 protein-protein interaction inhibitors that sensitize multidrug-resistant cancer cells to doxorubicin and the Akt inhibitor GSK690693.

scientific article

Discovery of a Novel, Isothiazolonaphthoquinone-Based Small Molecule Activator of FOXO Nuclear-Cytoplasmic Shuttling

scientific article published in 2016

FOXO transcription factors at the interface of metabolism and cancer

scientific article

Harmine and Piperlongumine Revert TRIB2-Mediated Drug Resistance

scientific article published on 09 December 2020

High content screening: seeing is believing.

scientific article published on 24 March 2010

High-Throughput Image-Based Screening to Identify Chemical Compounds Capable of Activating FOXO

scientific article published on 01 January 2019

High-content screening of natural products reveals novel nuclear export inhibitors

scientific article published on 17 September 2013

Human TRIB2 is a repressor of FOXO that contributes to the malignant phenotype of melanoma cells

scientific article published on 8 March 2010

Identification of Disease-Relevant Genes for Molecularly-Targeted Drug Discovery ⬇️

scientific article published on January 1, 2012

Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.

scientific article

Image-based Identification of Chemical Compounds Capable of Trapping FOXO in the Cell Nucleus

scientific article published on 01 January 2019

Image-based identification of nuclear export inhibitors from natural products

scientific article published on January 2015

Imaged-based High-Throughput Screening for Anti-Angiogenic Drug Discovery ⬇️

scientific article published on January 1, 2010

Imidazo[1,2-a]pyrazines as novel PI3K inhibitors

scientific article published on 28 January 2012

Immunology: Mind the immuno-connection gap

scientific article published on 24 April 2017

Induction of glycerol phosphate dehydrogenase gene expression during seizure and analgesia

scientific article published on 01 October 2000

Introduction to FOXO Biology

scientific article published on 01 January 2019

Knowledge-based drug discovery intensifies private appropriation of publicly financed research

scientific article published on 01 August 2018

Long live FOXO: unraveling the role of FOXO proteins in aging and longevity

scientific article

MAP17 inhibits Myc-induced apoptosis through PI3K/AKT pathway activation

scientific article published on 3 August 2007

Membrane localization of all class I PI 3-kinase isoforms suppresses c-Myc-induced apoptosis in Rat1 fibroblasts via Akt.

scientific article published in August 2005

Methylseleninic acid promotes antitumour effects via nuclear FOXO3a translocation through Akt inhibition.

scientific article published on 13 September 2015

Monitoring the Transcriptional Activity of FOXO Transcription Factors by Analyzing their Target Genes

article

Moving to the Core: Spatiotemporal Analysis of Forkhead Box O (FOXO) and Nuclear Factor‐κB (NF‐κB) Nuclear Translocation ⬇️

scientific article published on 02 January 2013

Nuclear accumulation of β-catenin and forkhead box O3a in colon cancer: Dangerous liaison ⬇️

scientific article published on September 26, 2012

Overexpression of cyclin D1 inhibits TNF-induced growth arrest

scientific article published in June 2003

Protein localization in disease and therapy.

scientific article published on October 2011

Rapid identification of ETP-46992, orally bioavailable PI3K inhibitor, selective versus mTOR.

scientific article

Special Review: Caught in the Crosshairs: Targeted Drugs and Personalized Medicine.

scientific article

TRIB2 as a biomarker for diagnosis and progression of melanoma.

scientific article published on 13 January 2015

TRIB2 confers resistance to anti-cancer therapy by activating the serine/threonine protein kinase AKT.

scientific article

Targeting nucleocytoplasmic transport in cancer therapy

scientific article

The BDNF gene: exemplifying complexity in Ca2+ -dependent gene expression.

scientific article

The DREAM-DRE interaction: key nucleotides and dominant negative mutants.

scientific article

The Emerging Therapeutic Landscape of Advanced Melanoma.

scientific article published on 24 January 2018

The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications

scientific article published on May 2008

The therapeutic potential of FOXO proteins

scientific article published in August 2011

Therapeutic strategies targeting FOXO transcription factors

scientific article published on 10 November 2020

Tribbles breaking bad: TRIB2 suppresses FOXO and acts as an oncogenic protein in melanoma.

scientific article

Understanding FOXO, New Views on Old Transcription Factors

scientific article published on 01 March 2010

Using multiplexed regulation of luciferase activity and GFP translocation to screen for FOXO modulators

scientific article

List of works by Wolfgang Link

A dual-color fluorescence-based platform to identify selective inhibitors of Akt signaling

A novel cyclometallated Pt(II)-ferrocene complex induces nuclear FOXO3a localization and apoptosis and synergizes with cisplatin to inhibit lung cancer cell proliferation.

A novel phosphatidylinositol 3-kinase (PI3K) inhibitor directs a potent FOXO-dependent, p53-independent cell cycle arrest phenotype characterized by the differential induction of a subset of FOXO-regulated genes

Adaptive mechanisms of resistance to anti-neoplastic agents

An HTS approach to screen for antagonists of the nuclear export machinery using high content cell-based assays

An integrated one-step system to extract, analyze and annotate all relevant information from image-based cell screening of chemical libraries

Biological characterization of ETP-46321 a selective and efficacious inhibitor of phosphoinositide-3-kinases.

CRISPR/Cas9-mediated genome editing: From basic research to translational medicine

Chemical genetic analysis of FOXO nuclear-cytoplasmic shuttling by using image-based cell screening

Chemical interrogation of FOXO3a nuclear translocation identifies potent and selective inhibitors of phosphoinositide 3-kinases

Components and regulation of nuclear transport processes

Context-dependent therapeutic potential of FOXO proteins in oral squamous cell carcinoma ⬇️

Day-night changes in downstream regulatory element antagonist modulator/potassium channel interacting protein activity contribute to circadian gene expression in pineal gland.

Discovery of 14-3-3 protein-protein interaction inhibitors that sensitize multidrug-resistant cancer cells to doxorubicin and the Akt inhibitor GSK690693.

Discovery of a Novel, Isothiazolonaphthoquinone-Based Small Molecule Activator of FOXO Nuclear-Cytoplasmic Shuttling

FOXO transcription factors at the interface of metabolism and cancer

Harmine and Piperlongumine Revert TRIB2-Mediated Drug Resistance

High content screening: seeing is believing.

High-Throughput Image-Based Screening to Identify Chemical Compounds Capable of Activating FOXO

High-content screening of natural products reveals novel nuclear export inhibitors

Human TRIB2 is a repressor of FOXO that contributes to the malignant phenotype of melanoma cells

Identification of Disease-Relevant Genes for Molecularly-Targeted Drug Discovery ⬇️

Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.

Image-based Identification of Chemical Compounds Capable of Trapping FOXO in the Cell Nucleus

Image-based identification of nuclear export inhibitors from natural products

Imaged-based High-Throughput Screening for Anti-Angiogenic Drug Discovery ⬇️

Imidazo[1,2-a]pyrazines as novel PI3K inhibitors

Immunology: Mind the immuno-connection gap

Induction of glycerol phosphate dehydrogenase gene expression during seizure and analgesia

Introduction to FOXO Biology

Knowledge-based drug discovery intensifies private appropriation of publicly financed research

Long live FOXO: unraveling the role of FOXO proteins in aging and longevity

MAP17 inhibits Myc-induced apoptosis through PI3K/AKT pathway activation

Membrane localization of all class I PI 3-kinase isoforms suppresses c-Myc-induced apoptosis in Rat1 fibroblasts via Akt.

Methylseleninic acid promotes antitumour effects via nuclear FOXO3a translocation through Akt inhibition.

Monitoring the Transcriptional Activity of FOXO Transcription Factors by Analyzing their Target Genes

Moving to the Core: Spatiotemporal Analysis of Forkhead Box O (FOXO) and Nuclear Factor‐κB (NF‐κB) Nuclear Translocation ⬇️

Nuclear accumulation of β-catenin and forkhead box O3a in colon cancer: Dangerous liaison ⬇️

Overexpression of cyclin D1 inhibits TNF-induced growth arrest

Protein localization in disease and therapy.

Rapid identification of ETP-46992, orally bioavailable PI3K inhibitor, selective versus mTOR.

Special Review: Caught in the Crosshairs: Targeted Drugs and Personalized Medicine.

TRIB2 as a biomarker for diagnosis and progression of melanoma.

TRIB2 confers resistance to anti-cancer therapy by activating the serine/threonine protein kinase AKT.

Targeting nucleocytoplasmic transport in cancer therapy

The BDNF gene: exemplifying complexity in Ca2+ -dependent gene expression.

The DREAM-DRE interaction: key nucleotides and dominant negative mutants.

The Emerging Therapeutic Landscape of Advanced Melanoma.

The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications

The therapeutic potential of FOXO proteins

Therapeutic strategies targeting FOXO transcription factors

Tribbles breaking bad: TRIB2 suppresses FOXO and acts as an oncogenic protein in melanoma.

Understanding FOXO, New Views on Old Transcription Factors

Using multiplexed regulation of luciferase activity and GFP translocation to screen for FOXO modulators