List of works - Mignon du Plessis

A mosaic tetracycline resistance gene tet(S/M) detected in an MDR pneumococcal CC230 lineage that underwent capsular switching in South Africa

scientific article published in March 2020

An unusual pneumococcal sequence type is the predominant cause of serotype 3 invasive disease in South Africa

scientific article

Analysis of penicillin-binding protein genes of clinical isolates of Streptococcus pneumoniae with reduced susceptibility to amoxicillin.

scientific article

Bacterial genome-wide association study of hyper-virulent pneumococcal serotype 1 identifies genetic variation associated with neurotropism

scientific article published on 08 October 2020

Challenges and clinical relevance of molecular detection of Bordetella pertussis in South Africa

scholarly article by Fahima Moosa et al published 21 March 2019 in BMC Infectious Diseases

Challenges of using molecular serotyping for surveillance of pneumococcal disease

scientific article

Clinical validation of multiplex real-time PCR assays for detection of bacterial meningitis pathogens

scientific article published on 14 December 2011

Clonal analysis of Neisseria meningitidis serogroup B strains in South Africa, 2002 to 2006: emergence of new clone ST-4240/6688.

scientific article

Declining incidence of invasive meningococcal disease in South Africa: 2003-2016

article

Distribution of factor H binding protein beyond serogroup B: variation among five serogroups of invasive Neisseria meningitidis in South Africa

scientific article published on 7 December 2010

Emergence of endemic serogroup W135 meningococcal disease associated with a high mortality rate in South Africa

scientific article published in February 2008

Emergence of levofloxacin-non-susceptible Streptococcus pneumoniae and treatment for multidrug-resistant tuberculosis in children in South Africa: a cohort observational surveillance study

scientific article

Enterovirus genotypes among patients with severe acute respiratory illness, influenza-like illness, and asymptomatic individuals in South Africa, 2012-2014.

scientific article published on 2 June 2017

Epidemiology and Molecular Identification and Characterization of Mycoplasma pneumoniae, South Africa, 2012-2015.

scientific article published in March 2018

Genomic analysis of nontypeable pneumococci causing invasive pneumococcal disease in South Africa, 2003-2013

scientific article

Genomic differences among carriage and invasive nontypeable pneumococci circulating in South Africa ⬇️

scientific article published on 11 October 2019

Genomic resolution of an aggressive, widespread, diverse and expanding meningococcal serogroup B, C and W lineage

scientific article

Global Distribution of Invasive Serotype 35D Streptococcus pneumoniae Isolates following Introduction of 13-Valent Pneumococcal Conjugate Vaccine. ⬇️

scientific article

Global emergence and population dynamics of divergent serotype 3 CC180 pneumococci

scientific article published on 26 November 2018

HIV and influenza virus infections are associated with increased blood pneumococcal load: a prospective, hospital-based observational study in South Africa, 2009-2011.

scientific article published on 6 August 2013

High nasopharyngeal pneumococcal density, increased by viral coinfection, is associated with invasive pneumococcal pneumonia

scientific article published on 6 June 2014

High prevalence of dihydropteroate synthase mutations in Pneumocystis jirovecii isolated from patients with Pneumocystis pneumonia in South Africa

scientific article

Impact of conjugate Haemophilus influenzae type b (Hib) vaccine introduction in South Africa.

scientific article published on October 2006

In vitro activity of faropenem against respiratory pathogens

scientific article published in March 2002

In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae

scientific article published on 17 November 2008

International genomic definition of pneumococcal lineages, to contextualise disease, antibiotic resistance and vaccine impact

scientific article published on 16 April 2019

Invasive Neisseria meningitidis with decreased susceptibility to fluoroquinolones in South Africa, 2009.

scientific article published on 4 August 2010

Invasive disease caused simultaneously by dual serotypes of Streptococcus pneumoniae

scientific article published on 8 November 2017

Invasive disease due to Haemophilus influenzae serotype b ten years after routine vaccination, South Africa, 2003-2009.

scientific article published on 26 November 2011

Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis

scholarly article

Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis

scientific article published on 15 May 2019

Meningococcal disease in South Africa, 1999-2002.

scientific article published on February 2007

Meningococcal serogroup Y lpxL1 variants from South Africa are associated with clonal complex 23 among young adults

article

Molecular Characterization of Corynebacterium diphtheriae Outbreak Isolates, South Africa, March-June 2015

scientific article

Molecular basis and clonal nature of increasing pneumococcal macrolide resistance in South Africa, 2000-2005.

scientific article published on 12 March 2008

Molecular characterization of emerging non-levofloxacin-susceptible pneumococci isolated from children in South Africa

scientific article published on 04 March 2009

Molecular characterization of invasive capsule null Neisseria meningitidis in South Africa ⬇️

scientific article

Neisseria meningitidis intermediately resistant to penicillin and causing invasive disease in South Africa in 2001 to 2005.

scientific article published on 23 July 2008

Phylogenetic Analysis of Invasive Serotype 1 Pneumococcus in South Africa, 1989 to 2013.

scientific article published on 9 March 2016

Pneumococcal lineages associated with serotype replacement and antibiotic resistance in childhood invasive pneumococcal disease in the post-PCV13 era: an international whole-genome sequencing study

scientific article published on 10 June 2019

Population snapshot of Streptococcus pneumoniae causing invasive disease in South Africa prior to introduction of pneumococcal conjugate vaccines

scientific article

Population snapshot of invasive serogroup B meningococci in South Africa from 2005 to 2008 ⬇️

scientific article

Prevalence of DHPS polymorphisms associated with sulfa resistance in South African Pneumocystis jirovecii strains.

scientific article

Putative novel cps loci in a large global collection of pneumococci

scientific article published on 11 June 2019

Quadriplex real-time polymerase chain reaction (lytA, mef, erm, pbp2b(wt)) for pneumococcal detection and assessment of antibiotic susceptibility

scientific article published on 11 October 2011

Region-specific diversification of the highly virulent serotype 1 Streptococcus pneumoniae

scientific article published on 11 August 2015

Sequence diversity of the factor H binding protein vaccine candidate in epidemiologically relevant strains of serogroup B Neisseria meningitidis

scientific article

Sequential triplex real-time PCR assay for detecting 21 pneumococcal capsular serotypes that account for a high global disease burden

scientific article published on 5 December 2012

Serotype 6C is associated with penicillin-susceptible meningeal infections in human immunodeficiency virus (HIV)-infected adults among invasive pneumococcal isolates previously identified as serotype 6A in South Africa

scientific article published on 23 August 2008

Single report of β-lactam resistance in an invasive Haemophilus influenzae isolate from South Africa mediated by mutations in penicillin-binding protein 3, 2003-2008.

scientific article published on 16 September 2010

The Fraction of Rhinovirus Detections Attributable to Mild and Severe Respiratory Illness in a Setting of High Human Immunodeficiency Virus Prevalence, South Africa, 2013–2015

scholarly article by Orienka Hellferscee et al published 22 December 2018 in Journal of Infectious Diseases

The global distribution and diversity of protein vaccine candidate antigens in the highly virulent Streptococcus pnuemoniae serotype 1.

scientific article published on 09 January 2017

Two cases of serotypeable and non-serotypeable variants of Streptococcus pneumoniae detected simultaneously during invasive disease

scientific article

Understanding pneumococcal serotype 1 biology through population genomic analysis

scientific article published on 8 November 2016

Visualizing variation within Global Pneumococcal Sequence Clusters (GPSCs) and country population snapshots to contextualize pneumococcal isolates

scientific article published on 30 April 2020

List of works by Mignon du Plessis

A mosaic tetracycline resistance gene tet(S/M) detected in an MDR pneumococcal CC230 lineage that underwent capsular switching in South Africa

An unusual pneumococcal sequence type is the predominant cause of serotype 3 invasive disease in South Africa

Analysis of penicillin-binding protein genes of clinical isolates of Streptococcus pneumoniae with reduced susceptibility to amoxicillin.

Bacterial genome-wide association study of hyper-virulent pneumococcal serotype 1 identifies genetic variation associated with neurotropism

Challenges and clinical relevance of molecular detection of Bordetella pertussis in South Africa

Challenges of using molecular serotyping for surveillance of pneumococcal disease

Clinical validation of multiplex real-time PCR assays for detection of bacterial meningitis pathogens

Clonal analysis of Neisseria meningitidis serogroup B strains in South Africa, 2002 to 2006: emergence of new clone ST-4240/6688.

Declining incidence of invasive meningococcal disease in South Africa: 2003-2016

Distribution of factor H binding protein beyond serogroup B: variation among five serogroups of invasive Neisseria meningitidis in South Africa

Emergence of endemic serogroup W135 meningococcal disease associated with a high mortality rate in South Africa

Emergence of levofloxacin-non-susceptible Streptococcus pneumoniae and treatment for multidrug-resistant tuberculosis in children in South Africa: a cohort observational surveillance study

Enterovirus genotypes among patients with severe acute respiratory illness, influenza-like illness, and asymptomatic individuals in South Africa, 2012-2014.

Epidemiology and Molecular Identification and Characterization of Mycoplasma pneumoniae, South Africa, 2012-2015.

Genomic analysis of nontypeable pneumococci causing invasive pneumococcal disease in South Africa, 2003-2013

Genomic differences among carriage and invasive nontypeable pneumococci circulating in South Africa ⬇️

Genomic resolution of an aggressive, widespread, diverse and expanding meningococcal serogroup B, C and W lineage

Global Distribution of Invasive Serotype 35D Streptococcus pneumoniae Isolates following Introduction of 13-Valent Pneumococcal Conjugate Vaccine. ⬇️

Global emergence and population dynamics of divergent serotype 3 CC180 pneumococci

HIV and influenza virus infections are associated with increased blood pneumococcal load: a prospective, hospital-based observational study in South Africa, 2009-2011.

High nasopharyngeal pneumococcal density, increased by viral coinfection, is associated with invasive pneumococcal pneumonia

High prevalence of dihydropteroate synthase mutations in Pneumocystis jirovecii isolated from patients with Pneumocystis pneumonia in South Africa

Impact of conjugate Haemophilus influenzae type b (Hib) vaccine introduction in South Africa.

In vitro activity of faropenem against respiratory pathogens

In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae

International genomic definition of pneumococcal lineages, to contextualise disease, antibiotic resistance and vaccine impact

Invasive Neisseria meningitidis with decreased susceptibility to fluoroquinolones in South Africa, 2009.

Invasive disease caused simultaneously by dual serotypes of Streptococcus pneumoniae

Invasive disease due to Haemophilus influenzae serotype b ten years after routine vaccination, South Africa, 2003-2009.

Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis

Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis

Meningococcal disease in South Africa, 1999-2002.

Meningococcal serogroup Y lpxL1 variants from South Africa are associated with clonal complex 23 among young adults

Molecular Characterization of Corynebacterium diphtheriae Outbreak Isolates, South Africa, March-June 2015

Molecular basis and clonal nature of increasing pneumococcal macrolide resistance in South Africa, 2000-2005.

Molecular characterization of emerging non-levofloxacin-susceptible pneumococci isolated from children in South Africa

Molecular characterization of invasive capsule null Neisseria meningitidis in South Africa ⬇️

Neisseria meningitidis intermediately resistant to penicillin and causing invasive disease in South Africa in 2001 to 2005.

Phylogenetic Analysis of Invasive Serotype 1 Pneumococcus in South Africa, 1989 to 2013.

Pneumococcal lineages associated with serotype replacement and antibiotic resistance in childhood invasive pneumococcal disease in the post-PCV13 era: an international whole-genome sequencing study

Population snapshot of Streptococcus pneumoniae causing invasive disease in South Africa prior to introduction of pneumococcal conjugate vaccines

Population snapshot of invasive serogroup B meningococci in South Africa from 2005 to 2008 ⬇️

Prevalence of DHPS polymorphisms associated with sulfa resistance in South African Pneumocystis jirovecii strains.

Putative novel cps loci in a large global collection of pneumococci

Quadriplex real-time polymerase chain reaction (lytA, mef, erm, pbp2b(wt)) for pneumococcal detection and assessment of antibiotic susceptibility

Region-specific diversification of the highly virulent serotype 1 Streptococcus pneumoniae

Sequence diversity of the factor H binding protein vaccine candidate in epidemiologically relevant strains of serogroup B Neisseria meningitidis

Sequential triplex real-time PCR assay for detecting 21 pneumococcal capsular serotypes that account for a high global disease burden

Serotype 6C is associated with penicillin-susceptible meningeal infections in human immunodeficiency virus (HIV)-infected adults among invasive pneumococcal isolates previously identified as serotype 6A in South Africa

Single report of β-lactam resistance in an invasive Haemophilus influenzae isolate from South Africa mediated by mutations in penicillin-binding protein 3, 2003-2008.

The Fraction of Rhinovirus Detections Attributable to Mild and Severe Respiratory Illness in a Setting of High Human Immunodeficiency Virus Prevalence, South Africa, 2013–2015

The global distribution and diversity of protein vaccine candidate antigens in the highly virulent Streptococcus pnuemoniae serotype 1.

Two cases of serotypeable and non-serotypeable variants of Streptococcus pneumoniae detected simultaneously during invasive disease

Understanding pneumococcal serotype 1 biology through population genomic analysis

Visualizing variation within Global Pneumococcal Sequence Clusters (GPSCs) and country population snapshots to contextualize pneumococcal isolates