List of works - Sabine Gerbal-Chaloin

512 IN VITRO PRODUCTION OF HEPATOCYTES FROM HUMAN EMBRYONIC STEM CELLS

Activation of the Constitutive Androstane Receptor induces hepatic lipogenesis and regulates Pnpla3 gene expression in a LXR-independent way.

scientific article published on 11 May 2016

Activation of the aryl hydrocarbon receptor decreases rifampicin-induced CYP3A4 expression in primary human hepatocytes and HepaRG.

scientific article

Analysis of Glycogen Synthase Kinase Inhibitors That Regulate Cytochrome P450 Expression in Primary Human Hepatocytes by Activation of β-Catenin, Aryl Hydrocarbon Receptor and Pregnane X Receptor Signaling.

scientific article published on 10 August 2015

Brief report: benchmarking human pluripotent stem cell markers during differentiation into the three germ layers unveils a striking heterogeneity: all markers are not equal.

scientific article published on September 2011

Chromatin dynamics of gene activation and repression in response to interferon alpha (IFN(alpha)) reveal new roles for phosphorylated and unphosphorylated forms of the transcription factor STAT2

scientific article

Cold Preservation of Human Adult Hepatocytes for Liver Cell Therapy

scientific article published on 23 January 2015

Comparative effects of microtubules disruption on glucocorticoid receptor functions in proliferating and quiescent cells.

scientific article published in May 2010

Comparison of hepatic-like cell production from human embryonic stem cells and adult liver progenitor cells: CAR transduction activates a battery of detoxification genes.

scientific article published on September 2011

Cross-talk between xenobiotic detoxication and other signalling pathways: clinical and toxicological consequences

scientific article

Dissecting the First Transcriptional Divergence During Human Embryonic Development ⬇️

scientific article published on March 1, 2012

Dual effect of dexamethasone on CYP3A4 gene expression in human hepatocytes. Sequential role of glucocorticoid receptor and pregnane X receptor.

scientific article published on December 2001

Epidermal Growth Factor represses Constitutive Androstane Receptor expression in primary human hepatocytes and favors regulation by Pregnane X Receptor

scientific article published on 21 December 2017

First step of the cell-penetrating peptide mechanism involves Rac1 GTPase-dependent actin-network remodelling

scientific article published on April 2007

Human induced pluripotent stem cells in hepatology: beyond the proof of concept.

scientific article

Human pluripotent stem cells: from biology to cell therapy.

scientific article published on April 2010

Increased Hepatic PDGF-AA Signaling Mediates Liver Insulin Resistance in Obesity Associated Type 2 Diabetes.

scientific article

Is nuclear factor kappa-B the missing link between inflammation, cancer and alteration in hepatic drug metabolism in patients with cancer?

scientific article

Isolation and culture of adult human liver progenitor cells: in vitro differentiation to hepatocyte-like cells.

scientific article

Isolation, characterization, and differentiation to hepatocyte-like cells of nonparenchymal epithelial cells from adult human liver.

scientific article published on 5 April 2007

Ketoconazole and miconazole are antagonists of the human glucocorticoid receptor: consequences on the expression and function of the constitutive androstane receptor and the pregnane X receptor.

scientific article

MitoCeption: Transferring Isolated Human MSC Mitochondria to Glioblastoma Stem Cells.

scientific article published on 22 February 2017

Mitochondrial Complex I activity signals antioxidant response through ERK5.

scientific article

Modular bioreactor for primary human hepatocyte culture: medium flow stimulates expression and activity of detoxification genes.

scientific article

Novel role for carbohydrate responsive element binding protein in the control of ethanol metabolism and susceptibility to binge drinking

scientific article published on 06 May 2015

Nuclear receptors in the cross-talk of drug metabolism and inflammation.

scientific article published on February 2013

On the Possible Effect of Phytic Acid (Myo-Inositol Hexaphosphoric Acid, IP6) on Cytochromes P450 and Systems of Xenobiotic Metabolism in Different Hepatic Models

scientific article published in 2024

On the mechanism of non-endosomial peptide-mediated cellular delivery of nucleic acids.

scientific article published in December 2004

PBPK modeling of irbesartan: incorporation of hepatic uptake.

scientific article

Pathophysiological factors affecting CAR gene expression.

scientific article published on November 2003

Role of CYP3A4 in the regulation of the aryl hydrocarbon receptor by omeprazole sulphide.

scientific article published on 16 August 2005

Sex dictates the constitutive expression of hepatic cytochrome P450 isoforms in Göttingen minipigs

scientific article published on 09 August 2019

Skatole (3-Methylindole) Is a Partial Aryl Hydrocarbon Receptor Agonist and Induces CYP1A1/2 and CYP1B1 Expression in Primary Human Hepatocytes

scientific article

Skeletal muscle interleukin-6 regulates hepatic cytochrome P450 expression; effects of 16 weeks high fat diet and exercise

scientific article published on 21 November 2017

Synergistic activation of human pregnane X receptor by binary cocktails of pharmaceutical and environmental compounds

scientific article

The Anti-Cancer Drug Dabrafenib Is a Potent Activator of the Human Pregnane X Receptor

scientific article published on 08 July 2020

The PDK1 Inhibitor Dichloroacetate Controls Cholesterol Homeostasis Through the ERK5/MEF2 Pathway

scientific article published on 6 September 2017

The WNT/β-catenin pathway is a transcriptional regulator of CYP2E1, CYP1A2, and aryl hydrocarbon receptor gene expression in primary human hepatocytes.

scientific article published on 16 September 2014

The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors.

scientific article

The pregnane X receptor down-regulates organic cation transporter 1 (SLC22A1) in human hepatocytes by competing for ("squelching") SRC-1 coactivator

scientific article published on 27 February 2016

The sodium/iodide symporter NIS is a transcriptional target of the p53-family members in liver cancer cells.

scientific article published on 19 September 2013

The tangle of nuclear receptors that controls xenobiotic metabolism and transport: crosstalk and consequences.

scientific article published on January 2008

p53-paralog DNp73 oncogene is repressed by IFNα/STAT2 through the recruitment of the Ezh2 polycomb group transcriptional repressor. ⬇️

scientific article

List of works by Sabine Gerbal-Chaloin

512 IN VITRO PRODUCTION OF HEPATOCYTES FROM HUMAN EMBRYONIC STEM CELLS

Activation of the Constitutive Androstane Receptor induces hepatic lipogenesis and regulates Pnpla3 gene expression in a LXR-independent way.

Activation of the aryl hydrocarbon receptor decreases rifampicin-induced CYP3A4 expression in primary human hepatocytes and HepaRG.

Analysis of Glycogen Synthase Kinase Inhibitors That Regulate Cytochrome P450 Expression in Primary Human Hepatocytes by Activation of β-Catenin, Aryl Hydrocarbon Receptor and Pregnane X Receptor Signaling.

Brief report: benchmarking human pluripotent stem cell markers during differentiation into the three germ layers unveils a striking heterogeneity: all markers are not equal.

Chromatin dynamics of gene activation and repression in response to interferon alpha (IFN(alpha)) reveal new roles for phosphorylated and unphosphorylated forms of the transcription factor STAT2

Cold Preservation of Human Adult Hepatocytes for Liver Cell Therapy

Comparative effects of microtubules disruption on glucocorticoid receptor functions in proliferating and quiescent cells.

Comparison of hepatic-like cell production from human embryonic stem cells and adult liver progenitor cells: CAR transduction activates a battery of detoxification genes.

Cross-talk between xenobiotic detoxication and other signalling pathways: clinical and toxicological consequences

Dissecting the First Transcriptional Divergence During Human Embryonic Development ⬇️

Dual effect of dexamethasone on CYP3A4 gene expression in human hepatocytes. Sequential role of glucocorticoid receptor and pregnane X receptor.

Epidermal Growth Factor represses Constitutive Androstane Receptor expression in primary human hepatocytes and favors regulation by Pregnane X Receptor

First step of the cell-penetrating peptide mechanism involves Rac1 GTPase-dependent actin-network remodelling

Human induced pluripotent stem cells in hepatology: beyond the proof of concept.

Human pluripotent stem cells: from biology to cell therapy.

Increased Hepatic PDGF-AA Signaling Mediates Liver Insulin Resistance in Obesity Associated Type 2 Diabetes.

Is nuclear factor kappa-B the missing link between inflammation, cancer and alteration in hepatic drug metabolism in patients with cancer?

Isolation and culture of adult human liver progenitor cells: in vitro differentiation to hepatocyte-like cells.

Isolation, characterization, and differentiation to hepatocyte-like cells of nonparenchymal epithelial cells from adult human liver.

Ketoconazole and miconazole are antagonists of the human glucocorticoid receptor: consequences on the expression and function of the constitutive androstane receptor and the pregnane X receptor.

MitoCeption: Transferring Isolated Human MSC Mitochondria to Glioblastoma Stem Cells.

Mitochondrial Complex I activity signals antioxidant response through ERK5.

Modular bioreactor for primary human hepatocyte culture: medium flow stimulates expression and activity of detoxification genes.

Novel role for carbohydrate responsive element binding protein in the control of ethanol metabolism and susceptibility to binge drinking

Nuclear receptors in the cross-talk of drug metabolism and inflammation.

On the Possible Effect of Phytic Acid (Myo-Inositol Hexaphosphoric Acid, IP6) on Cytochromes P450 and Systems of Xenobiotic Metabolism in Different Hepatic Models

On the mechanism of non-endosomial peptide-mediated cellular delivery of nucleic acids.

PBPK modeling of irbesartan: incorporation of hepatic uptake.

Pathophysiological factors affecting CAR gene expression.

Role of CYP3A4 in the regulation of the aryl hydrocarbon receptor by omeprazole sulphide.

Sex dictates the constitutive expression of hepatic cytochrome P450 isoforms in Göttingen minipigs

Skatole (3-Methylindole) Is a Partial Aryl Hydrocarbon Receptor Agonist and Induces CYP1A1/2 and CYP1B1 Expression in Primary Human Hepatocytes

Skeletal muscle interleukin-6 regulates hepatic cytochrome P450 expression; effects of 16 weeks high fat diet and exercise

Synergistic activation of human pregnane X receptor by binary cocktails of pharmaceutical and environmental compounds

The Anti-Cancer Drug Dabrafenib Is a Potent Activator of the Human Pregnane X Receptor

The PDK1 Inhibitor Dichloroacetate Controls Cholesterol Homeostasis Through the ERK5/MEF2 Pathway

The WNT/β-catenin pathway is a transcriptional regulator of CYP2E1, CYP1A2, and aryl hydrocarbon receptor gene expression in primary human hepatocytes.

The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors.

The pregnane X receptor down-regulates organic cation transporter 1 (SLC22A1) in human hepatocytes by competing for ("squelching") SRC-1 coactivator

The sodium/iodide symporter NIS is a transcriptional target of the p53-family members in liver cancer cells.

The tangle of nuclear receptors that controls xenobiotic metabolism and transport: crosstalk and consequences.

p53-paralog DNp73 oncogene is repressed by IFNα/STAT2 through the recruitment of the Ezh2 polycomb group transcriptional repressor. ⬇️