List of works - Nicholas D.E. Greene

A new mechanism for cannabidiol in regulating the one-carbon cycle and methionine levels in Dictyostelium and in mammalian epilepsy models

scientific article published on 03 January 2020

A novel mouse model for genetic variation in 10-formyltetrahydrofolate synthetase exhibits disturbed purine synthesis with impacts on pregnancy and embryonic development

scientific journal article

A targeted sequencing panel identifies rare damaging variants in multiple genes in the cranial neural tube defect, anencephaly.

scientific article

Abnormalities of floor plate, notochord and somite differentiation in the loop-tail (Lp) mouse: a model of severe neural tube defects.

scientific article published on April 1998

Analysis of CLN3-protein interactions using the yeast two-hybrid system.

scientific article

Analysis of the planar cell polarity gene Vangl2 and its co-expressed paralogue Vangl1 in neural tube defect patients.

scientific article published in July 2005

Apoptosis is not required for mammalian neural tube closure.

scholarly article

Biomechanical coupling facilitates spinal neural tube closure in mouse embryos

scientific article

Bloomsbury report on mouse embryo phenotyping: recommendations from the IMPC workshop on embryonic lethal screening

Both the folate cycle and betaine-homocysteine methyltransferase contribute methyl groups for DNA methylation in mouse blastocysts.

scientific article published on 2 December 2014

Cardiovascular defects associated with abnormalities in midline development in the Loop-tail mouse mutant

scientific journal article

Cellular basis of neuroepithelial bending during mouse spinal neural tube closure.

scientific article published on 12 June 2015

Cellular mechanisms underlying Pax3-related neural tube defects and their prevention by folic acid

scientific article published on 22 November 2019

Claudins are essential for cell shape changes and convergent extension movements during neural tube closure

scientific article published on 22 May 2017

Convergent extension, planar-cell-polarity signalling and initiation of mouse neural tube closure

scientific journal article

D-chiro-inositol is more effective than myo-inositol in preventing folate-resistant mouse neural tube defects.

scientific article published in September 2002

Development of the vertebrate central nervous system: formation of the neural tube.

scientific article published on April 2009

Developmental expression of palmitoyl protein thioesterase in normal mice

scientific journal article

Differential protein expression at the stage of neural tube closure in the mouse embryo.

scientific article published on 27 August 2002

Do cells become homeless during neural tube closure?

scientific article published on 12 August 2009

Dynamic acetylation profile during mammalian neurulation

scientific article published on 23 November 2019

EphrinA-EphA receptor interactions in mouse spinal neurulation: implications for neural fold fusion.

scientific article published in January 2009

Epithelial fusion during neural tube morphogenesis.

scientific article published on 03 September 2012

Evaluation of folate metabolism gene polymorphisms as risk factors for open and closed neural tube defects

article

Excess methionine suppresses the methylation cycle and inhibits neural tube closure in mouse embryos

scientific article published on 21 April 2006

Expression of MUL, a gene encoding a novel RBCC family ring-finger protein, in human and mouse embryogenesis

scientific article (publication date: October 2001)

Expression pattern of glypican-4 suggests multiple roles during mouse development.

scientific article published in July 2005

Formate supplementation enhances folate-dependent nucleotide biosynthesis and prevents spina bifida in a mouse model of folic acid-resistant neural tube defects

scientific article published on 23 February 2016

Gene-environment interactions in the causation of neural tube defects: folate deficiency increases susceptibility conferred by loss of Pax3 function.

scientific article published on 26 August 2008

Genetic interactions between planar cell polarity genes cause diverse neural tube defects in mice

scientific article

Genetics and development of neural tube defects.

scientific article

Genetics of human neural tube defects

scientific article

Glycine decarboxylase deficiency causes neural tube defects and features of non-ketotic hyperglycinemia in mice

scientific article

Grainyhead genes and mammalian neural tube closure.

scientific article published on October 2008

High dietary folate in pregnant mice leads to pseudo-MTHFR deficiency and altered methyl metabolism, with embryonic growth delay and short-term memory impairment in offspring.

scientific article

High folic acid consumption leads to pseudo-MTHFR deficiency, altered lipid metabolism, and liver injury in mice.

scientific article

Host-Microbe Co-metabolism Dictates Cancer Drug Efficacy in C. elegans

scientific article

Identification of a transactivation motif in the CLN3 protein.

scientific article published in May 2001

Identification of the genomic mutation in Epha4(rb-2J/rb-2J) mice.

scientific article published in July 2016

Impaired folate 1-carbon metabolism causes formate-preventable hydrocephalus in glycine decarboxylase-deficient mice

scientific article published on 01 March 2020

Increased expression of Grainyhead-like-3 rescues spina bifida in a folate-resistant mouse model

scientific article published on 24 August 2007

Inositol for prevention of neural tube defects: a pilot randomised controlled trial - CORRIGENDUM

scientific article published on 26 February 2016

Inositol for the prevention of neural tube defects: a pilot randomised controlled trial

scientific article published on 5 February 2016

Inositol prevents folate-resistant neural tube defects in the mouse.

scientific article published in January 1997

Inositol, neural tube closure and the prevention of neural tube defects.

scientific article

Integrity of the methylation cycle is essential for mammalian neural tube closure.

scientific article

Lamin b1 polymorphism influences morphology of the nuclear envelope, cell cycle progression, and risk of neural tube defects in mice

scientific journal article

Mechanical properties measured by atomic force microscopy define health biomarkers in ageing C. elegans

scientific article published on 25 February 2020

Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism.

scientific article published on March 2013

Microtubules, polarity and vertebrate neural tube morphogenesis.

scientific article published on 29 March 2016

Mouse models of neural tube defects: investigating preventive mechanisms.

scientific article

Mutations in ZMYND10, a gene essential for proper axonemal assembly of inner and outer dynein arms in humans and flies, cause primary ciliary dyskinesia

scientific article

Mutations in radial spoke head protein genes RSPH9 and RSPH4A cause primary ciliary dyskinesia with central-microtubular-pair abnormalities

scientific article

Mutations in the planar cell polarity genes CELSR1 and SCRIB are associated with the severe neural tube defect craniorachischisis

scientific article

Neural plate morphogenesis during mouse neurulation is regulated by antagonism of Bmp signalling.

scientific article published in September 2007

Neural tube closure depends on expression of Grainyhead-like 3 in multiple tissues.

scientific article published in February 2018

Neural tube closure: cellular, molecular and biomechanical mechanisms

scientific article published on February 2017

Neural tube defects

scientific article published on 01 January 2014

Neural tube defects induced by folate deficiency in mutant curly tail (Grhl3) embryos are associated with alteration in folate one-carbon metabolism but are unlikely to result from diminished methylation

scientific article published on August 2010

Neural tube defects--disorders of neurulation and related embryonic processes

scientific article

Neural tube defects: prevention by folic acid and other vitamins.

scientific article

Novel exomphalos genetic mouse model: the importance of accurate phenotypic classification

scientific article

Novel mouse model of encephalocele: post-neurulation origin and relationship to open neural tube defects

scientific article published on 14 November 2019

Nucleotide precursors prevent folic acid-resistant neural tube defects in the mouse.

scientific article published on 08 August 2013

Over-expression of Grhl2 causes spina bifida in the Axial defects mutant mouse

scientific journal article

Oxidative Stress and Apoptosis in Benzo[a]pyrene-Induced Neural Tube Defects.

scientific article published on 5 January 2018

Partitioning of One-Carbon Units in Folate and Methionine Metabolism Is Essential for Neural Tube Closure

scientific article published in November 2017

Planar cell polarity genes and neural tube closure.

scientific article published on November 2003

Protein deiminases: new players in the developmentally regulated loss of neural regenerative ability.

scientific article published on 22 April 2011

Quantitative analysis of myo-inositol in urine, blood and nutritional supplements by high-performance liquid chromatography tandem mass spectrometry.

scientific article

Quantitative analysis of s-adenosylmethionine and s-adenosylhomocysteine in neurulation-stage mouse embryos by liquid chromatography tandem mass spectrometry

scientific article published on 04 August 2006

Refinement of inducible gene deletion in embryos of pregnant mice

scientific article published on 03 December 2019

Regional differences in the expression of laminin isoforms during mouse neural tube development.

scientific article published on 16 April 2011

Regulation of cell protrusions by small GTPases during fusion of the neural folds.

scientific article published on 26 April 2016

Regulation of glycine metabolism by the glycine cleavage system and conjugation pathway in mouse models of Non-Ketotic Hyperglycinemia

scientific article published on 02 August 2020

Rho GTPases in mammalian spinal neural tube closure.

scientific article published on 21 October 2016

Rho-kinase-dependent actin turnover and actomyosin disassembly are necessary for mouse spinal neural tube closure.

scientific article published on 3 June 2015

Sharing of PPT mutations between distinct clinical forms of neuronal ceroid lipofuscinoses in patients from Scotland.

scientific article published on September 1998

Specific isoforms of protein kinase C are essential for prevention of folate-resistant neural tube defects by inositol ⬇️

scientific article published on November 12, 2003

Spina bifida-predisposing heterozygous mutations in Planar Cell Polarity genes and Zic2 reduce bone mass in young mice.

scientific article published on 20 February 2018

Spinal neural tube closure depends on regulation of surface ectoderm identity and biomechanics by Grhl2.

scientific article published on 6 June 2019

Targeted Disruption of the Cln3 Gene Provides a Mouse Model for Batten Disease

article

The arginine methyltransferase <i>Carm1</i> is necessary for heart development

scientific article published in 2022

The genetic basis of mammalian neurulation.

scientific article

The recurrence risk of neural tube defects (NTDs) in a population with high prevalence of NTDs in northern China.

scientific article published on 3 August 2017

Understanding the causes and prevention of neural tube defects: Insights from the splotch mouse model.

scientific article published on April 2009

Use of high-frequency ultrasound to study the prenatal development of cranial neural tube defects and hydrocephalus in Gldc-deficient mice

scientific article published on 05 January 2017

Valproic acid disrupts the biomechanics of late spinal neural tube closure in mouse embryos.

scientific article published on 7 December 2017

Vangl-dependent planar cell polarity signalling is not required for neural crest migration in mammals.

scientific article

Vangl2 disruption alters the biomechanics of late spinal neurulation leading to spina bifida in mouse embryos.

scientific article published on 21 March 2018

Zic4, a zinc-finger transcription factor, is expressed in the developing mouse nervous system.

scientific article published in July 2005

List of works by Nicholas D.E. Greene

A new mechanism for cannabidiol in regulating the one-carbon cycle and methionine levels in Dictyostelium and in mammalian epilepsy models

A novel mouse model for genetic variation in 10-formyltetrahydrofolate synthetase exhibits disturbed purine synthesis with impacts on pregnancy and embryonic development

A targeted sequencing panel identifies rare damaging variants in multiple genes in the cranial neural tube defect, anencephaly.

Abnormalities of floor plate, notochord and somite differentiation in the loop-tail (Lp) mouse: a model of severe neural tube defects.

Analysis of CLN3-protein interactions using the yeast two-hybrid system.

Analysis of the planar cell polarity gene Vangl2 and its co-expressed paralogue Vangl1 in neural tube defect patients.

Apoptosis is not required for mammalian neural tube closure.

Biomechanical coupling facilitates spinal neural tube closure in mouse embryos

Bloomsbury report on mouse embryo phenotyping: recommendations from the IMPC workshop on embryonic lethal screening

Both the folate cycle and betaine-homocysteine methyltransferase contribute methyl groups for DNA methylation in mouse blastocysts.

Cardiovascular defects associated with abnormalities in midline development in the Loop-tail mouse mutant

Cellular basis of neuroepithelial bending during mouse spinal neural tube closure.

Cellular mechanisms underlying Pax3-related neural tube defects and their prevention by folic acid

Claudins are essential for cell shape changes and convergent extension movements during neural tube closure

Convergent extension, planar-cell-polarity signalling and initiation of mouse neural tube closure

D-chiro-inositol is more effective than myo-inositol in preventing folate-resistant mouse neural tube defects.

Development of the vertebrate central nervous system: formation of the neural tube.

Developmental expression of palmitoyl protein thioesterase in normal mice

Differential protein expression at the stage of neural tube closure in the mouse embryo.

Do cells become homeless during neural tube closure?

Dynamic acetylation profile during mammalian neurulation

EphrinA-EphA receptor interactions in mouse spinal neurulation: implications for neural fold fusion.

Epithelial fusion during neural tube morphogenesis.

Evaluation of folate metabolism gene polymorphisms as risk factors for open and closed neural tube defects

Excess methionine suppresses the methylation cycle and inhibits neural tube closure in mouse embryos

Expression of MUL, a gene encoding a novel RBCC family ring-finger protein, in human and mouse embryogenesis

Expression pattern of glypican-4 suggests multiple roles during mouse development.

Formate supplementation enhances folate-dependent nucleotide biosynthesis and prevents spina bifida in a mouse model of folic acid-resistant neural tube defects

Gene-environment interactions in the causation of neural tube defects: folate deficiency increases susceptibility conferred by loss of Pax3 function.

Genetic interactions between planar cell polarity genes cause diverse neural tube defects in mice

Genetics and development of neural tube defects.

Genetics of human neural tube defects

Glycine decarboxylase deficiency causes neural tube defects and features of non-ketotic hyperglycinemia in mice

Grainyhead genes and mammalian neural tube closure.

High dietary folate in pregnant mice leads to pseudo-MTHFR deficiency and altered methyl metabolism, with embryonic growth delay and short-term memory impairment in offspring.

High folic acid consumption leads to pseudo-MTHFR deficiency, altered lipid metabolism, and liver injury in mice.

Host-Microbe Co-metabolism Dictates Cancer Drug Efficacy in C. elegans

Identification of a transactivation motif in the CLN3 protein.

Identification of the genomic mutation in Epha4(rb-2J/rb-2J) mice.

Impaired folate 1-carbon metabolism causes formate-preventable hydrocephalus in glycine decarboxylase-deficient mice

Increased expression of Grainyhead-like-3 rescues spina bifida in a folate-resistant mouse model

Inositol for prevention of neural tube defects: a pilot randomised controlled trial - CORRIGENDUM

Inositol for the prevention of neural tube defects: a pilot randomised controlled trial

Inositol prevents folate-resistant neural tube defects in the mouse.

Inositol, neural tube closure and the prevention of neural tube defects.

Integrity of the methylation cycle is essential for mammalian neural tube closure.

Lamin b1 polymorphism influences morphology of the nuclear envelope, cell cycle progression, and risk of neural tube defects in mice

Mechanical properties measured by atomic force microscopy define health biomarkers in ageing C. elegans

Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism.

Microtubules, polarity and vertebrate neural tube morphogenesis.

Mouse models of neural tube defects: investigating preventive mechanisms.

Mutations in ZMYND10, a gene essential for proper axonemal assembly of inner and outer dynein arms in humans and flies, cause primary ciliary dyskinesia

Mutations in radial spoke head protein genes RSPH9 and RSPH4A cause primary ciliary dyskinesia with central-microtubular-pair abnormalities

Mutations in the planar cell polarity genes CELSR1 and SCRIB are associated with the severe neural tube defect craniorachischisis

Neural plate morphogenesis during mouse neurulation is regulated by antagonism of Bmp signalling.

Neural tube closure depends on expression of Grainyhead-like 3 in multiple tissues.

Neural tube closure: cellular, molecular and biomechanical mechanisms

Neural tube defects

Neural tube defects induced by folate deficiency in mutant curly tail (Grhl3) embryos are associated with alteration in folate one-carbon metabolism but are unlikely to result from diminished methylation

Neural tube defects--disorders of neurulation and related embryonic processes

Neural tube defects: prevention by folic acid and other vitamins.

Novel exomphalos genetic mouse model: the importance of accurate phenotypic classification

Novel mouse model of encephalocele: post-neurulation origin and relationship to open neural tube defects

Nucleotide precursors prevent folic acid-resistant neural tube defects in the mouse.

Over-expression of Grhl2 causes spina bifida in the Axial defects mutant mouse

Oxidative Stress and Apoptosis in Benzo[a]pyrene-Induced Neural Tube Defects.

Partitioning of One-Carbon Units in Folate and Methionine Metabolism Is Essential for Neural Tube Closure

Planar cell polarity genes and neural tube closure.

Protein deiminases: new players in the developmentally regulated loss of neural regenerative ability.

Quantitative analysis of myo-inositol in urine, blood and nutritional supplements by high-performance liquid chromatography tandem mass spectrometry.

Quantitative analysis of s-adenosylmethionine and s-adenosylhomocysteine in neurulation-stage mouse embryos by liquid chromatography tandem mass spectrometry

Refinement of inducible gene deletion in embryos of pregnant mice

Regional differences in the expression of laminin isoforms during mouse neural tube development.

Regulation of cell protrusions by small GTPases during fusion of the neural folds.

Regulation of glycine metabolism by the glycine cleavage system and conjugation pathway in mouse models of Non-Ketotic Hyperglycinemia

Rho GTPases in mammalian spinal neural tube closure.

Rho-kinase-dependent actin turnover and actomyosin disassembly are necessary for mouse spinal neural tube closure.

Sharing of PPT mutations between distinct clinical forms of neuronal ceroid lipofuscinoses in patients from Scotland.

Specific isoforms of protein kinase C are essential for prevention of folate-resistant neural tube defects by inositol ⬇️