List of works - Gianni Chessari

ASTX660, a novel non-peptidomimetic antagonist of cIAP1/2 and XIAP, potently induces TNF-α dependent apoptosis in cancer cell lines and inhibits tumor growth

scientific article

An evaluation of force-field treatments of aromatic interactions

scientific article published on 01 July 2002

Application of fragment screening and fragment linking to the discovery of novel thrombin inhibitors.

scientific article published in February 2006

Application of fragment-based lead generation to the discovery of novel, cyclic amidine beta-secretase inhibitors with nanomolar potency, cellular activity, and high ligand efficiency

scientific article

Discovery of a Potent Nonpeptidomimetic, Small-Molecule Antagonist of Cellular Inhibitor of Apoptosis Protein 1 (cIAP1) and X-Linked Inhibitor of Apoptosis Protein (XIAP).

scientific article

Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function

scientific article

Diverse, high-quality test set for the validation of protein-ligand docking performance.

scientific article

Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Discovery of a Non-Alanine Lead Series with Dual Activity Against cIAP1 and XIAP

scientific article

From fragment to clinical candidate--a historical perspective.

scientific article published on 07 May 2009

Modeling water molecules in protein-ligand docking using GOLD.

scientific article

Noncovalent Functional-Group–Arene Interactions

scientific article published on 01 January 2007

PTEN deficiency promotes macrophage infiltration and hypersensitivity of prostate cancer to IAP antagonist/radiation combination therapy.

scientific article published on 20 January 2016

Recent developments in fragment-based drug discovery

scientific article

Resin dynamics contributes to the NMR line broadening of organic molecules grafted onto a polystyrene resin

scientific article published on 01 June 2002

Rotor synchronization of radiofrequency and gradient pulses in high-resolution magic angle spinning NMR

Sequence-specific minor groove binding by bis-benzimidazoles: water molecules in ligand recognition.

scientific article

Singly bridged calix

scientific article published on 01 August 2000

Trisubstituted acridine derivatives as potent and selective telomerase inhibitors.

scientific article published in October 2003

List of works by Gianni Chessari

ASTX660, a novel non-peptidomimetic antagonist of cIAP1/2 and XIAP, potently induces TNF-α dependent apoptosis in cancer cell lines and inhibits tumor growth

An evaluation of force-field treatments of aromatic interactions

Application of fragment screening and fragment linking to the discovery of novel thrombin inhibitors.

Application of fragment-based lead generation to the discovery of novel, cyclic amidine beta-secretase inhibitors with nanomolar potency, cellular activity, and high ligand efficiency

Discovery of a Potent Nonpeptidomimetic, Small-Molecule Antagonist of Cellular Inhibitor of Apoptosis Protein 1 (cIAP1) and X-Linked Inhibitor of Apoptosis Protein (XIAP).

Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function

Diverse, high-quality test set for the validation of protein-ligand docking performance.

Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Discovery of a Non-Alanine Lead Series with Dual Activity Against cIAP1 and XIAP

From fragment to clinical candidate--a historical perspective.

Modeling water molecules in protein-ligand docking using GOLD.

Noncovalent Functional-Group–Arene Interactions

PTEN deficiency promotes macrophage infiltration and hypersensitivity of prostate cancer to IAP antagonist/radiation combination therapy.

Recent developments in fragment-based drug discovery

Resin dynamics contributes to the NMR line broadening of organic molecules grafted onto a polystyrene resin

Rotor synchronization of radiofrequency and gradient pulses in high-resolution magic angle spinning NMR

Sequence-specific minor groove binding by bis-benzimidazoles: water molecules in ligand recognition.

Singly bridged calix

Trisubstituted acridine derivatives as potent and selective telomerase inhibitors.