List of works - Steve Goldstein

A common cardiac sodium channel variant associated with sudden infant death in African Americans, SCN5A S1103Y

scientific article

A minK-HERG complex regulates the cardiac potassium current I(Kr)

scientific article (publication date: 17 July 1997)

A new family of outwardly rectifying potassium channel proteins with two pore domains in tandem.

scientific article

A point mutation in a Shaker K+ channel changes its charybdotoxin binding site from low to high affinity.

scientific article

A structural vignette common to voltage sensors and conduction pores: canaliculi.

scientific article published on April 1996

Alternative translation initiation in rat brain yields K2P2.1 potassium channels permeable to sodium

scientific article

Block of Kcnk3 by protons. Evidence that 2-P-domain potassium channel subunits function as homodimers.

scientific article published on 17 May 2001

Charybdotoxin Binding in the IKs Pore Demonstrates Two MinK Subunits in Each Channel Complex

scientific article published on 01 September 2003

Commentary: Analysis of SUMO1-conjugation at synapses

scientific article published on 30 October 2017

Designer and natural peptide toxin blockers of the KcsA potassium channel identified by phage display

scientific article

Determination of fluphenazine, related phenothiazine drugs and metabolites by combined high-performance liquid chromatography and radioimmunoassay ⬇️

scientific article published on 01 April 1981

Disease-associated mutations in KCNE potassium channel subunits (MiRPs) reveal promiscuous disruption of multiple currents and conservation of mechanism

scientific article (publication date: March 2002)

Do all voltage-gated potassium channels use MiRPs?

scientific article published in May 2001

Forward Transport of K2p3.1: mediation by 14-3-3 and COPI, modulation by p11.

scientific article published on 24 October 2007

Forward transport. 14-3-3 binding overcomes retention in endoplasmic reticulum by dibasic signals

scientific article (publication date: 15 November 2002)

Genomic organization and chromosomal localization of the murine 2 P domain potassium channel gene Kcnk8: conservation of gene structure in 2 P domain potassium channels

scientific article

Hyperpolarization moves S4 sensors inward to open MVP, a methanococcal voltage-gated potassium channel

scientific article (publication date: April 2003)

Hypoxia Produces Pro-arrhythmic Late Sodium Current in Cardiac Myocytes by SUMOylation of NaV1.5 Channels

scientific article published on 01 February 2020

I SA channel complexes include four subunits each of DPP6 and Kv4.2

scientific article

IKs channels open slowly because KCNE1 accessory subunits slow the movement of S4 voltage sensors in KCNQ1 pore-forming subunits

scientific article

Immunity to K1 killer toxin: internal TOK1 blockade

scientific article

Individual IKs channels at the surface of mammalian cells contain two KCNE1 accessory subunits

scientific article

International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels

scientific article

Ion channels: structural basis for function and disease.

scientific article published on December 1996

Ito channels are octomeric complexes with four subunits of each Kv4.2 and K+ channel-interacting protein 2

scientific article

K2P channels and their protein partners.

scientific article

K2P potassium channels, mysterious and paradoxically exciting.

scientific article published on 26 July 2011

KCNK2: reversible conversion of a hippocampal potassium leak into a voltage-dependent channel

scientific article (publication date: May 2001)

KCNKØ: opening and closing the 2-P-domain potassium leak channel entails "C-type" gating of the outer pore.

scientific article published in November 2001

Kcne4 deletion sex- and age-specifically impairs cardiac repolarization in mice

scientific article

Kcnkø: single, cloned potassium leak channels are multi-ion pores

scientific article

Mechanism of charybdotoxin block of a voltage-gated K+ channel.

scientific article

MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia

scientific article

MiRP2 forms potassium channels in skeletal muscle with Kv3.4 and is associated with periodic paralysis

scientific article (publication date: 26 January 2001)

MinK endows the I(Ks) potassium channel pore with sensitivity to internal tetraethylammonium

scientific article

MinK potassium channels are heteromultimeric complexes.

scientific article published in January 1997

One SUMO is sufficient to silence the dimeric potassium channel K2P1

scientific article

Phosphorylation and protonation of neighboring MiRP2 sites: function and pathophysiology of MiRP2-Kv3.4 potassium channels in periodic paralysis

scientific article

Pore- and state-dependent cadmium block of I(Ks) channels formed with MinK-55C and wild-type KCNQ1 subunits

scientific article

Potassium leak channels and the KCNK family of two-P-domain subunits

scientific article (publication date: March 2001)

Role of human Hv1 channels in sperm capacitation and white blood cell respiratory burst established by a designed peptide inhibitor.

scientific article published on 26 November 2018

SUMO modification of cell surface Kv2.1 potassium channels regulates the activity of rat hippocampal neurons ⬇️

scientific article

SUMOylation determines the voltage required to activate cardiac IKs channels

scientific article published on 25 July 2017

SUMOylation of NaV1.2 channels mediates the early response to acute hypoxia in central neurons.

scientific article published on 28 December 2016

SUMOylation silences heterodimeric TASK potassium channels containing K2P1 subunits in cerebellar granule neurons.

scientific article

Serial perturbation of MinK in IKs implies an alpha-helical transmembrane span traversing the channel corpus.

scientific article

Sodium leak through K2P potassium channels and cardiac arrhythmia, an emerging theme

scientific article published on 03 March 2017

Subunit composition of minK potassium channels.

scientific article published in June 1995

Tethered peptide neurotoxins display two blocking mechanisms in the K+ channel pore as do their untethered analogs

scientific article published on 04 March 2020

The conduction pore of a cardiac potassium channel

scientific article

Three-dimensional structure of I(to); Kv4.2-KChIP2 ion channels by electron microscopy at 21 Angstrom resolution

scientific article

Voltage-sensor movements describe slow inactivation of voltage-gated sodium channels I: Wild-type skeletal muscle NaV1.4 ⬇️

scientific article published on February 11, 2013

Voltage-sensor movements describe slow inactivation of voltage-gated sodium channels II: a periodic paralysis mutation in Na(V)1.4 (L689I)

scientific article published on 11 February 2013

List of works by Steve Goldstein

A common cardiac sodium channel variant associated with sudden infant death in African Americans, SCN5A S1103Y

A minK-HERG complex regulates the cardiac potassium current I(Kr)

A new family of outwardly rectifying potassium channel proteins with two pore domains in tandem.

A point mutation in a Shaker K+ channel changes its charybdotoxin binding site from low to high affinity.

A structural vignette common to voltage sensors and conduction pores: canaliculi.

Alternative translation initiation in rat brain yields K2P2.1 potassium channels permeable to sodium

Block of Kcnk3 by protons. Evidence that 2-P-domain potassium channel subunits function as homodimers.

Charybdotoxin Binding in the IKs Pore Demonstrates Two MinK Subunits in Each Channel Complex

Commentary: Analysis of SUMO1-conjugation at synapses

Designer and natural peptide toxin blockers of the KcsA potassium channel identified by phage display

Determination of fluphenazine, related phenothiazine drugs and metabolites by combined high-performance liquid chromatography and radioimmunoassay ⬇️

Disease-associated mutations in KCNE potassium channel subunits (MiRPs) reveal promiscuous disruption of multiple currents and conservation of mechanism

Do all voltage-gated potassium channels use MiRPs?

Forward Transport of K2p3.1: mediation by 14-3-3 and COPI, modulation by p11.

Forward transport. 14-3-3 binding overcomes retention in endoplasmic reticulum by dibasic signals

Genomic organization and chromosomal localization of the murine 2 P domain potassium channel gene Kcnk8: conservation of gene structure in 2 P domain potassium channels

Hyperpolarization moves S4 sensors inward to open MVP, a methanococcal voltage-gated potassium channel

Hypoxia Produces Pro-arrhythmic Late Sodium Current in Cardiac Myocytes by SUMOylation of NaV1.5 Channels

I SA channel complexes include four subunits each of DPP6 and Kv4.2

IKs channels open slowly because KCNE1 accessory subunits slow the movement of S4 voltage sensors in KCNQ1 pore-forming subunits

Immunity to K1 killer toxin: internal TOK1 blockade

Individual IKs channels at the surface of mammalian cells contain two KCNE1 accessory subunits

International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels

Ion channels: structural basis for function and disease.

Ito channels are octomeric complexes with four subunits of each Kv4.2 and K+ channel-interacting protein 2

K2P channels and their protein partners.

K2P potassium channels, mysterious and paradoxically exciting.

KCNK2: reversible conversion of a hippocampal potassium leak into a voltage-dependent channel

KCNKØ: opening and closing the 2-P-domain potassium leak channel entails "C-type" gating of the outer pore.

Kcne4 deletion sex- and age-specifically impairs cardiac repolarization in mice

Kcnkø: single, cloned potassium leak channels are multi-ion pores

Mechanism of charybdotoxin block of a voltage-gated K+ channel.

MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia

MiRP2 forms potassium channels in skeletal muscle with Kv3.4 and is associated with periodic paralysis

MinK endows the I(Ks) potassium channel pore with sensitivity to internal tetraethylammonium

MinK potassium channels are heteromultimeric complexes.

One SUMO is sufficient to silence the dimeric potassium channel K2P1

Phosphorylation and protonation of neighboring MiRP2 sites: function and pathophysiology of MiRP2-Kv3.4 potassium channels in periodic paralysis

Pore- and state-dependent cadmium block of I(Ks) channels formed with MinK-55C and wild-type KCNQ1 subunits

Potassium leak channels and the KCNK family of two-P-domain subunits

Role of human Hv1 channels in sperm capacitation and white blood cell respiratory burst established by a designed peptide inhibitor.

SUMO modification of cell surface Kv2.1 potassium channels regulates the activity of rat hippocampal neurons ⬇️

SUMOylation determines the voltage required to activate cardiac IKs channels

SUMOylation of NaV1.2 channels mediates the early response to acute hypoxia in central neurons.

SUMOylation silences heterodimeric TASK potassium channels containing K2P1 subunits in cerebellar granule neurons.

Serial perturbation of MinK in IKs implies an alpha-helical transmembrane span traversing the channel corpus.

Sodium leak through K2P potassium channels and cardiac arrhythmia, an emerging theme

Subunit composition of minK potassium channels.

Tethered peptide neurotoxins display two blocking mechanisms in the K+ channel pore as do their untethered analogs

The conduction pore of a cardiac potassium channel

Three-dimensional structure of I(to); Kv4.2-KChIP2 ion channels by electron microscopy at 21 Angstrom resolution

Voltage-sensor movements describe slow inactivation of voltage-gated sodium channels I: Wild-type skeletal muscle NaV1.4 ⬇️

Voltage-sensor movements describe slow inactivation of voltage-gated sodium channels II: a periodic paralysis mutation in Na(V)1.4 (L689I)