List of works by Juan F M Leal

Activation of phosphatidylinositol 3-kinase by membrane localization of p110alpha predisposes mammary glands to neoplastic transformation

scientific article

CBX7 controls the growth of normal and tumor-derived prostate cells by repressing the Ink4a/Arf locus.

scientific article

Characterization of the p53 response to oncogene-induced senescence

scientific article

Cytotoxic Anomoian B and Aplyzanzine B, New Bromotyrosine Alkaloids from Indonesian Sponges.

scientific article published on 12 July 2017

Dynamic cellular maps of molecular species: Application to drug-target interactions

scientific article

Inhibition of phosphatidylinositol-3-kinase synergizes with gemcitabine in low-passage tumor cell lines correlating with Bax translocation to the mitochondria

scientific article published on October 2005

Irvalec inserts into the plasma membrane causing rapid loss of integrity and necrotic cell death in tumor cells

scientific article (publication date: 2011)

Levels of p27(kip1) determine Aplidin sensitivity

scientific article published on April 2007

Loss-of-function genetic screening identifies a cluster of ribosomal proteins regulating p53 function

scientific article published on 29 May 2008

MAP17 enhances the malignant behavior of tumor cells through ROS increase

scientific article

MAP17 inhibits Myc-induced apoptosis through PI3K/AKT pathway activation

scientific article published on 3 August 2007

MAP17 overexpression is a common characteristic of carcinomas

scientific article

Molecular pharmacology and antitumor activity of Zalypsis in several human cancer cell lines

scientific article

Mst1, RanBP2 and eIF4G are new markers for in vivo PI3K activation in murine and human prostate

scientific article published on 19 March 2007

On the Mechanism of Action of Dragmacidins I and J, Two New Representatives of a New Class of Protein Phosphatase 1 and 2A Inhibitors.

scientific article published on 3 April 2018

PIM2 inhibition as a rational therapeutic approach in B-cell lymphoma

scientific article published on 21 September 2011

PPP1CA contributes to the senescence program induced by oncogenic Ras.

scientific article published on 19 January 2008

PTEN, more than the AKT pathway

scientific article published on 6 March 2007

Pim 1 kinase inhibitor ETP-45299 suppresses cellular proliferation and synergizes with PI3K inhibition

scientific article published on 3 November 2010

Promoters of ASCL1- and NEUROD1-dependent genes are specific targets of lurbinectedin in SCLC cells

scientific article published on 09 March 2022

Specific Effects of Trabectedin and Lurbinectedin on Human Macrophage Function and Fate-Novel Insights

scientific article published on 20 October 2020

The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications

scientific article published on May 2008

Vorinostat interferes with the signaling transduction pathway of T-cell receptor and synergizes with phosphoinositide-3 kinase inhibitors in cutaneous T-cell lymphoma.

scientific article

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