List of works - Graham S Timmins

13[C]-urea breath test as a novel point-of-care biomarker for tuberculosis treatment and diagnosis

scientific article

A Proof of Concept Study to Detect Urease Producing Bacteria in Lungs Using Aerosolized 13C-Urea.

scientific article published on June 2016

A nondestructive technique to determine the rate of oxygen permeation into solid dosage forms.

scientific article

A study of photochemically-generated protein radical spin adducts on bovine serum albumin: the detection of genuine spin-trapping and artefactual, non-radical addition in the same molecule.

scientific article

A study of the effects of complexation of heme by hemopexin upon its reactions with organic peroxides

scientific article published on 01 May 1995

Ambroxol and Ciprofloxacin Show Activity Against SARS-CoV2 in Vero E6 Cells at Clinically-Relevant Concentrations

scientific article published on 11 August 2020

Ambroxol induces autophagy and potentiates Rifampin antimycobacterial activity

scientific article published on 27 August 2018

An EPR spin trapping study of albumin protein radicals formed by the photodynamic action of haematoporphyrin

scientific article published on 01 December 1993

Application of in vivo EPR in brain research: monitoring tissue oxygenation, blood flow, and oxidative stress

scientific article published on 01 August 2004

Applications of in vivo electron paramagnetic resonance (EPR) spectroscopy: measurements of pO2 and NO in endotoxin shock

scientific article published on 01 March 2001

Autophagy Mediates Astrocyte Death During Zinc-Potentiated Ischemia--Reperfusion Injury

scientific article

Autophagy protects against active tuberculosis by suppressing bacterial burden and inflammation

scientific article

Azithromycin and ciprofloxacin have a chloroquine-like effect on respiratory epithelial cells

scientific article published on 01 April 2020

Comparison of cross-linked polyethylene materials for orthopaedic applications.

scientific article

Confinement-induced quorum sensing of individual Staphylococcus aureus bacteria.

scientific article

Conformational changes induced in bovine serum albumin by the photodynamic action of haematoporphyrin

scientific article published on 01 July 1994

Detecting virulence and drug-resistance mycobacterial phenotypes in vivo.

scientific article

Detection of protein radicals formed by the photodynamic action of porphyrin sensitizers

scientific article published on 01 May 1995

Determining the site of spin trapping of the equine myoglobin radical by combined use of EPR, electrophoretic purification, and mass spectrometry

scientific article

Deuterated drugs: where are we now?

scientific article

Deuterated drugs; updates and obviousness analysis

scientific article published on 8 September 2017

Direct visualization of mouse brain oxygen distribution by electron paramagnetic resonance imaging: application to focal cerebral ischemia.

scientific article published on 15 July 2009

Drugs: From Discovery to Approval:Drugs: From Discovery to Approval

scientific article published on 26 May 2009

Endosomal hyperacidification in cystic fibrosis is due to defective nitric oxide-cylic GMP signalling cascade

scientific article

Endothelin-1-mediated increase in reactive oxygen species and NADPH Oxidase activity in hearts of aryl hydrocarbon receptor (AhR) null mice.

scientific article published on 17 August 2005

Enhancement of lung levels of antibiotics by ambroxol and bromhexine

scientific article published on 07 February 2019

Firefly flashing is controlled by gating oxygen to light-emitting cells.

scientific article published on August 2001

Free radical formation in murine skin treated with tumour promoting organic peroxides

scientific article published on 01 August 1993

Immunologic manifestations of autophagy

scientific article

In vitro and in vivo studies of a rapid and selective breath test for tuberculosis based upon mycobacterial CO dehydrogenase.

scientific article published on 15 April 2014

Interstitial pO2 in ischemic penumbra and core are differentially affected following transient focal cerebral ischemia in rats

scientific article published on 01 March 2004

Lipid peroxidation-dependent chemiluminescence from the cyclization of alkylperoxyl radicals to dioxetane radical intermediates

scientific article published on 01 October 1997

Low concentration of arsenite exacerbates UVR-induced DNA strand breaks by inhibiting PARP-1 activity

scientific article

Measurement of S-nitrosothiols in extracellular fluids from healthy human volunteers and rheumatoid arthritis patients, using electron paramagnetic resonance spectrometry

scientific article

Measurement of oxygen partial pressure, its control during hypoxia and hyperoxia, and its effect upon light emission in a bioluminescent elaterid larva

scientific article published on 01 October 1999

Microarray analysis and functional characterization of the nitrosative stress response in nonmucoid and mucoid Pseudomonas aeruginosa.

scientific article

Molecular and physiological effects of mycobacterial oxyR inactivation

scientific article published on April 2006

Mycobacteria inhibit nitric oxide synthase recruitment to phagosomes during macrophage infection

scientific article published on May 2004

Mycobacterium tuberculosis prevents inflammasome activation

scientific article published on April 2008

Nitric oxide generated from isoniazid activation by KatG: source of nitric oxide and activity against Mycobacterium tuberculosis

scientific article

Nitrosative stress inhibits production of the virulence factor alginate in mucoid Pseudomonas aeruginosa

article

Normobaric Hyperoxia Reduces Blood Occludin Fragments in Rats and Patients With Acute Ischemic Stroke

scientific article

Nox2 modification of LDL is essential for optimal apolipoprotein B-mediated control of agr type III Staphylococcus aureus quorum-sensing.

scientific article

Pharmaceutical screen identifies novel target processes for activation of autophagy with a broad translational potential.

scientific article published on 27 October 2015

Pharmacological modulation of cGMP levels by phosphodiesterase 5 inhibitors as a therapeutic strategy for treatment of respiratory pathology in cystic fibrosis

scientific article

Photodynamically Generated Bovine Serum Albumin Radicals: Evidence for Damage Transfer and Oxidation at Cysteine and Tryptophan Residues ⬇️

scientific article published on March 15, 1998

Protein hydroperoxides and carbonyl groups generated by porphyrin-induced photo-oxidation of bovine serum albumin

scientific article published on 01 February 1998

Rapid in vivo detection of isoniazid-sensitive Mycobacterium tuberculosis by breath test

scientific article

Reporter phage and breath tests: emerging phenotypic assays for diagnosing active tuberculosis, antibiotic resistance, and treatment efficacy.

scientific article published on November 2011

Requirements for nitric oxide generation from isoniazid activation in vitro and inhibition of mycobacterial respiration in vivo

scientific article

Spray-Dried Multiscale Nano-biocomposites Containing Living Cells.

scientific article

Stable isotope biomarker breath tests for human metabolic and infectious diseases: a review of recent patent literature

scientific article published on 28 July 2016

Stable isotope-labeled excipients for drug product identification and counterfeit detection

scientific article published on 19 June 2010

Stool microbiome reveals diverse bacterial ureases as confounders of oral urea breath testing for Helicobacter pylori and Mycobacterium tuberculosis in Bamako, Mali

scientific article

The synthesis and use of a (15)N and (2)H isotopically-labelled derivative of the spin-trap 3, 5-dibromo-4-nitrosobenzenesulphonic acid

scientific article published on 01 December 1996

Trapping of free radicals with direct in vivo EPR detection: a comparison of 5,5-dimethyl-1-pyrroline-N-oxide and 5-diethoxyphosphoryl-5-methyl-1-pyrroline-N-oxide as spin traps for HO* and SO4*-

scientific article published on 01 August 1999

UV radiation induces delayed hyperrecombination associated with hypermutation in human cells.

scientific article

Use of isotopically labelled spin-traps to determine definitively the presence or absence of non-radical addition artefacts in EPR spin-trapping systems

scientific article published on 01 April 1997

List of works by Graham S Timmins

13[C]-urea breath test as a novel point-of-care biomarker for tuberculosis treatment and diagnosis

A Proof of Concept Study to Detect Urease Producing Bacteria in Lungs Using Aerosolized 13C-Urea.

A nondestructive technique to determine the rate of oxygen permeation into solid dosage forms.

A study of photochemically-generated protein radical spin adducts on bovine serum albumin: the detection of genuine spin-trapping and artefactual, non-radical addition in the same molecule.

A study of the effects of complexation of heme by hemopexin upon its reactions with organic peroxides

Ambroxol and Ciprofloxacin Show Activity Against SARS-CoV2 in Vero E6 Cells at Clinically-Relevant Concentrations

Ambroxol induces autophagy and potentiates Rifampin antimycobacterial activity

An EPR spin trapping study of albumin protein radicals formed by the photodynamic action of haematoporphyrin

Application of in vivo EPR in brain research: monitoring tissue oxygenation, blood flow, and oxidative stress

Applications of in vivo electron paramagnetic resonance (EPR) spectroscopy: measurements of pO2 and NO in endotoxin shock

Autophagy Mediates Astrocyte Death During Zinc-Potentiated Ischemia--Reperfusion Injury

Autophagy protects against active tuberculosis by suppressing bacterial burden and inflammation

Azithromycin and ciprofloxacin have a chloroquine-like effect on respiratory epithelial cells

Comparison of cross-linked polyethylene materials for orthopaedic applications.

Confinement-induced quorum sensing of individual Staphylococcus aureus bacteria.

Conformational changes induced in bovine serum albumin by the photodynamic action of haematoporphyrin

Detecting virulence and drug-resistance mycobacterial phenotypes in vivo.

Detection of protein radicals formed by the photodynamic action of porphyrin sensitizers

Determining the site of spin trapping of the equine myoglobin radical by combined use of EPR, electrophoretic purification, and mass spectrometry

Deuterated drugs: where are we now?

Deuterated drugs; updates and obviousness analysis

Direct visualization of mouse brain oxygen distribution by electron paramagnetic resonance imaging: application to focal cerebral ischemia.

Drugs: From Discovery to Approval:Drugs: From Discovery to Approval

Endosomal hyperacidification in cystic fibrosis is due to defective nitric oxide-cylic GMP signalling cascade

Endothelin-1-mediated increase in reactive oxygen species and NADPH Oxidase activity in hearts of aryl hydrocarbon receptor (AhR) null mice.

Enhancement of lung levels of antibiotics by ambroxol and bromhexine

Firefly flashing is controlled by gating oxygen to light-emitting cells.

Free radical formation in murine skin treated with tumour promoting organic peroxides

Immunologic manifestations of autophagy

In vitro and in vivo studies of a rapid and selective breath test for tuberculosis based upon mycobacterial CO dehydrogenase.

Interstitial pO2 in ischemic penumbra and core are differentially affected following transient focal cerebral ischemia in rats

Lipid peroxidation-dependent chemiluminescence from the cyclization of alkylperoxyl radicals to dioxetane radical intermediates

Low concentration of arsenite exacerbates UVR-induced DNA strand breaks by inhibiting PARP-1 activity

Measurement of S-nitrosothiols in extracellular fluids from healthy human volunteers and rheumatoid arthritis patients, using electron paramagnetic resonance spectrometry

Measurement of oxygen partial pressure, its control during hypoxia and hyperoxia, and its effect upon light emission in a bioluminescent elaterid larva

Microarray analysis and functional characterization of the nitrosative stress response in nonmucoid and mucoid Pseudomonas aeruginosa.

Molecular and physiological effects of mycobacterial oxyR inactivation

Mycobacteria inhibit nitric oxide synthase recruitment to phagosomes during macrophage infection

Mycobacterium tuberculosis prevents inflammasome activation

Nitric oxide generated from isoniazid activation by KatG: source of nitric oxide and activity against Mycobacterium tuberculosis

Nitrosative stress inhibits production of the virulence factor alginate in mucoid Pseudomonas aeruginosa

Normobaric Hyperoxia Reduces Blood Occludin Fragments in Rats and Patients With Acute Ischemic Stroke

Nox2 modification of LDL is essential for optimal apolipoprotein B-mediated control of agr type III Staphylococcus aureus quorum-sensing.

Pharmaceutical screen identifies novel target processes for activation of autophagy with a broad translational potential.

Pharmacological modulation of cGMP levels by phosphodiesterase 5 inhibitors as a therapeutic strategy for treatment of respiratory pathology in cystic fibrosis

Photodynamically Generated Bovine Serum Albumin Radicals: Evidence for Damage Transfer and Oxidation at Cysteine and Tryptophan Residues ⬇️

Protein hydroperoxides and carbonyl groups generated by porphyrin-induced photo-oxidation of bovine serum albumin

Rapid in vivo detection of isoniazid-sensitive Mycobacterium tuberculosis by breath test

Reporter phage and breath tests: emerging phenotypic assays for diagnosing active tuberculosis, antibiotic resistance, and treatment efficacy.

Requirements for nitric oxide generation from isoniazid activation in vitro and inhibition of mycobacterial respiration in vivo

Spray-Dried Multiscale Nano-biocomposites Containing Living Cells.

Stable isotope biomarker breath tests for human metabolic and infectious diseases: a review of recent patent literature

Stable isotope-labeled excipients for drug product identification and counterfeit detection

Stool microbiome reveals diverse bacterial ureases as confounders of oral urea breath testing for Helicobacter pylori and Mycobacterium tuberculosis in Bamako, Mali

The synthesis and use of a (15)N and (2)H isotopically-labelled derivative of the spin-trap 3, 5-dibromo-4-nitrosobenzenesulphonic acid

Trapping of free radicals with direct in vivo EPR detection: a comparison of 5,5-dimethyl-1-pyrroline-N-oxide and 5-diethoxyphosphoryl-5-methyl-1-pyrroline-N-oxide as spin traps for HO* and SO4*-

UV radiation induces delayed hyperrecombination associated with hypermutation in human cells.

Use of isotopically labelled spin-traps to determine definitively the presence or absence of non-radical addition artefacts in EPR spin-trapping systems