List of works - Nigel Klein

A novel form of integrin dysfunction involving beta1, beta2, and beta3 integrins

scientific article

Abacavir, zidovudine, or stavudine as paediatric tablets for African HIV-infected children (CHAPAS-3): an open-label, parallel-group, randomised controlled trial

scientific article published on 5 October 2015

Age and CD4 count at initiation of antiretroviral therapy in HIV-infected children: effects on long-term T-cell reconstitution.

scientific article

Alteration in glycosaminoglycan metabolism and surface charge on human umbilical vein endothelial cells induced by cytokines, endotoxin and neutrophils

scientific article published on August 1, 1992

Anthropometric measurements and lipid profiles to detect early lipodystrophy in antiretroviral therapy experienced HIV-infected children in the CHAPAS-3 trial

scientific article

Anti-neutrophil cytoplasmic antibodies stimulate release of neutrophil microparticles

scientific article published on 3 November 2011

Antibiotic choices for meningitis beyond the neonatal period ⬇️

scientific article published on February 1, 1992

Are there opportunities to decrease nosocomial infection by choice of analgesic regimen? Evidence for immunity and pain interactions

scientific article published on November 2003

Association between maternal dental periapical infections and pregnancy outcomes: results from a cross-sectional study in Malawi

scientific article published on 30 July 2015

Autoinflammatory periodic fever, immunodeficiency, and thrombocytopenia (PFIT) caused by mutation in actin-regulatory gene WDR1

scientific article

Bacterial communities found in placental tissues are associated with severe chorioamnionitis and adverse birth outcomes

scientific article

Bacterial-epithelial contact is a key determinant of host innate immune responses to enteropathogenic and enteroaggregative Escherichia coli.

scientific article published on 28 October 2011

Baseline Inflammatory Biomarkers Identify Subgroups of HIV-Infected African Children With Differing Responses to Antiretroviral Therapy

scientific article published on 18 May 2016

Changes in neutrophil CD11b/CD18 andl-selectin expression and release of interleukin 8 and elastase in paediatric cardiopulmonary bypass ⬇️

scientific article published on 01 January 1993

Characterising Post-mortem Bacterial Translocation Under Clinical Conditions Using 16S rRNA Gene Sequencing in Two Animal Models

scientific article published on 31 May 2021

Characterization of two conjugative Yersinia plasmids mobilizing pYV.

scientific article published on January 2003

Co-causation of reduced newborn size by maternal undernutrition, infections, and inflammation

scientific article published on 8 January 2018

Cotrimoxazole reduces systemic inflammation in HIV infection by altering the gut microbiome and immune activation

scientific article published on 01 April 2019

Differing prevalence and diversity of bacterial species in fetal membranes from very preterm and term labor

scientific article

Direct maternal deaths attributable to HIV in the era of ART: evidence from three population-based HIV cohorts with verbal autopsy

scientific article published on 08 May 2020

Discordant Immune Response with Antiretroviral Therapy in HIV-1: A Systematic Review of Clinical Outcomes

scientific article

Distinguishing the Signals of Gingivitis and Periodontitis in Supragingival Plaque: a Cross-Sectional Cohort Study in Malawi.

scientific article published on 12 August 2016

Early and Highly Suppressive Antiretroviral Therapy Are Main Factors Associated With Low Viral Reservoir in European Perinatally HIV-Infected Children

article

Early antiretroviral therapy in children perinatally infected with HIV: a unique opportunity to implement immunotherapeutic approaches to prolong viral remission

scientific article published on 14 July 2015

Early severe neutropenia and thrombocytopenia identifies the highest risk cases of severe meningococcal disease

scientific article

Expression of the inflammatory chemokines CCL5, CCL3 and CXCL10 in juvenile idiopathic arthritis, and demonstration of CCL5 production by an atypical subset of CD8+ T cells

scientific article

Extended extraocular phenotype of PROM1 mutation in kindreds with known autosomal dominant macular dystrophy

scientific article

Febrile neutropenia: past, present and future.

scientific article published in January 2004

Genetic and functional properties of the self-transmissible Yersinia enterocolitica plasmid pYE854, which mobilizes the virulence plasmid pYV.

scientific article published on 30 November 2007

Gut overgrowth with abnormal flora: the missing link in parenteral nutrition-related sepsis in surgical neonates ⬇️

scientific article published on 01 April 2003

Healthcare environments and spatial variability of healthcare associated infection risk: cross-sectional surveys

scientific article

Hematologically important mutations: leukocyte adhesion deficiency (first update).

scientific article

Hepatitis C Co-Infection and CD4+ T Cell Recovery in HIV-Infected Children Receiving Anti-Retroviral Therapy

scientific article

Hospital door handle design and their contamination with bacteria: a real life observational study. Are we pulling against closed doors?

scientific article

Immunohistochemical expression of inflammatory markers in sudden infant death; ancillary tests for identification of infection

scientific article published on 3 October 2014

Increased thymic output after initiation of antiretroviral therapy in human immunodeficiency virus type 1-infected children in the Paediatric European Network for Treatment of AIDS (PENTA) 5 Trial

scientific article published on 5 July 2002

Inflammatory biomarkers in HIV-infected children hospitalized for severe malnutrition in Uganda and Zimbabwe

scientific article published on 01 July 2019

Interleukin-8 (CXCL8) production is a signatory T cell effector function of human newborn infants.

scientific article

Interplay between the temperate phages PY54 and N15, linear plasmid prophages with covalently closed ends

scientific article published on 7 September 2007

Investigation of childhood central nervous system vasculitis: magnetic resonance angiography versus catheter cerebral angiography

scientific article

LOS oligosaccharide modification enhances dendritic cell responses to meningococcal native outer membrane vesicles expressing a non-toxic lipid A

scientific article

Lactobacillus-deficient vaginal microbiota dominate post-partum women in rural Malawi.

scientific article published on 5 January 2018

Microbial translocation does not drive immune activation in Ugandan children with HIV

article

Neuroblastoma killing properties of Vδ2 and Vδ2-negative γδT cells following expansion by artificial antigen-presenting cells

scientific article published on 3 June 2014

Perinatal risk factors for neonatal encephalopathy: an unmatched case-control study.

scientific article published on 05 August 2017

Pharmacokinetics, safety, and tolerability of voriconazole in immunocompromised children

scientific article

Plasticity of the Immune System in Children Following Treatment Interruption in HIV-1 Infection

scientific article published on 29 July 2021

Platelet and soluble CD40L in meningococcal sepsis.

scientific article

Predicting patterns of long-term CD4 reconstitution in HIV-infected children starting antiretroviral therapy in sub-Saharan Africa: a cohort-based modelling study

scientific article

Prevalence of bloodstream pathogens is higher in neonatal encephalopathy cases vs. controls using a novel panel of real-time PCR assays

scientific article

Preventing tuberculosis in paediatric kidney transplant recipients: is there a role for BCG immunisation pre-transplantation in low tuberculosis incidence countries?

scientific article published on 27 November 2020

Prevention of inflammation-induced endothelial dysfunction: a novel vasculo-protective action of aspirin

scientific article (publication date: 4 June 2002)

Raltegravir-intensified initial antiretroviral therapy in advanced HIV disease in Africa: A randomised controlled trial

article

Randomised controlled trial of inhaled corticosteroids (fluticasone propionate) in cystic fibrosis ⬇️

scientific article published on August 1, 1997

Reactivity of routine HIV antibody tests in children who initiated antiretroviral therapy in early infancy as part of the Children with HIV Early Antiretroviral Therapy (CHER) trial: a retrospective analysis

scientific article published in June 2015

Reduction of the anticoagulant activity of glycosaminoglycans on the surface of the vascular endothelium by endotoxin and neutrophils: evaluation by an amidolytic assay

scientific article published on September 15, 1992

Regulatory B cells are induced by gut microbiota-driven interleukin-1β and interleukin-6 production

scientific article

Relationship between changes in thymic emigrants and cell-associated HIV-1 DNA in HIV-1-infected children initiating antiretroviral therapy

scientific article published on 01 January 2005

Revealing individual signatures of human T cell CDR3 sequence repertoires with Kidera Factors

scientific article (publication date: 2014)

Risk and protective factors for meningococcal disease in adolescents: matched cohort study

scientific article

Role for mannose binding lectin in the prevention of Mycoplasma infection.

scientific article

Sequence analysis of the genome of the temperate Yersinia enterocolitica phage PY54.

scientific article published on August 2003

Shedding of Large Functionally Active CD11/CD18 Integrin Complexes from Leukocyte Membranes during Synovial Inflammation Distinguishes Three Types of Arthritis through Differential Epitope Exposure

scientific article (publication date: 8 September 2010)

Targeted gene delivery to human airway epithelial cells with synthetic vectors incorporating novel targeting peptides selected by phage display

scientific article

The immunological and virological consequences of planned treatment interruptions in children with HIV infection

scientific article

The role of mannose-binding lectin in susceptibility to infection in preterm neonates

scientific article published on 01 June 2008

Thymic Output and CD4 T-Cell Reconstitution in HIV-Infected Children on Early and Interrupted Antiretroviral Treatment: Evidence from the Children with HIV Early Antiretroviral Therapy Trial.

scientific article published on 20 September 2017

Understanding the slow depletion of memory CD4+ T cells in HIV infection

scientific article

Unique case of Helicobacter sp. osteomyelitis in an immunocompetent child diagnosed by broad-range 16S PCR.

scientific article

Using CD4 percentage and age to optimize pediatric antiretroviral therapy initiation

scientific article

Virological response and resistance among HIV-infected children receiving long-term antiretroviral therapy without virological monitoring in Uganda and Zimbabwe: Observational analyses within the randomised ARROW trial

scientific article published on 14 November 2017

Weekends-off efavirenz-based antiretroviral therapy in HIV-infected children, adolescents and young adults (BREATHER): Extended follow-up results of a randomised, open-label, non-inferiority trial.

scientific article published on 23 April 2018

‘If I am on ART, my new-born baby should be put on treatment immediately’: Exploring the acceptability, and appropriateness of Cepheid Xpert HIV-1 Qual assay for early infant diagnosis of HIV in Malawi

scientific article published in 2023

List of works by Nigel Klein

A novel form of integrin dysfunction involving beta1, beta2, and beta3 integrins

Abacavir, zidovudine, or stavudine as paediatric tablets for African HIV-infected children (CHAPAS-3): an open-label, parallel-group, randomised controlled trial

Age and CD4 count at initiation of antiretroviral therapy in HIV-infected children: effects on long-term T-cell reconstitution.

Alteration in glycosaminoglycan metabolism and surface charge on human umbilical vein endothelial cells induced by cytokines, endotoxin and neutrophils

Anthropometric measurements and lipid profiles to detect early lipodystrophy in antiretroviral therapy experienced HIV-infected children in the CHAPAS-3 trial

Anti-neutrophil cytoplasmic antibodies stimulate release of neutrophil microparticles

Antibiotic choices for meningitis beyond the neonatal period ⬇️

Are there opportunities to decrease nosocomial infection by choice of analgesic regimen? Evidence for immunity and pain interactions

Association between maternal dental periapical infections and pregnancy outcomes: results from a cross-sectional study in Malawi

Autoinflammatory periodic fever, immunodeficiency, and thrombocytopenia (PFIT) caused by mutation in actin-regulatory gene WDR1

Bacterial communities found in placental tissues are associated with severe chorioamnionitis and adverse birth outcomes

Bacterial-epithelial contact is a key determinant of host innate immune responses to enteropathogenic and enteroaggregative Escherichia coli.

Baseline Inflammatory Biomarkers Identify Subgroups of HIV-Infected African Children With Differing Responses to Antiretroviral Therapy

Changes in neutrophil CD11b/CD18 andl-selectin expression and release of interleukin 8 and elastase in paediatric cardiopulmonary bypass ⬇️

Characterising Post-mortem Bacterial Translocation Under Clinical Conditions Using 16S rRNA Gene Sequencing in Two Animal Models

Characterization of two conjugative Yersinia plasmids mobilizing pYV.

Co-causation of reduced newborn size by maternal undernutrition, infections, and inflammation

Cotrimoxazole reduces systemic inflammation in HIV infection by altering the gut microbiome and immune activation

Differing prevalence and diversity of bacterial species in fetal membranes from very preterm and term labor

Direct maternal deaths attributable to HIV in the era of ART: evidence from three population-based HIV cohorts with verbal autopsy

Discordant Immune Response with Antiretroviral Therapy in HIV-1: A Systematic Review of Clinical Outcomes

Distinguishing the Signals of Gingivitis and Periodontitis in Supragingival Plaque: a Cross-Sectional Cohort Study in Malawi.

Early and Highly Suppressive Antiretroviral Therapy Are Main Factors Associated With Low Viral Reservoir in European Perinatally HIV-Infected Children

Early antiretroviral therapy in children perinatally infected with HIV: a unique opportunity to implement immunotherapeutic approaches to prolong viral remission

Early severe neutropenia and thrombocytopenia identifies the highest risk cases of severe meningococcal disease

Expression of the inflammatory chemokines CCL5, CCL3 and CXCL10 in juvenile idiopathic arthritis, and demonstration of CCL5 production by an atypical subset of CD8+ T cells

Extended extraocular phenotype of PROM1 mutation in kindreds with known autosomal dominant macular dystrophy

Febrile neutropenia: past, present and future.

Genetic and functional properties of the self-transmissible Yersinia enterocolitica plasmid pYE854, which mobilizes the virulence plasmid pYV.

Gut overgrowth with abnormal flora: the missing link in parenteral nutrition-related sepsis in surgical neonates ⬇️

Healthcare environments and spatial variability of healthcare associated infection risk: cross-sectional surveys

Hematologically important mutations: leukocyte adhesion deficiency (first update).

Hepatitis C Co-Infection and CD4+ T Cell Recovery in HIV-Infected Children Receiving Anti-Retroviral Therapy

Hospital door handle design and their contamination with bacteria: a real life observational study. Are we pulling against closed doors?

Immunohistochemical expression of inflammatory markers in sudden infant death; ancillary tests for identification of infection

Increased thymic output after initiation of antiretroviral therapy in human immunodeficiency virus type 1-infected children in the Paediatric European Network for Treatment of AIDS (PENTA) 5 Trial

Inflammatory biomarkers in HIV-infected children hospitalized for severe malnutrition in Uganda and Zimbabwe

Interleukin-8 (CXCL8) production is a signatory T cell effector function of human newborn infants.

Interplay between the temperate phages PY54 and N15, linear plasmid prophages with covalently closed ends

Investigation of childhood central nervous system vasculitis: magnetic resonance angiography versus catheter cerebral angiography

LOS oligosaccharide modification enhances dendritic cell responses to meningococcal native outer membrane vesicles expressing a non-toxic lipid A

Lactobacillus-deficient vaginal microbiota dominate post-partum women in rural Malawi.

Microbial translocation does not drive immune activation in Ugandan children with HIV

Neuroblastoma killing properties of Vδ2 and Vδ2-negative γδT cells following expansion by artificial antigen-presenting cells

Perinatal risk factors for neonatal encephalopathy: an unmatched case-control study.

Pharmacokinetics, safety, and tolerability of voriconazole in immunocompromised children

Plasticity of the Immune System in Children Following Treatment Interruption in HIV-1 Infection

Platelet and soluble CD40L in meningococcal sepsis.

Predicting patterns of long-term CD4 reconstitution in HIV-infected children starting antiretroviral therapy in sub-Saharan Africa: a cohort-based modelling study

Prevalence of bloodstream pathogens is higher in neonatal encephalopathy cases vs. controls using a novel panel of real-time PCR assays

Preventing tuberculosis in paediatric kidney transplant recipients: is there a role for BCG immunisation pre-transplantation in low tuberculosis incidence countries?

Prevention of inflammation-induced endothelial dysfunction: a novel vasculo-protective action of aspirin

Raltegravir-intensified initial antiretroviral therapy in advanced HIV disease in Africa: A randomised controlled trial

Randomised controlled trial of inhaled corticosteroids (fluticasone propionate) in cystic fibrosis ⬇️

Reactivity of routine HIV antibody tests in children who initiated antiretroviral therapy in early infancy as part of the Children with HIV Early Antiretroviral Therapy (CHER) trial: a retrospective analysis

Reduction of the anticoagulant activity of glycosaminoglycans on the surface of the vascular endothelium by endotoxin and neutrophils: evaluation by an amidolytic assay

Regulatory B cells are induced by gut microbiota-driven interleukin-1β and interleukin-6 production

Relationship between changes in thymic emigrants and cell-associated HIV-1 DNA in HIV-1-infected children initiating antiretroviral therapy

Revealing individual signatures of human T cell CDR3 sequence repertoires with Kidera Factors

Risk and protective factors for meningococcal disease in adolescents: matched cohort study

Role for mannose binding lectin in the prevention of Mycoplasma infection.

Sequence analysis of the genome of the temperate Yersinia enterocolitica phage PY54.

Shedding of Large Functionally Active CD11/CD18 Integrin Complexes from Leukocyte Membranes during Synovial Inflammation Distinguishes Three Types of Arthritis through Differential Epitope Exposure

Targeted gene delivery to human airway epithelial cells with synthetic vectors incorporating novel targeting peptides selected by phage display

The immunological and virological consequences of planned treatment interruptions in children with HIV infection

The role of mannose-binding lectin in susceptibility to infection in preterm neonates

Thymic Output and CD4 T-Cell Reconstitution in HIV-Infected Children on Early and Interrupted Antiretroviral Treatment: Evidence from the Children with HIV Early Antiretroviral Therapy Trial.

Understanding the slow depletion of memory CD4+ T cells in HIV infection

Unique case of Helicobacter sp. osteomyelitis in an immunocompetent child diagnosed by broad-range 16S PCR.

Using CD4 percentage and age to optimize pediatric antiretroviral therapy initiation

Virological response and resistance among HIV-infected children receiving long-term antiretroviral therapy without virological monitoring in Uganda and Zimbabwe: Observational analyses within the randomised ARROW trial

Weekends-off efavirenz-based antiretroviral therapy in HIV-infected children, adolescents and young adults (BREATHER): Extended follow-up results of a randomised, open-label, non-inferiority trial.

‘If I am on ART, my new-born baby should be put on treatment immediately’: Exploring the acceptability, and appropriateness of Cepheid Xpert HIV-1 Qual assay for early infant diagnosis of HIV in Malawi