List of works - Patricia Lepage

A human gut microbial gene catalogue established by metagenomic sequencing

scientific article

A metagenomic insight into our gut's microbiome

scientific article

Altered gut microbiota composition in immune-impaired Nod2(-/-) mice

article

Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota

scientific article published on 5 November 2015

Bacterial protein signals are associated with Crohn's disease

scientific article

Baseline gut microbiota predicts clinical response and colitis in metastatic melanoma patients treated with ipilimumab

scientific article published on 27 March 2017

Biodiversity of the mucosa-associated microbiota is stable along the distal digestive tract in healthy individuals and patients with IBD.

scientific article

Clostridium difficile colonization in early infancy is accompanied by changes in intestinal microbiota composition

scientific article

Colon Immune-Related Adverse Events: Anti-CTLA-4 and Anti-PD-1 Blockade Induce Distinct Immunopathological Entities.

scientific article

Dietary Protein Intake Level Modulates Mucosal Healing and Mucosa-Adherent Microbiota in Mouse Model of Colitis

scientific article published on 28 February 2019

Does our food (environment) change our gut microbiome ('in-vironment'): a potential role for inflammatory bowel disease?

scientific article published on January 2012

Dysbiosis in inflammatory bowel disease: a role for bacteriophages?

scholarly article by Patricia Lepage et al published 1 March 2008 in Gut

Early-life establishment of the swine gut microbiome and impact on host phenotypes

scientific article published on 6 May 2015

Effects of enteral polymeric diet on gut microbiota in children with Crohn's disease

article by Chloé Guinet-Charpentier et al published 27 January 2016 in Gut

Enhancing the clinical coverage and anticancer efficacy of immune checkpoint blockade through manipulation of the gut microbiota

scientific article published on 18 February 2016

Enteric Delivery of Regenerating Family Member 3 alpha Alters the Intestinal Microbiota and Controls Inflammation in Mice With Colitis

scientific article

Enterococcus hirae and Barnesiella intestinihominis Facilitate Cyclophosphamide-Induced Therapeutic Immunomodulatory Effects

scientific article

Enterocolitis due to immune checkpoint inhibitors: a systematic review

scholarly article by Emilie Soularue et al published 21 August 2018 in Gut

Epidemiology of inflammatory bowel disease in a German twin cohort: results of a nationwide study

scientific article published in July 2008

Extensive expression differences along porcine small intestine evidenced by transcriptome sequencing

scientific article

Gut microbiome and anticancer immune response: really hot Sh*t!

scientific article

Harnessing the intestinal microbiome for optimal therapeutic immunomodulation

scientific article

Hemidesmosome integrity protects the colon against colitis and colorectal cancer

scientific article published on July 2016

High-fat diet alters gut microbiota physiology in mice

scientific article

Host-microbe interactions in distal airways: relevance to chronic airway diseases

scientific article

Immunome differences between porcine ileal and jejunal Peyer's patches revealed by global transcriptome sequencing of gut-associated lymphoid tissues.

scientific article

Inflammatory bowel disease and cancer response due to anti-CTLA-4: is it in the flora?

scientific article published on 16 January 2017

Intestinal TM7 bacterial phylogenies in active inflammatory bowel disease

scientific article

Intestinal inhibition of Atg7 prevents tumour initiation through a microbiome-influenced immune response and suppresses tumour growth.

scientific article published on 27 July 2015

Intestinal microbiota contributes to individual susceptibility to alcoholic liver disease.

scientific article published on 7 December 2015

Intestinal microbiota determines development of non-alcoholic fatty liver disease in mice.

scientific article

Intestinal microbiota in metabolic diseases: from bacterial community structure and functions to species of pathophysiological relevance

scientific article

Involvement of tissue bacteria in the onset of diabetes in humans: evidence for a concept

scientific article published on December 2011

Le microbiome digestif humain : interactions avec l’hôte et dysfonctions

Metabolic interplay between gut bacteria and their host

scientific article

Microbial ecology perturbation in human IgA deficiency

scientific article published on 01 May 2018

Microbiota Is Involved in Post-resection Adaptation in Humans with Short Bowel Syndrome

scientific article

Mining gut microbiome oligopeptides by functional metaproteome display

scientific article

Modulation of the microbiota by oral antibiotics treats immunoglobulin A nephropathy in humanized mice

scientific article published on 01 July 2019

Molecular comparison of dominant microbiota associated with injured versus healthy mucosa in ulcerative colitis.

scientific article published on January 2007

Nod2 Deficiency Leads to a Specific and Transmissible Mucosa-associated Microbial Dysbiosis Which Is Independent of the Mucosal Barrier Defect.

scientific article

Nutritional strategies and gut microbiota composition as risk factors for necrotizing enterocolitis in very-preterm infants

scientific article published on 28 June 2017

Patchy distribution of mucosal lesions in ileal Crohn's disease is not linked to differences in the dominant mucosa-associated bacteria: a study using fluorescence in situ hybridization and temporal temperature gradient gel electrophoresis

scientific article

Phylogenetic network analysis applied to pig gut microbiota identifies an ecosystem structure linked with growth traits

scientific article published on 13 May 2016

Rapid analysis of bile acids in different biological matrices using LC-ESI-MS/MS for the investigation of bile acid transformation by mammalian gut bacteria

scientific article published on 7 November 2016

Resilience of the dominant human fecal microbiota upon short-course antibiotic challenge

scientific article

Resistance Mechanisms to Immune-Checkpoint Blockade in Cancer: Tumor-Intrinsic and -Extrinsic Factors

scientific article published on June 2016

Respective Roles of Hematopoietic and Nonhematopoietic Nod2 on the Gut Microbiota and Mucosal Homeostasis

scientific article

Review article: gut flora and inflammatory bowel disease.

scientific article published in October 2004

Search for localized dysbiosis in Crohn's disease ulcerations by temporal temperature gradient gel electrophoresis of 16S rRNA.

scientific article published in September 2005

Specificities of the fecal microbiota in inflammatory bowel disease

scholarly article by Harry Sokol et al published February 2006 in Inflammatory Bowel Diseases

Structural robustness of the gut mucosal microbiota is associated with Crohn's disease remission after surgery

scientific article

Systemic short chain fatty acids limit antitumor effect of CTLA-4 blockade in hosts with cancer

scientific article published on 01 May 2020

TREM-1 Inhibition Restores Impaired Autophagy Activity and Reduces Colitis in Mice

scientific article published on 16 September 2017

Temperature gradient gel electrophoresis of fecal 16S rRNA reveals active Escherichia coli in the microbiota of patients with ulcerative colitis

scientific article

The gut microbiota drives the impact of bile acids and fat source in diet on mouse metabolism

scientific article published on 02 August 2018

The human gut microbiome and its dysfunctions

scientific article

The human gut microbiome and its dysfunctions through the meta-omics prism

scientific article published on 4 March 2016

The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide

scientific article

Transcriptional activity of the dominant gut mucosal microbiota in chronic inflammatory bowel disease patients

scientific article

Twin study indicates loss of interaction between microbiota and mucosa of patients with ulcerative colitis

scientific article

Why should we need the gut microbiota to respond to cancer therapies?

scientific article

List of works by Patricia Lepage

A human gut microbial gene catalogue established by metagenomic sequencing

A metagenomic insight into our gut's microbiome

Altered gut microbiota composition in immune-impaired Nod2(-/-) mice

Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota

Bacterial protein signals are associated with Crohn's disease

Baseline gut microbiota predicts clinical response and colitis in metastatic melanoma patients treated with ipilimumab

Biodiversity of the mucosa-associated microbiota is stable along the distal digestive tract in healthy individuals and patients with IBD.

Clostridium difficile colonization in early infancy is accompanied by changes in intestinal microbiota composition

Colon Immune-Related Adverse Events: Anti-CTLA-4 and Anti-PD-1 Blockade Induce Distinct Immunopathological Entities.

Dietary Protein Intake Level Modulates Mucosal Healing and Mucosa-Adherent Microbiota in Mouse Model of Colitis

Does our food (environment) change our gut microbiome ('in-vironment'): a potential role for inflammatory bowel disease?

Dysbiosis in inflammatory bowel disease: a role for bacteriophages?

Early-life establishment of the swine gut microbiome and impact on host phenotypes

Effects of enteral polymeric diet on gut microbiota in children with Crohn's disease

Enhancing the clinical coverage and anticancer efficacy of immune checkpoint blockade through manipulation of the gut microbiota

Enteric Delivery of Regenerating Family Member 3 alpha Alters the Intestinal Microbiota and Controls Inflammation in Mice With Colitis

Enterococcus hirae and Barnesiella intestinihominis Facilitate Cyclophosphamide-Induced Therapeutic Immunomodulatory Effects

Enterocolitis due to immune checkpoint inhibitors: a systematic review

Epidemiology of inflammatory bowel disease in a German twin cohort: results of a nationwide study

Extensive expression differences along porcine small intestine evidenced by transcriptome sequencing

Gut microbiome and anticancer immune response: really hot Sh*t!

Harnessing the intestinal microbiome for optimal therapeutic immunomodulation

Hemidesmosome integrity protects the colon against colitis and colorectal cancer

High-fat diet alters gut microbiota physiology in mice

Host-microbe interactions in distal airways: relevance to chronic airway diseases

Immunome differences between porcine ileal and jejunal Peyer's patches revealed by global transcriptome sequencing of gut-associated lymphoid tissues.

Inflammatory bowel disease and cancer response due to anti-CTLA-4: is it in the flora?

Intestinal TM7 bacterial phylogenies in active inflammatory bowel disease

Intestinal inhibition of Atg7 prevents tumour initiation through a microbiome-influenced immune response and suppresses tumour growth.

Intestinal microbiota contributes to individual susceptibility to alcoholic liver disease.

Intestinal microbiota determines development of non-alcoholic fatty liver disease in mice.

Intestinal microbiota in metabolic diseases: from bacterial community structure and functions to species of pathophysiological relevance

Involvement of tissue bacteria in the onset of diabetes in humans: evidence for a concept

Le microbiome digestif humain : interactions avec l’hôte et dysfonctions

Metabolic interplay between gut bacteria and their host

Microbial ecology perturbation in human IgA deficiency

Microbiota Is Involved in Post-resection Adaptation in Humans with Short Bowel Syndrome

Mining gut microbiome oligopeptides by functional metaproteome display

Modulation of the microbiota by oral antibiotics treats immunoglobulin A nephropathy in humanized mice

Molecular comparison of dominant microbiota associated with injured versus healthy mucosa in ulcerative colitis.

Nod2 Deficiency Leads to a Specific and Transmissible Mucosa-associated Microbial Dysbiosis Which Is Independent of the Mucosal Barrier Defect.

Nutritional strategies and gut microbiota composition as risk factors for necrotizing enterocolitis in very-preterm infants

Patchy distribution of mucosal lesions in ileal Crohn's disease is not linked to differences in the dominant mucosa-associated bacteria: a study using fluorescence in situ hybridization and temporal temperature gradient gel electrophoresis

Phylogenetic network analysis applied to pig gut microbiota identifies an ecosystem structure linked with growth traits

Rapid analysis of bile acids in different biological matrices using LC-ESI-MS/MS for the investigation of bile acid transformation by mammalian gut bacteria

Resilience of the dominant human fecal microbiota upon short-course antibiotic challenge

Resistance Mechanisms to Immune-Checkpoint Blockade in Cancer: Tumor-Intrinsic and -Extrinsic Factors

Respective Roles of Hematopoietic and Nonhematopoietic Nod2 on the Gut Microbiota and Mucosal Homeostasis

Review article: gut flora and inflammatory bowel disease.

Search for localized dysbiosis in Crohn's disease ulcerations by temporal temperature gradient gel electrophoresis of 16S rRNA.

Specificities of the fecal microbiota in inflammatory bowel disease

Structural robustness of the gut mucosal microbiota is associated with Crohn's disease remission after surgery

Systemic short chain fatty acids limit antitumor effect of CTLA-4 blockade in hosts with cancer

TREM-1 Inhibition Restores Impaired Autophagy Activity and Reduces Colitis in Mice

Temperature gradient gel electrophoresis of fecal 16S rRNA reveals active Escherichia coli in the microbiota of patients with ulcerative colitis

The gut microbiota drives the impact of bile acids and fat source in diet on mouse metabolism

The human gut microbiome and its dysfunctions

The human gut microbiome and its dysfunctions through the meta-omics prism

The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide

Transcriptional activity of the dominant gut mucosal microbiota in chronic inflammatory bowel disease patients

Twin study indicates loss of interaction between microbiota and mucosa of patients with ulcerative colitis

Why should we need the gut microbiota to respond to cancer therapies?