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List of works by Thomas Huber

A simple method for enhancing the bioorthogonality of cyclooctyne reagent

scientific article

Ancient Family of Retinal Proteins Brought to Light "Sight-Unseen"

scientific article published on 30 November 2018

Antibody epitopes on g protein-coupled receptors mapped with genetically encoded photoactivatable cross-linkers.

scientific article published on 18 February 2014

Bilateral olfactory sensory input enhances chemotaxis behavior.

scientific article published on 23 December 2007

Bioorthogonal Labeling of Ghrelin Receptor to Facilitate Studies of Ligand-Dependent Conformational Dynamics.

scientific article published on 3 November 2015

Bioorthogonal fluorescent labeling of functional G-protein-coupled receptors

scientific article published on 18 July 2014

Chemical biology methods for investigating G protein-coupled receptor signaling.

scientific article

Curvature and hydrophobic forces drive oligomerization and modulate activity of rhodopsin in membranes.

scientific article published on 29 September 2006

Direct evidence that the GPCR CysLTR2 mutant causative of uveal melanoma is constitutively active with highly biased signaling

scientific article published on 06 December 2020

Direct measurement of thermal stability of expressed CCR5 and stabilization by small molecule ligands.

scientific article

Escaping the flatlands: new approaches for studying the dynamic assembly and activation of GPCR signaling complexes.

scientific article published on 15 April 2011

FRET sensors reveal the retinal entry pathway in the G protein-coupled receptor rhodopsin

scientific article published on 11 March 2022

FTIR analysis of GPCR activation using azido probes.

scientific article

Frizzled BRET sensors based on bioorthogonal labeling of unnatural amino acids reveal WNT-induced dynamics of the cysteine-rich domain

scientific article published on 10 November 2021

Functional role of the "ionic lock"--an interhelical hydrogen-bond network in family A heptahelical receptors.

scientific article published on 17 May 2008

G Protein-Coupled Receptors Self-Assemble in Dynamics Simulations of Model Bilayers

article

G protein subtype-specific signaling bias in a series of CCR5 chemokine analogs

article

GPCRs globally coevolved with receptor activity-modifying proteins, RAMPs

scientific article published on 23 October 2017

Genetically encoded photo-cross-linkers map the binding site of an allosteric drug on a G protein-coupled receptor.

scientific article

Genetically encoded photocrosslinkers locate the high-affinity binding site of antidepressant drugs in the human serotonin transporter

scientific article published on 19 April 2016

Genetically-encoded molecular probes to study G protein-coupled receptors

scientific article published on 13 September 2013

Homogeneous time-resolved fluorescence assay to probe folded G protein-coupled receptors

scientific article published on January 2013

Labeling and Single-Molecule Methods To Monitor G Protein-Coupled Receptor Dynamics.

scientific article published on 24 June 2016

Mapping a ligand binding site using genetically encoded photoactivatable crosslinkers.

scientific article published on January 2013

Mapping substance P binding sites on the neurokinin-1 receptor using genetic incorporation of a photoreactive amino acid

scientific article

Measurement of Slow Spontaneous Release of 11-cis-Retinal from Rhodopsin.

scientific article

Micelle-Enhanced Bioorthogonal Labeling of Genetically Encoded Azido Groups on the Lipid-Embedded Surface of a GPCR.

scientific article published on 11 May 2015

Multiplex detection of functional G protein-coupled receptors harboring site-specifically modified unnatural amino acids

scientific article

Multiplexed analysis of the secretin-like GPCR-RAMP interactome

scientific article published on 18 September 2019

Purinergic Receptors Crosstalk with CCR5 to Amplify Ca2+ Signaling

scientific article published on 20 November 2020

Quantitative Multi-color Detection Strategies for Bioorthogonally Labeled GPCRs

scientific article published on 01 January 2015

Rapid Incorporation of Functional Rhodopsin into Nanoscale Apolipoprotein Bound Bilayer (NABB) Particles

scientific article published on 02 February 2008

Recurrent activating mutations of G-protein-coupled receptor CYSLTR2 in uveal melanoma

scientific article published on 18 April 2016

Rhodopsin forms a dimer with cytoplasmic helix 8 contacts in native membranes.

scientific article published on 27 February 2012

Rhodopsin's active state is frozen like a DEER in the headlights

scholarly article

Site-specific epitope tagging of G protein-coupled receptors by bioorthogonal modification of a genetically encoded unnatural amino acid.

scientific article published on 30 January 2013

Site-specific incorporation of keto amino acids into functional G protein-coupled receptors using unnatural amino acid mutagenesis.

scientific article published on 8 November 2007

Site-specific labeling of genetically encoded azido groups for multicolor, single-molecule fluorescence imaging of GPCRs.

scientific article

Structural basis for ligand binding and specificity in adrenergic receptors: implications for GPCR-targeted drug discovery.

scientific article published on 27 September 2008

Structural determinants of the supramolecular organization of G protein-coupled receptors in bilayers.

scientific article

Structure of docosahexaenoic acid-containing phospholipid bilayers as studied by (2)H NMR and molecular dynamics simulations.

scientific article published in January 2002

The Energetics of Chromophore Binding in the Visual Photoreceptor Rhodopsin.

scientific article published on July 2017

Unnatural Amino Acid Mutagenesis of GPCRs Using Amber Codon Suppression and Bioorthogonal Labeling

scientific article published on 01 January 2013

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