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List of works by Javier Hernandez-Losa

A mouse model uncovers LKB1 as an UVB-induced DNA damage sensor mediating CDKN1A (p21WAF1/CIP1) degradation

scientific article

ALDH1A3 is epigenetically regulated during melanocyte transformation and is a target for melanoma treatment

scientific article published on 05 June 2017

Aprataxin tumor levels predict response of colorectal cancer patients to irinotecan-based treatment.

scientific article published on 06 April 2010

Atrophy of mesenteric sympathetic innervation may contribute to splanchnic vasodilation in rat portal hypertension.

scientific article published on 30 November 2009

Brush border myosin Ia has tumor suppressor activity in the intestine.

scientific article published on 18 January 2012

Brush border myosin Ia inactivation in gastric but not endometrial tumors.

scientific article

Cancer as an ecomolecular disease and a neoplastic consortium

scientific article

Cell signaling in endometrial carcinoma: phosphorylated 4E-binding protein-1 expression in endometrial cancer correlates with aggressive tumors and prognosis.

scientific article published on 9 May 2009

Clinical response to a lapatinib-based therapy for a Li-Fraumeni syndrome patient with a novel HER2V659E mutation.

scientific article

Clinicopathological and Molecular Characterization of Metastatic Gastrointestinal Stromal Tumors with Prolonged Benefit to Frontline Imatinib

scientific article published on 20 August 2018

Differential expression of Kv1.3 and Kv1.5 voltage-dependent K+ channels in human skeletal muscle sarcomas

scientific article published on 01 March 2012

Down-regulation of spinophilin in lung tumours contributes to tumourigenesis

scientific article published on 19 May 2011

E1a is an exogenous in vivo tumour suppressor.

scientific article published on 14 April 2017

Effect of low doses of actinomycin D on neuroblastoma cell lines

scientific article

Emerging role for the voltage-dependent K+ channel Kv1.5 in B-lymphocyte physiology: expression associated with human lymphoma malignancy.

scientific article published on 11 July 2013

Epithelial-mesenchymal transition markers and HER3 expression are predictors of elisidepsin treatment response in breast and pancreatic cancer cell lines

scientific article

ErbB3 expression predicts sensitivity to elisidepsin treatment: in vitro synergism with cisplatin, paclitaxel and gemcitabine in lung, breast and colon cancer cell lines ⬇️

scientific article published on April 3, 2012

ErbBs inhibition by lapatinib blocks tumor growth in an orthotopic model of human testicular germ cell tumor.

scientific article

Evaluation of the intraoperative human papillomavirus test as a marker of early cure at 12 months after electrosurgical excision procedure in women with cervical high-grade squamous intraepithelial lesion: a prospective cohort study

scientific article published on 25 September 2019

Expression patterns and bioinformatic analysis of miR-1260a and miR-1274a in Prostate Cancer Tunisian patients

scientific article published on 24 September 2018

Fluorescence in situ hybridization and immunohistochemistry as diagnostic methods for ALK positive non-small cell lung cancer patients

scientific article

Focal epithelial hyperplasia by human papillomavirus (HPV)-32 misdiagnosed as HPV-16 and treated with combination of retinoids, imiquimod and quadrivalent HPV vaccine.

scientific article published on 5 June 2015

Genetic Profiles of Squamous Cell Carcinomas Associated with Recessive Dystrophic Epidermolysis Bullosa Unveil NOTCH and TP53 Mutations and an Increased MYC Expression.

scientific article published on 29 December 2017

Genetic evolution of nevus of Ota reveals clonal heterogeneity acquiring BAP1 and TP53 mutations.

scientific article

Genetic profile of GNAQ-mutated blue melanocytic neoplasms reveals mutations in genes linked to genomic instability and the PI3K pathway.

scientific article published on 4 April 2016

Identification and genotyping of human papillomavirus in a Spanish cohort of penile squamous cell carcinomas: Correlation with pathologic subtypes, p16INK4a expression, and prognosis ⬇️

scientific article published on August 3, 2012

Identification of somatic gene mutations in penile squamous cell carcinoma.

scientific article published on 27 July 2015

Identification of the novel mutation m.5658T>C in the mitochondrial tRNA(Asn) gene in a patient with myopathy, bilateral ptosis and ophthalmoparesis.

scientific article

Increased voltage-dependent K(+) channel Kv1.3 and Kv1.5 expression correlates with leiomyosarcoma aggressiveness

scientific article

Insight into the Role and Regulation of Gap Junction Genes in Lung Cancer and Identification of Nuclear Cx43 as a Putative Biomarker of Poor Prognosis

article

Integrating clinical, molecular, proteomic and histopathological data within the tissue context: tissunomics

scientific article published on 14 May 2019

JC virus and human colon carcinoma: an intriguing and inconclusive association.

scientific article published in January 2003

Lack of association of polyomavirus and herpesvirus types 6 and 7 in human lymphomas

scientific article published on 01 January 2005

Lkb1 loss promotes tumor progression of BRAF(V600E)-induced lung adenomas

scientific article

Loss of the EPH receptor B6 contributes to colorectal cancer metastasis

scientific article published on 06 March 2017

Lymphangioleiomyomatosis Biomarkers Linked to Lung Metastatic Potential and Cell Stemness

scientific article published on 13 July 2015

Methylthioadenosine (MTA) inhibits melanoma cell proliferation and in vivo tumor growth

scientific article

Modulation of PI3K/Akt pathway by E1a mediates sensitivity to cisplatin.

scientific article

Modulation of the p38 MAPK (mitogen-activated protein kinase) pathway through Bcr/Abl: implications in the cellular response to Ara-C.

scientific article

Molecular profiling of patients with colorectal cancer and matched targeted therapy in phase I clinical trials.

scientific article

Myo5b knockout mice as a model of microvillus inclusion disease.

scientific article published on 23 July 2015

Phenformin-Induced Mitochondrial Dysfunction Sensitizes Hepatocellular Carcinoma for Dual Inhibition of mTOR.

scientific article published on 24 April 2018

Prevalence and clinical outcomes for patients with ALK-positive resected stage I to III adenocarcinoma: results from the European Thoracic Oncology Platform Lungscape Project.

scientific article published on 28 July 2014

RAS/MAPK pathway hyperactivation determines poor prognosis in undifferentiated pleomorphic sarcomas.

scientific article published on 19 October 2015

RHOA inactivation enhances Wnt signalling and promotes colorectal cancer.

scientific article

RSK4 inhibition results in bypass of stress-induced and oncogene-induced senescence.

scientific article published on 14 January 2011

Regulation of replicative and stress-induced senescence by RSK4, which is down-regulated in human tumors.

scientific article

Regulation of the transcriptional activity of c-Fos by ERK. A novel role for the prolyl isomerase PIN1.

scientific article published on 25 August 2005

Risk factors of high-grade anal intraepithelial neoplasia recurrence in HIV-infected MSM.

scientific article published on March 2017

S-adenosylhomocysteine hydrolase downregulation contributes to tumorigenesis.

scientific article published on 19 August 2008

Schwannomas, benign tumors with a senescent phenotype

scientific article published on 12 November 2013

Spinophilin acts as a tumor suppressor by regulating Rb phosphorylation

Spiny hyperkeratosis (trichodysplasia spinulosa-like eruption): a cutaneous adverse effect of Hedgehog pathway inhibitors involving expression of p16

scientific article published on 30 August 2016

Stem cell-like transcriptional reprogramming mediates metastatic resistance to mTOR inhibition.

scientific article

Targeting the voltage-dependent K(+) channels Kv1.3 and Kv1.5 as tumor biomarkers for cancer detection and prevention.

scientific article published on January 2012

The New Antitumor Drug ABTL0812 Inhibits the Akt/mTORC1 Axis by Upregulating Tribbles-3 Pseudokinase.

scientific article published on 15 December 2015

The dual PI3K/mTOR inhibitor PI-103 promotes immunosuppression, in vivo tumor growth and increases survival of sorafenib-treated melanoma cells.

scientific article published on April 2010

The effect of p-4E-BP1 and p-eIF4E on cell proliferation in a breast cancer model.

scientific article published on 8 July 2011

The patient has the diagnosis

scientific article published on 01 October 2010

The receptor tyrosine kinase EPHB4 has tumor suppressor activities in intestinal tumorigenesis.

scientific article

The role of oncogenic HPV determination for diagnosis of high-grade anal intraepithelial neoplasia in HIV-infected MSM.

scientific article published on 18 July 2017

The umbilical cord, preeclampsia and the VEGF family

scientific article published on 28 November 2018

The voltage-dependent K(+) channels Kv1.3 and Kv1.5 in human cancer.

scientific article published on 10 October 2013

Validation of Cell-Free DNA Collection Tubes for Determination of EGFR Mutation Status in Liquid Biopsy from NSCLC Patients

scientific article published on 19 August 2019

Voltage-dependent potassium channels Kv1.3 and Kv1.5 in human fetus.

scientific article published on 24 August 2010

c-Abl activates p38 MAPK independently of its tyrosine kinase activity: Implications in cisplatin-based therapy.

scientific article

mTOR signaling pathway in penile squamous cell carcinoma: pmTOR and peIF4E over expression correlate with aggressive tumor behavior.

scientific article published on 11 June 2013

miR-125b acts as a tumor suppressor in breast tumorigenesis via its novel direct targets ENPEP, CK2-α, CCNJ, and MEGF9.

scientific article

miR-99a reveals two novel oncogenic proteins E2F2 and EMR2 and represses stemness in lung cancer.

scientific article published on 26 October 2017

peIF4E as an independent prognostic factor and a potential therapeutic target in diffuse infiltrating astrocytomas.

scientific article published on 20 July 2016

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