List of works - John W Scott

1,2,6-Thiadiazinones as Novel Narrow Spectrum Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CaMKK2) Inhibitors.

scientific article

AMP-activated protein kinase complexes containing the β2 regulatory subunit are up-regulated during and contribute to adipogenesis

scientific article published on 26 June 2019

AMP-activated protein kinase selectively inhibited by the type II inhibitor SBI-0206965.

scientific article published on 25 April 2018

AMP-activated protein kinase--development of the energy sensor concept.

scientific article

AMPK functions as an adenylate charge-regulated protein kinase.

scientific article published on 26 January 2012

AMPK is a direct adenylate charge-regulated protein kinase.

scientific article

AMPK structure and regulation from three angles.

scientific article published in October 2007

AMPK/SNF1 structure: a menage a trois of energy-sensing

scientific article published on January 2009

ATP sensitive bi-quinoline activator of the AMP-activated protein kinase.

scientific article published on 8 December 2013

Allosteric regulation of AMP-activated protein kinase by adenylate nucleotides and small-molecule drugs

scientific article published on 18 April 2019

Analysis of the LKB1-STRAD-MO25 complex

scientific article

Autophosphorylation of CaMKK2 generates autonomous activity that is disrupted by a T85S mutation linked to anxiety and bipolar disorder

scientific article

Ca2+/Calmodulin-dependent protein kinase kinase beta is regulated by multisite phosphorylation.

scientific article

CaMKK2 is inactivated by cAMP-PKA signaling and 14-3-3 adaptor proteins

scientific article published on 09 September 2020

Calcium/calmodulin-dependent protein kinase kinase 2 regulates hepatic fuel metabolism

publication published on 11 May 2022

Fake Inhibitors: AMPK Activation Trumps Inhibition

scientific article published in July 2017

Fatal congenital heart glycogenosis caused by a recurrent activating R531Q mutation in the gamma 2-subunit of AMP-activated protein kinase (PRKAG2), not by phosphorylase kinase deficiency

scientific article

Fatal infantile cardiac glycogenosis with phosphorylase kinase deficiency and a mutation in the gamma2-subunit of AMP-activated protein kinase

scientific article published on 01 October 2007

Functional analysis of an R311C variant of Ca2+ -calmodulin-dependent protein kinase kinase-2 (CaMKK2) found as a de novo mutation in a patient with bipolar disorder

scientific article published on 25 March 2020

Germline deletion of AMP-activated protein kinase beta subunits reduces bone mass without altering osteoclast differentiation or function

scientific article

Impact of Genetic Variation on Human CaMKK2 Regulation by Ca2+-Calmodulin and Multisite Phosphorylation.

scientific article published on 23 February 2017

In Depth Analysis of Kinase Cross Screening Data to Identify CAMKK2 Inhibitory Scaffolds

scientific article published on 13 January 2020

Inhibition of AMP-Activated Protein Kinase at the Allosteric Drug-Binding Site Promotes Islet Insulin Release.

scientific article published on June 2015

Inhibition of Adenosine Monophosphate-Activated Protein Kinase-3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Signaling Leads to Hypercholesterolemia and Promotes Hepatic Steatosis and Insulin Resistance.

scientific article

Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK β1 isoforms

scientific article published on 27 July 2020

Management of cellular energy by the AMP-activated protein kinase system

scientific article

Metformin and salicylate synergistically activate liver AMPK, inhibit lipogenesis and improve insulin sensitivity

scientific article published on May 2015

Mitochondrial fission protein Drp1 inhibition promotes cardiac mesodermal differentiation of human pluripotent stem cells.

scientific article published on 5 March 2018

Mutant TDP-43 deregulates AMPK activation by PP2A in ALS models.

scientific article

Neuropeptide Y1 receptor antagonism protects β-cells and improves glycemic control in type 2 diabetes

publication published on 07 December 2021

New perspectives on the role of Drp1 isoforms in regulating mitochondrial pathophysiology

scientific article published on 28 May 2020

Phenformin and 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) activation of AMP-activated protein kinase inhibits transepithelial Na+ transport across H441 lung cells.

scientific article published on 26 May 2005

Protein kinase substrate recognition studied using the recombinant catalytic domain of AMP-activated protein kinase and a model substrate.

scientific article published in March 2002

Small molecule drug A-769662 and AMP synergistically activate naive AMPK independent of upstream kinase signaling.

scientific article

SnRK1 from Arabidopsis thaliana is an atypical AMPK.

scientific article

Structural Determinants for Small-Molecule Activation of Skeletal Muscle AMPK α2β2γ1 by the Glucose Importagog SC4.

scientific article published on 7 April 2018

Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding

scientific article published on 8 March 2016

Structure and function of AMP-activated protein kinase.

scientific article

The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs

scientific article published on 18 September 2017

The sweet side of AMPK signaling: regulation of GFAT1.

scientific article

Thienopyridone drugs are selective activators of AMP-activated protein kinase beta1-containing complexes.

scientific article published in November 2008

Transient Expression of AMPK Heterotrimer Complexes in Mammalian Cells.

scientific article published in January 2018

Whole body deletion of AMP-activated protein kinase {beta}2 reduces muscle AMPK activity and exercise capacity.

scientific article

mTORC1 directly inhibits AMPK to promote cell proliferation under nutrient stress

scientific article published on 20 January 2020

β-Subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK) ⬇️

scientific article published on October 25, 2010

β-subunit myristoylation functions as an energy sensor by modulating the dynamics of AMP-activated Protein Kinase

scientific article published on 21 December 2016

List of works by John W Scott

1,2,6-Thiadiazinones as Novel Narrow Spectrum Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CaMKK2) Inhibitors.

AMP-activated protein kinase complexes containing the β2 regulatory subunit are up-regulated during and contribute to adipogenesis

AMP-activated protein kinase selectively inhibited by the type II inhibitor SBI-0206965.

AMP-activated protein kinase--development of the energy sensor concept.

AMPK functions as an adenylate charge-regulated protein kinase.

AMPK is a direct adenylate charge-regulated protein kinase.

AMPK structure and regulation from three angles.

AMPK/SNF1 structure: a menage a trois of energy-sensing

ATP sensitive bi-quinoline activator of the AMP-activated protein kinase.

Allosteric regulation of AMP-activated protein kinase by adenylate nucleotides and small-molecule drugs

Analysis of the LKB1-STRAD-MO25 complex

Autophosphorylation of CaMKK2 generates autonomous activity that is disrupted by a T85S mutation linked to anxiety and bipolar disorder

Ca2+/Calmodulin-dependent protein kinase kinase beta is regulated by multisite phosphorylation.

CaMKK2 is inactivated by cAMP-PKA signaling and 14-3-3 adaptor proteins

Calcium/calmodulin-dependent protein kinase kinase 2 regulates hepatic fuel metabolism

Fake Inhibitors: AMPK Activation Trumps Inhibition

Fatal congenital heart glycogenosis caused by a recurrent activating R531Q mutation in the gamma 2-subunit of AMP-activated protein kinase (PRKAG2), not by phosphorylase kinase deficiency

Fatal infantile cardiac glycogenosis with phosphorylase kinase deficiency and a mutation in the gamma2-subunit of AMP-activated protein kinase

Functional analysis of an R311C variant of Ca2+ -calmodulin-dependent protein kinase kinase-2 (CaMKK2) found as a de novo mutation in a patient with bipolar disorder

Germline deletion of AMP-activated protein kinase beta subunits reduces bone mass without altering osteoclast differentiation or function

Impact of Genetic Variation on Human CaMKK2 Regulation by Ca2+-Calmodulin and Multisite Phosphorylation.

In Depth Analysis of Kinase Cross Screening Data to Identify CAMKK2 Inhibitory Scaffolds

Inhibition of AMP-Activated Protein Kinase at the Allosteric Drug-Binding Site Promotes Islet Insulin Release.

Inhibition of Adenosine Monophosphate-Activated Protein Kinase-3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Signaling Leads to Hypercholesterolemia and Promotes Hepatic Steatosis and Insulin Resistance.

Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK β1 isoforms

Management of cellular energy by the AMP-activated protein kinase system

Metformin and salicylate synergistically activate liver AMPK, inhibit lipogenesis and improve insulin sensitivity

Mitochondrial fission protein Drp1 inhibition promotes cardiac mesodermal differentiation of human pluripotent stem cells.

Mutant TDP-43 deregulates AMPK activation by PP2A in ALS models.

Neuropeptide Y1 receptor antagonism protects β-cells and improves glycemic control in type 2 diabetes

New perspectives on the role of Drp1 isoforms in regulating mitochondrial pathophysiology

Phenformin and 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) activation of AMP-activated protein kinase inhibits transepithelial Na+ transport across H441 lung cells.

Protein kinase substrate recognition studied using the recombinant catalytic domain of AMP-activated protein kinase and a model substrate.

Small molecule drug A-769662 and AMP synergistically activate naive AMPK independent of upstream kinase signaling.

SnRK1 from Arabidopsis thaliana is an atypical AMPK.

Structural Determinants for Small-Molecule Activation of Skeletal Muscle AMPK α2β2γ1 by the Glucose Importagog SC4.

Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding

Structure and function of AMP-activated protein kinase.

The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs

The sweet side of AMPK signaling: regulation of GFAT1.

Thienopyridone drugs are selective activators of AMP-activated protein kinase beta1-containing complexes.

Transient Expression of AMPK Heterotrimer Complexes in Mammalian Cells.

Whole body deletion of AMP-activated protein kinase {beta}2 reduces muscle AMPK activity and exercise capacity.

mTORC1 directly inhibits AMPK to promote cell proliferation under nutrient stress

β-Subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK) ⬇️

β-subunit myristoylation functions as an energy sensor by modulating the dynamics of AMP-activated Protein Kinase